Therapeutic efficacy validation of castor oil via reverse pharmacology.
Journal name: World Journal of Pharmaceutical Research
Original article title: Validation of therapeutic efficacy of castor oil (eranda taila) through reverse pharmacology
The WJPR includes peer-reviewed publications such as scientific research papers, reports, review articles, company news, thesis reports and case studies in areas of Biology, Pharmaceutical industries and Chemical technology while incorporating ancient fields of knowledge such combining Ayurveda with scientific data.
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Yadav Jyotsana, Mishra H. S. and Agarwal Ajay Kumar
World Journal of Pharmaceutical Research:
(An ISO 9001:2015 Certified International Journal)
Full text available for: Validation of therapeutic efficacy of castor oil (eranda taila) through reverse pharmacology
Source type: An International Peer Reviewed Journal for Pharmaceutical and Medical and Scientific Research
Doi: 10.20959/wjpr202320-29819
Copyright (license): WJPR: All rights reserved
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Summary of article contents:
Introduction
Castor oil, known as "Eranda taila" in Ayurveda, is derived from the seeds of the plant Ricinus communis Linn. This oil has been traditionally used for its various medicinal benefits and is recognized for its high therapeutic value across different parts of the plant, including the roots, leaves, and seeds. While castor oil is employed extensively in folk and traditional medicine, it has also gained approval as a stimulant laxative from the FDA. Its applications range from treating eye infections and liver disorders to being utilized in pharmaceuticals and organic pesticides.
Importance of Castor Oil in Ayurveda
In Ayurveda, castor oil holds a significant place among the "chatusnehas," which refers to the four essential oils used in managing diseases linked to vata dosha. According to classical Ayurvedic texts, castor oil facilitates the management of conditions caused by vitiation of vata, such as gout (vatarakta), abdominal lumps (gulma), and heart diseases (hridroga). The oil is recognized for its qualities of relieving pain and facilitating purgation, making it a common treatment for various ailments. It hence serves as a key therapeutic agent due to its capability to clear obstructions in the body channels (srotas).
Pharmacological Properties and Mechanisms
Castor oil exhibits multiple pharmacological properties rooted in its chemistry, particularly high levels of ricinoleic acid, which is responsible for its laxative effect. When ingested, castor oil is broken down in the intestines where ricinoleic acid is released. This substance stimulates intestinal glands and enhances propulsive gut activity, resulting in a laxative effect characterized by pain-free liquid stools. Additionally, preclinical studies suggest that ricinoleic acid possesses antioxidant and anti-inflammatory properties, which contribute to its therapeutic potential in wound healing and pain relief. Moreover, castor oil has been studied for its antibacterial activity against pathogens like Staphylococcus aureus and Shigella dysenteriae, enhancing its utility in treating infections.
Clinical Applications and Efficacy
Recent clinical studies have underscored the diverse applications of castor oil in modern medicine. For instance, it has been shown to promote labor induction in pregnant women and to be effective in managing knee osteoarthritis, yielding significant improvements without adverse effects commonly associated with pharmaceuticals like diclofenac sodium. Castor oil's efficacy extends to other conditions such as rheumatoid arthritis, where it has demonstrated better symptom control compared to other treatment modalities, highlighting its relevance in both traditional and contemporary medical practices.
Conclusion
Castor oil, or Eranda taila, is a versatile medicinal oil with a rich history in Ayurveda and modern medicine. Its wide-ranging applications in treating vata-related diseases showcase its importance in therapeutic practices. The combination of its traditional uses with innovative applications, such as labor induction and osteoarthritis management, marks castor oil as a valuable substance that bridges ancient wisdom with contemporary scientific understanding. Given its therapeutic benefits and minimal side effects when used appropriately, castor oil is rightly positioned as a potent remedy for various chronic ailments.
FAQ section (important questions/answers):
What is the main source and benefit of castor oil?
Castor oil, derived from the seeds of the castor plant (Ricinus communis), is known for its medicinal properties and is primarily used as a stimulant laxative, with applications in treating various health conditions, including eye infections and liver disorders.
How is castor oil prepared for use?
Castor oil is obtained through two primary methods: cold pressing, which produces a light-colored oil, and hot pressing, where seeds are boiled to extract the oil. The cold-drawn oil is often preferred for medicinal purposes.
What are the traditional therapeutic uses of castor oil in Ayurveda?
In Ayurveda, castor oil is valued for its ability to alleviate 'vata' disorders, improve digestion, and act as a purgative. It is effective in managing conditions like rheumatoid arthritis and various gastrointestinal issues.
What adverse effects are associated with castor oil usage?
Using castor oil may lead to side effects such as abdominal cramps, nausea, diarrhea, and dizziness. It is essential to use it under medical supervision to avoid unwanted complications.
Can castor oil pose any toxicity risks?
Yes, castor oil contains ricin, a toxic compound present in the seeds. Although ricin is largely removed during oil extraction, improper dosage can lead to severe symptoms and toxicity.
How does contemporary science view the benefits of castor oil?
Modern studies highlight castor oil's anti-inflammatory, analgesic, and antimicrobial properties. It is explored for roles in drug delivery and has shown potential in treating various diseases, including infections and certain cancers.
Glossary definitions and references:
Scientific and Ayurvedic Glossary list for “Therapeutic efficacy validation of castor oil via reverse pharmacology.”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.
1) Castor:
The term "Castor" primarily refers to the castor oil plant, scientifically known as Ricinus communis. It is significant in both traditional and modern usages due to its oil that possesses numerous medicinal properties. Castor oil is used as a laxative in medical treatments and has therapeutic applications in various ailments.
[Note: The above list is limited to 75. Total glossary definitions available: 176]
Other Science Concepts:
Discover the significance of concepts within the article: ‘Therapeutic efficacy validation of castor oil via reverse pharmacology.’. Further sources in the context of Science might help you critically compare this page with similair documents:
Ayurveda, Pittadosha, Ricinus communis, Castor oil, Laxative effect, Adverse effect, Traditional medicine, Pharmacological properties, Wound healing, Clinical study, Therapeutic efficacy, Anti-inflammatory properties, Ayurvedic manuscripts, Adjuvant therapy, Labor induction, Gastrointestinal obstruction, Ricinoleic acid, Insecticidal activity, Toxic compound.