A review on medicinal plant used in treatment of rheumatoid arthritis

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Journal name: World Journal of Pharmaceutical Research
Original article title: A review on medicinal plant used in treatment of rheumatoid arthritis
The WJPR includes peer-reviewed publications such as scientific research papers, reports, review articles, company news, thesis reports and case studies in areas of Biology, Pharmaceutical industries and Chemical technology while incorporating ancient fields of knowledge such combining Ayurveda with scientific data.
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Author:

Sanjay Vyas, Pooja Khanpara, Vishva Khunt and Dr. Shital Faldu


World Journal of Pharmaceutical Research:

(An ISO 9001:2015 Certified International Journal)

Full text available for: A review on medicinal plant used in treatment of rheumatoid arthritis

Source type: An International Peer Reviewed Journal for Pharmaceutical and Medical and Scientific Research

Doi: 10.20959/wjpr202320-30255

Copyright (license): WJPR: All rights reserved


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Summary of article contents:

Introduction

Rheumatoid arthritis (RA) is an autoimmune disorder characterized by chronic inflammation, primarily affecting the joints, but potentially impacting other organs as well. It occurs when the immune system erroneously attacks healthy tissues, causing symptoms such as swollen joints, stiffness, fatigue, and systemic inflammation. Epidemiological studies suggest that about 1% of the global population suffers from RA, with a higher prevalence in women. Traditional therapies generally involve synthetic medications to alleviate symptoms; however, many patients look to herbal medicine as a safer alternative to avoid adverse effects associated with long-term use.

The Role of Natural Plant Extracts in RA Treatment

Natural plant extracts and compounds (NPECs) have gained attention as potential therapeutic options for treating rheumatoid arthritis. Many medicinal herbs possess anti-inflammatory properties that can help relieve joint pain and reduce inflammation. For instance, ginger and turmeric have been documented for their effectiveness in alleviating inflammatory responses, making them valuable in managing RA symptoms. Recent research into the use of NPECs as a treatment option signifies a promising development in integrative medicine, blending traditional herbal knowledge with modern clinical approaches.

Medicinal Herbs with Anti-inflammatory Properties

Various medicinal plants have been identified for their anti-inflammatory effects in treating RA. Herbs such as willow bark, Himalayan cedar, and ashwagandha have shown significant efficacy in reducing pain and swelling. Willow bark, in particular, contains salicylates that act similarly to aspirin, alleviating discomfort associated with joint inflammation. Similarly, ashwagandha contains several alkaloids that contribute to its pain-relieving properties, showcasing the diverse possibilities of herbal therapies in managing chronic conditions.

Challenges and Considerations in Herbal Therapy

Despite the potential benefits, the use of herbal treatments warrants careful consideration. The complexity of RA, which exhibits a heterogeneous clinical presentation, necessitates further scientific evaluation of ancient remedies to ensure safety and efficacy. Many patients still rely on conventional treatments such as Disease-Modifying Antirheumatic Drugs (DMARDs) and Non-Steroidal Anti-Inflammatory Drugs (NSAIDs), pointing to the need for a cohesive approach that combines herbal and synthetic options rather than replacing one with the other.

Conclusion

Herbal therapy offers a compelling alternative for patients seeking relief from rheumatoid arthritis symptoms while minimizing the risks associated with conventional medications. A growing body of research emphasizes the potential of various medicinal plants in managing RA effectively. This review argues for increased exploration and integration of traditional herbal practices into modern medical frameworks, encouraging healthcare professionals to consider these natural remedies as viable options for holistic rheumatoid arthritis management. The emphasis on natural plant compounds signifies a noteworthy shift towards more inclusive healthcare solutions aimed at enhancing patient quality of life.

FAQ section (important questions/answers):

What is rheumatoid arthritis and its main characteristics?

Rheumatoid arthritis is an autoimmune disorder causing chronic inflammation in the joints and other body parts. It primarily leads to swollen joints and can impact multiple organs, affecting overall health and quality of life.

What are natural plant extracts used for in rheumatoid arthritis treatment?

Natural plant extracts and compounds (NPECs) are utilized as therapeutic options to alleviate symptoms of rheumatoid arthritis, providing anti-inflammatory and pain-relief benefits without the side effects often associated with synthetic medications.

What are some common symptoms of rheumatoid arthritis?

Common symptoms include joint pain, morning stiffness, joint swelling, fatigue, and fever. Nearly all experienced patients report joint tenderness and prolonged stiffness lasting for six weeks or more.

Can herbal plants effectively treat rheumatoid arthritis?

Yes, many herbal plants, such as turmeric, ginger, and ashwagandha, possess anti-inflammatory properties. They are effective in reducing pain and swelling associated with rheumatoid arthritis and are increasingly being researched for safer treatment options.

What are the risk factors for developing rheumatoid arthritis?

Risk factors include gender (more common in women), genetics, environmental exposures, and age. Individuals with a family history or other autoimmune disorders are also at higher risk.

Is there ongoing research into new rheumatoid arthritis treatments?

Yes, ongoing research is exploring the potential of stem cells and various natural compounds as novel treatment options. This promises innovative approaches with fewer adverse effects compared to traditional therapies.

Glossary definitions and references:

Scientific and Ayurvedic Glossary list for “A review on medicinal plant used in treatment of rheumatoid arthritis”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.

1) Rheumatoid arthritis:
Rheumatoid arthritis is a chronic autoimmune condition characterized by inflammation in the joints, where the body's immune system mistakenly attacks its own tissues. It leads to symptoms such as pain, stiffness, and swelling, ultimately affecting one’s quality of life. Understanding this condition is essential, especially when exploring herbal treatments.

2) Family:
In botanical terms, 'family' refers to a group of related plants that share common characteristics and genetic traits. For example, Zingiberaceae includes ginger and turmeric, both used for their anti-inflammatory properties. Understanding plant family classifications helps in identifying potential medicinal uses in traditional medicine.

3) India:
India is known for its rich tradition of herbal and Ayurvedic medicine, where many medicinal plants have been used for treating ailments, including rheumatoid arthritis. Its diverse flora offers numerous plants with therapeutic properties, highlighting the importance of traditional practices in modern healthcare.

4) Inflammation:
Inflammation is a biological response to harmful stimuli, such as pathogens or irritants, often associated with pain and swelling. In conditions like rheumatoid arthritis, inflammation occurs in joints leading to significant discomfort. Natural anti-inflammatory compounds from plants are frequently researched for their therapeutic potential in managing such conditions.

5) Gujarat:
Gujarat, a state in India, is recognized for its rich biodiversity and traditional practices in herbal medicine. The state's climate allows for the growth of various medicinal plants, contributing to the holistic approaches seen in Ayurvedic and traditional healing systems prevalent in the region.

6) Pain:
Pain is a significant symptom of rheumatoid arthritis, resulting from inflammation and joint damage. Understanding various pain management strategies, including herbal remedies, is vital in providing effective relief to individuals suffering from chronic conditions, thereby enhancing their quality of life.

7) Medicine:
Medicine encompasses a range of practices and substances used to prevent, diagnose, and treat illnesses. The exploration of traditional medicine, particularly herbal approaches, plays a critical role in expanding treatment options for diseases such as rheumatoid arthritis.

8) Activity:
In the context of pharmacology, 'activity' refers to the biological effects of a substance, including its efficacy in treating diseases. Evaluating the activity of natural plant extracts against inflammation can help identify potential treatments for rheumatoid arthritis.

9) Indian:
Indian herbal medicine forms a significant part of traditional healing practices, leveraging the country's vast biodiversity. Many plants, such as turmeric and ginger, are integral to Ayurvedic remedies aimed at treating inflammatory diseases, showcasing the importance of cultural practices in medicine.

10) Tree:
Trees often provide vital resources for herbal medicine. Their bark, leaves, and fruits contribute to various treatments, showcasing nature's wide array of medicinal properties.

11) Phytochemical:
Phytochemicals are bioactive compounds found in plants with beneficial effects on health. They play crucial roles in traditional medicine and can exhibit anti-inflammatory, antioxidant, or anticancer properties, contributing to the therapeutic potentials of various herbs used in treating rheumatoid arthritis.

12) Cina:
China boasts a long history of traditional medicine practices, including the use of herbal remedies. Plants like green tea (Camellia sinensis) have been extensively studied for their health benefits and roles in managing inflammatory diseases, such as rheumatoid arthritis, highlighting the global significance of herbalism.

13) Syzygium cumini:
Syzygium cumini, commonly known as jambolan, is a medicinal plant used in Ayurveda for its anti-inflammatory properties. Its leaves possess bioactive compounds that may alleviate symptoms of rheumatoid arthritis, showcasing the therapeutic potentials of indigenous plants.

14) Ashvagandha (Ashva-gandha, Ashvagamdha, Ashwagandha, Asvagandha):
Ashwagandha (Withania somnifera) is an adaptogenic herb celebrated for its stress-relieving and anti-inflammatory properties. Its roots are often employed in traditional medicine for alleviating joint pain, making it an essential component in the treatment of rheumatoid arthritis.

15) Swelling:
Swelling, a hallmark symptom of inflammatory conditions like rheumatoid arthritis, results from increased fluid accumulation in joints. Identifying and using natural anti-inflammatory agents can help mitigate swelling, offering a way to enhance patient comfort and mobility.

16) Disease:
Diseases, especially those caused by inflammation, pose significant health challenges. Exploring both pharmacological and herbal approaches can provide effective treatment options, particularly for conditions such as rheumatoid arthritis.

17) Stiffness:
Stiffness, particularly in joints, is a common symptom of rheumatoid arthritis, often most noticeable in the morning. Herbal treatments targeting stiffness can provide significant relief, emphasizing the therapeutic role of plants in managing such symptoms.

18) Science (Scientific):
Sciences encompass various fields studying natural and applied phenomena. In the context of medicine, integrating scientific research into herbal practices enhances understanding and develops effective treatment approaches for chronic conditions.

19) Patha:
Patha, or Cissampelos pareira, is a medicinal plant known for its anti-inflammatory properties. It is utilized in traditional medicine systems to treat various ailments, demonstrating the importance of local flora in developing treatments for conditions like rheumatoid arthritis.

20) Delhi:
Delhi serves as a hub for research and education in herbal medicine in India. Institutions and universities in Delhi actively study the medicinal properties of various plants, striving to integrate traditional and modern medicine for better health outcomes.

21) Rani:
In botanical terminology, 'Rani' often refers to certain medicinal plants or their applications in traditional medicine. In the context of herbal treatment, understanding the indigenous names and uses of plants contributes to enriching the scope of herbal research.

22) Sah:
Shah could refer to landmarks in pharmacological science or traditional medicine practices in India. Recognizing historical figures or scholars contributes to understanding the development of herbal practices and their significance in contemporary medicine.

23) Life:
In the context of health, life signifies a state of well-being, often affected by diseases such as rheumatoid arthritis. Promoting alternative treatments can enhance life quality by minimizing symptoms and improving mobility.

24) Rat:
Rats are often used as experimental models in pharmacological research. Studies involving herbal extracts on rat models can provide valuable insights into the efficacy and safety of potential treatments for chronic conditions like rheumatoid arthritis.

25) Zingiber officinale:
Zingiber officinale, commonly known as ginger, is renowned for its anti-inflammatory properties. Its use in traditional medicine has been documented for treating digestive issues and arthritis, exemplifying how culinary and herbal applications converge in health.

26) Withania somnifera:
Withania somnifera, widely known as Ashwagandha, is utilized in Ayurvedic medicine. Known to help alleviate stress and inflammation, it plays a crucial role in managing symptoms of rheumatoid arthritis, showcasing its significance in holistic health.

27) Curcuma longa:
Curcuma longa, or turmeric, contains curcumin, a potent anti-inflammatory compound. Its application in traditional medicine for treating arthritis highlights the importance of natural substances in achieving therapeutic benefits and managing chronic diseases.

28) New Delhi:
New Delhi is pivotal for health research in India, focusing on integrating traditional and modern medicine practices. The city's initiatives promote the understanding and use of herbal treatment options on a broader scale for various ailments.

29) Pharmacological:
Pharmacological studies investigate the biochemical mechanisms through which plant extracts exert their therapeutic effects. Understanding the pharmacological properties of herbal remedies helps in developing new treatments for conditions like rheumatoid arthritis.

30) Turmeric:
Turmeric, derived from Curcuma longa, is a spice known for its vibrant yellow color and significant anti-inflammatory properties. It has gained recognition as a powerful natural remedy useful in treating joint-related inflammation.

31) Shri-lanka (Srilanka, Sri-lanka, Shrilanka):
Sri Lanka is recognized for its rich biodiversity, leading to a treasure of medicinal plants used in traditional healing. The local flora plays a significant role in the management of several health conditions, including rheumatoid arthritis.

32) Vasaka (Vashaka):
Vasaka, or Justicia gendarussa, is a medicinal plant known for its anti-inflammatory properties. Its use in traditional healing reflects the importance of natural remedies in providing relief from painful conditions, such as rheumatoid arthritis.

33) Ashoka (Asoka):
The Ashoka tree (Saraca asoca) is traditionally used in Ayurvedic medicine for its anti-inflammatory effects. Its inclusion in herbal therapies emphasizes the therapeutic potential of plants in managing arthritis symptoms.

34) Satta (Shatta):
Satta may reference traditional medical practices or theories related to herbalism. Understanding local terminologies and their meanings can help enhance the application of herbal remedies in modern medical settings.

35) Adusa:
Adusa (Justicia gendarussa) is famed in Ayurveda for its anti-inflammatory effects. Utilizing this plant in treatments underscores the potential of indigenous flora in managing various health conditions, including joint pain.

36) Chang:
The term 'Chang' can represent various contexts in herbal and traditional medicine studies. It possibly acknowledges contributors or researchers in the study of medicinal properties of indigenous plants.

37) Fever:
Fever can accompany inflammatory diseases such as rheumatoid arthritis. Natural remedies are often explored for their ability to reduce fever and provide symptomatic relief, highlighting the need for effective herbal treatments.

38) Study (Studying):
Studies are crucial for establishing the efficacy of herbal remedies in treating conditions like rheumatoid arthritis. Research helps validate traditional knowledge, ensuring that plant-based therapies are backed by scientific evidence.

39) Hand:
In the context of rheumatoid arthritis, 'hand' refers to the specific joints often impacted by the disease, and understanding its implications helps devise targeted treatment options for affected individuals.

40) Veda:
The Vedas are ancient texts originating in India, which compile knowledge including medicine and herbal treatment practices. They reflect the foundational aspects of Ayurvedic principles and natural healing methods used in contemporary practice.

41) Devi:
Devis could reflect significant contributions of individuals in herbal studies or practices. Their work aids in understanding traditional methods and integrating them with modern healthcare systems.

42) Rice (Rce):
Rice, a staple food, holds nutritional value while also having potential anti-inflammatory properties. Its consumption can complement herbal treatments, contributing to overall well-being in individuals with chronic inflammatory conditions.

43) Drug:
Drugs are synthesized or extracted compounds utilized for treating diseases. Herbal drugs derived from plants showcase a rich history of natural medicine, reinforcing the importance of plant-based therapies.

44) Ter:
Therapeutic approaches involve strategies employed in the treatment of diseases. Integrating traditional herbal medicines into therapeutic regimens offers possibilities for improved patient outcomes in managing conditions such as rheumatoid arthritis.

45) Cinnamomum zeylanicum:
Cinnamomum zeylanicum, or Ceylon cinnamon, is noted for its anti-inflammatory properties. Useful in numerous culinary and medicinal applications, its compounds may support relief from symptoms associated with inflammatory diseases.

46) Cinnamomum cassia:
Cinnamomum cassia, commonly known as cassia or Chinese cinnamon, exhibits anti-inflammatory properties. It is used in traditional medicine systems to treat pain, aligning with the goals of alleviating rheumatoid arthritis symptoms.

47) Argyreia nervosa:
Argyreia nervosa, known as Hawaiian Baby Woodrose, has a history of traditional use for its psychoactive properties, as well as potential medicinal applications. It demonstrates the diversity of medicinal plants utilized in various cultural practices.

48) Pharmacology:
Pharmacology is the study of how drugs interact with biological systems. Researching the pharmacological properties of herbal remedies provides insight necessary for developing effective treatments for chronic diseases.

49) Saraca asoca:
Saraca asoca, known as the Ashoka tree, is valued in traditional medicine for its anti-inflammatory and mood-enhancing properties. Its role in managing conditions like rheumatoid arthritis represents the integration of nature in healthcare.

50) Afghanistan:
Afghanistan's rich biodiversity contributes to its array of medicinal plants used in traditional medicine. Recognizing how local flora supports health interventions, particularly in managing inflammatory conditions, is essential.

51) Knowledge:
Knowledge of herbal medicines encompasses understanding the properties and uses of plants in treating diseases. Preserving and expanding this knowledge is crucial for the continued incorporation of traditional remedies into healthcare practices.

52) Attacking:
In the context of rheumatoid arthritis, 'attacking' refers to the immune system's mistakenly targeting healthy joint tissues, leading to inflammation and damage. Understanding this process is vital for developing targeted treatments.

53) Flavonoid:
Flavonoids are natural compounds found in many plants known for their antioxidant and anti-inflammatory properties. They contribute to the therapeutic effects of various herbal remedies, assisting with chronic inflammation and diseases.

54) Cinnamon:
Cinnamon, derived from the bark of Cinnamomum species, is well-known for its anti-inflammatory and antioxidant properties. Its potential role in traditional medicine is notable in treating various inflammatory conditions.

55) Trivrit (Tri-vrit, Trivrt):
Trivrit (Argyreia nervosa) is noted in traditional medicine for its psychoactive properties. Understanding diverse plants used in historical and cultural contexts enriches the field of ethnopharmacology and its applications.

56) Perumal:
Perumal could refer to scholars or historical figures in traditional medicine. Comprehending their contributions aids the understanding of the evolution and application of herbal treatments in modern practices.

57) Quality:
Quality is essential in herbal medicine, determining the efficacy and safety of treatments. Establishing standards for herbal products ensures reliability and effectiveness in managing health conditions like rheumatoid arthritis.

58) Species:
Species refer to groups of plants or organisms classified based on shared characteristics. Understanding various plant species aids in categorizing their medicinal applications, vital for developing targeted therapies.

59) Allergy:
Allergies often exacerbate conditions like rheumatoid arthritis. Researching natural remedies with anti-inflammatory properties can be beneficial in alleviating allergic reactions and improving overall health in affected individuals.

60) Company:
Companies involved in herbal medicine play a crucial role in the quality assurance and distribution of herbal products. Their commitment to research and development ensures the efficacy of plant-based treatments for various conditions.

61) Animal:
Animal models play a vital role in biomedical research, particularly in testing the efficacy of herbal treatments. The insights gained contribute significantly to advancing understanding in pharmacology and treatment development.

62) Vaidya:
Vaidya refers to traditional healers or practitioners of Ayurveda in India. Their extensive knowledge of herbal medicine is essential for integrating traditional healing practices into contemporary healthcare frameworks.

63) Vishva (Visva, Vishvasa):
Vishva could relate to individuals or concepts in medicinal studies or alternative therapies. Understanding contributions from various cultures enriches the narrative of herbal medicine research.

64) Bombay:
Bombay, now known as Mumbai, is a major urban center in India, serving as a gateway for herbal medicine research and education. The city's rich cultural history is reflected in its approach to traditional healing.

65) Cancer:
Cancer is a serious condition characterized by uncontrolled cell growth. Research into herbal remedies highlights potential natural treatments that may yield positive outcomes in managing symptoms and improving quality of life for patients.

66) Bitter:
Bitter is often used to describe the taste profiles of certain herbal remedies. Bitter compounds can stimulate digestive processes and possess therapeutic benefits, contributing to their use in traditional medicine.

67) Medium:
Medium denotes the methods or substances used to extract or deliver herbal properties. Understanding various extraction techniques is essential for optimizing the effectiveness of plant-based therapies.

68) Costus:
Costus, particularly Costus speciosus, is recognized in traditional healing systems for its medicinal properties. Understanding its uses enhances the depth of knowledge regarding the efficacy of various plants in herbal medicine.

69) Valley:
Valleys often host diverse plant species, contributing to their biodiversity. Understanding the ecological significance of valleys aids research in identifying and utilizing local plants for medicinal purposes.

70) Lanka (Lamka, Lànkà):
Lanka, often synonymous with Sri Lanka, is rich in herbal diversity. The local flora plays a significant role in traditional medicine, highlighting the vast range of plants available for therapeutic use.

71) Gupta:
Gupta may refer to historical figures or scholarly contributions in herbal medicine. Recognizing their importance in advancing traditional practices enriches the narrative of alternative healing methods.

72) Indus:
The Indus Valley region is known for its ancient civilizations, which employed herbal remedies extensively. Understanding historical practices informs current approaches in the use of plants for therapeutic purposes.

73) Kumar:
Kumar may reference patents or researchers in the field of herbal studies. Acknowledging their contributions is essential in recognizing the progressive work within traditional and modern medicine.

74) Patel:
Patel could be a reference to notable individuals or families involved in herbal medicine practices. Their influence may highlight the integration of traditional healing methods in contemporary settings.

75) Patil:
Patil may also denote significant contributors or scholars in herbal and Ayurvedic practices, emphasizing the historical importance of their findings in understanding the efficacy of herbal treatments.

[Note: The above list is limited to 75. Total glossary definitions available: 87]

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Discover the significance of concepts within the article: ‘A review on medicinal plant used in treatment of rheumatoid arthritis’. Further sources in the context of Science might help you critically compare this page with similair documents:

Medicinal plant, Rheumatoid arthritis, Traditional medicine, Ayurvedic medicine, Chronic inflammation, Anti-inflammatory properties, Joint stiffness, Joint pain, Inflammatory condition, Herbal therapy, Genetic and environmental factors, Unani medicine, Clinical therapy, Natural plant extracts, Phytochemical constituent.

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