Prelim pharmacognostic and phytochemical analysis of Apamarga fruit.
Journal name: World Journal of Pharmaceutical Research
Original article title: Preliminary pharmacognostical and phytochemical analysis of fruit of apamarga (achyranthes aspera linn.)
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Dr. Mohammed Faisal and Dr Niveditha Shetty
World Journal of Pharmaceutical Research:
(An ISO 9001:2015 Certified International Journal)
Full text available for: Preliminary pharmacognostical and phytochemical analysis of fruit of apamarga (achyranthes aspera linn.)
Source type: An International Peer Reviewed Journal for Pharmaceutical and Medical and Scientific Research
Doi: 10.20959/wjpr202320-30241
Copyright (license): WJPR: All rights reserved
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Summary of article contents:
Introduction
The study conducted by Dr. Mohammed Faisal and Dr. Niveditha Shetty focuses on the preliminary pharmacognostical and phytochemical analysis of the fruit of Apamarga (Achyranthes aspera Linn). Emphasizing the importance of drug standardization in the context of identification, purity, safety, strength, and effectiveness, the research aims to provide foundational data for further experimentation. Apamarga is a traditional medicinal herb known for treating various conditions such as eczema, wounds, and poisoning. It exhibits a range of pharmacological actions, including diuretic, antimicrobial, and hypoglycemic effects.
Pharmacognostical Analysis
One of the significant aspects of this study is the detailed pharmacognostical analysis of the Apamarga fruit. The macroscopic characteristics reveal that the fruit is a one-seeded, cylindrical, shiny brown utricle measuring approximately 3mm in length and 1.5mm in thickness. Upon microscopic examination, the transverse sections exhibited rich internal structures, including a spool-shaped perisperm filled with starch grains, alongside vascular bundles and aleurone grains embedded in the cotyledons. The analysis established high-quality parameters through various physicochemical tests, affirming the fruit’s integrity as a medicinal source.
Phytochemical Composition
The preliminary phytochemical analysis identified several key compounds within the Apamarga fruit. The study utilized various extraction methods, producing observed extracts through aqueous, alcoholic, chloroform, and ethyl acetate. The results indicated the presence of alkaloids, steroids, carbohydrates, tannins, flavonoids, coumarins, and quinones among other phytochemicals. Interestingly, alkaloids and carbohydrates were consistent across most extracts, while steroids were primarily isolated in the chloroform extract. Such findings provide critical insights into the biochemical properties of Apamarga, supporting its efficacy in traditional medicine.
Physicochemical Analysis
The research also conducted comprehensive physicochemical evaluations, determining various parameters indicative of the fruit's characteristics. Loss on drying was assessed at 1.79%, indicating moisture content, while total ash content measured at 6.215%. Additionally, the acid-insoluble ash and water-soluble content revealed insights into the inorganic composition and the potential bioactive secondary metabolites. These physicochemical constants not only serve as benchmarks for standardization but also enhance the understanding of the Apamarga fruit’s quality and potency as a therapeutic agent.
Conclusion
In conclusion, this study provides vital pharmacognostical and phytochemical evidence of Apamarga (Achyranthes aspera Linn), contributing significantly to its standardization and elucidation of its medicinal properties. The incorporation of physicochemical constants alongside detailed analyses establishes a foundation for future studies, including animal experiments and clinical trials. Such research could pave the way for developing new therapeutic agents based on traditional Ayurvedic knowledge, validating the historical use of Apamarga in holistic medicine. The results underscore the fruit's relevance in contemporary pharmacological applications, offering reference standards for research and potential clinical utilization.
FAQ section (important questions/answers):
What is the significance of pharmacognostical analysis in drug standardization?
Pharmacognostical analysis is essential for identifying the drug's purity, safety, strength, and effectiveness, which are critical for further research and clinical applications.
What traditional uses are associated with Apamarga's fruit?
The fruit of Apamarga is traditionally used for treating conditions like Kandu, Vrana, and Visha, and is recognized for pharmacological actions such as diuretic and antimicrobial effects.
What were the main findings from the macroscopic analysis of Apamarga?
The fruit was identified as one-seeded, cylindrical, oblong, shiny brown, measuring about 3mm in length and 1.5mm in thickness, with a mealy sweet taste.
What physicochemical parameters were recorded for Achyranthes aspera fruit?
The total ash content was 6.215%, with specific values for loss on drying, acid insoluble ash, and water-soluble ash, aiding in the standardization of the drug.
Which phytochemicals were identified in the extracts of Apamarga fruit?
The study identified alkaloids, steroids, carbohydrates, tannins, flavonoids, coumarins, and quinones in various extracts, which contribute to the plant's clinical efficacy.
What is the impact of this research on future studies involving Apamarga?
This research establishes reference standards for pharmacognostical and phytochemical properties, facilitating animal experiments and clinical trials for new drug development.
Glossary definitions and references:
Scientific and Ayurvedic Glossary list for “Prelim pharmacognostic and phytochemical analysis of Apamarga fruit.”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.
1) Water:
Water is essential in pharmacognostic studies, particularly for extracting phytochemicals from plants. In the context of this study, water is used to prepare aqueous extracts of Apamarga, which helps in identifying water-soluble compounds that contribute to its medicinal properties and therapeutic effectiveness against various ailments.
2) Phytochemical:
Phytochemicals are bioactive compounds derived from plants, crucial for therapeutic effects. This study identifies various phytochemicals in Apamarga, indicating their potential contributions to its effectiveness against health issues, thereby supporting its traditional applications in medicine.
3) Drug:
In this context, a drug refers to a substance derived from plants, like Apamarga, utilized for therapeutic purposes. The study's objective is to standardize the drug through pharmacognostical analysis, ensuring its identification, purity, safety, and efficacy in treating specific health conditions.
4) Apamarga:
Apamarga, also known as Achyranthes aspera, is a medicinal plant extensively used in Ayurvedic practices. The study focuses on its fruit, analyzing its pharmacognostic and phytochemical properties to elucidate its traditional applications for various health problems, including respiratory issues and skin diseases.
5) Study (Studying):
The study is a scientific investigation focusing on the preliminary pharmacognostical and phytochemical analysis of Apamarga's fruit. It aims to provide reliable data on the plant's properties, contributing to the development of standards for its safe and effective use in herbal medicine.
6) Powder:
Powder refers to the form of the dried fruit of Apamarga that is analyzed in the study. Powder microscopy is employed to identify microscopic characteristics such as starch grains and fiber structures, which aid in confirming the plant's identity and quality as a medicinal substance.
7) Pharmacognostical:
Pharmacognostical analysis involves studying the physical and chemical properties of medicinal plants. In this study, it is crucial for establishing standard parameters for Apamarga, which ensures the quality and authenticity of the medicinal drug used in treating various ailments.
8) Flavonoid:
A flavonoid refers to an individual compound from the flavonoid group, detected during phytochemical analysis of Apamarga. Identifying specific flavonoids enhances understanding of the plant's therapeutic profile and its role in alleviating symptoms associated with various diseases.
9) Ayurveda (Ayus-veda):
Ayurveda is an ancient system of medicine from India, emphasizing the use of natural herbs for healing. The study relates to Ayurveda by investigating how the traditional use of Apamarga aligns with modern scientific standards of safety and efficacy in treating various health conditions.
10) Dravyaguna (Dravya-guna):
Dravyaguna is a branch of Ayurveda that focuses on understanding the properties and benefits of medicinal plants. The research carried out falls under this discipline, analyzing Apamarga's qualities to provide a scientific basis for its traditional uses.
11) Dravya:
Dravya refers to substances or materials in Ayurveda that possess medicinal properties. In this study, the fruit of Apamarga is investigated as a dravya, to establish its significance in herbal formulations and treatments for various ailments.
12) Field:
Field in this context refers to the natural habitat where Apamarga is collected. The study emphasizes the importance of sourcing plants in their natural environment to ensure the quality and authenticity of the raw materials for pharmacognostical analysis.
13) Pharmacological:
Pharmacological pertains to the study of drug actions and effects on biological systems. This study of Apamarga addresses the pharmacological activities related to its phytochemical constituents, which may validate its traditional uses in treating specific health conditions.
14) Discussion:
The discussion section of the study interprets the results from the analysis of Apamarga, linking findings to existing knowledge. It contextualizes the significance of identified phytochemicals within traditional medicinal practices, and their potential pharmacological impacts.
15) Disease:
Disease is a state of health impairment that Apamarga is used to address. The study investigates the fruit's properties to support its use in treating diseases, ultimately aiming to validate traditional knowledge through scientific methods.
16) Atyagni:
Atyagni is an Ayurvedic term that describes an aggravated digestive fire condition. The study of Apamarga explores its traditional application for symptom relief of Atyagni, aiming to provide a pharmacological basis for its effectiveness in digestive health.
17) Kashaya (Kasaya):
Kashaya refers to an astringent herbal decoction in Ayurvedic practice. Apamarga is often used in preparing kashaya, and the study seeks to analyze its therapeutic properties, providing insights into how it can be beneficial for various health conditions.
18) Surface:
Surface in this context may refer to the structure observed during powder microscopy, highlighting external characteristics of the plant material. Understanding surface features aids in the identification and quality assessment of Apamarga as a medicinal drug.
19) Animal:
Animal studies are crucial for validating the therapeutic effects of medicinal plants. The findings from this study may pave the way for future animal experiments to further explore the pharmacological activities of Apamarga and its potential efficacy in clinical settings.
20) Kandu (Kamdu):
Kandu is a term for itching or skin-related conditions in Ayurveda. This study discusses how Apamarga can be beneficial in treating conditions like Kandu, aiming to substantiate its traditional use through scientific findings.
21) Glass:
Glass refers to the laboratory equipment used during the experiments, such as glass beakers and flasks. This equipment is essential for performing chemical analyses and phytochemical extractions of Apamarga, ensuring accurate and reproducible results.
22) Table:
Table refers to the organized presentation of data, such as results of physicochemical and phytochemical analyses. Tables provide clarity and facilitate comparisons, playing a significant role in visualizing the findings of the study on Apamarga.
23) Visha (Visa):
Visha denotes toxicity or poisoning in Ayurveda. Apamarga is traditionally used for antidotal effects against Visha, and this study aims to analyze its pharmacological properties that can confirm its application in treating toxic conditions.
24) Leucoderma:
Leucoderma refers to a skin condition characterized by loss of pigmentation. The study points toward Apamarga's traditional use in addressing leucoderma, seeking to validate its effectiveness through pharmacognostical and phytochemical examination.
25) Snake-bite:
Snake-bite is a medical emergency treated in Ayurveda with various herbal remedies, including Apamarga. The study emphasizes the plant's potential therapeutic properties, aiming to provide scientific evidence supporting its traditional use in managing snake-bite symptoms.
26) Samgrahana (Sangrahana):
Sangrahana in Ayurveda relates to the collection or gathering process of herbs. The study underlines the importance of proper Sangrahana methods in collecting Apamarga, ensuring the quality and efficacy of the medicinal product utilized in treatments.
27) Antibiotic (Antibacterial):
Antibiotic refers to substances used to combat bacterial infections. The identified phytochemicals in Apamarga, as reported in the study, suggest potential antibiotic activity, supporting its traditional applications in managing infections.
28) Karnataka:
Karnataka is a state in India where the study was conducted. The region is significant for its rich biodiversity and traditional knowledge of medicinal plants like Apamarga, providing a suitable setting for researching its pharmacognostical properties.
29) Inference:
Inference refers to conclusions drawn from the analysis and findings of the study. Inferences regarding the pharmacological actions of Apamarga's phytochemicals are crucial for validating its traditional uses and for guiding future research.
30) Bleeding:
Bleeding refers to loss of blood due to injury or medical conditions. The study highlights Apamarga's traditional applications in managing bleeding, seeking to validate its effectiveness and foundation in the Ayurvedic approach to treating such conditions.
31) Scorpion:
Scorpion refers to a type of venomous creature whose sting can cause serious health issues. The study investigates Apamarga's traditional use as an antidote for scorpion stings, aiming to establish its efficacy through scientific evaluation.
32) Debility:
Debility signifies weakness or lack of strength in the body, often due to illness. The study emphasizes the use of Apamarga in treating conditions of debility, exploring its potential restorative properties supported by pharmacognostical evidence.
33) Samhita:
A Samhita refers to a specific text or compilation within the Ayurvedic tradition. The relevance of Samhitas is acknowledged in the study as a source of traditional knowledge guiding the understanding of Apamarga's medicinal properties.
34) Madhura:
Madhura means sweet in Ayurveda, referring to the taste of the fruit of Apamarga. The study discusses its Madhura rasa as a key characteristic that can influence its therapeutic effects in treating digestive conditions and more.
35) Habitat:
Habitat denotes the natural environment where Apamarga is found. Identifying the habitat is crucial for understanding the plant's ecological context, which impacts its growth, chemical composition, and consequent therapeutic properties.
36) Science (Scientific):
Science refers to the systematic study of the natural world through observation and experimentation. In this context, the research on Apamarga exemplifies the application of scientific methodologies to validate traditional medicinal practices and understand phytochemical properties.
37) Vipaka:
Vipaka pertains to the post-digestive effects of food and herbs. The study examines Apamarga's influence on Vipaka, which helps in understanding its broader impact on health and its suitability for various Ayurvedic formulations.
38) Vyadhin (Vyadhi):
Vyadhi is a Sanskrit term for disease or disorder in Ayurveda. The study investigates how Apamarga addresses different Vyadhi, aiming to provide evidence for its traditional use and validating its therapeutic role in managing various health conditions.
39) Family:
Family refers to the taxonomic classification of plants. Apamarga belongs to the Amaranthaceae family, and understanding its familial relationships aids in identifying related species with similar phytochemical properties and therapeutic potential.
40) Purity:
Purity in the context of pharmacognosy refers to the authenticity and quality of the medicinal plant. This study ensures the purity of Apamarga by conducting thorough analyses to confirm its identity and absence of contaminants, vital for effective treatment.
41) Vrana:
Vrana refers to ulcers or wounds in Ayurvedic terminology. The study aims to explore the applications of Apamarga in treating Vrana, substantiating its traditional use through empirical research in pharmacognostical and phytochemical contexts.
42) India:
India is the birthplace of Ayurveda and home to diverse medicinal flora including Apamarga. The study underscores the importance of Indian heritage in traditional medicine and lays emphasis on evolving medicinal research aligned with ancient practices.
43) Sindhi (Sindh, Shindhi):
Sindh is a region in Pakistan known for its historical use of medicinal plants. The mention of Sindh in the study of Apamarga highlights the geographical spread and traditional knowledge associated with this medicinal plant beyond India.
44) Cina:
China, like India, has a rich tradition of herbal medicine. Including China in the context of Apamarga indicates the plant's widespread use and recognition in various traditional medicinal practices across different cultures.
45) Hair:
Hair elements, especially glandular trichomes, noticed during examination of Apamarga, may provide additional medicinal value or defense mechanisms. Investigating these components sheds light on their potential roles in the plant's pharmacological effects.
46) Wall:
The term wall relates to the structural components of plant cells, significant in pharmacognostical studies. Analyzing wall properties aids in understanding the physical characteristics of Apamarga that can influence its efficacy as a medicinal substance.
47) Rasa (Rasha):
Rasa refers to the taste in Ayurveda that plays a significant role in the therapeutic effects of medicinal plants. The study considers the Rasa of Apamarga to comprehend its influence on patient treatment outcomes.
48) Yoga:
Yoga in this context typically refers to a method of preparing herbal formulations in Ayurveda. The study connects Apamarga to the broader Ayurvedic principles of Yoga, reflecting on how these principles contribute to its medicinal applications.
49) Dish (Dis):
A dish in this context is likely referring to laboratory glassware used to hold samples during analysis. Proper use of a dish is essential for conducting accurate tests, ensuring reliable results throughout the study of Apamarga.
Other Science Concepts:
Discover the significance of concepts within the article: ‘Prelim pharmacognostic and phytochemical analysis of Apamarga fruit.’. Further sources in the context of Science might help you critically compare this page with similair documents:
Kandu, Visha, Vrina, Flavonoid, Analytical study, Microscopy, Clinical trial, Loss on drying, Powder microscopy, Water soluble ash, Total ash, Physicochemical analysis, Aqueous extract, Pharmacological action, Acid insoluble ash, Diuretic, Antimicrobial, Extractive value, Tannin, Alcoholic extract, Achyranthes aspera Linn, Steroid, Standardization of drug, Ethyl Acetate, Alkaloid, World Journal of Pharmaceutical Research, Chloroform fraction, Coumarin, Phytochemical parameter, Carbohydrate, Spasmolytic, Macroscopy, Hypoglycemic, Macroscopic parameters, Quinone.