A study of pharmacognostic and pharmacological review on terminalia bellirica
Journal name: World Journal of Pharmaceutical Research
Original article title: A study of pharmacognostic and pharmacological review on terminalia bellirica
The WJPR includes peer-reviewed publications such as scientific research papers, reports, review articles, company news, thesis reports and case studies in areas of Biology, Pharmaceutical industries and Chemical technology while incorporating ancient fields of knowledge such combining Ayurveda with scientific data.
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P. Prabhavathi, Y. Prapurnachandra, M. Sreenivasulu, P. Thushara, S. Dayana, N. Kavya
World Journal of Pharmaceutical Research:
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Full text available for: A study of pharmacognostic and pharmacological review on terminalia bellirica
Source type: An International Peer Reviewed Journal for Pharmaceutical and Medical and Scientific Research
Doi: 10.20959/wjpr202321-30443
Copyright (license): WJPR: All rights reserved
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Summary of article contents:
Introduction
Terminalia bellirica is a significant Ayurvedic herb that has been recognized for its preventive and medicinal properties. Commonly known as Bheda, it is derived from the dried fruit pericarp of the large deciduous tree Terminalia bellirica Roxb. This plant is known to contain a variety of bioactive secondary metabolites, contributing to its therapeutic applications. Its popularity in traditional medicine can be attributed to the growing interest in herbal remedies for various ailments, particularly in regions such as India, Sri Lanka, and Southeast Asia. The phytochemical constituents found in Terminalia bellirica include glucosides, tannins, gallic acid, and others that confer numerous pharmacological benefits.
Antioxidant and Antimicrobial Effects
One of the most notable pharmacological effects of Terminalia bellirica is its antioxidant properties. Laboratory studies demonstrated that acetone extracts of the fruit exhibit significant free radical scavenging activity, making them effective in various in-vitro antioxidant assays. The ethyl acetate fraction was particularly noted for its superior antioxidant activity as compared to the crude acetone extracts. Additionally, Terminalia bellirica has shown broad-spectrum antimicrobial activity against various human pathogens, with aqueous extracts demonstrating significant inhibition against bacteria such as Staphylococcus aureus. This capacity to combat oxidative stress and microbial infections highlights its potential as a natural therapeutic agent.
Antidiabetic and Antihypertensive Properties
Terminalia bellirica’s role in managing diabetes has been substantiated through various studies. Gallic acid, an active compound isolated from the fruit, exhibited significant antidiabetic effects when tested in diabetic rat models. Administration of gallic acid led to marked reductions in plasma glucose levels and improved overall metabolic parameters, demonstrating its potential as a glucose-lowering agent. Furthermore, research indicated that Terminalia bellirica has antihypertensive effects, showing a reduction in blood pressure in animal studies. These findings reflect the plant’s utility in managing metabolic disorders effectively.
Additional Pharmacological Benefits
In addition to its antioxidant, antimicrobial, and antidiabetic properties, Terminalia bellirica has been documented for several other beneficial effects, including analgesic, antipyretic, and hepatoprotective activities. Various extracts have demonstrated pain relief in models of induced pain, confirming its traditional use for treating pain and discomfort. The antipyretic properties were confirmed in studies where both aqueous and ethanolic extracts mitigated fever in mice. The hepatoprotective effects were observed through the recovery of biochemical markers following CCl4-induced liver damage, further affirming the therapeutic potential of this plant.
Conclusion
Terminalia bellirica stands out as a versatile medicinal plant with diverse pharmacological properties driven by its rich phytochemical composition. Its applications in traditional medicine are supported by substantial scientific evidence highlighting its antioxidant, antimicrobial, antidiabetic, antihypertensive, analgesic, antipyretic, and hepatoprotective effects. However, there remains a need for further studies to explore and characterize the bioactive compounds in Terminalia bellirica to fully understand its medicinal potential. This knowledge can facilitate the development of new herbal therapies and contribute to holistic healthcare practices, emphasizing the significance of natural products in modern medicine.
FAQ section (important questions/answers):
What ailments can Terminalia bellirica be used to treat?
Terminalia bellirica can be used to treat various ailments such as conjunctivitis, asthma, migraine, baldness, constipation, and poor vision, among others.
What are the key phytoconstituents of Terminalia bellirica?
Key phytoconstituents of Terminalia bellirica include glucoside, tannins, gallic acid, ellagic acid, ethyl gallate, and chebulinic acid, contributing to its pharmacological properties.
What pharmacological effects does Terminalia bellirica exhibit?
Terminalia bellirica exhibits various pharmacological effects such as antioxidant, antimicrobial, antidiarrheal, anticancer, antihypertensive, antidiabetic, analgesic, and hepatoprotective properties.
How does Terminalia bellirica function as an antioxidant?
Terminalia bellirica exhibits antioxidant effects via free radical scavenging activity, particularly in extracts with high polyphenolic content.
What is the significance of gallic acid in Terminalia bellirica?
Gallic acid, isolated from Terminalia bellirica, shows significant antidiabetic effects by reducing plasma glucose levels and regenerating pancreatic beta-islet cells in diabetic models.
Where is Terminalia bellirica commonly found?
Terminalia bellirica is commonly found in India, Sri Lanka, Pakistan, and Bangladesh, thriving in monsoon and mixed deciduous forests.
Glossary definitions and references:
Scientific and Ayurvedic Glossary list for “A study of pharmacognostic and pharmacological review on terminalia bellirica”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.
1) Activity:
Activity relates to the inherent capabilities of Terminalia bellirica in influencing biological processes, such as its antibacterial, antioxidant, and anticancer effects. Each activity fosters therapeutic applications and demonstrates the plant’s potential in preventing or treating human ailments, thereby validating its role in traditional and modern medicine.
2) Terminalia bellirica:
Terminalia bellirica is a significant herbal plant, widely recognized in traditional medicine, especially in Ayurveda. It exhibits diverse medicinal properties and contains various phytochemicals. Its therapeutic potential in managing ailments underscores its relevance in both folkloric and scientific pharmacology, making it a focal point for ethnobotanical research.
3) India:
India is a rich repository of biodiversity and traditional medicinal knowledge, with Terminalia bellirica being extensively utilized. The country's cultural heritage includes Ayurvedic practices that leverage indigenous plants for healing, positioning India as a leader in herbal medicine, and emphasizing the need for research to validate these time-tested practices.
4) Pharmacological:
Pharmacological refers to the study of how drugs interact with biological systems, encompassing the therapeutic effects and mechanisms of action of substances like Terminalia bellirica. Understanding its pharmacological properties helps in developing effective treatments and validating traditional remedies, thereby bridging ancient knowledge with modern science.
5) Tree:
The term 'tree' highlights the botanical characteristics of Terminalia bellirica, which is a large deciduous tree. Its morphology includes substantial height and broad crown, contributing to its ecological significance. The plant's components, like bark and fruits, are integral to its medicinal properties, underlying its traditional and scientific importance.
6) Rat:
Rats have been used extensively in pharmacological studies to assess the efficacy and safety of plant extracts such as Terminalia bellirica. These animal models are crucial for understanding dosage, effects, and mechanisms before human trials, emphasizing their role in biomedical research and drug development.
7) Medicine:
Medicines include substances utilized for treating ailments. Terminalia bellirica is integral to traditional medicine systems, representing the importance of herbal remedies in healthcare, and emphasizing the necessity of research to substantiate their healing claims.
8) Cancer:
Cancer refers to a group of diseases characterized by uncontrolled cell growth. Research into Terminalia bellirica reveals its potential anticancer properties, suggesting that the phytochemicals it contains may inhibit tumor growth or contribute to cancer treatment, thus offering hope for new therapeutic strategies.
9) Phytochemical:
Phytochemicals are compounds produced by plants that contribute to their color, flavor, and disease resistance. Terminalia bellirica contains numerous beneficial phytochemicals, which are the basis for many of its health-promoting properties, thereby highlighting the significance of plant-based resources in medicine.
10) Antibiotic (Antibacterial):
Antibacterial refers to the ability of substances to combat bacterial infections. Terminalia bellirica demonstrates significant antibacterial properties, which are critical for developing natural remedies against pathogenic bacteria, thereby contributing to public health and the fight against antibiotic resistance.
11) Forest:
A forest, as a large area dominated by trees, is essential for maintaining environmental health. Terminalia bellirica thrives in forest ecosystems, showcasing the interconnectedness of plant life and medicinal uses, emphasizing the necessity of preserving these natural habitats.
12) Beta:
Beta often refers to a type of phytochemical, such as beta-sitosterol present in Terminalia bellirica. These compounds are known for various health benefits, including cholesterol management, and underscore the significance of studying specific constituents in herbal remedies for their therapeutic potential.
13) Shri-lanka (Srilanka, Sri-lanka, Shrilanka):
Sri Lanka is one of the native habitats of Terminalia bellirica, where traditional medicine practices utilize this plant. The recognition of indigenous plant species within local healthcare systems highlights the importance of preserving botanical diversity for future medicinal discoveries.
14) Disease:
Disease refers to a pathological condition of a bodily part. Terminalia bellirica is thought to be effective against several diseases due to its various pharmacological activities. Research into its effects broadens the knowledge base regarding natural treatments for ailments prevalent in various populations.
15) Species:
Species refers to a specific group of organisms with similar characteristics. Terminalia bellirica is part of the Terminalia genus, which contains various species, each with unique properties and potential applications in medicine, emphasizing biodiversity's role in pharmaceutical research.
16) Castor:
Castor often relates to castor oil, which is used in studies analyzing the efficacy of medicinal plants like Terminalia bellirica. Its association in research signifies the importance of establishing protective effects against ailments induced in experimental models.
17) Bahera:
Bahera is a common name for Terminalia bellirica. Known for its traditional medicinal applications, the name reflects its regional significance in folk medicine, facilitating its recognition and utilization in various cultural practices aligned with herbal health solutions.
18) Lanka (Lamka, Lànkà):
Lanka, referring to Sri Lanka, is significant as a native region for Terminalia bellirica. The cultural and historical connections between the plant and the land illustrate the importance of preserving traditional medicine while integrating modern research for effective healthcare practices.
19) Fever:
Fever is a common symptom indicating infection or disease. The potential antipyretic effects of Terminalia bellirica contribute to its traditional uses, emphasizing the relevance of studying its impact on temperature regulation and showcasing its significance in natural therapies.
20) Study (Studying):
Study signifies the systematic investigation of various aspects of Terminalia bellirica, including its pharmacological properties and phytochemical constituents. Research is critical to validate traditional knowledge and explore new therapeutic possibilities, bridging the gap between ancient practices and modern science.
21) Genu:
Genu refers to a joint or bend, a term mainly used in anatomy. While not directly related to Terminalia bellirica, contexts of joint health may be explored through traditional remedies, implying connections to studies of health benefits in herbal treatments.
22) Pain:
Pain is a distressing sensation indicating potential damage to the body. Terminalia bellirica is traditionally employed for pain relief, highlighting the need for scientific exploration of its analgesic properties, validating its use in managing various pain conditions.
23) Male:
Male often pertains to biological sex in studies, such as those involving rats. In research involving Terminalia bellirica, using male subjects can help eliminate sexual dimorphism in findings, ensuring accurate assessments of pharmacological effects across genders.
24) Pharmacology:
Pharmacology is the study of drug actions and interactions within biological systems. Research on Terminalia bellirica’s pharmacological properties enhances understanding of how its compounds can be utilized in therapeutic applications, promoting a greater integration of plant-based therapies in healthcare.
25) Purification:
Purification refers to the processes used to isolate active compounds from plant materials. In studies of Terminalia bellirica, purification techniques are essential for identifying specific phytochemicals that contribute to its therapeutic effects, paving the way for potential drug development.
26) Maharashtra (Maharastra, Maha-rashtra):
Maharashtra is a state in India where Terminalia bellirica is found. The region’s biodiversity and use of herbal medicine underscore the relevance of indigenous plants in local health practices, emphasizing the importance of documenting traditional knowledge for future research.
27) Anti-aging:
Anti-aging relates to properties that counteract the effects of aging. Terminalia bellirica is studied for its cosmetic applications in promoting skin health, showcasing the intersection of traditional herbal use and contemporary beauty care markets.
28) Developing:
Developing countries often rely on traditional medicinal practices. Terminalia bellirica plays a significant role in these systems, providing accessible healthcare options and addressing gaps in modern medicine, highlighting the importance of integrating local knowledge into global health solutions.
29) Substance:
Substance refers to a specific chemical compound or material. In studies involving Terminalia bellirica, identifying active substances is crucial for understanding their roles in pharmacological activities and facilitating the development of effective herbal remedies.
30) Knowledge:
Knowledge encompasses understanding gained through experience and study. Research on Terminalia bellirica enhances the collective knowledge of herbal medicine, contributing to the validation of traditional practices in contemporary health applications and promoting awareness of its benefits.
31) Ayurveda (Ayus-veda):
Ayurveda is a holistic healing system originating from India, wherein Terminalia bellirica is prominently featured. Its incorporation into Ayurvedic practices underscores the significance of natural remedies in promoting health and wellness, combining ancient wisdom with contemporary therapeutic approaches.
32) Triphala (Tri-phala):
Triphala is a traditional herbal formulation comprising three myrobalans, including Terminalia bellirica. Known for its broad health benefits, Triphala reflects synergy in herbal medicine, highlighting the importance of compound formulations in enhancing therapeutic outcomes.
33) Rasayana (Rasa-ayana):
Rasayana refers to a category of Ayurvedic herbs believed to promote longevity and rejuvenation. Terminalia bellirica’s inclusion in Rasayana formulations emphasizes its significance in enhancing vitality and health, tying traditional practices to modern health trends focused on wellness and aging.
34) Sanskrit:
Sanskrit is an ancient language of India, rich in medicinal literature. The historical references to Terminalia bellirica in Sanskrit texts signify its longstanding importance in traditional medicine, highlighting the cultural context of herbal remedies.
35) Surface:
Surface refers to the outer layer of any object. In botanical studies, understanding the plant surface properties of Terminalia bellirica may provide insights into its interaction with the environment and its absorption capabilities, relevant for pharmacological applications.
36) Marathi:
Marathi is a language spoken in Maharashtra, India, where Terminalia bellirica is utilized in folk medicine. The vernacular knowledge surrounding the plant emphasizes the cultural significance of its medicinal applications and the need to document and preserve such traditional practices.
37) Kannada:
Kannada is the language of a southern Indian state where Terminalia bellirica is known for its traditional uses. Understanding the regional languages associated with medicinal plants highlights the cultural context and local knowledge related to herbal medicine.
38) Habitat:
Habitat refers to the natural environment in which a species resides. Terminalia bellirica thrives in diverse habitats, which supports ecological balance. Recognizing and preserving these habitats is vital for ensuring the sustainability of medicinal plants and their benefits.
39) Leprosy:
Leprosy is an infectious disease historically treated with herbal remedies, including those from Terminalia bellirica. The plant’s traditional applications for various ailments highlight the importance of exploring herbal medicine as an alternative treatment option for historical diseases.
40) Tibetan:
Tibetan refers to the traditional medicinal practices from Tibet, which may utilize Terminalia bellirica. The shared knowledge across cultures emphasizes the significance of integrating different herbal traditions to enhance healthcare practices globally.
41) Siddha:
Siddha is a traditional medicine system in South India, which incorporates herbs like Terminalia bellirica. The presence of the plant in Siddha highlights the intercultural aspects of herbal medicine and the importance of documenting these practices for future health applications.
42) Madhya:
Madhya refers to the central region in India, where Terminalia bellirica is present. The area's unique biodiversity plays a significant role in traditional medicine, underscoring the need for thorough research to validate the efficacy of native herbal remedies.
43) Shanti (Santi, Samti, Shamti):
Shanti is a term that means peace in several Indian languages. The holistic health benefits provided by Terminalia bellirica contribute to overall well-being and balance, similar to the concept of shanti, highlighting the relationship between mental health and herbal medicine.
44) Akshaka (Aksaka):
Aksaka is a synonym for Terminalia bellirica in some Indian languages. Such vernacular naming underscores the cultural significance of the plant and reflects the diverse linguistic heritage associated with its medicinal use.
45) Aureus:
Aureus refers to Staphylococcus aureus, a bacteria against which Terminalia bellirica has demonstrated antibacterial properties. Understanding the interactions between medicinal plants and such pathogens is essential for developing effective natural treatments and addressing antibiotic resistance.
46) Punjab:
Punjab is a northern Indian state where Terminalia bellirica is found. The utilization of this plant in local medicinal knowledge signifies the cultural relevance of herbal medicine in addressing regional health issues, enhancing the understanding of its applications across diverse landscapes.
47) Family:
Family indicates the broader categorical classification in taxonomy, with Terminalia belonging to the Combretaceae family. Understanding its classification aids researchers in exploring related species, thereby contextualizing traditional uses and promoting further exploration of plant properties.
48) Nature:
Nature encompasses the environment and ecosystems where plants like Terminalia bellirica thrive. The natural properties of this plant and its contributions to biodiversity highlight the importance of environmental conservation for sustaining traditional remedies and future pharmaceutical developments.
49) Parrot:
Parrot refers to the color of young leaves, which have a striking copper-red hue resembling that of certain parrot species. This morphological characteristic highlights the aesthetic and ecological value of Terminalia bellirica within its habitat.
50) Indian:
Indian refers to the geographical and cultural context of Terminalia bellirica, emphasizing its significance in traditional medicine throughout India. The plant's extensive use and recognition within various cultural frameworks highlight the importance of preserving indigenous knowledge.
51) Aksha (Aksa):
Aksa is a vernacular name for Terminalia bellirica in certain Indian cultures. Its significance reflects the plant's traditional uses and the necessity for recognizing local terminologies in the broader understanding of herbal medicine.
52) Bheda:
Bheda is another name for Terminalia bellirica, commonly used in Ayurvedic practices. Its local terminology reflects the deep-rooted cultural significance and extensive applications of this plant within healing traditions.
53) Water:
Water is essential for plant growth, including Terminalia bellirica, and plays a significant role in its phytochemical production. The importance of understanding water's role emphasizes the ecological requirements for sustainable cultivation and conservation of medicinal plants.
54) Honey:
Honey is often associated with traditional remedies and health benefits. The strong honey-like odor of Terminalia bellirica's flowers signifies its ecological interactions, potentially attracting pollinators and enhancing its reproductive success in natural habitats.
55) Hindi (Himdi):
Hindi is a widely spoken language in India, where Terminalia bellirica is commonly referenced. The cultural and linguistic connections associated with the plant highlight the importance of regional languages in preserving traditional medicinal knowledge.
56) Cina:
China is another region where Terminalia bellirica is found and utilized in traditional medicine practices. The shared use across different cultures signifies the global relevance of herbal medicine and the need for cross-cultural research into therapeutic applications.
57) Tamil:
Tamil refers to the language spoken in the southern Indian state of Tamil Nadu, where Terminalia bellirica is recognized and used in folk medicine. Understanding regional languages reflects the cultural heritage of medicinal practices associated with the plant.
58) Hela (Helá):
Hela relates to cervical carcinoma cells used in cancer research. The effectiveness of Terminalia bellirica against such cell lines emphasizes the plant's potential as a complementary therapy in cancer treatment, showcasing the need for exploring herbal solutions.
59) Rich (Rch):
Rich in context often refers to the abundance of phytochemicals present in Terminalia bellirica. The wealth of bioactive compounds validates the plant's medicinal potential, underscoring the importance of research to fully explore its therapeutic applications.
60) Line:
Line signifies the continuous nature of research findings regarding Terminalia bellirica. In pharmacological studies, the evolution of knowledge over time creates a 'line' of inquiry that supports the plant's integration into modern medicine.
61) Pur:
Poor health conditions are prevalent in many regions, leading populations to rely on traditional medicines like Terminalia bellirica. This reliance emphasizes the importance of documenting and validating herbal remedies as viable alternatives to conventional pharmaceuticals in underserved communities.
Other Science Concepts:
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Herbal medicine, Therapeutic use, Bioactive substances, Analgesic effect, Antihypertensive effect, Phytochemical Profile, Hepatoprotective effect, Clinical approval, Antioxidant Effect, Antimicrobial effect, Antipyretic effect, Antidiabetic effect, Traditional medicinal system, Pharmacological effect, Anticancer effect, Phytoconstituent.