The truth about expired drugs

an in-depth review

| Posted in: Science

Journal name: World Journal of Pharmaceutical Research
Original article title: The truth about expired drugs
The WJPR includes peer-reviewed publications such as scientific research papers, reports, review articles, company news, thesis reports and case studies in areas of Biology, Pharmaceutical industries and Chemical technology while incorporating ancient fields of knowledge such combining Ayurveda with scientific data.
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Subtitle: an in-depth review

Original source:

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Author:

Pooja Agrawal, Virendra Kushwaha, Geeta Singh Rana, B. K. Shoraisham and Sonali Chandra


World Journal of Pharmaceutical Research:

(An ISO 9001:2015 Certified International Journal)

Full text available for: The truth about expired drugs

Source type: An International Peer Reviewed Journal for Pharmaceutical and Medical and Scientific Research

Doi: 10.20959/wjpr202321-30355

Copyright (license): WJPR: All rights reserved


Download the PDF file of the original publication


Summary of article contents:

Summary of "The Truth About Expired Drugs: An In-Depth Review"

Introduction

The article reviews the topic of drug expiration, emphasizing the significance of expiration dates as indicators of a medication's safety and effectiveness. The FDA mandates that pharmaceutical producers include expiration dates on their products, which helps to ensure that consumers are informed about the use of medications. Research indicates that many medications can retain their potency for a considerable time beyond their expiration dates, leading to discussions about proper management of expired drugs, disposal methods, and public awareness.

The Lasting Potency of Medications

Research suggests that a significant number of medications can maintain approximately 90% of their potency for at least five years after their labeled expiration date, given they are stored under optimal conditions. This notion, bolstered by studies like the FDA's Shelf Life Extension Program (SLEP), indicates that the expiration date does not necessarily signal the cessation of a drug's effectiveness. Certain drugs, especially those with solid dosage forms such as tablets and capsules, often have a greater stability beyond their specified expiration dates compared to liquid formulations, which can lose efficacy more rapidly.

Risks Associated with Expired Pharmaceuticals

Despite the potential longevity of many medications, caution is advised with certain drugs, such as nitroglycerin, insulin, epinephrine, and tetracycline, which should not be used past their expiration dates due to the risk of adverse effects. The article further discusses the dangers associated with the improper disposal of expired drugs, which can lead to environmental contamination and risks to wildlife and human health. The WHO has raised concerns regarding the impacts of low-quality antibiotics, including expired medications, on the emergence of antimicrobial resistance, particularly in lower-income countries.

Strategies for Managing Expired Drugs

Efforts to manage expired pharmaceuticals effectively include improved inventory management by healthcare providers, patient education on expiration date significance, and facilitating return programs for expired medications. Proper disposal methods for various pharmaceutical categories are also outlined, emphasizing the need for careful waste management to mitigate harmful environmental effects. Community pharmacists play a crucial role in dispensing information and practices regarding the safe disposal of expired drugs, paving the way for a responsible approach to medication management.

Conclusion

The expiration dates of medications serve as a guideline for their optimal effectiveness and safety. However, many drugs may still be potent after these dates, prompting debates about their use and the necessity for more refined policies regarding pharmaceuticals. It is essential to adhere to storage conditions, recognize vital exceptions to the use of expired medicines, and practice responsible disposal methods to prevent harm to individuals and the environment. Collaboration among government entities, pharmacists, and the pharmaceutical industry is vital to instill awareness about the proper handling of expired drugs and reduce associated risks.

FAQ section (important questions/answers):

What does drug expiration mean in pharmaceuticals?

Drug expiration refers to the specific date when a medication is no longer considered safe or effective for consumption. This date is determined by the manufacturer based on stability studies.

Can expired medications still be effective after their expiration date?

Research indicates that many medications can maintain up to 90% of their potency for at least five years past the expiration date if stored properly, although this varies by medication type.

What should be done with expired pharmaceuticals?

Expired medications should be properly disposed of to prevent harm. Community pharmacists can offer guidance on suitable disposal methods and may facilitate return programs for expired medications.

Are there any risks associated with using expired medications?

Using expired medications can lead to reduced effectiveness or potential adverse effects. Some medications, like nitroglycerin and tetracycline, should never be used after expiration due to safety concerns.

How does the FDA regulate drug expiration dates?

Since 1979, the FDA mandates that pharmaceutical manufacturers print expiration dates on medication labels, indicating the period during which efficacy and safety are guaranteed.

What role do pharmacists play in managing expired drugs?

Pharmacists educate patients about the importance of checking expiration dates and implementing proper disposal methods. They also facilitate safe return programs for expired medications.

Glossary definitions and references:

Scientific and Ayurvedic Glossary list for “The truth about expired drugs”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.

1) Drug:
Drugs are chemical substances that alter physiological processes in the body. The management of drugs includes understanding their potency over time, the impact of expiration dates, and the role of healthcare providers in educating patients about the safety and effectiveness of medications past these dates.

2) Antibiotic (Antibacterial):
Antibiotics are specific types of medicines that combat bacterial infections. The importance of their proper usage, adherence to expiration dates, and awareness of their potential to contribute to antibiotic resistance emphasizes the need for ongoing education and responsible management in healthcare settings.

3) Medicine:
Medicines are substances used for treatment or prevention of diseases. Knowledge of their expiry, storage conditions, and disposal is crucial to ensure safety and efficacy, highlighting the need for education among patients and healthcare providers regarding the effective management of medicines.

4) Study (Studying):
A study refers to a systematic investigation of a specific topic. Relevant studies on drug expiration demonstrate that many medications retain efficacy well beyond their labeled expiration dates, leading to discussions on proper management practices and potential policy revisions in the pharmaceutical industry.

5) Food:
Food substances, while primarily for nutrition, have parallels in the pharmaceutical realm regarding safety and quality. The relevance of understanding how expiration dates apply to food can inform perceptions of drug safety and potency, suggesting that expiration isn't an absolute indicator of ineffectiveness.

6) Life:
Life signifies the biological state of living organisms, which can be impacted by pharmacological interventions. Therefore, medicines play a vital role in enhancing quality of life, necessitating understanding their expiration to ensure that treatments remain effective and do not harm users.

7) Substance:
Substances encompass various materials, including drugs and biologically active chemicals. In pharmacology, the behavior of substances under different storage conditions and their effectiveness after expiration is a critical area of study for ensuring patient safety and optimal therapeutic outcomes.

8) Medium:
Medium may refer to a means or environment in which substances are stored or processed. In pharmacology, the appropriate medium for storage of medicines can affect their stability and potency, indicating the need for awareness regarding environmental factors impacting drug efficacy.

9) Knowledge:
Knowledge encompasses the information and understanding gained through experience or education. In pharmacology, effective knowledge-sharing about drug expiration and management among patients and providers is essential for minimizing risks and ensuring proper use of pharmaceuticals.

10) Pose:
Pose refers to presenting a particular question, situation, or challenge. In the medical field, the expiration of drugs poses significant issues related to safety, efficacy, and environmental concerns, necessitating thorough discussion and strategies for effective drug management.

11) Container:
Container signifies a vessel for holding substances. In pharmaceuticals, containers influence drug stability and integrity. Understanding the importance of proper packaging and storage conditions helps ensure that medications remain effective until their expiration date.

12) Quality:
Quality refers to the standard or grade of a substance. The quality of medicines is paramount in healthcare, as it directly impacts their efficacy and safety, emphasizing the role of manufacturers in ensuring that drugs retain their quality until their expiration date.

13) Water:
Water is a critical resource in both the formulation and consumption of medicines. In pharmacology, the purity and quality of water used in drug preparation and the implications of pharmaceutical waste on water sources are important topics in ensuring public health.

14) Pharmacology:
Pharmacology is the study of drugs and their interactions with biological systems. It encompasses understanding drug mechanisms, efficacy, and safety, including the implications of drug expiration on therapeutic applications and patient outcomes in clinical practice.

15) Education:
Education is vital in informing patients and healthcare providers about the proper management of medications, including adherence to expiration dates and the safe disposal of expired drugs, thereby enhancing public safety and optimizing therapeutic efficacy.

16) Activity:
Activity in pharmacological terms refers to the extent of a drug's effectiveness in producing a desired therapeutic effect. Understanding how drug activity may decline after expiration is essential for maintaining patient safety and effective treatment regimens.

17) Raising:
Raising pertains to the act of elevating or increasing awareness. In the pharmaceutical context, raising awareness about the implications of drug expiration and the importance of safe disposal practices is essential for protecting public health and ensuring responsible usage.

18) Powder:
Powder often refers to a solid substance composed of finely ground particles. In pharmaceuticals, the stability, dissolution, and efficacy of powdered medications can vary post-expiration, making understanding their properties and proper handling crucial for maintaining patient safety.

19) Pooja:
Pooja is a given name of the corresponding author of the reviewed article. Her contributions to the study emphasize the importance of collaborative efforts in advancing knowledge surrounding pharmaceutical expiration dates and their implications for public health.

20) Table:
Table refers to a systematic arrangement of data. In the context of the article, the table of drug types and their average extension times illustrates important findings related to the efficacy of medications beyond their labeled expiration dates, aiding in understanding drug management.

21) Blood:
Blood is a critical component of the human body often involved in health management. The efficacy of medications that affect blood processes, such as anticoagulants, must be carefully monitored with respect to expiration to prevent adverse effects and ensure patient safety.

22) Pharmacological:
Pharmacological relates to pharmacology and pertains to the effects of drugs on biological systems. Understanding pharmacological principles helps in managing medication usage, particularly in the context of how drugs behave after their expiration dates and their implications for therapeutic effectiveness.

23) Transformation (Transform, Transforming):
Transformation in pharmacology refers to chemical alterations drugs may undergo. Some medications could potentially change their chemical nature post-expiration, leading to unexpected effects, emphasizing the need for caution and adherence to expiration guidelines in medication management.

24) Accumulation (Accumulating, Accumulate):
Accumulation refers to the process of gathering or collecting over time. In the context of expired medications, the accumulation of unused pharmaceuticals presents potential health risks, necessitating effective disposal strategies to prevent adverse outcomes for both individuals and the environment.

25) Observation:
Observation signifies the act of watching, monitoring, or noting phenomena. Effective observation in drug studies underscores the importance of ongoing research regarding the stability and effectiveness of medications post-expiration, shaping guidelines for safe medical practices.

26) Discussion:
Discussion refers to the exchange of ideas or arguments on a topic. In pharmacology, discussions about drug expiration influence policy decisions, enhance understanding of medication management, and provide valuable insights for improving public health practices.

27) Science (Scientific):
Scientific relates to systematic knowledge-based inquiries. In the context of drug expiration, scientific studies provide empirical evidence about the efficacy and safety of medications, informing best practice guidelines in healthcare for medication management post-expiration.

28) Virendra:
Virendra is a co-author mentioned in the article, highlighting collaborative research efforts in the field of pharmaceutical sciences. His contributions strengthen the body of knowledge regarding drug expiration and its implications for patient safety and public health.

29) Toxicity:
Toxicity refers to the degree to which a substance can cause harm. Understanding drug toxicity in relation to expired medications is crucial, as certain drugs may become harmful after their expiration dates, requiring careful evaluation in clinical practices.

30) Chandra:
Chandra is mentioned as a co-author of the study, reflecting the collaborative nature of research in pharmacy. His involvement is significant in addressing pharmaceutical practices, particularly concerning drug expiration and safe management in healthcare settings.

31) Burning (Burn, Burned, Burnt):
Burn refers to incineration as a disposal method for expired pharmaceuticals. Properly executed burning reduces environmental contamination and safety risks associated with expired drugs, ensuring they do not pose harm to humans or ecosystems.

32) Hygiene (Hygienic):
Hygiene refers to practices that promote health and prevent disease. In the context of expired medications, maintaining hygiene in storage and disposal processes is critical to ensuring that drugs do not cause contamination or health risks.

33) Debate:
Debate refers to a discussion involving differing viewpoints. In pharmacology, debate surrounding drug expiration dates highlights the need for ongoing research and policy reform regarding medication safety and the management of expired pharmaceuticals.

34) Labour (Labor):
Labour signifies effort exerted to accomplish a task. In the context of the article, the labor of researchers and healthcare providers in managing expired drugs underscores the collective effort required to enhance patient safety and optimize pharmaceutical practices.

35) Street:
Street may refer to public health implications stemming from pharmaceutical disposal. The presence of expired medications in public spaces raises concerns about environmental contamination and accident risks, making community education on proper disposal practices essential.

36) Glass:
Glass is a material often used in pharmaceutical packaging. Understanding the properties of glass containers, including how they preserve medication integrity until expiration, is crucial for ensuring the safety and effectiveness of pharmaceuticals.

37) Tank:
Tank refers to any large vessel used in storage. In the context of expired drugs, tanks utilized for pharmaceutical waste management play a critical role in determining approaches to safely handle and contain hazardous substances in an environmentally sound manner.

38) Rana:
Rana is named as a co-author in the research study, illustrating collaborative contributions to understanding drug management. His role in this research emphasizes the importance of teamwork in advancing knowledge regarding pharmaceutical impact on health.

39) Sign:
Sign refers to indicators or symbols. In pharmacology, expiry dates printed on drug packaging are critical signs that alert users to the time frame in which medications are expected to be safe and effective for consumption.

40) Wall:
Wall can refer to barriers or boundaries in physical spaces, metaphorically highlighting the challenges faced in addressing drug expiration issues. Interventions to break down these barriers are necessary for effective pharmaceutical management practices.

41) Pain:
Pain refers to an unpleasant sensory experience often treated with medications. Managing pain effectively requires understanding the efficacy of pain-relief medications, especially how expiration impacts their effectiveness in providing relief and ensuring patient comfort.

42) Hand:
Hand can signify actions taken to manage medications, particularly in the context of disposal practices. The role hands play in handling expired drugs underscores the importance of proper management techniques to prevent harm and ensure safety.

43) Cow:
Cows may symbolize the environmental impact of pharmaceutical use, particularly in veterinary practices. The health risks posed by discarded or expired medications can extend to livestock, highlighting the need for responsible pharmaceutical management in agriculture.

Other Science Concepts:

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Discover the significance of concepts within the article: ‘The truth about expired drugs’. Further sources in the context of Science might help you critically compare this page with similair documents:

Adverse effect, Environmental pollution, Psychological factor, World Health Organisation, Medication management, Financial burden, Solid dosage form, Patient education, Food and Drug Administration, Government responsibility, Expiry date, Healthcare provider, Community pharmacist, Inventory management, Public hospital.

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