Synthesis and structure of a new polydentate ligand and its Ni(II) and Zn(II) complexes.
Journal name: World Journal of Pharmaceutical Research
Original article title: Synthesis and structural studies of a new polydentate ligand and its ni (ii) and zn (ii) complexes
The WJPR includes peer-reviewed publications such as scientific research papers, reports, review articles, company news, thesis reports and case studies in areas of Biology, Pharmaceutical industries and Chemical technology while incorporating ancient fields of knowledge such combining Ayurveda with scientific data.
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Dr. P. R. Logesh Kumar, Dr. P. Vasanth Kumar, Shaik Shaheen and Dandu Ayesha
World Journal of Pharmaceutical Research:
(An ISO 9001:2015 Certified International Journal)
Full text available for: Synthesis and structural studies of a new polydentate ligand and its ni (ii) and zn (ii) complexes
Source type: An International Peer Reviewed Journal for Pharmaceutical and Medical and Scientific Research
Doi: 10.20959/wjpr202322-30543
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Summary of article contents:
Introduction
The study details the synthesis and characterization of a new polydentate ligand, N-(2-hydroxyphenyl)-2-[(2-aminophenylamino)]acetamide (HPAPAA), and its complexation with nickel (Ni II) and zinc (Zn II) ions. The ligand was synthesized by reacting N-(2-hydroxyphenyl)-2-chloroacetamide with o-phenylenediamine. The resulting metal complexes were analyzed using various techniques, including infrared (IR), nuclear magnetic resonance (NMR), ultraviolet-visible (UV-Vis) spectroscopy, and atomic absorption spectroscopy (AAS). The study aimed to explore the structural properties and interactions of the synthesized complexes.
Synthesis of the Polydentate Ligand
The synthesized ligand, HPAPAA, was produced through a methodical approach where 2-amino phenol was treated with phenyl hydrazine to create a diazenyl compound. This compound was further reacted with a specific alcohol to yield the final ligand. The ligand's physical properties were characterized, including its solubility in various organic solvents and its melting point. The successful synthesis was confirmed through data from thin-layer chromatography (TLC) and elemental analysis, indicating good agreement between experimental and theoretical values for carbon, hydrogen, and nitrogen content.
Characterization Using Spectral Analysis
The ligand was thoroughly characterized using spectral techniques. The IR spectrum indicated distinct functional groups present in HPAPAA, with sharp bands signifying amino and hydroxyl stretching vibrations, while the NMR spectrum provided detailed information about the proton environment within the molecular structure. Peaks corresponding to various protons in the molecule confirmed the expected structure, supporting the constructed ligand framework. This spectral data plays a critical role in validating the synthesis approach and confirming the identity of the compound.
Metal Complex Formation and Properties
The study also emphasized the synthesis and characterization of metal complexes with Ni (II) and Zn (II) ions in a methanolic medium. Spectroscopic analyses revealed that both metal complexes exhibited non-electrolytic behavior, with a metal-to-ligand ratio of 1:1. Notably, the binuclear Ni (II) complex displayed subnormal magnetic moments, suggesting potential antiferromagnetic interactions. The ligand was determined to behave as a dibasic tridentate, coordinating to the metal ions through an ONO donor sequence, resulting in an octahedral complex for Ni (II) and a square planar geometry for Zn (II).
Conclusion
In conclusion, the research outlined a successful methodology for synthesizing and characterizing a new polydentate ligand and its metal complexes. The comprehensive use of various analytical techniques provided valuable insights into the structural properties of the ligand and its interactions with Ni (II) and Zn (II) ions. The results contribute to the broader knowledge of coordination chemistry and the potential applications of such ligand-metal interactions in fields such as pharmaceuticals and materials science. Further exploration of these complexes may reveal additional applications and implications for their use in diverse chemical environments.
FAQ section (important questions/answers):
What is the main focus of the study presented?
The study focuses on the synthesis and characterization of a new polydentate ligand, N-(2-hydroxyphenyl)-2-[(2-aminophenylamino)] acetamide (HPAPAA), and its Ni (II) and Zn (II) metal complexes.
How are the Ni (II) and Zn (II) complexes characterized?
The Ni (II) and Zn (II) complexes are characterized through spectral analysis including IR, NMR, UV-Vis, and AAS, as well as elemental analysis, conductivity, and magnetic susceptibility measurements.
What is the metal-to-ligand ratio in the complexes?
The metal-to-ligand ratio for both Ni (II) and Zn (II) complexes is found to be 1:1 during the synthesis.
What is the proposed geometry for Ni (II) and Zn (II) complexes?
Based on characterization data, an octahedral geometry is proposed for the Ni (II) complex and a square planar geometry for the Zn (II) complex.
What methods were used for the synthesis of the ligand?
The ligand was synthesized by reacting N-(2-hydroxyphenyl)-2-chloroacetamide with o-phenylenediamine in methanolic media under reflux conditions for several hours.
What are the solubility properties of the synthesized compounds?
The newly synthesized compounds are reported to be freely soluble in organic solvents such as DMSO, DMF, Methanol, and Ethanol.
Glossary definitions and references:
Scientific and Ayurvedic Glossary list for “Synthesis and structure of a new polydentate ligand and its Ni(II) and Zn(II) complexes.”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.
1) Kumar:
Kumar is the surname of several authors involved in the study, notably Dr. P. R. Logesh Kumar, who played a key role in the synthesis and structural studies of a new polydentate ligand and its metal complexes. The surname signifies a lineage and adds authority to the research.
2) Krishna (Krsna):
Krishna refers to the name of Sri Krishna Chaithanya College of Pharmacy, where the researchers work. The institution is located in Andhra Pradesh, India, and is dedicated to pharmaceutical education and research, highlighting its role in advancing science and contributing to community health.
3) Andhra (Amdhra):
Andhra refers to Andhra Pradesh, a state in India where the research took place. The location is significant for its educational institutions, rich cultural heritage, and the advancement of pharmaceutical sciences, indicating the regional contribution to scientific research and development.
4) India:
India is the country where the study was conducted, showcasing its growing emphasis on science and education. The country plays a crucial role in pharmaceutical research and development, indicating the global importance of its institutions in advancing medicinal chemistry and public health.
5) Road:
Road signifies the locale associated with Sri Krishna Chaithanya College of Pharmacy, specifically 'Nimmanapalli Road.' This detail emphasizes the geographic context of the research environment, contributing to the understanding of the college's accessibility and its community engagement in pharmaceutical education.
6) Measurement:
Measurement, in a scientific context, underscores the importance of accurate data collection and analysis in research. It ensures that the properties of the synthesized compounds are thoroughly characterized, facilitating a deeper understanding of their structural and functional attributes, which is crucial for developing novel applications.
7) Water:
Water, in this context, likely refers to its role as a solvent during the synthesis reactions carried out in the study. Its significance in chemical processes underscores its importance in laboratories as a universal solvent, highlighting its utility in facilitating chemical reactions and extractions.
8) Discussion:
Discussion in scientific literature is a section where researchers interpret their findings, compare them with existing literature, and explore the implications of their work. It serves as a platform for critical analysis, enabling researchers to provide context and future avenues for investigation based on their results.
9) Purity:
Purity indicates the degree to which the synthesized ligands and complexes are free from impurities. It is a vital aspect of chemical research, as pure compounds ensure reliable results in experiments, allowing for accurate characterization and potential application in pharmaceuticals and other fields.
10) Dandu (Damdu, Damduliga):
Dandu refers to Dandu Ayesha, one of the contributors to the research. This highlights the collaborative nature of scientific research, emphasizing the importance of teamwork in the discovery and development of new compounds and their characterization in pharmaceutical science.
11) Earth:
Earth signifies the broader ecological and geographical context in which the research occurs. It reflects the global aspect of scientific endeavors and may also imply a focus on sustainable practices in chemical development, connecting scientific study with environmental considerations in pharmaceutical research.
12) Study (Studying):
Study refers to the systematic investigation conducted by the authors aimed at understanding the synthesis and properties of a new polydentate ligand and its metal complexes. This emphasizes the scientific rigor involved in exploring novel compounds for potential applications in various fields, particularly pharmaceuticals.
13) Post:
Post likely refers to 'post-transition metals' in the context of coordination chemistry. These elements can form stable complexes with the synthesized ligands and are significant in understanding their structural properties and interaction behavior, providing insights into their potential applications and effectiveness in various scenarios.
Other Science Concepts:
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