Study on nitya virechana's effect in rheumatoid arthritis.
Journal name: World Journal of Pharmaceutical Research
Original article title: A clinical study to evaluate the effect of nitya virechana in amavata w.s.r rheumatoid arthritis
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Dr. Sangamesh Patil, Dr. Manjunath Kanthi and Dr. Niranjan Rao
World Journal of Pharmaceutical Research:
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Full text available for: A clinical study to evaluate the effect of nitya virechana in amavata w.s.r rheumatoid arthritis
Source type: An International Peer Reviewed Journal for Pharmaceutical and Medical and Scientific Research
Doi: 10.20959/wjpr202321-30340
Copyright (license): WJPR: All rights reserved
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Summary of article contents:
Introduction
This clinical study aimed to evaluate the efficacy of "Nitya Virechana" using "Gandharva Hastadi Erandataila" for patients suffering from "Amavata," which correlates closely with Rheumatoid Arthritis. Amavata is characterized by an imbalance of the body's doshas—specifically "Vata," "Pitta," and "Kapha"—along with the presence of "Ama." The study was conducted at Sri Dharmasthala Manjunatheshwara College of Ayurveda, and involved a single-blind, pre-test and post-test design with a total of 20 patients diagnosed with Amavata.
Understanding Amavata
Amavata is closely related to Rheumatoid Arthritis, a chronic autoimmune disease that primarily affects joints, leading to inflammation, pain, and potential joint damage. The condition affects about 1% of the population, with a higher prevalence in women, and it typically manifests between the ages of 35 and 50. The etiology is complex, involving genetic predisposition and various environmental triggers. The symptoms resemble those of Amavata, creating a challenge in treatment owing to the simultaneous need to balance the doshas and manage inflammation.
The Role of Nitya Virechana
"Nitya Virechana" serves as a critical therapeutic advance in managing Amavata by promoting the elimination of vitiated doshas through a detoxification process. This treatment aims to alleviate the accumulation of "Ama," thereby reducing the intensity of various symptoms such as pain, stiffness, and inflammatory markers. In this study, Nitya Virechana was administered for a duration of seven days, and the assessment was made on the first and seventh days to measure the improvements in clinical symptoms and relevant inflammatory markers.
Evidence of Effectiveness
The study results demonstrated significant improvements in numerous clinical parameters, such as reduced swelling, tenderness, and range of motion, alongside meaningful reductions in inflammatory markers like CRP, RA factor, and ASLO titers. For instance, the CRP levels showed a 27.96% improvement post-treatment, while RA factor levels improved by 27.70%. Such findings indicate that Nitya Virechana is an effective treatment protocol for patients suffering from Amavata, delivering promising results in symptomatic relief and overall disease management.
Conclusion
In conclusion, the clinical study illustrates that Nitya Virechana, coupled with Gandharva Hastadi Erandataila, is a promising and efficacious treatment approach for Amavata. The protocol not only aids in detoxifying the body but also significantly reduces inflammation and symptoms associated with this chronic condition. The favorable outcomes emphasize the necessity for holistic approaches in treating autoimmune disorders while also documenting the significant role of traditional Ayurvedic practices in contemporary medicine. Future studies with larger sample sizes and varied demographics could further validate these findings and enhance our understanding of treating Rheumatoid Arthritis through Ayurvedic methods.
FAQ section (important questions/answers):
What is Amavata and how does it relate to rheumatoid arthritis?
Amavata is an Ayurvedic term for a condition resembling rheumatoid arthritis, characterized by the involvement of morbid doshas (vata, pitta, kapha) and Ama. It leads to joint pain and inflammation, similar to the symptoms seen in rheumatoid arthritis.
What is Nitya Virechana and how is it administered?
Nitya Virechana is a therapeutic procedure in Ayurveda that involves daily cleansing through medicated oils. In this study, patients were given Gandharva Hastadi Erandataila for seven days to manage symptoms of Amavata.
What were the primary objectives of this clinical study?
The study aimed to evaluate the efficacy of Nitya Virechana with Gandharva Hastadi Erandataila in improving symptoms of Amavata, assessed through clinical signs and inflammatory markers over a seven-day treatment period.
What significant improvements were observed after treatment?
Post-treatment, significant improvements were noted in symptoms like pain, swelling, and inflammatory markers such as CRP, RA factor, and ASLO titers, indicating a positive response to the Nitya Virechana treatment.
Who were the subjects included in this study?
The study included 20 patients diagnosed with Amavata, aged 18-70, who satisfied specific diagnostic criteria. Exclusion criteria included individuals with systemic illnesses or other connective tissue disorders.
What are the implications of this study for Amavata treatment?
The study suggests that Nitya Virechana may be an effective treatment option for Amavata, significantly improving patient symptoms and inflammatory markers, and emphasizing the importance of a comprehensive treatment approach in Ayurveda.
Glossary definitions and references:
Scientific and Ayurvedic Glossary list for “Study on nitya virechana's effect in rheumatoid arthritis.”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.
1) Rheumatoid arthritis:
Rheumatoid arthritis is a chronic autoimmune disease characterized by inflammation of the joints, leading to pain, swelling, stiffness, and potential disability. This condition is more prevalent in women and typically affects peripheral joints symmetrically. In modern medicine, it is recognized for its complex interactions involving genetic and environmental factors.
2) Amavata (Ama-vata):
Amavata is an Ayurvedic term used to describe a condition that mimics rheumatoid arthritis, involving the interplay of vitiated doshas, particularly vata, pitta, and kapha, along with the presence of ama (toxins). It highlights a system in Ayurvedic philosophy that emphasizes balance and the treatment of chronic inflammatory conditions.
3) Disease:
Disease refers to a pathological condition of a living organism resulting from various factors like infection, genetics, or environmental influences. In the context of Amavata and rheumatoid arthritis, disease signifies the chronic nature of inflammatory conditions affecting joints, emphasizing the importance of comprehensive treatment strategies.
4) Patil:
Dr. Sangamesh Patil is a researcher and primary author of the study evaluating Nitya Virechana in Amavata. His work sheds light on Ayurvedic interventions for rheumatoid arthritis, contributing to the understanding of traditional medicine's relevance in contemporary healthcare through clinical studies and empirical evidence.
5) Nitya:
Nitya refers to the concept of regularity or consistency in Ayurveda. In the context of this study, it signifies the daily practice of Virechana (therapeutic purgation) to cleanse and detoxify the body, aiming at long-term improvement in patients suffering from Amavata or other chronic conditions.
6) Study (Studying):
The study is a scientific investigation that assesses the efficacy of Nitya Virechana in patients diagnosed with Amavata. Utilizing a clinical trial design with pre- and post-test measures, it aims to provide empirical data on the effectiveness of Ayurvedic treatments for rheumatoid arthritis, enhancing clinical understanding.
7) Dosha (Dosa):
Dosha refers to the three fundamental energies (vata, pitta, kapha) in Ayurvedic medicine that govern physiological and psychological processes. The balance between these doshas is critical for health; imbalances can lead to diseases like Amavata, illustrating the necessity of holistic approaches in treatment.
8) Table:
In the context of this study, the term 'Table' refers to organized data presentations that summarize findings, particularly the effects of Nitya Virechana on various symptoms and parameters associated with Amavata. It aids in the clear visualization of quantitative results from clinical assessments.
9) Ayurveda (Ayus-veda):
Ayurveda is an ancient system of medicine originating from India, emphasizing the balance between mind, body, and spirit. It incorporates natural therapies, including herbal remedies, dietary practices, and lifestyle modifications. The study exemplifies Ayurveda's relevance in managing chronic conditions like rheumatoid arthritis.
10) Swelling:
Swelling, or edema, is a hallmark symptom of inflammatory conditions such as Amavata and rheumatoid arthritis, characterized by fluid accumulation in tissues around affected joints. Reducing swelling is a primary goal of treatment strategies in both traditional and modern medical practices.
11) Pain:
Pain is a significant symptom associated with many diseases, including Amavata and rheumatoid arthritis. In the clinical study, pain assessment is crucial for evaluating the treatment's effectiveness, reflecting the patient's overall health status and quality of life.
12) Varanasi (Varanashi):
Varanasi is a city in India known as a cultural and spiritual hub. It is also a significant center for traditional medicine and Ayurveda. The study conducted by researchers from this region highlights the rich heritage of Ayurvedic practices integrated into modern healthcare methodologies.
13) Gandharva (Gamdharva, Gamdharvadurve):
Gandharva in the context of Ayurvedic medicine often refers to a class of herbal preparations. The term is associated with Gandharvahastadi Erandataila, a specific formulation used in the study for Virechana. Understanding its components is crucial for recognizing the potential benefits in treating Amavata.
14) Stiffness:
Stiffness is a common symptom in rheumatoid arthritis and Amavata, affecting the range of motion in joints. It signifies the underlying inflammation and joint damage. Analyzing stiffness in patients helps gauge treatment efficacy and impacts overall mobility and function.
15) Aruci:
Aruchi, or loss of appetite, is a symptom frequently associated with Amavata. In Ayurveda, it reflects digestive imbalances and can significantly affect a patient's overall health. Identifying and addressing Aruchi are integral in managing chronic conditions through dietary adjustments and treatment protocols.
16) Kapha:
Kapha is one of the three doshas in Ayurveda, representing the earth and water elements. Its imbalance is believed to contribute to various health issues, including those mimicking rheumatoid arthritis. Treatments aim to balance Kapha through dietary, herbal, and lifestyle strategies to restore health.
17) Karma (Karman):
Karma in Ayurvedic terminology refers to actions or treatments used to address health concerns. Nitya Virechana is an example of a therapeutic karma aimed at detoxifying the body. Understanding these practices helps ascertain their role in alleviating symptoms associated with chronic diseases.
18) Vata:
Vata is one of the three doshas in Ayurveda, characterized by qualities of movement and change. An imbalance in Vata is often implicated in chronic pain and inflammation, such as those seen in Amavata and rheumatoid arthritis, necessitating specific treatment approaches to restore balance.
19) Drug:
Drugs in the context of medicine refer to substances used to diagnose, cure, or prevent diseases. This study explores Ayurvedic drugs used for Nitya Virechana, highlighting their effectiveness in managing symptoms of chronic conditions like Amavata from both traditional and modern perspectives.
20) Inflammation:
Inflammation is a biological response to unwanted stimuli and is a key feature of chronic diseases like rheumatoid arthritis and Amavata. Effective treatments aim to reduce inflammation, alleviating symptoms such as pain, swelling, and stiffness, thus improving patients' quality of life.
21) Samshodhana (Samsodhana):
Samshodhana refers to detoxification and purificatory measures in Ayurveda. It includes techniques such as Virechana to cleanse the body of excess doshas, particularly in conditions like Amavata. Understanding these procedures is vital for implementing effective treatment protocols.
22) Kaphadosha (Kaphadosa, Kapha-dosha):
Kapha-dosha, one of the three body energies, relates to fluid balance, structure, and lubrication. Its imbalance can lead to excess mucus and swelling in joints, contributing to conditions like Amavata. Therapies aim to restore balance, mitigating disease symptoms.
23) Lakshana (Laksana):
Lakshanas are the specific characteristics or signs of a condition in Ayurvedic medicine. Identifying the Lakshanas of Amavata is crucial for diagnosis and guides treatment decisions aimed at alleviating symptoms through appropriate therapeutic measures.
24) Alasya:
Alasya, or lethargy, is a symptom associated with various health conditions, including Amavata. It signifies a decrease in energy and motivation, reflecting underlying imbalances. Addressing Alasya is crucial in holistic treatment plans to improve overall well-being and activity levels.
25) Hindi (Himdi):
Hindi is one of the principal languages spoken in India and is often used in Ayurvedic literature. The inclusion of Hindi in clinical studies helps disseminate findings to a broader audience, allowing practitioners and patients to engage with traditional practices in their native language.
26) Sign:
Sign, in a clinical context, refers to observable evidence of a disease. Understanding signs associated with Amavata and rheumatoid arthritis is essential for accurate diagnosis and treatment effectiveness, leading to tailored interventions and improved patient care.
27) Observation:
Observation in a clinical study context represents the meticulous assessment of patient responses to treatment. Detailed observations inform practitioners about the efficacy of Nitya Virechana in treating Amavata, aiding in refining treatment protocols and enhancing patient outcomes.
28) Agnimandya (Agni-mandya, Agnimamdya):
Agnimandhya, or impaired digestion, is a condition noted in Ayurveda that affects overall health and wellness. It is particularly relevant in the management of Amavata, as restoring digestive function is crucial for addressing underlying imbalances and promoting recovery.
29) Shodhana (Sodhana):
Shodhana translates to purification in Ayurveda, encompassing processes designed to detoxify the body from excess doshas. These techniques, including Virechana, are essential in treating chronic conditions like Amavata, ultimately facilitating the restoration of balance and health.
30) Medicine:
Medicine encompasses the science and art of diagnosing, treating, and preventing disease. In the context of this study, it refers to both Ayurvedic practices, which are holistic, and modern pharmacological approaches, aiming for comprehensive care for conditions like rheumatoid arthritis.
31) Anupana:
Anupana refers to the substance that accompanies a medicinal preparation, enhancing its effects. In the study, Shunti Kashaya served as an Anupana for Gandharvahastadi Erandataila, facilitating better absorption and efficacy of the main treatment.
32) Kashaya (Kasaya):
Kashaya is a type of Ayurvedic decoction made from boiling herbs in water. It is often used as a vehicle for administering medicine, enhancing its therapeutic effects. In this study, Kashaya plays a crucial role in the administration of the treatment for Amavata.
33) Eranda (Eramda):
Eranda, or Castor oil, is a significant herbal ingredient in Ayurveda, known for its purgative properties. It is a key component in Gandharvahastadi Erandataila, used for Nitya Virechana, supporting the detoxification process in managing conditions like Amavata.
34) Pitta:
Pitta is one of the three doshas in Ayurveda, representing fire and transformation. Its balance is crucial for digestion and metabolism. In conditions like Amavata, regulating Pitta is necessary as its disturbance contributes to inflammatory responses and symptoms.
35) Taila (Thaila):
Taila means oil in Sanskrit, frequently used in Ayurvedic treatments for its therapeutic properties. In this study, Gandharvahastadi Erandataila highlights the use of medicated oils to facilitate detoxification and manage symptoms of Amavata effectively.
36) Shri (Sri, Sr):
Shri is an honorific title used in India as a sign of respect, often prefixed to names, particularly in academic and professional contexts. It emphasizes the cultural and traditional importance, reflecting the authors' backgrounds and their contributions to Ayurveda.
37) Hand:
Hands are often the site of pain and disability in conditions like rheumatoid arthritis. Assessment of hand function is essential in both clinical evaluations and daily living activities, emphasizing the importance of treatment strategies that improve mobility and functionality.
38) Post:
Post indicates the phase following a treatment or assessment period. In this research, 'post' refers to evaluations made after Nitya Virechana to determine changes in symptoms and overall health status of the patients.
39) Shamanacikitsa (Samanacikitsa, Shamana-cikitsa):
Shamana-chikitsa refers to palliative treatments in Ayurveda focused on alleviating symptoms without necessarily eliminating the underlying causes of a disease. This concept is essential in managing conditions like Amavata, where symptom control is crucial for enhancing quality of life.
40) Gandharvahastadi:
Gandharvahastadi is a specific Ayurvedic formulation used in the study for treating Amavata. Understanding its composition and therapeutic effects is critical for evaluating its role in the detoxification process and alleviating symptoms associated with rheumatoid arthritis.
41) Madhavanidana (Madhava-nidana):
Madhava-nidana is a classical Ayurvedic text that outlines principles of diagnosis and treatment. Its relevance lies in providing foundational knowledge for practitioners, enabling them to understand diseases like Amavata and guiding interventions based on traditional wisdom.
42) Vijayarakshita (Vijayaraksita):
Vijayarakshita is a significant figure associated with Ayurvedic literature and clinical practice. His contributions to the understanding of Ayurvedic pathologies, including Amavata, are critical for practitioners to effectively employ traditional remedies in modern contexts.
43) Nidraviparyaya:
Nidraviparyaya signifies sleep disturbances, which are often associated with chronic pain conditions. In the context of Amavata, addressing Nidraviparyaya is important for holistic treatment strategies aimed at improving overall well-being and quality of life.
44) Madhavakara:
Madhavakara is traditionally recognized as a significant contributor to Ayurvedic literature, particularly in diagnostics and treatment methodologies. The insights provided by Madhavakara form the basis for many modern Ayurvedic practices, especially concerning chronic diseases like rheumatoid arthritis.
45) Samshamana (Samsamana):
Samshamana refers to treatment strategies aimed at balancing doshas through dietary and lifestyle modifications without forcibly eliminating them. This approach is essential in managing chronic conditions like Amavata, providing complementary support alongside detoxification therapies.
46) Sudarshana (Sudarsana):
Sudarshana is often associated with various forms of Ayurvedic healing, emphasizing clarity and balance. The term represents a holistic approach in treatment protocols, ensuring that patients receive comprehensive care, particularly for conditions like Amavata.
47) Vatadosha (Vatadosa, Vata-dosha):
Vatadosha, the dosha embodying air and space characteristics, when vitiated can lead to various disorders, including Amavata. Understanding its properties and treatment approaches is fundamental in Ayurvedic practices aimed at restoring balance and alleviating symptoms.
48) Angamarda (Amgamarda, Anga-marda):
Angamarda signifies body ache or generalized pain in Ayurveda. This symptom frequently presents in Amavata and signals the need for therapeutic interventions, making its assessment central to evaluating treatment efficacy in clinical studies.
49) Vidyotini:
Vidyotini is a commentary on traditional Ayurvedic texts, providing explanations and interpretations that enhance understanding of ancient practices. Such commentaries play a pivotal role in bridging ancient knowledge with modern applications in treating diseases like Amavata.
50) Suffering:
Suffering in this context refers to the physical and emotional pain experienced by patients with chronic conditions like Amavata. Recognizing the multifaceted nature of suffering is crucial for holistic treatment approaches that aim to improve patient quality of life.
51) Virecana:
Virecana is a therapeutic purgation process in Ayurveda part of detoxification strategies. It is employed to remove excess doshas, particularly in Amavata, facilitating the alleviation of symptoms and aiding in the restoration of overall health.
52) Madhyama:
Madhyama refers to the intermediate channels in Ayurvedic anatomy where various bodily functions occur. Understanding the role of these channels is essential for effective Ayurvedic treatment strategies that target specific imbalances contributing to chronic diseases like Amavata.
53) Narayana (Nara-ayana, Nara-yana):
Narayana is a revered figure in Indian tradition often associated with healing and wellness. His principles and teachings underline many Ayurvedic practices, emphasizing the importance of holistic health approaches in managing conditions like rheumatoid arthritis and Amavata.
54) Mandagni (Mamdagni, Manda-agni):
Mandagni denotes weak or slow digestion in Ayurveda. It is seen as a contributing factor to the accumulation of ama, leading to conditions like Amavata. Addressing Mandagni is essential in treatment regimens to ensure effective assimilation and elimination processes.
55) Agnivesha (Agni-vesha, Agnivesa):
Agnivesa is recognized as a foundational figure in Ayurveda, credited with significant contributions to ancient medical texts. His teachings and concepts form the bedrock of many contemporary Ayurvedic practices, especially in the management of chronic diseases like Amavata.
56) Samgraha (Sangraha):
Sangraha refers to a compilation or collection of knowledge. In Ayurvedic contexts, it often encompasses texts that provide insights into diagnosis and treatment strategies, aiding practitioners in understanding and managing complex conditions such as Amavata.
57) Vitiation (Vitiated):
Vitiated describes the state of doshas that are out of balance or imbalanced, leading to disease. In the context of Amavata, recognizing vitiated doshas is crucial for effective treatment planning aimed at restoring harmony in the body.
58) Sanskrit:
Sanskrit is the classical language of India widely used in ancient texts, including those on Ayurveda. Knowledge of Sanskrit is essential for practitioners to effectively interpret and apply the wisdom contained within Ayurvedic literature related to diseases like Amavata.
59) Science (Scientific):
Science refers to the systematic study of the natural world, looking for evidence-based solutions. In the study of Ayurveda, integrating scientific methodology with traditional practices enhances understanding, demonstrating the efficacy of remedies like Nitya Virechana in addressing conditions like Amavata.
60) Trishna (Trsna):
Trishna translates to thirst in Ayurveda, often indicating imbalances that affect bodily functions. In the context of Amavata, addressing Trishna can help restore better health and well-being through dietary and lifestyle modifications.
61) Samanya:
Samanya signifies common or general principles in Ayurveda. It relates to broad treatment categories applicable to various diseases, providing practitioners with guidelines for approaching patient care holistically and effectively.
62) Madhava:
Madhava refers to a specific Ayurvedic text and its author, offering insights into diagnostic criteria and treatment methodologies. Understanding Madhava's contributions enhances the knowledge base for practitioners treating chronic diseases like Amavata.
63) Avipaka:
Avipaka refers to impaired digestion, regularly associated with various ailments in Ayurveda. Addressing Avipaka is vital in managing Amavata as it directly impacts the accumulation of ama and consequent illness.
64) Samana (Shamana):
Shamana constitutes palliative treatment strategies in Ayurveda focused on alleviating symptoms without eliminating the root cause. This approach is essential in chronic conditions like Amavata, where symptom relief significantly impacts patients' quality of life.
65) Ceshta (Cesta, Cheshtaa):
Cheshta refers to physical and mental activities or efforts in Ayurveda. Understanding a patient's Cheshta can give insights into their lifestyle and influences on health, particularly in conditions like Amavata where lifestyle management plays a crucial role.
66) Purana:
Purana refers to ancient literature that often encompasses mythology and teachings within Hinduism, including aspects of health and healing. In an Ayurvedic context, understanding Puranic principles can inspire holistic healing approaches, fostering connections between spirituality and health management.
67) Caraka:
Caraka is a pivotal text in Ayurveda, providing foundational knowledge regarding diseases and treatments. Practitioners utilize Caraka’s teachings to inform their clinical practices, especially in managing chronic health conditions like Amavata effectively.
68) Sandhi (Shandhi, Samdhi):
Sandhi translates to joints in Sanskrit, which are key areas affected in conditions like Amavata. Understanding joint health and functionality is crucial for developing effective treatment strategies to alleviate pain and improve mobility.
69) Vedana:
Vedana signifies sensations, particularly pain, described in Ayurvedic texts. Understanding Vedana is essential for practitioners assessing patients' conditions. In the context of Amavata, evaluating pain responses helps tailor effective therapeutic interventions.
70) Shotha (Sotha):
Shotha refers to swelling or edema related to inflammation, particularly in joints affected by conditions like rheumatoid arthritis. Its assessment is critical in evaluating treatment efficacy and guiding appropriate management strategies in Ayurveda.
71) Vaidya:
Vaidya refers to a traditional healer or Ayurvedic practitioner. The role of the Vaidya is crucial in diagnosing and treating conditions like Amavata, emphasizing the need for a deep understanding of Ayurvedic principles and practices.
72) Vamana:
Vamana is a therapeutic emesis performed in Ayurveda as part of detoxification protocols. It is used to expel excess kapha and is essential in comprehensive treatments for conditions like Amavata, improving patients' health and vitality.
73) Nidana:
Nidana signifies diagnosis in Ayurvedic practice, an essential process for identifying the specific nature of a disease. Accurate Nidana is crucial for determining appropriate treatment strategies for conditions like Amavata.
74) Kanthi (Kamthi):
Dr. Manjunath Kanthi is a contributing author to the study, bringing expertise from his role as an assistant professor in Ayurvedic medicine. His involvement represents the collaborative effort in advancing research on traditional practices aimed at managing chronic illnesses.
75) Ajirna:
Ajirna translates to indigestion or impaired digestion in Ayurveda. It is often linked to the development of ama, contributing to conditions like Amavata. Recognizing and managing Ajirna is vital in holistic treatment protocols.
[Note: The above list is limited to 75. Total glossary definitions available: 87]
Other Science Concepts:
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