Study of reactive lymph nodes in Ayurveda via FNAC: Case study

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Journal name: World Journal of Pharmaceutical Research
Original article title: A study on reactive lymph node in ayurveda with special reference to fnac examination- a case study
The WJPR includes peer-reviewed publications such as scientific research papers, reports, review articles, company news, thesis reports and case studies in areas of Biology, Pharmaceutical industries and Chemical technology while incorporating ancient fields of knowledge such combining Ayurveda with scientific data.
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Original source:

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Author:

Dr. Hemen Kalita and Dr. Satyajit pathak


World Journal of Pharmaceutical Research:

(An ISO 9001:2015 Certified International Journal)

Full text available for: A study on reactive lymph node in ayurveda with special reference to fnac examination- a case study

Source type: An International Peer Reviewed Journal for Pharmaceutical and Medical and Scientific Research

Doi: 10.20959/wjpr202322-30579


Download the PDF file of the original publication


Summary of article contents:

Introduction

The study examines reactive lymph nodes through the lens of Ayurveda, particularly focusing on a case study in which Fine Needle Aspiration Cytology (FNAC) was utilized for diagnostic purposes. Reactive lymph nodes are a benign neoplasm reflecting alterations in size, number, or texture, and although Ayurvedic literature does not explicitly describe such conditions, analogous diseases like arbuda and granthi offer relevant frameworks for understanding these lymphatic changes. The integration of cytomorphological analysis is emphasized as essential for establishing empirical evidence supporting alternative treatments in Ayurveda.

Correlation with Ayurvedic Concepts

Despite the absence of specific descriptions of reactive lymph nodes in Ayurvedic texts, the study correlates these conditions with various diseases. The authors suggest that terms such as arbuda, granthi, and apachi can offer a comprehensive context for understanding reactive lymph nodes. The study emphasizes a need for effective integration of Ayurvedic diagnosis with modern cytological assessments to provide a coherent treatment paradigm. By leveraging traditional Ayurvedic classifications, practitioners can identify and manage these cases more effectively.

FNAC Examination Findings

The FNAC examination, carried out on a 9-year-old female patient with a lump on her neck, revealed a proliferation of lymphoid cells, including centroblasts and centrocytes. These findings led to a provisional diagnosis of reactive lymph node. The cytological study showcases the diverse generations of lymphoid cells present in the sample, indicating the immune system's response. This type of cellular proliferation is essential for understanding the lymphatic system's functioning and providing insights into the disease process at play.

Ayurvedic Interpretation of the Findings

From an Ayurvedic perspective, the study interprets the FNAC results in relation to the concept of doshas, particularly the involvement of vata dosha. The palpable lymph nodes were associated with mamsa dhatu within the gala pradesha, and the study links this to mamsapradoshaja vikara. It also discusses the maturity of lymphoid cells, categorizing them as apachit dhatu, indicating an immaturity or underdevelopment that may stem from poor metabolic capacity (dhatwagni manda) at the site. This interpretation bridges the gap between Ayurvedic ancient knowledge and modern medical science.

Conclusion

The case study illustrates how a clinically diagnosed granthi according to Ayurvedic principles can be correlated with a provisionally diagnosed reactive lymph node through FNAC results. The findings confirm that cellular proliferation may result from vata dosha involvement, with the lymph node characterized as apachit mamsa dhatu. This integrative approach underscores the relevance of combining traditional Ayurvedic diagnostic methods with contemporary cytological examinations, offering a holistic perspective on managing reactive lymph nodes and enhancing patient care through alternative treatment options.

FAQ section (important questions/answers):

What is a reactive lymph node?

A reactive lymph node is a benign neoplasm characterized by abnormal size, number, or consistency, responding to various stimuli such as infections or tissue injury.

How is reactive lymph node treatment approached in Ayurveda?

Ayurveda may correlate reactive lymph nodes with conditions like granthi and treats them holistically, although specific descriptions are not found in classical texts.

What is Fine Needle Aspiration Cytology (FNAC)?

FNAC is a diagnostic procedure that uses a thin needle to sample tissue from lumps, allowing for cytological examination to identify conditions like reactive lymph nodes.

What findings were observed in the presented case study?

The case study identified a freely movable lump diagnosed as granthi in Ayurveda. FNAC revealed proliferation of lymphoid cells, indicating reactive lymph node.

How do Ayurvedic parameters relate to modern diagnoses?

Ayurvedic parameters may correlate with modern medical findings, with conditions like granthi being associated with reactive lymph nodes based on cytomorphological analysis.

What implications does the study have for alternative treatments?

The study emphasizes the need for effective Ayurvedic treatments for reactive lymph nodes, providing evidence-based alternatives to conventional treatments like antibiotics.

Glossary definitions and references:

Scientific and Ayurvedic Glossary list for “Study of reactive lymph nodes in Ayurveda via FNAC: Case study”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.

1) Study (Studying):
The term 'study' refers to the systematic investigation conducted to understand reactive lymph nodes from both Ayurvedic and cytological perspectives. This research aims to correlate traditional Ayurvedic diagnosis with modern techniques like Fine Needle Aspiration Cytology (FNAC), highlighting the need for an evidence-based understanding of disease management.

2) Ayurveda (Ayus-veda):
Ayurveda, the ancient Indian system of medicine, emphasizes holistic health through balance in bodily systems. The relevance in this context lies in its concepts of dosha and dhatu, providing frameworks to understand diseases. It enables the classification of reactive lymph nodes alongside Ayurvedic terminologies such as granthi and arbuda.

3) Dhatu:
Dhatu refers to the body's fundamental tissues in Ayurveda, each with specific functions and characteristics. In this case, 'mamsa dhatu' indicates muscle or flesh tissue. Understanding the status of dhatu assists in diagnosing health issues based on tissue quality and health, demonstrating the interconnectedness of physical health with Ayurvedic thought.

4) Disease:
The term 'diseases' encompasses various pathological conditions affecting bodily systems. In this case, diseases such as 'arbuda' and 'gandamala' are referenced to connect reactive lymph nodes with Ayurvedic classifications, emphasizing the scope of traditional medicine in understanding diverse health issues.

5) Granthi (Gramthi):
In Ayurveda, 'granthi' designates a type of benign swelling or lump, often characterized by firmness and immobility. The term’s relevance surfaces in diagnosing the patient’s condition in the case study, where granthi aligns with symptoms observed in the reactive lymph node, underlining Ayurvedic taxonomies to medical imagery.

6) Kalita:
Dr. Hemen Kalita is one of the authors of the study, representing the expertise behind the research findings. His scholarly contributions are pivotal for integrating Ayurvedic practices with modern medical assessments, thereby aiming to validate traditional diagnostic methods in light of contemporary scientific evaluations like FNAC.

7) Mamsa (Mamsha):
Mamsa translates to muscle or flesh in Ayurveda, one of the dhatus. It is significant in assessing the condition of soft tissue such as lymph nodes. In this study, the understanding of mamsa aids in categorizing the physical characteristics of the lymph node in the patient, thus enriching the diagnostic process.

8) Mamsadhatu (Mamsha-dhatu):
Mamsa-dhatu represents the muscle tissue in Ayurvedic physiology, vital for understanding structural and functional aspects of the body. The study reveals that lymph nodes are an extension of mamsa-dhatu, thus facilitating diagnosis and helping classify the reactive lymph node as a pathological manifestation of this dhatu.

9) Roga:
In Ayurveda, 'roga' signifies disease or disorder, encompassing a wide array of health conditions. This term indicates the conditions diagnosed in the case study, which assists in establishing the relationship between Ayurvedic classifications and modern cytological findings, ultimately promoting a more comprehensive approach to treatment.

10) Vatadosha (Vatadosa, Vata-dosha):
Vata-dosha is one of the three essential energies in Ayurveda, representing air and space elements within the body. Its relevance is highlighted in the discussion of pathogenesis for the reactive lymph node, where Vata imbalance may lead to cellular proliferation and associated pathological changes.

11) Dosha (Dosa):
The term 'dosha' refers to functional energies that govern physiological processes in Ayurveda, including Vata, Pitta, and Kapha. Grasping dosha dynamics helps in understanding how imbalances relate to health conditions, such as the observed reactive lymph nodes in this study indicating an aggravated Vata dosha.

12) Vata:
Vata, an Ayurvedic concept, is associated with movement and communication within the body. The study suggests that an imbalance or excess of Vata may lead to the proliferation of lymphoid cells, implying the necessity to regard Vata's influence on the pathophysiology of diseases like reactive lymph nodes.

13) Gandamala (Ganda-mala):
Gandamala, translated as 'nodular swelling,' correlates to certain types of swellings in Ayurveda that may resemble the characteristics of reactive lymph nodes. This term highlights the overlap between ancient Ayurvedic descriptions and modern pathological findings, maneuvering deeper investigation into diagnosis and treatment.

14) Pradesha (Pradesa):
Meaning 'area' or 'region,' the term 'pradesha' becomes significant as it refers to the localization of symptoms within the body. In the study, the pradesha for the lymph node was specified, aiding in precise diagnosis according to Ayurvedic diagnostic methods and establishing connections to anatomical terms.

15) Apachi:
Apachi denotes a condition in Ayurveda that implies a non-suppurative swelling, suggesting that not all lumps or lymph nodes lead to infection. This classification played a role in diagnosing the patient’s lymph node, contributing to the determination as 'Reactive Lymph Node' diagnosed using FNAC.

16) Arbuda:
Arbuda refers to a growth or tumor described in Ayurveda. In the context of this study, it provides a perspective on distinguishing between types of swellings like reactive lymph nodes and neoplastic formations, showcasing Ayurveda’s breadth in defining various pathological states and guiding clinical evaluation.

17) Manda (Mamda):
Manda indicates weakness or low function, particularly related to the digestive fire (Agni) in Ayurveda. The study cites 'dhatwagni manda' to suggest a diminished capability of tissues to mature, explaining the immature lymphocyte findings in the FNAC, showcasing how metabolic health impacts lymph node conditions.

18) Gala (Galam):
Gala refers to the throat or neck region in Ayurveda. In this case, the reactive lymph node discovered in the gala pradesha emphasizes Ayurvedic topography's importance in diagnosis, linking localized symptoms to specific locations and informing targeted therapeutic measures within both traditional and modern practices.

19) Vayu:
Vayu signifies the air element in Ayurveda and is fundamentally linked to movement and change within physiological processes. The implication of Vayu in cellular proliferation observed in the lymph node highlights Ayurvedic understandings of how elemental balances affect health, paralleling modern concepts of immune response.

20) Mamsapinda (Mamsa-pinda):
Mamsa-pinda refers to solid growths or lumps associated with mamsa dhatu. In this study, the lymph node's classification as mamsa-pinda assists in explaining the characteristics of the lump, thereby enriching Ayurvedic diagnosis by elucidating its physical attributes through clinical examination.

21) Reliability:
Reliability indicates the consistency and trustworthiness of the diagnostic methods employed. The study emphasizes the reliability of FNAC as an effective technique for evaluating reactive lymph nodes, thus merging traditional Ayurvedic assessments with modern medical practices to provide an integrative healthcare approach.

22) Antibiotic (Antibacterial):
An antibiotic is a type of medication used specifically to combat bacterial infections. In the context of conventional treatment for reactive lymph nodes, the challenges associated with their use highlight the necessity for alternative treatment modalities, such as those offered by Ayurveda, which aim at promoting holistic health.

23) Discussion:
The discussion elaborates on the findings of the study, connecting Ayurvedic and cytological perspectives to present a comprehensive evaluation of the case. This section emphasizes the significance of integrating traditional knowledge with modern medical practices, fostering a broader understanding of diagnostic and therapeutic approaches.

24) Alparuja (Alpa-ruja):
Alpa-ruja refers to mild or minimal pain in Ayurvedic terms. The mention of alpa-ruja in the case study underscores the characteristic findings during diagnosis, providing insight into symptom severity and contributing to understanding disease dynamics in the context of reactive lymph nodes within Ayurvedic frameworks.

25) Swelling:
Swelling is an increase in size or volume of body parts, typically indicating inflammation or pathology. The study focuses on the presence of a lump or swelling in the lymph node, framing it within both Ayurvedic and modern medical analyses to appreciate the multifaceted nature of such symptoms.

26) Language:
Language in this study refers to the communication methods used to explain the diagnostic process and treatment options to the patient, enhancing understanding and facilitating consent. This transparency is crucial in patient education, especially in integrating traditional Ayurvedic concepts with contemporary medical language.

27) Surface:
Surface pertains to the outer layer or appearance of the lymph node during examination. The smooth surface of the lymph node described in the study provides critical data that aids in clinical assessment, bridging subjective interpretations from Ayurveda with objective findings from cytological studies.

28) Vikara:
Vikara is a term meaning disorder or imbalance in Ayurveda. The concept of vikara provides a crucial framework for understanding reactive lymph nodes in this study, helping categorize the condition in relation to bodily functions and disturbances that can lead to the proliferation of cells in lymphoid tissue.

29) Edema (Oedema):
Oedema refers to swelling caused by excess fluid trapped in tissues, an important clinical sign to assess. The absence of oedema in this case reinforces the non-inflammatory nature of the lymph node issue, aligning it with characteristics described in Ayurveda for conditions like granthi.

30) Karma (Karman):
Karma in this context refers to the action or effect that influences health and disease outcomes. Understanding karma's role is vital in evaluating how different doshas interact and affect the body's systems, thereby influencing the pathophysiology of conditions like reactive lymph nodes.

31) Pandu (Pamdu, Pamde):
Pandu denotes pallor or a pale condition, often indicating underlying health issues such as anemia. The case report notes the patient's physical state, which is critical as it contributes to overall symptomatology and guides the diagnostic process both in Ayurveda and modern medicine.

32) Pinda (Pimda):
Pinda means a lump or mass in Ayurvedic terminology. It signifies specific physical characteristics relevant to diagnosing conditions like reactive lymph nodes. Understanding pinda helps bridge the gap between Ayurvedic diagnostics and clinical findings in modern medical practices, enriching patient care.

33) Apaka:
Apaka indicates a non-suppurative condition where a lump doesn’t produce pus. Its relevance in the study highlights the nature of the reactive lymph node, assisting in developing a treatment plan that reflects Ayurvedic perspectives while validating them with modern clinical observations.

34) Varna:
Varna refers to color, which is an essential diagnostic parameter in Ayurveda. The study tips emphasis on varna helps in assessing the lump's characteristics and correlates them with Ayurvedic diagnoses, ensuring that color observations lead to a comprehensive understanding of pathologies.

35) Fever:
Fever is a common indicator of infection or inflammation, often guiding diagnostic approaches. The absence of fever in the case study supports a diagnosis of a benign condition like a reactive lymph node, emphasizing the importance of symptomatology in both modern and Ayurvedic practices.

36) Cira:
Chira means long-lasting or chronic in Ayurvedic context. This term's usage in the study highlights the nature of the lump, indicating its slow progression, and reflects the importance of understanding chronic conditions in evaluating health and determining appropriate treatment protocols.

38) Ruja:
Ruja means pain in Ayurvedic terminology. The study's focus on pain characteristics, specifically alpa-ruja, is crucial for understanding the patient's condition. This aids in treatment planning and aligns Ayurvedic assessments with modern medical evaluations of lymph node conditions.

39) Alpa:
Alpa means small or less in quantity in Ayurvedic terms. Its mention in the study regarding symptoms such as alpa-ruja indicates the severity of the condition, driving home the need to assess symptoms in accordance with Ayurvedic frameworks that guide clinical evaluation.

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