Evaluation of anti-ulcer capsules from Curcuma longa herbal product.
Journal name: World Journal of Pharmaceutical Research
Original article title: Formulation and evaluation of anti-peptic ulcer capsules of curcuma longa herbal product
The WJPR includes peer-reviewed publications such as scientific research papers, reports, review articles, company news, thesis reports and case studies in areas of Biology, Pharmaceutical industries and Chemical technology while incorporating ancient fields of knowledge such combining Ayurveda with scientific data.
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Prof. Dr. Mahmoud Mahyoob Alburyhi and Prof. Dr. Amina El-Shaibany
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World Journal of Pharmaceutical Research:
(An ISO 9001:2015 Certified International Journal)
Full text available for: Formulation and evaluation of anti-peptic ulcer capsules of curcuma longa herbal product
Source type: An International Peer Reviewed Journal for Pharmaceutical and Medical and Scientific Research
Doi: 10.20959/wjpr202322-30741
Copyright (license): WJPR: All rights reserved
Summary of article contents:
Introduction
Curcuma longa, commonly known as turmeric, has a long history of use in traditional medicine for various ailments, including gastrointestinal issues such as inflammation, gastritis, and gastric ulcers. The present study focused on the formulation and evaluation of anti-peptic ulcer capsules using an ethanolic extract of C. longa. The research aimed to investigate the efficacy of this herbal remedy in treating peptic ulcers and to assess the physicochemical properties of the formulated capsules. This work also highlights the broader significance of herbal medicines in contemporary therapeutic practices.
Anti-Peptic Ulcer Activity
The study examined the anti-ulcer properties of ethanolic extracts of C. longa across different dosages (100 mg/kg, 125 mg/kg, 250 mg/kg, and 500 mg/kg) using several ulcerated rat models. The findings indicated that higher doses, particularly 500 mg/kg, exhibited significant antiulcer activity comparable to traditional medications like omeprazole. This reinforces the potential of curcumin, the active compound in turmeric, as a natural treatment for gastric ulcers by inhibiting gastric acid secretion and protecting the gastric mucosa.
Formulation Properties of Capsules
The research detailed the formulation of C. longa capsules, highlighting their organoleptic properties, solubility, particle size, density, and flowability. The capsules were characterized as having a fine particle size, good flow properties, and appropriate moisture content (4%). The solubility tests showed that the freeze-dried extract dissolved well in pH 6.8 buffer, essential for bioavailability. These attributes are critical for ensuring that the capsules effectively deliver the therapeutic benefits of C. longa.
Stability and Storage of Formulated Capsules
Stability studies evaluated the organoleptic properties and moisture content of C. longa capsules stored under various environmental conditions. Results indicated minimal changes in the physical characteristics and moisture levels during storage, suggesting that the capsules maintained their integrity over time. The study found that storing the capsules in glass containers protected them against moisture, thereby ensuring their shelf stability.
Conclusion
The research findings support the efficacy of freeze-dried C. longa extract in treating peptic ulcers, emphasizing its potential as a natural remedy in modern medicine. The formulated capsules exhibited favorable physicochemical characteristics, indicating good stability, solubility, and flow properties. This study reinforces the importance of C. longa as a source of herbal medicine and its applicability in developing effective therapeutic formulations for gastrointestinal disorders. Further investigations could enhance our understanding of its broader implications in healthcare.
FAQ section (important questions/answers):
What is Curcuma longa and its traditional uses?
Curcuma longa, commonly known as turmeric, has been traditionally used for various ailments, including inflammation, gastritis, and gastric ulcers. Its rhizome is valued for its medicinal properties in traditional medicine, especially in Ayurveda.
What is the main active component of Curcuma longa?
Curcumin is the most active component of Curcuma longa. It exhibits significant gastroprotective and anti-ulcerogenic effects, helping to alleviate gastric issues and protect against ulcers.
How was the anti-peptic ulcer activity of Curcuma longa evaluated?
The anti-peptic ulcer activity of Curcuma longa was tested using ethanolic extracts at doses of 100 mg/kg in rat models. Results indicated effectiveness comparable to standard ulcer medications.
What was observed about the solubility of Curcuma longa capsules?
The solubility testing of the freeze-dried extract showed it was soluble in pH 6.8 buffer, indicating good potential for absorption and bioavailability in the body.
What were the capsule formulation ingredients for Curcuma longa?
The capsules contained 100 mg of Curcuma longa extract, along with excipients such as starch, aerosil, magnesium stearate, and sodium lauryl sulfate, ensuring proper stability and effectiveness.
What are the stability results for Curcuma longa capsules?
Curcuma longa capsules maintained their organoleptic properties and moisture levels during a stability study over 12 weeks, under different temperature and humidity conditions, indicating good storage stability.
Glossary definitions and references:
Scientific and Ayurvedic Glossary list for “Evaluation of anti-ulcer capsules from Curcuma longa herbal product.”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.
1) Curcuma longa:
Curcuma longa is the scientific name for turmeric, a rhizomatous herbaceous plant known for its medicinal properties, particularly in traditional medicine for treating inflammatory diseases and ulcers. Its active component, curcumin, has been extensively studied for its bioactive effects, including antioxidant and anti-inflammatory actions, making it relevant in pharmacology and herbal medicine.
2) Powder:
In the context of herbal medicine, 'powder' refers to the form in which the extracted phytochemicals of Curcuma longa are processed. The powdered form enhances solubility and absorption, important for maximizing the bioactivity of turmeric supplements and ensuring effective delivery of its medicinal properties when consumed.
3) Turmeric:
Turmeric, the common name for Curcuma longa, has been used in culinary and traditional medicine for centuries. Its bright yellow color is due to curcumin, a key compound associated with numerous health benefits, including antibacterial and anti-inflammatory effects, making turmeric a significant subject of investigation in phytotherapy.
4) Ulcer:
Ulcers are open sores that can occur in various parts of the body, commonly associated with gastrointestinal issues. Studying the effects of Curcuma longa on ulcers underlines its therapeutic potential and aligns with traditional uses in managing digestive health.
5) Table:
In scientific studies, a 'table' refers to a structured arrangement of data, often used to summarize findings. Tables enhance clarity in presenting information on aspects like dosage, effects of Curcuma longa, and other variables in research, aiding in effective communication of results within the scientific community.
6) Activity:
Activity in pharmacological research indicates the efficacy of a substance in eliciting a biological response. In the context of Curcuma longa, understanding its anti-ulcer and anti-inflammatory activity is critical to pharmacognosy and provides insights into potential applications for therapeutic interventions in gastrointestinal disorders.
7) Study (Studying):
The term 'study' refers to systematic investigation aimed at acquiring knowledge. The study of Curcuma longa and its effects on health is relevant for understanding its pharmacological properties. Scientific studies help validate traditional uses, leading to the development of effective natural medicines for various ailments.
8) Medicine:
Medicines encompass a wide range of substances used for treating disease and promoting health. The examination of Curcuma longa in the context of herbal medicines illustrates its potential for inclusion in therapeutic strategies, particularly for conditions related to inflammation and digestive health.
9) Drug:
Drugs refer to substances used for medicinal purposes. The exploration of herbal drugs like Curcuma longa expands the understanding of natural pharmacology and encourages integrating traditional remedies into contemporary medical practices, providing patients with more holistic options for treatment.
10) Glass:
Glass is often used in laboratory settings to contain and store substances due to its inert nature. In the context of storing herbal extracts or capsules, glass containers help maintain the stability of Curcuma longa products, preventing unwanted reactions that could compromise their efficacy.
11) Container:
A container is a vessel used to hold substances. In pharmaceutical contexts, the choice of container for storing herbal capsules, like those formulated from Curcuma longa, affects the product's stability and shelf-life, imparting relevance in the formulation and preservation of herbal medicines.
12) Water:
Water is a universal solvent essential for various biological processes. It plays a crucial role in the solubility required for the absorption of herbal extracts such as Curcuma longa. Its interaction with active compounds is often studied for its impact on bioavailability and therapeutic effects.
13) Shana (Sana):
Sana refers to Sana'a, the capital of Yemen, which is culturally significant and the location of institutions conducting research on herbal medicines. The study of plants like Curcuma longa in Sana represents the broader interest in traditional practices and the validation of these practices through scientific exploration.
14) Disease:
The term 'disease' embodies a broader understanding of the specific conditions affecting health. The relevance of studying Curcuma longa lies in its potential to provide alternative remedies for various diseases, including peptic ulcers, showcasing the importance of plant-based treatments alongside conventional medical practices.
15) Filling (Filled):
Filled indicates the state of capsules once they contain the desired amount of powdered substance. For Curcuma longa capsules, achieving proper filling ensures that patients receive effective doses of the extract, essential for maximizing its health benefits in treating various conditions.
16) India:
India is the native region of turmeric (Curcuma longa) and has a rich cultural history of utilizing this herb in traditional medicine systems like Ayurveda. The geographical significance of India informs contemporary research on turmeric's medicinal properties and its global role in herbal therapies.
17) Inflammation:
Inflammation is a biological response to harmful stimuli or injury and can contribute to various diseases. The anti-inflammatory properties of Curcuma longa, particularly through curcumin, have made it a focal point in studies aimed at understanding how herbal medicines can mitigate inflammatory conditions.
18) Science (Scientific):
Scientific denotes an empirical approach to knowledge through observation and experimentation. The study of Curcuma longa involves scientific methodologies to verify its medicinal claims, promoting evidence-based practices within herbal medicine, which is essential for gaining acceptance in conventional healthcare settings.
19) Substance:
Substances are materials with distinct physical and chemical properties. The study of various substances within Curcuma longa, such as curcuminoids, focuses on their individual and synergistic effects, informing their applications in health and wellness, enabling the development of effective herbal remedies.
20) Cancer:
Cancer represents a category of diseases characterized by uncontrolled cell growth. Research into the anticancer potential of curcumin from Curcuma longa is significant, highlighting the plant’s relevance in developing novel therapies and understanding natural compounds that could play roles in cancer treatment or prevention.
21) Bitter:
Bitter describes a taste that is often associated with many medicinal plants, including Curcuma longa. The flavor profile influences the acceptability and palatability of herbal preparations, as bitter-tasting compounds can deter some individuals despite their potential health benefits.
22) Rat:
Rats are frequently used as model organisms in scientific research to study the effects of substances, including those derived from herbal remedies like Curcuma longa. Findings from rat studies provide valuable preliminary insights into the efficacy and safety of herbal treatments before human applications.
23) Antibiotic (Antibacterial):
Anti-bacterial properties refer to the ability of substances to combat bacterial infections. The relevance of Curcuma longa includes its potential as a natural alternative to antibiotics, urging further research into integrating herbal options into health systems to address rising antibiotic resistance.
24) Ayurveda (Ayus-veda):
Ayurveda is a traditional Indian system of medicine that emphasizes the use of natural remedies, including herbs like Curcuma longa. Its principles guide the understanding of holistic health, positioning turmeric as a key ingredient in maintaining balance and treating various ailments.
25) Sanskrit:
Sanskrit is an ancient language of India where many traditional medicinal texts are composed. The study of Curcuma longa benefits from a rich historical backdrop, as ancient texts document its medicinal uses, providing cultural context for contemporary research in pharmacognosy.
26) Quality:
Quality refers to the degree of excellence of a product. In herbal formulations like Curcuma longa capsules, quality assurance ensures that the end product meets specified standards, directly impacting efficacy, safety, and patient trust in herbal medicine.
27) Company:
A company in the context of this research refers to an entity involved in the production and research of herbal medicines. Collaboration with pharmaceutical companies can enhance the commercialization of natural products like Curcuma longa, bridging traditional knowledge with modern industrial practices.
28) Nature:
Nature signifies the inherent characteristics or properties of a substance. Understanding the natural properties of Curcuma longa aids researchers in harnessing its health benefits, supporting claims of efficacy while fostering respect for natural systems and their roles in medicine.
29) Medium:
In pharmacological and laboratory contexts, 'medium' refers to the environment in which reactions or interactions occur. For Curcuma longa studies, the choice of dissolution medium impacts bioavailability assessments and determines how effectively the active compounds can exert therapeutic effects.
30) Insect:
Insects are often studied in the context of natural remedies due to their interactions with plants. Turmeric, known for its insect repellent properties, illustrates how herbal substances can have benefits beyond human health, influencing pest control and ecological balance.
31) Indian:
Indian refers to native practices, cultures, or products from India. The significance of Curcuma longa in Indian culture extends to its extensive use in Ayurveda, embodying the integration of traditional herbal practices within contemporary health paradigms worldwide.
32) Cina:
China represents another geographical context where traditional herbal medicine plays a central role. Researching Curcuma longa within Chinese medicine highlights its historical significance and potential integration into broader Asian herbal practices, enhancing its global relevance.
33) Hair:
Hair often appears in studies relating to the cosmetic uses of herbal extracts. Turmeric's impact on hair health, such as promoting luster or controlling dandruff, is explored alongside its medicinal benefits, blending beauty and wellness applications.
34) Oil:
Oils derived from plants like Curcuma longa contain active compounds with potential therapeutic benefits. Essential oils may play a role in natural remedies, enhancing the bioavailability of active ingredients or providing additional health properties when used in formulations.
35) Snake poison (Snake venom):
Snake venom refers to the toxic secretion from snakes, which has been studied for potential medicinal applications. Research into curcumin's effects against snake venom underscores the broader scope of phytochemical studies and the relevance of Curcuma longa in developing antidotes or treatments.
36) Human body:
The human body is the target of various medicinal interventions. Studies on Curcuma longa aim to understand its effects on human health, facilitating the development of herbal treatments that address specific ailments or promote overall well-being.
37) Phytochemical:
Phytochemicals are bioactive compounds derived from plants. Curcuma longa is rich in phytochemicals, particularly curcumin, which are studied for their health benefits, supporting the use of plant-based remedies in treating a variety of diseases and enhancing overall health.
38) Purification:
Purification often refers to processes aimed at isolating specific compounds for medicinal use. In relation to Curcuma longa, purification techniques enhance the yield of active ingredients, ensuring that formulations contain adequate concentrations for therapeutic efficacy in treating conditions like ulcers.
39) Snake-bite:
Snake-bite is a critical medical emergency that requires immediate treatment. The investigation into Curcuma longa's effectiveness in treating snake-bite reflects the proactive approach to utilizing herbal medications to address urgent health issues through natural remedies.
40) Prosperity:
Prosperity in cultural contexts may relate to the use of turmeric in rituals and celebrations. The traditional significance of turmeric extends beyond health, symbolizing auspiciousness and positivity, illustrating how herbal substances permeate daily life and cultural practices.
41) Discussion:
Discussion in scientific literature refers to the analytical discourse interpreting research findings. Discussing results from Curcuma longa studies helps elucidate implications for health and wellness, bridging the gap between ancient wisdom and contemporary scientific understanding.
42) Colouring (Coloring):
Colouring often pertains to the pigmented components of plants used in food and medicine. Turmeric’s vibrant yellow color, derived from curcumin, makes it valuable as a natural coloring agent, showcasing its multifaceted applications beyond medicinal uses.
43) Rasayana (Rasa-ayana):
Rasayana is a term in Ayurveda referring to rejuvenating herbs that promote longevity and health. Curcuma longa's inclusion as a rasayana highlights its esteemed status in traditional medicine as a remedy for various ailments, supporting vitality and overall well-being.
44) Learning:
Learning refers to the acquisition of knowledge obtained through research and study. Understanding the benefits of Curcuma longa contributes to the broader field of herbal medicine, enhancing the integration of traditional knowledge with scientifically validated practices.
45) Mourning:
Mourning relates to cultural practices surrounding death and loss. While turmeric is associated with auspiciousness, its use is often restricted in mourning contexts, reflecting the deep cultural connections between plants, rituals, and societal beliefs.
46) Relative:
Relative refers to relationships or comparisons between different entities. In scientific research, the relative efficacy or safety of Curcuma longa compared to other treatments is significant for understanding its place in therapeutic protocols and guiding evidence-based practice.
47) Pregnant:
Pregnant pertains to the state of carrying offspring, and understanding the effects of herbal remedies like Curcuma longa on pregnant individuals is vital. Research ensures safety and efficacy for expectant mothers, emphasizing the need for careful consideration of herbal supplementation during pregnancy.
48) Buddhism (Buddhist tradition):
Buddhist relates to the spiritual and cultural practices of Buddhism, where turmeric may have ceremonial significance. Its use in rituals among Buddhist communities parallels its therapeutic applications, merging spirituality with health concepts rooted in traditional herbal practices.
49) Haridra:
Haridra is the Sanskrit term for turmeric, reflecting its rich historical use in traditional Indian medicine. Studying its cultural etymology emphasizes the plant's significance and ongoing relevance in promoting health and wellness through herbal therapy.
50) Species:
Species refers to a specific group of organisms classified by shared characteristics. Understanding the classification of Curcuma longa within the Zingiberaceae family informs its botanical lineage and relevance in the context of medicinal plants and their applications.
51) Allergy:
Allergy refers to hypersensitivity reactions elicited by certain substances. Investigating the role of Curcuma longa in managing allergies underscores the broader health benefits of herbal remedies, contributing to potential therapeutic strategies for addressing allergic conditions.
52) Itching:
Itching is an uncomfortable sensation often associated with skin irritations or allergies. The anti-inflammatory properties of Curcuma longa can be explored for their potential to relieve itching, demonstrating the significance of herbal remedies in dermatological treatments.
53) Gelatin:
Gelatin is a natural polymer used in the creation of capsule shells. Its relevance in the context of Curcuma longa capsules is significant, aiding in preserving the integrity of the extract while ensuring an appropriate delivery system for consumption.
54) Siddha:
Siddha refers to an ancient Indian system of medicine similar to Ayurveda, emphasizing the use of natural herbs for holistic healing. Curcuma longa’s incorporation into Siddha practices enhances its cultural significance and showcases the diverse applications of this traditional plant within global health trends.
55) Family:
Family in botanical terms refers to a group of related plants. The significance of Curcuma longa belonging to the Zingiberaceae family highlights its connections to other medicinal plants and can guide research towards understanding their combined effects and potential therapeutic applications.
56) Gold (Golden):
Golden often describes the vibrant yellow hue of turmeric, derived from curcumin. This feature accentuates its appeal in cooking and cosmetics while reinforcing its cultural associations with purity and well-being in various traditional practices.
57) Aryan:
Aryan refers to historical ethnic groups in South Asia. The ties between Aryan culture and the use of turmeric intertwine cultural heritage with health practices, emphasizing the enduring significance of plants like Curcuma longa throughout history and across civilizations.
58) Visit:
Visit typically refers to the act of going to a location. The cultural significance of turmeric is often highlighted during visits and rites, showcasing its role in maintaining tradition and honoring cultural practices across different communities.
59) House:
House often signifies a dwelling where people reside. The cultural practices surrounding the use of turmeric in homes reflect its importance in rituals and daily life, emphasizing the intertwining of plant usage with societal norms and health practices.
60) Tamil:
Tamil denotes an ethnic group and language predominantly found in Southern India. The historical usage of turmeric in Tamil culture connects a specific regional significance to the broader applications of Curcuma longa across various Indian traditions, emphasizing its medicinal and ceremonial importance.
61) Food:
Food encompasses the substances consumed for nourishment. Turmeric's incorporation into food not only adds distinct flavor and color but also aligns with its health benefits, reinforcing the growing interest in functional foods that contribute to well-being and disease prevention.
62) Wall:
The word 'wall' may seem less relevant but can symbolize barriers or divisions in medicinal practices. Understanding various cultural perceptions of plants like Curcuma longa, including how different communities embrace or reject them, reveals deeper insights into global health paradigms.
63) Pain:
Pain is an unpleasant sensory and emotional experience that indicates injury or illness. Studying the analgesic properties of Curcuma longa contributes valuable knowledge to herbal therapies aimed at alleviating pain, enhancing its applications in organic medicine.
64) Soil:
Soil refers to the upper layer of earth where plants grow, and its quality significantly influences the phytochemical content of plants like Curcuma longa. Understanding the interaction between soil conditions and plant health is essential for optimizing the cultivation of medicinal herbs.
65) Pur:
Poor often refers to inadequate health standards or resource access. Research on affordable herbal remedies like Curcuma longa addresses health disparities, exploring how traditional medicines can provide accessible care options for underrepresented populations.
66) Dish (Dis):
Dish signifies food prepared for eating, often reflecting cultural significances. The incorporation of turmeric into various dishes not only enhances flavor and nutrition but also illustrates the integration of health practices and dietary choices across cultures, promoting well-being.
67) Life:
Life encapsulates the living state of beings and is intricately connected to health practices. The health benefits attributed to Curcuma longa resonate with life quality, positioning herbal remedies as vital components in promoting a healthier existence for individuals and communities.
Other Science Concepts:
Discover the significance of concepts within the article: ‘Evaluation of anti-ulcer capsules from Curcuma longa herbal product.’. Further sources in the context of Science might help you critically compare this page with similair documents:
Curcuma longa, Medicinal properties, Turmeric powder, Traditional medicine, Western medicine, Alternative medicine, Bioavailability, Moisture content, Ethanolic extract, Organoleptic properties, Compressibility index, Cultural use, Dissolution profile, Capsule dosage form, Formulation and Evaluation, Particle size determination, Storage condition, Anti-peptic ulcer, Phytochemical component.