Phytochemical and pharmacological review on basella alba linn
Journal name: World Journal of Pharmaceutical Research
Original article title: Phytochemical and pharmacological review on basella alba linn
The WJPR includes peer-reviewed publications such as scientific research papers, reports, review articles, company news, thesis reports and case studies in areas of Biology, Pharmaceutical industries and Chemical technology while incorporating ancient fields of knowledge such combining Ayurveda with scientific data.
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Honey Haridas, Fathimmatu Sadiyah, Ayshath Mahshooma K. K., Ayishath Mubashira, Ziyad Noorudheen Ahmed and Ajith Babu T. K.
World Journal of Pharmaceutical Research:
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Full text available for: Phytochemical and pharmacological review on basella alba linn
Source type: An International Peer Reviewed Journal for Pharmaceutical and Medical and Scientific Research
Doi: 10.20959/wjpr20222-22848
Copyright (license): WJPR: All rights reserved
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Summary of article contents:
Introduction
Basella alba, commonly referred to as Malabar spinach, Indian spinach, or vine spinach, belongs to the Basellaceae family and is well-known for its numerous phytochemical and pharmacological properties. This fast-growing perennial vine thrives in warm climates such as Malaysia, the Philippines, and parts of India, where it is cultivated for its rich nutritional value. The plant possesses a variety of healing properties that contribute to its use in traditional medicine, particularly in India and China. Its chemical composition includes an array of beneficial compounds such as basellasaponins, kaempherol, and various flavonoids, which contribute to its diverse therapeutic effects.
Anti-Inflammatory Activity
One of the most significant pharmacological benefits of B. alba is its anti-inflammatory activity. Research has shown that both the methanolic and aqueous extracts of the plant exhibit in vitro anti-inflammatory effects, with the aqueous extract demonstrating notable membrane stabilization on human red blood cells. Further studies using animal models revealed that B. alba could significantly reduce inflammation when tested with various phlogistic agents. This suggests that the extracts have the potential to serve as natural alternatives or supplements to traditional anti-inflammatory medications like phenylbutazone and diclofenac sodium.
Anti-Ulcer Activity
Basella alba also shows promise as an anti-ulcer agent. In experiments where ulceration was induced in Wistar rats using aspirin, treatments with B. alba leaf extract resulted in the restoration of multiple physiological parameters that had been disturbed by the ulcerative agent. The protective effects against ulcers indicate the plant's role in gastrointestinal health. This finding aligns with the growing interest in natural remedies for managing gastrointestinal disorders, showcasing B. alba's potential to contribute to alternative therapeutic strategies.
Wound Healing Properties
The wound healing abilities of B. alba have also been a subject of investigation. Studies conducted on male albino rats with burn wounds demonstrated that treatment with B. alba leaf extract promoted significant wound closure compared to controls. The results of this research underline the plant's potential application in wound management and healing, further emphasizing the therapeutic significance of B. alba in traditional medicine practices.
Conclusion
In summary, Basella alba exhibits a wide range of pharmacological properties, particularly in the domains of anti-inflammatory, anti-ulcer, and wound healing activities. The plant's rich phytochemical composition plays a crucial role in these beneficial effects, and scientific studies support its traditional uses. As interest in natural and holistic remedies continues to rise, the potential for B. alba to be utilized in modern medicine appears promising. Future research may uncover even more applications and therapeutic benefits of this versatile plant.
FAQ section (important questions/answers):
What is Basella alba commonly known as?
Basella alba is commonly known as Malabar spinach, Indian spinach, Ceylon spinach, or vine spinach. It belongs to the family Basellaceae and is a fast-growing, heat-tolerant perennial vine.
What are the health benefits of Basella alba?
Basella alba offers various health benefits, including anti-inflammatory, antioxidant, antiulcer, antibacterial, and wound healing properties. It is used to treat diseases in humans and animals.
What phytochemicals are found in Basella alba?
Basella alba contains basellasaponins, kaempherol, diterpenes, flavonoids, tannins, and phenolic compounds, among others. It is also rich in vitamins and essential amino acids.
How does Basella alba exhibit anti-inflammatory activity?
The aqueous and methanolic extracts of Basella alba demonstrate significant anti-inflammatory activity by stabilizing human red blood cell membranes and reducing inflammation in rats tested with various agents.
What is the antioxidant potential of Basella alba?
Basella alba is a potential source of natural colorants and exhibits excellent antioxidant activity, effectively scavenging various free radicals based on scientific studies.
Is Basella alba effective for wound healing?
Yes, studies indicate that Basella alba enhances wound healing capacity in rats, showing significant wound closure when treated with its leaf extract.
Glossary definitions and references:
Scientific and Ayurvedic Glossary list for “Phytochemical and pharmacological review on basella alba linn”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.
1) Activity:
Activity in this context refers to the biological or pharmacological effects produced by the extracts from Basella alba. Various activities like anti-inflammatory, anti-ulcer, and antioxidant are discussed in the review, showcasing the diverse therapeutic potentials of this plant and its relevance to human health.
2) Haridas:
Haridas is the name of the corresponding author of the study. He is associated with Malik Deenar College of Pharmacy in Kerala, India. His contributions, along with his colleagues, provide insights into the medicinal properties and phytochemical profiles of Basella alba, highlighting its importance in pharmacognosy.
3) Ulcer:
Ulcer refers to the sores or lesions that can occur in the gastrointestinal tract. The article mentions the anti-ulcer activity of Basella alba, demonstrating its potential therapeutic use in managing ulcers, which is significant for both pharmaceutical research and clinical applications.
4) Rat:
Rats are common laboratory animals used in pharmacological studies to assess the effects of various compounds. The study utilizes rats in experiments to test the anti-ulcer and wound healing activities of Basella alba, which helps in understanding the efficacy of the plant in a controlled setting.
5) India:
India is significant as it is one of the primary countries where Basella alba is used traditionally for medicinal purposes. The research reflects the plant's cultural and historical relevance in Indian herbal medicine, emphasizing the need for scientific evaluation of local flora for their therapeutic potential.
6) Antibiotic (Antibacterial):
Antibacterial activity refers to the ability of a substance to inhibit bacterial growth. The review discusses the antibacterial properties of Basella alba, indicating its potential utility in treating infections, which is crucial for developing new antimicrobial agents in the face of rising antibiotic resistance.
7) Drug:
Drugs refer to substances used for medical treatment. The review on Basella alba highlights its potential as a source of pharmacologically active compounds, indicating its importance in the development of new therapeutic drugs derived from natural products.
8) Pharmacological:
Pharmacological pertains to the study of drug action and the effects of substances on biological systems. The article reviews various pharmacological activities of Basella alba, providing insights into its therapeutic properties, thereby contributing to the body of knowledge in pharmacology and herbal medicine.
9) Phytochemical:
Phytochemical refers to the chemical compounds produced by plants that have biological significance. The article emphasizes the various phytochemicals found in Basella alba, such as flavonoids and saponins, which are responsible for its medicinal properties and justify its traditional uses.
10) Kasaragod:
Kasaragod is a district in Kerala, India, where Malik Deenar College of Pharmacy is located. As the college plays a central role in the research conducted on Basella alba, its regional significance highlights the local utilization and importance of traditional medicine in that area.
11) Flavonoid:
Flavonoids are a group of natural compounds known for their health benefits, particularly their antioxidant properties. The review mentions the presence of flavonoids in Basella alba, referencing their role in promoting health and preventing diseases, relevant in dietary and therapeutic contexts.
12) Kerala:
Kerala is a state in India noted for its rich biodiversity and traditional medicinal practices. The research conducted in this region showcases the importance of local flora like Basella alba, emphasizing the need to scientifically validate traditional knowledge of medicinal plants.
13) Family:
In botanical terms, 'family' refers to a group of related plants. Basella alba belongs to the Basellaceae family, indicating its classification within the plant kingdom and serving as a basis for understanding its characteristics and potential uses in medicine.
14) Malik:
Malik refers to Malik Deenar College of Pharmacy, the institution affiliated with the authors of the article, including Honey Haridas. The college plays a pivotal role in pharmaceutical education and research, contributing to the understanding of medicinal plants like Basella alba.
15) Honey:
Honey is the first name of the corresponding author, Honey Haridas, who contributed to the review study. His work focuses on exploring the phytochemical and pharmacological properties of Basella alba, contributing to the advancement of knowledge in herbal medicine.
16) Study (Studying):
The study refers to the comprehensive review article that evaluates the phytochemical and pharmacological properties of Basella alba. It synthesizes existing research, highlighting both its traditional uses and scientific findings, which is vital for academic and practical applications in herbal medicine.
17) Bela:
Bela refers to a locality in Kasaragod, Kerala, where the Malik Deenar College of Pharmacy is situated. Its mention emphasizes the geographic context of the study and the integration of local knowledge in understanding the medicinal properties of regional plants.
18) Inflammation:
Inflammation is the body’s response to injury or infection, often associated with pain and swelling. The review details the anti-inflammatory properties of Basella alba, showcasing its potential as a natural treatment option for inflammatory conditions.
19) Substance:
In pharmacological terms, a substance refers to a chemical compound. The article explores various substances derived from Basella alba that demonstrate significant biological activities, indicating their potential application in medicine and the importance of studying plant-derived compounds.
20) Swelling:
Swelling is often a symptom related to inflammation. The text refers to the anti-inflammatory properties of Basella alba, which could help mitigate swelling. Understanding this relationship is crucial for developing herbal remedies for inflammatory conditions.
21) Disease:
Disease refers to a condition that results in impaired bodily function. The review highlights how traditional use of Basella alba is related to treating various diseases, showcasing its relevance in both historical and modern medicinal practices.
22) Mineral:
Mineral indicates essential inorganic nutrients that are required for various physiological functions. The review mentions the presence of minerals in Basella alba, highlighting its role as a nutritious food source that contributes to overall health.
23) Krishna (Krsna):
Krishna refers to one of the authors or researchers involved in studying the anti-inflammatory properties of Basella alba. His findings contribute to the overall understanding of the plant's therapeutic potential and its application in treating inflammation-related conditions.
24) Animal:
Animal refers to the use of living organisms, especially rats, in experimental studies to gauge the effects of Basella alba. These studies are essential for translating findings from natural products to potential therapies for human use.
25) Chanda (Chamda):
Chanda refers to one of the authors of the cited research studies in analyzing the antioxidant activity of Basella alba. His work contributes to the understanding of the plant's health benefits and potential applications in natural medicine.
26) Palada (Pala-ada):
Palada refers to one of the authors whose research was cited regarding the nutritional benefits of Basella alba. His contributions highlight the importance of studying traditional plants and their phytochemical properties in the context of modern nutrition and medicine.
27) Cancer:
Cancer is a critical health condition characterized by uncontrolled cell growth. The article discusses the cytotoxic properties of Basella alba, suggesting its potential application in cancer treatment, which is crucial given the increasing incidence of cancer globally.
28) Powder:
Powder refers to the processed form of plant material. The research includes studies that involve the powdered extracts of Basella alba, indicating the methods of preparation that enhance the phytochemical potentials of the plant for pharmacological assessments.
29) Cotton:
Cotton in this context relates to the cotton pellet-induced granuloma model used for testing anti-inflammatory effects of Basella alba. This method is significant for evaluating the plant's therapeutic efficacy in pre-clinical studies.
30) Indian:
Indian refers to the geographical and cultural context of the research, emphasizing the traditional medicinal practices prevalent in India related to Basella alba. The relevance underscores the need for scientific validation of indigenous knowledge concerning local flora.
31) Kumar:
Kumar refers to an author involved in studies examining the antioxidant potential of Basella alba. His findings enrich the understanding of the plant's health benefits and emphasize the importance of such natural products in health promotion.
32) Water:
Water is essential for the extraction of phytochemicals from plants. The study highlights various extraction methods, including aqueous extracts of Basella alba, emphasizing their importance in evaluating the plant’s health benefits.
33) Field:
Field may refer to field studies or experiments conducted to observe the effects and applications of Basella alba in natural settings. The results from such studies are crucial for understanding the practical uses of plant-derived treatments.
34) Blood:
Blood refers to the biological fluid in the body that serves as a medium for transport. The article discusses how certain extracts from Basella alba demonstrate stabilizing effects on human red blood cell membranes, highlighting its potential application in treating blood-related conditions.
35) Cina:
China is significant as it is one of the countries where Basella alba is also traditionally used. Mentioning China emphasizes the broader geographical use of the plant and the potential for its application in various cultural medicinal practices globally.
36) Babu:
Babu refers to one of the authors of the study, Ajith Babu T. K., contributing to the research on pharmacological properties of Basella alba. His work helps expand the scientific understanding of the plant's therapeutic applications.
37) Line:
Line might refer to the lineage or classification context of Basella alba within its plant family or species. Understanding the botanical classification is important for exploring the phytochemical and pharmacological potential of various plant species.
38) Burning (Burn, Burned, Burnt):
Burn refers to the type of wound created for the study on wound healing capacity of Basella alba. This model is relevant for examining the effective use of the plant extract in promoting recovery from burn injuries.
39) Male:
Male typically refers to the gender of the albino rats used in the experiments. Research often specifies the sex of the subjects to account for any biological differences that may affect the study's outcomes.
Other Science Concepts:
Discover the significance of concepts within the article: ‘Phytochemical and pharmacological review on basella alba linn’. Further sources in the context of Science might help you critically compare this page with similair documents:
Basella alba, Longitudinal studies, Nutritive value, Antibacterial activity, Anti-inflammatory activity, Antioxidant activity, Wound healing activity, Aqueous extract, Cytotoxic activity, Folic Acid, CNS depressant activity, Anti-ulcer activity, Phytochemical review, Methanolic extract, Phenolic compound, Betacyanin.