Pilot study on bhringarajadi vati for managing khalitya (hair fall).

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Journal name: World Journal of Pharmaceutical Research
Original article title: A clinical study of bhringarajadi vati (a herbomineral ayurvedic formulation) in the management of khalitya (hair fall) – a pilot study
The WJPR includes peer-reviewed publications such as scientific research papers, reports, review articles, company news, thesis reports and case studies in areas of Biology, Pharmaceutical industries and Chemical technology while incorporating ancient fields of knowledge such combining Ayurveda with scientific data.
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Author:

Dr. Vivek Salvi, Dr. Murari Girare, Dr. Nikita Mishra, Dr. Vandana Saraf, Dr. Niranjan Saraf and Dr. Prakash Joshi


World Journal of Pharmaceutical Research:

(An ISO 9001:2015 Certified International Journal)

Full text available for: A clinical study of bhringarajadi vati (a herbomineral ayurvedic formulation) in the management of khalitya (hair fall) – a pilot study

Source type: An International Peer Reviewed Journal for Pharmaceutical and Medical and Scientific Research

Doi: 10.20959/wjpr20222-23069

Copyright (license): WJPR: All rights reserved


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Summary of article contents:

Introduction

Khalitya, commonly understood as hair fall, is a significant clinical condition affecting individuals' quality of life across gender and age. This condition impacts approximately 40% of men and 25% of women in India, with those aged 18 to 40 being particularly susceptible. The Ayurvedic perspective attributes hair loss to an imbalance of the Pitta Dosha and recognizes various factors contributing to this issue, including nutritional deficiencies, hormonal imbalances, and stress. To address this widespread problem, a pilot study was conducted to evaluate the safety and efficacy of "Bhringarajadi Vati," a herbomineral Ayurvedic formulation designed to manage Khalitya.

Efficacy of Bhringarajadi Vati

The study involved a randomized, single-group pilot design that analyzed 20 patients diagnosed with Khalitya at the Government Dhanwantari Ayurveda Medical College and Hospital during July and August 2020. Participants received a treatment of Bhringarajadi Vati, dosed at 500 mg twice daily for one month. The study's statistical analysis demonstrated a highly significant efficacy of the formulation in treating hair fall, with no adverse effects reported. Results indicated substantial improvement in various subjective symptoms associated with hair fall, confirming the formulation's safety and effectiveness.

Herbal Composition and Mechanism of Action

Bhringarajadi Vati comprises ten effective ingredients, including Bhringaraja (Eclipta alba), Aamalki (Emblica officinalis), Haritaki (Terminalia chebula), and several others. Each ingredient contributes uniquely to combatting hair fall: Bhringaraja is renowned for its properties promoting hair health, while Aamalki serves as a primary source of vitamin C, vital for hair nourishment. Additionally, ingredients like Kushmanda beej act as DHT (Dihydrotestosterone) reducers, targeting one of the primary hormonal causes of hair fall. The synergistic effects of these components provide a multi-faceted approach to alleviating Khalitya, addressing both internal and external factors influencing hair health.

Statistical Improvements and Assessment

Assessment of the treatment's impact focused on several parameters, including hair fall frequency (Kesh Patanam) and scalp conditions like dandruff (Darunak) and overall hair quality. Results demonstrated a significant reduction in hair fall, with 75% of participants showing improvement. Improvements in symptoms like dryness (Kesh Rukshatvam) and scalp itching (Shirah Kandu) were also profound, with rates of relief reaching upwards of 85%. This statistical data underscores the formulation’s effectiveness and highlights a collective improvement in patients’ hair health over the study duration.

Conclusion

This pilot study concluded that Bhringarajadi Vati is a safe and effective Ayurvedic treatment for managing Khalitya (hair fall). It reaffirms Ayurveda's holistic approach to health by addressing the physical and psychological aspects of hair loss. Given the escalating concerns surrounding hair health and the limited options available in modern medicine, Bhringarajadi Vati emerges as a promising alternative that harnesses traditional knowledge to address contemporary challenges related to hair fall. Further research and larger trials could help bolster its use in mainstream treatment regimens for hair-related issues.

FAQ section (important questions/answers):

What is Khalitya, and how does it affect individuals?

Khalitya refers to hair fall, a common condition impacting self-esteem and social interactions. It affects up to 40% of men and 25% of women in India, significantly influencing their quality of life.

What is Bhringarajadi Vati, and what are its main ingredients?

Bhringarajadi Vati is an Ayurvedic herbomineral formulation aimed at managing hair fall. It contains key ingredients like Bhringaraja, Aamalki, Haritaki, and Yashtimadhu, known for their effectiveness in promoting hair health.

How was the pilot study on Bhringarajadi Vati conducted?

The pilot study involved 20 clinically diagnosed Khalitya patients taking Bhringarajadi Vati for one month. Results were assessed using various subjective parameters before and after treatment.

What were the significant findings from the study on hair fall?

The study showed a significant reduction in hair fall and improvement in related symptoms such as dandruff and dryness. About 75% of participants experienced notable relief.

What are some common causes of hair fall identified in the study?

Common causes include nutritional deficiencies, hormonal imbalance, high stress levels, and environmental factors. Ayurveda recognizes an imbalance in Pitta Dosha as a significant factor leading to Khalitya.

What conclusion can be drawn regarding the effectiveness of Bhringarajadi Vati?

Bhringarajadi Vati proved to be a safe and effective treatment for Khalitya, significantly alleviating symptoms related to hair fall, according to the pilot study results.

Glossary definitions and references:

Scientific and Ayurvedic Glossary list for “Pilot study on bhringarajadi vati for managing khalitya (hair fall).”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.

1) Hair:
In this context, 'hairs' relates to the physical strands that grow from the scalp. The study focuses on the health, loss, and treatment options for hair, primarily through the Ayurvedic formulation Bhringarajadi Vati targeting issues related to Khalitya.

2) Khalitya:
Khalitya refers to hair loss or baldness in Ayurvedic medicine. It is characterized as a disorder that affects both genders and can greatly impact mental health, emphasizing the imbalance of dosha (body energies) as a cause for this condition.

3) Vati:
Vati refers to a form of Ayurvedic medication often prepared in tablet or pill form. It denotes a specific treatment method for ailments, such as Khalitya, in this study where Bhringarajadi Vati is used to address hair loss.

4) Bhringarajadi (Bhrngarajadi):
Bhringarajadi refers to a specific Ayurvedic formulation comprising various herbomineral ingredients. This mixture is believed to promote hair growth and prevent hair loss, reflecting the significant role of traditional medicine in treating Khalitya.

5) Study (Studying):
The study conducted aims to evaluate the efficacy and safety of Bhringarajadi Vati in the management of Khalitya. It highlights the scientific inquiry into Ayurveda's ability to address contemporary health issues regarding hair loss.

6) Ayurveda (Ayus-veda):
Ayurveda is a traditional Indian system of medicine that emphasizes balance in bodily systems through natural remedies. It plays a central role in the study, providing the framework for understanding and treating hair loss and other disorders.

7) Observation:
Observations refer to the systematic collection of data regarding patients’ conditions and their responses to the treatment throughout the study, providing crucial insights into the effectiveness of the Ayurvedic formulation.

8) Ujjain:
Ujjain is a city in India where the clinical study took place. It reflects the local context of Ayurvedic practice and underscores the importance of geographical and cultural influences in the research surrounding hair fall treatments.

9) Burning sensation:
Burning sensation on the scalp is one of the symptoms evaluated in the study. It links to Khalitya symptoms and indicates the need for effective treatment to improve patients' quality of life.

10) Bhringaraja (Bhrngaraja, Bhringa-raja, Bhrimgaraja):
Bhringaraja, or Eclipta alba, is a key ingredient in the formulation Bhringarajadi Vati. It is renowned in Ayurveda for its purported benefits in promoting hair health and growth, which are central to managing Khalitya.

11) Burning (Burn, Burned, Burnt):
Burning, often associated with discomfort or irritation, is a symptom examined in the context of scalp health. It serves as a clinical indicator of the condition's severity in patients suffering from hair fall.

12) Itching:
Itching on the scalp is another symptom evaluated in the study. It can be associated with various dermatological conditions, including Khalitya, highlighting the multifactorial nature of hair loss issues.

13) Bhasma (Bhasman):
Bhasma refers to an Ayurvedic method of processing minerals and metals into therapeutic compounds. It signals the approach of incorporating mineral-based remedies in treatments such as Bhringarajadi Vati for hair-related issues.

14) India:
India is the country where Ayurveda originated and the study is conducted. The cultural context is crucial in understanding traditional remedies and their relevance in contemporary health issues like hair loss.

15) Yashtimadhu (Yastimadhu, Yashti-madhu):
Yashtimadhu, or Glycyrrhiza glabra, is included in the formulation. It's known for its antioxidant properties and potential health benefits, aiding in the treatment of conditions like Khalitya as part of Ayurvedic practices.

16) Snigdha:
Snigdha denotes a quality in Ayurveda indicating properties that are oily or moistening. In the context of hair treatments, this attribute is associated with promoting healthy hair and preventing dryness.

17) Ruksha (Ruksa):
Ruksha describes a dry quality that can affect hair condition. It is significant in the study as it relates to the assessment of hair quality issues faced by patients with Khalitya.

18) Pitta:
Pitta is one of the three doshas in Ayurveda, representing heat and metabolism. Its imbalance is believed to contribute to Khalitya, making it crucial for understanding the pathogenesis of hair loss.

19) Ushna (Usna):
Ushna refers to a quality associated with heat. In Ayurveda, certain treatments aim to balance Ushna to address conditions like Khalitya by balancing the Pitta dosha.

20) Table:
In this study, tables are used to systematically present research data, observations, and results. They facilitate clear communication of findings to assess the effectiveness of treatments on various symptoms.

21) Vata:
Vata is another Ayurvedic dosha representing movement and space. Its imbalance can exacerbate health issues, including hair loss, making it important in the study of Khalitya management.

22) Drug:
Drugs in the context of this study refer to herbal and mineral-based formulations used in Ayurveda to treat conditions like Khalitya. The categorization reflects the diverse methods available for managing hair loss.

23) Varanasi (Varanashi):
Varanasi is a significant city in India synonymous with Ayurveda. While not the study site, it reflects the broader cultural and medicinal traditions that influence practices and beliefs surrounding hair loss treatments.

24) Krishna (Krsna):
Krishna refers to Krishna Tila, an ingredient in Bhringarajadi Vati. It is recognized in Ayurvedic medicine for nourishing hair and supporting overall health, relevant for addressing Khalitya.

25) Powder:
In this study, 'powder' denotes the form of the herbal ingredients used to prepare the formulation Bhringarajadi Vati. The powdered form is common in Ayurvedic medicines for ease of consumption and efficacy.

26) Dosha (Dosa):
Dosha is a fundamental concept in Ayurveda representing the three energies—Vata, Pitta, Kapha—that govern physiological and psychological functions. Understanding dosha balance is vital in treating conditions like Khalitya.

27) Laghu:
Laghu refers to a quality indicating lightness in Ayurvedic terminology. It is relevant in the study, particularly in assessing ingredients’ effects on hair density and overall health in the context of Khalitya treatments.

28) Guru:
Guru signifies heaviness in Ayurveda. This quality is relevant in the formulation of Bhringarajadi Vati, as heavier substances are thought to contribute to strengthening hair and overall vitality.

29) Tila:
Tila refers to sesame seeds in Ayurveda, particularly Krishna Tila. It is included in Bhringarajadi Vati for its nourishing and hair-strengthening properties, essential in managing Khalitya.

30) Loha:
Loha refers to iron in Ayurvedic tradition. Its inclusion in the formulation aims to address nutritional deficiencies related to hair health, which is pertinent in treating Khalitya.

31) Male:
Male is significant in the study, as statistics indicate a higher prevalence of Khalitya among men compared to women. Understanding gender differences is crucial in tailoring treatment approaches.

32) Shankhapushpi (Sankhapuspi, Samkhapuspi):
Shankhapushpi, or Convolvulus pluricaulis, is an herb included in the formulation due to its reputed cognitive and stress-relieving properties, potentially beneficial for addressing hair loss concerning psychological factors.

33) Vibhitaki:
Vibhitaki is one of the three fruits in Triphala, known for its detoxifying effects. Its inclusion in Bhringarajadi Vati aims to enhance overall hair health and counteract hair fall.

34) Haritaki:
Haritaki is another component of Triphala, valued in Ayurveda for its digestive benefits and detoxification properties. Its presence in the formulation may help maintain overall health impacting hair growth.

35) Sanskrit:
Sanskrit is the classical language of ancient Indian texts, including Ayurvedic texts. Many terms in the study are derived from Sanskrit, reflecting the traditional knowledge and practices embedded in Ayurveda.

36) Samhita:
Samhita refers to the ancient compilations of Ayurvedic texts containing clinical guidelines and formulations. The knowledge found in Samhitas underpins the principles applied in this study on hair loss treatment.

37) Samaka (Shamaka):
Shamaka indicates balancing properties in Ayurveda, relevant in context to formulations aiming to mitigate specific symptoms like hair loss or dandruff by restoring dosha balance.

38) Kashaya (Kasaya):
Kashaya refers to astringent properties in Ayurvedic medicine. This quality applies to many ingredients used in the formulation, thought to contribute to hair health and mitigate excessive oiliness on the scalp.

39) Bitter:
Bitter is one of the six tastes recognized in Ayurveda, with a role in promoting digestion and detoxification. Ingredients with this taste in Bhringarajadi Vati are associated with health benefits for hair.

40) Phala:
Phala means fruit in Sanskrit and symbolizes the end product or results in Ayurvedic context. In terms of hair treatment, it reflects the desired outcomes of using formulations like Bhringarajadi Vati.

41) Kapha:
Kapha is one of the three doshas in Ayurveda, characterized by water and earth elements. Its imbalance can contribute to skin and hair issues, making it relevant in discussions about Khalitya management.

42) Rakta:
Rakta refers to blood in Ayurvedic terminology. It is significant regarding hair health as proper blood circulation is essential for nourishing hair follicles, playing a role in the development of Khalitya.

43) Tikta:
Tikta denotes a bitter taste in Ayurveda. Ingredients characterized by this taste are often included for their detoxifying effects, which can indirectly benefit hair health in formulations like Bhringarajadi Vati.

44) Kandu (Kamdu):
Kandu refers to itching, particularly on the scalp. It's an important symptom investigated in the study, as addressing itching can improve comfort and overall hair quality for patients.

45) Kesa (Kesha):
Kesha is a Sanskrit term referring to hair in Ayurveda. Understanding Kesha's health is crucial for addressing Khalitya, emphasizing the significance of hair in personal identity and beauty.

46) Hindi (Himdi):
Hindi is a widely spoken language in India, providing accessibility to Ayurvedic concepts for the common populace. The use of Hindi terms enhances understanding of the study's findings among local populations.

47) Daha:
Daha indicates a burning sensation experienced on the scalp. This symptom may result from various skin conditions and is assessed in the study as part of understanding Khalitya's implications.

48) Gorakshanatha (Goraksanatha, Gorakhanatha, Gorakhnath, Goraksha-natha, Gorakha-natha):
Gorakh-nath refers to an influential figure in Indian spirituality and yogic traditions. His name in the study highlights the historical and cultural context of Ayurvedic practices, reflecting its deep roots in Indian philosophy.

49) Vatapitta (Vata-pitta):
Vatapitta is a combination of two doshas—Vata and Pitta. Understanding this interaction is essential in Ayurvedic treatment for Khalitya, as it can influence the pathology and management of hair loss.

50) Kushmanda (Kusmanda, Kushmamda):
Kushmanda, or Benincasa hispida, is recognized for its beneficial properties in Ayurveda. It is included in Bhringarajadi Vati, potentially contributing to nutritional support for hair health and mitigating hair loss.

51) Vidyotini:
Vidyotini refers to a commentary that aids in interpreting ancient Ayurvedic texts. It reflects the ongoing scholarly effort to understand and apply traditional knowledge in modern contexts such as hair loss treatment.

52) Triphala (Tri-phala):
Triphala is an Ayurvedic formulation consisting of three fruits, widely recognized for its detoxification properties. Its inclusion in the study signifies its relevance in treating conditions associated with hair health.

53) Kathinya:
Kathinya means harshness and is evaluated in the study as a symptom associated with hair quality. Addressing this symptom is essential in providing comprehensive Ayurvedic treatment for hair-related disorders.

54) Bhavana (Bha-vana):
Bhavana refers to the process of potentiating Ayurvedic remedies through various preparations. This concept is integral in the formulation of Bhringarajadi Vati, enhancing its therapeutic efficacy against hair loss.

55) Tanutva:
Tanutva means thinness, a quality assessed among the patients in relation to hair health. Recognizing this symptom helps in understanding the severity of Khalitya and tailoring appropriate treatment approaches.

56) Disease:
Diseases are pathological conditions that can disrupt physiological functions. Khalitya is one of many diseases examined in Ayurveda, underscoring the need for effective treatments customized to individual needs.

57) Shiras (Siras, Siro, Shirash):
Shirah translates to head in Sanskrit. It's relevant in discussing Khalitya as it relates to the site of hair growth and loss, being a focal point in evaluating the effects of treatments.

58) Gorakha (Gorakh):
Gorakh references Gorakh-nath, emphasizing the spiritual aspect intertwined with Ayurvedic practices. This connection enriches the cultural understanding of treatments aimed at conditions like Khalitya.

59) Katu:
Katu denotes a pungent taste in Ayurveda. This characteristic can contribute positively or negatively to health depending on the context, and it's relevant in evaluating the effects of various ingredients in the study.

60) Emblica officinalis:
Emblica officinalis, or Aamalki, is an important ingredient known for its high vitamin C content. Its addition to Bhringarajadi Vati enhances the formulation's efficacy against hair loss and promotes overall health.

61) Glycyrrhiza glabra:
Glycyrrhiza glabra, known as Yashtimadhu, is included for its soothing properties that could benefit hair and skin health. Its role emphasizes the importance of using herbs with multiple therapeutic properties in Ayurveda.

62) Terminalia chebula:
Terminalia chebula, or Haritaki, is used for its detoxification qualities. Its presence in Bhringarajadi Vati signifies the emphasis on cleansing and promoting overall health as a strategy for managing hair loss.

63) Mental health:
Mental health is a critical aspect impacted by Khalitya, as hair loss can lead to psychological distress. The study acknowledges this relationship and aims to promote both physical and emotional well-being in treatment.

64) Terminalia bellirica:
Terminalia bellirica, or Vibhitaki, is another component of Triphala known for enhancing digestive health. Its role in Bhringarajadi Vati underlines the holistic approach of Ayurveda in addressing issues related to hair loss.

65) Benincasa hispida:
Benincasa hispida, or Kushmanda, plays a role in Ayurvedic treatments for its nourishing effects. Its inclusion in the formulation highlights the variety of ingredients used for promoting optimal hair health.

66) Sushruta-samhita (Susruta-samhita):
Sushruta-samhita is an ancient Ayurvedic text detailing surgical techniques and herbal remedies. Its mention underscores the historical foundation of the study and the significance of traditional wisdom in managing hair loss.

67) Sesamum indicum:
Sesamum indicum, or Tila, known for its rich oil content, is vital for maintaining hair health. Its use in the formulation aims to nourish and strengthen hair, directly addressing Khalitya.

68) Tridoshajanya (Tridosajanya, Tridosha-janya):
Tridoshajanya refers to diseases involving an imbalance of the three doshas. Khalitya is classified under this category in Ayurveda, representing the need for holistic treatment approaches that restore balance.

69) Kshudraroga (Kshudra-roga, Ksudraroga):
Kshudraroga signifies minor diseases that, while not life-threatening, can cause significant distress. Khalitya is categorized under this classification, underscoring the need for treatment that can effectively manage such conditions.

70) Viruddhahara (Viruddha-ahara):
Viruddhahara translates to incompatible dietary practices. These practices are often implicated in many diseases, including hair fall, emphasizing the need for proper dietary education in conjunction with treatments for Khalitya.

71) Asthidhatu (Asthi-dhatu):
Asthi-dhatu refers to the bone tissue in Ayurveda. The link to Khalitya is made through the understanding that hair is connected to the health of Asthi-dhatu, emphasizing the interconnectivity of bodily systems.

72) Kaphadosha (Kaphadosa, Kapha-dosha):
Kapha-dosha, associated with stability and bodily structure, is another element in Ayurvedic theory. Its role in hair health is crucial, particularly in understanding the causes and management of Khalitya.

73) Agnimandya (Agni-mandya, Agnimamdya):
Agnimandhya refers to the diminished digestive fire or metabolism. This condition can lead to nutritional deficiencies impacting hair health and is addressed in the study as part of the broader understanding of hair loss issues.

74) Dravyaguna (Dravya-guna):
Dravyaguna signifies the study of medicinal properties of drugs and herbs in Ayurveda. This science forms the basis for selecting appropriate ingredients in formulations like Bhringarajadi Vati for effective treatment.

75) Perception:
Perception in this context refers to how individuals view their health and body image, particularly linked with hair. Assessing perception is vital in understanding the psychological impact of Khalitya.

[Note: The above list is limited to 75. Total glossary definitions available: 114]

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Discover the significance of concepts within the article: ‘Pilot study on bhringarajadi vati for managing khalitya (hair fall).’. Further sources in the context of Science might help you critically compare this page with similair documents:

Kshudraroga, Pittadosha, Self perception, Nutritional deficiency, Statistical analysis, Quality of life, Ayurvedic literature, Clinical study, Ayurvedic formulation, Pilot study, Safety and efficacy, Significant relief, Vata and Kapha Dosha, Hair fall, Tridoshajanya Vyadhi, Management of Khalitya, Herbo Mineral Preparation, Psychosocial consequences, Essential nutrient.

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