Study on nimabaaragwadha lepa and nimbaargwadha malahara.

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Journal name: World Journal of Pharmaceutical Research
Original article title: Comparative physico-chemical and pharmaceutical study on nimabaaragwadha lepa and nimbaargwadha malahara
The WJPR includes peer-reviewed publications such as scientific research papers, reports, review articles, company news, thesis reports and case studies in areas of Biology, Pharmaceutical industries and Chemical technology while incorporating ancient fields of knowledge such combining Ayurveda with scientific data.
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Author:

Sindhura R. Rao, Dr. Soumya Saraswathi M. and Dr. Subrahmanya Padyana


World Journal of Pharmaceutical Research:

(An ISO 9001:2015 Certified International Journal)

Full text available for: Comparative physico-chemical and pharmaceutical study on nimabaaragwadha lepa and nimbaargwadha malahara

Source type: An International Peer Reviewed Journal for Pharmaceutical and Medical and Scientific Research

Doi: 10.20959/wjpr20222-22863

Copyright (license): WJPR: All rights reserved


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Summary of article contents:

Introduction

Ayurveda, recognized globally for its holistic approach to health, emphasizes updating and enhancing classical medicinal practices to align with contemporary health trends. The present study focuses on two Ayurvedic formulations, Nimbaaragwadha Lepa and Nimbaaragwadha Malahara, both targeting a specific skin condition known as Padminikantaka. This condition is aligned with Acne vulgaris in modern dermatology, characterized by specific symptoms linked to the vitiation of Kapha and Vata. The study aims to prepare, modify, and standardize these formulations for effective therapeutic use.

Development of Nimbaaragwadha Lepa

Nimbaaragwadha Lepa is a traditional Ayurvedic paste made from the barks of two plants, Azadirachta indica (Nimba) and Cassia fistula (Aragwadha). The preparation process involves cleaning, drying, and grinding the barks into fine powder, followed by a careful blending to prevent clumping. The study meticulously followed Ayurvedic guidelines, ensuring the formulation retained its therapeutic properties. The resulting Lepa is characterized by its fine powder form, brownish-red color, and specific organoleptic properties. The pharmaceutical analysis confirmed its physicochemical profile, indicating consistency with traditional formulations.

Formulation of Nimbaaragwadha Malahara

Nimbaaragwadha Malahara is another innovative formulation derived from Nimbaaragwadha Lepa, adapted for better applicability on the skin. By modifying the original paste into an ointment, the study improved its consistency, shelf life, and ease of use. The preparation involved creating a Kalka (paste) with the same bark powders, combined with sesame oil and water in specified ratios. The resulting ointment had a unique yellow color and distinct aromatic qualities, contributing to its therapeutic efficacy. Analytical results indicated satisfactory physicochemical properties suitable for skin application.

Phenolic and Phytochemical Analysis

Both formulations underwent extensive phyto-chemical analysis to identify their constituents and their respective pharmacological effects. Components such as carbohydrates, proteins, and tannins were present in Nimbaaragwadha Lepa, contributing to its medicinal properties including antibacterial and anti-inflammatory effects. The presence of flavonoids and phenolic compounds was also confirmed, indicating promising therapeutic activities against skin ailments. These analyses bolster the traditional uses of these formulations, providing a scientific basis for their efficacy in treating Padminikantaka and associated symptoms.

Conclusion

The study effectively demonstrates that both Nimbaaragwadha Lepa and Nimbaaragwadha Malahara hold significant therapeutic potential in managing Padminikantaka, or acne-related conditions. Although acne is not regarded as a life-threatening issue, it substantially impacts individuals' self-esteem, highlighting the importance of effective treatments. The formulations developed in the study suggest a pathway for modern adaptations in cosmetic forms while retaining their Ayurvedic essence. Further research could validate these findings and expand their application in cosmetic dermatology, aiming for standardization and enhanced therapeutic efficacy.

FAQ section (important questions/answers):

What is the main purpose of the study on Nimbaaragwadha Lepa?

The study aims to compare the physico-chemical and pharmaceutical properties of Nimbaaragwadha Lepa and Nimbaaragwadha Malahara, both formulations used in Ayurvedic medicine, particularly for treating Acne vulgaris or Padminikantaka.

Who are the authors involved in the research?

The research is conducted by Sindhura R. Rao, Dr. Soumya Saraswathi M., and Dr. Subrahmanya Padyana from Alva's Ayurveda Medical College, Karnataka.

What condition is Padminikantaka traditionally compared to in modern medicine?

Padminikantaka is traditionally compared to Acne vulgaris, characterized by circular pimples and skin symptoms associated with Kapha-Vata vitiation.

What ingredients are used in preparing Nimbaaragwadha Lepa?

Key ingredients for Nimbaaragwadha Lepa include Nimba Twak (bark of Azadirachta indica) and Aragwadha Twak (bark of Cassia fistula), which are processed into fine powders.

What are the key results from the physicochemical analysis?

Results indicated a loss on drying of 2.70% for Lepa Churna and a pH of 5.80. For Malahara, loss on drying was 1.65% with a pH of 5.40, indicating stability and compatibility.

How do Nimbaaragwadha Lepa and Malahara benefit skin health?

Both formulations exhibit antibacterial and anti-inflammatory properties, helping to treat skin conditions such as acne, improve skin clarity, and restore confidence in users.

Glossary definitions and references:

Scientific and Ayurvedic Glossary list for “Study on nimabaaragwadha lepa and nimbaargwadha malahara.”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.

1) Lepa:
Lepa refers to a type of paste or topical formulation used in Ayurveda, primarily for skin applications. It is made by grinding herbal ingredients with a liquid medium to form a semi-solid consistency that is effective in treating various skin conditions, including those characterized by inflammation, lesions, or infections.

2) Drug:
In the context of Ayurveda, a drug can refer to any substance used in the composition of herbal formulations for therapeutic purposes. The term encompasses a wide range of natural products, including herbs and their extracts, each possessing specific medicinal properties that contribute to healing in patients.

3) Taila (Thaila):
Taila is the Sanskrit term for oil used in Ayurvedic formulations. It serves as a medium for delivering medicinal properties to the skin or body through topical applications. Oils also enhance absorption, making the active components more effective in promoting health and alleviating symptoms of various ailments.

4) Ayurveda (Ayus-veda):
Ayurveda is an ancient Indian system of medicine that emphasizes a holistic approach to health and wellness. It encompasses various practices, including herbal medicine, dietary recommendations, and lifestyle adjustments, aiming to balance the three doshas—Vata, Pitta, and Kapha—in individuals for optimal health.

5) Nimba:
Nimba, or Azadirachta indica, commonly known as neem, is a revered medicinal plant in Ayurveda. It has potent antibacterial, antifungal, and antiviral properties. Its leaves and bark are used in various formulations to treat skin ailments, promote wound healing, and detoxify the body, making it an essential herb.

6) Sikta:
Sikta refers to beeswax in Ayurvedic formulations, often used as an emulsifying agent in topical preparations. It helps to improve the texture and consistency of ointments and pastes, enhancing their application and effectiveness. Beeswax also adds stability and can contribute moisturizing properties to formulations.

7) Powder:
In Ayurveda, powder refers to the finely ground form of herbal ingredients used to create formulations like lepas and churnas. The micronized particles enhance the surface area for better absorption and efficacy in therapeutic applications, allowing the bioactive compounds of the herbs to act more efficiently.

8) Study (Studying):
The term study in this context pertains to the systematic investigation of the properties, efficacy, and preparation methods of Ayurvedic formulations. It encompasses scientific research methodologies aimed at validating the traditional uses of herbal drugs and their effectiveness through rigorous testing and analysis.

9) Tilataila (Tila-taila):
Tila-taila translates to sesame oil in Ayurveda, often used as a base for preparing medicinal oils and formulations. It is valued for its nutritional benefits, including omega fatty acids, and serves as an effective medium for extracting and delivering the therapeutic properties of herbal ingredients.

10) Samaka (Shamaka):
Shamaka denotes the properties of a substance or treatment that pacifies or balances the doshas in Ayurveda. Medicines or formulations described as Shamaka aim to restore equilibrium in the body, alleviating symptoms caused by imbalances of Vata, Pitta, or Kapha, thus promoting overall health.

11) Siddha:
Siddha, which means achieved or perfected, refers to formulations that are prepared according to precise Ayurvedic standards. Siddha medicines are expected to possess proven therapeutic benefits, having undergone rigorous preparation and validation, ensuring their efficacy and safety for treating various health conditions.

12) Kapha:
Kapha is one of the three doshas in Ayurveda, characterized by elements of earth and water. It governs structure, stability, and lubrication in the body. When balanced, it contributes to vitality and stamina, but when aggravated, it can lead to ailments associated with excess moisture and heaviness.

13) Kalka:
Kalka refers to a specific form of herbal paste made in Ayurveda by grinding fresh or dried herbal ingredients with water. This paste is typically utilized for external applications or for preparing potent medicinal formulations. It aids in the therapeutic delivery of active constituents from herbs.

14) Roga:
Roga translates to disease or ailment in Sanskrit, and is a central concept in Ayurveda. Understanding the nature of Rogas involves identifying the imbalance of doshas within the body. Ayurvedic treatments aim to restore health by correcting these imbalances, thus treating the root causes of various medical conditions.

15) Jala:
Jala denotes water in Sanskrit and serves as an essential medium in various Ayurvedic preparations. It is used to create herbal pastes, decoctions, and infusions, aiding in the extraction of medicinal properties from herbs. Water is also vital for maintaining proper hydration and balance in bodily functions.

16) Life:
Life in the Ayurvedic context emphasizes the importance of wellness, balance, and holistic health. Ayurveda considers the interplay of physical, mental, and spiritual well-being essential for a fulfilled life. Treatments and lifestyle recommendations aim to enhance quality of life by addressing health from multiple dimensions.

17) Pharmacological:
Pharmacological pertains to the study and application of drugs and their effects on the body. In Ayurveda, it relates to understanding the active principles in herbal medicines, their mechanisms of action, and how they influence physiological processes, helping to validate the traditional uses of these substances scientifically.

18) Antibiotic (Antibacterial):
Antibacterial refers to substances that inhibit the growth of bacteria or kill them outright. Many Ayurvedic herbs, such as Nimba, possess these properties and are used in formulations aimed at treating infections and skin ailments, thus contributing significantly to the health and wellness provided by Ayurvedic treatments.

19) Kshudraroga (Kshudra-roga, Ksudraroga):
Kshudra-roga translates to minor ailments or diseases in Ayurveda. This term encompasses a range of conditions that may not be life-threatening but can affect quality of life, like skin disorders such as acne. Treatments for Kshudra-roga aims to alleviate symptoms and restore balance without requiring extensive interventions.

20) Dravyaguna (Dravya-guna):
Dravyaguna is the branch of Ayurveda studying the characteristics and effects of medicinal substances. This discipline aids practitioners in understanding how different herbs interact in formulations and their therapeutic properties, making it essential for effective treatment plans that address imbalances and promote holistic health.

21) Bhaishajya (Bhaisajya):
Bhaishajya translates to medicine or pharmaceutical preparation in Ayurveda. It encompasses all healing substances, including herbs, minerals, and prepared formulations. An understanding of Bhaishajya is crucial for practitioners in developing appropriate treatment plans and enhancing therapeutic outcomes based on ancient Ayurvedic traditions.

22) Vatapitta (Vata-pitta):
Vata-pitta refers to the combination of the Vata and Pitta doshas in an individual. Analyzing the balance of these doshas helps practitioners identify unique health needs. When imbalances occur, they can lead to various health issues, necessitating treatments tailored to restore balance and well-being.

23) Krimighna (Krmighna, Krimi-ghna):
Krimighna signifies the property of a substance or preparation that acts against parasites and microorganisms. This term is significant in Ayurveda as many formulations incorporate herbs with Krimighna properties to combat infections, promoting health and healing through natural means. This makes it a crucial aspect of Ayurvedic medicine.

24) Kandughna (Kandu-ghna):
Kandughna refers to substances that alleviate itching or irritation, a common symptom in various skin conditions. Ayurvedic formulations labeled as Kandughna hold significance in treating conditions like eczema and dermatitis, enhancing patient comfort and promoting skin health by addressing discomfort often associated with these ailments.

25) Container:
Containers are critical in the preparation and storage of Ayurvedic formulations, ensuring that herbs and substances remain effective and uncontaminated. Proper selection and maintenance of containers preserve the integrity and potency of herbal medicines, thus directly influencing their efficacy when administered to patients.

26) Tridosha (Tri-dosha, Tridosa):
Tridosha is a fundamental concept in Ayurveda, referring to the three vital energies or doshas: Vata, Pitta, and Kapha. Each dosha embodies specific qualities in the body and mind. Health in Ayurveda is about balancing these doshas, as imbalances can lead to illness and other health concerns.

27) Sindhura (Simdhura):
Sindhura, a term associated with the author's name, represents the individual contributing to the research. This name reflects the personal connection to the study's subject and the significance of the findings, as they pertain to the development and standardization of Ayurvedic formulations for therapeutic purposes.

28) Sukshma (Shukshma, Suksma):
Sukshma refers to the fine or subtle forms of substances or powders in Ayurveda. Creating Sukshma preparations enhances the efficacy of herbal medicines by increasing surface area for absorption. Fine powders can more readily interact with biological systems, ensuring active ingredients are delivered effectively for therapeutic outcomes.

29) Kalpana:
Kalpana refers to the preparation or formulation of medicines in Ayurveda. It encompasses the methods and techniques by which herbs and ingredients are transformed into effective therapeutic forms, ensuring that their medicinal properties are fully utilized. Knowledge of Kalpana is essential for developing precise Ayurvedic treatments.

30) Dravya:
Dravya means substance in Sanskrit and is a core concept in Ayurveda. Understanding Dravya is fundamental for practitioners, as it relates to physical and philosophical properties of various substances used in treatments. This knowledge aids in selecting appropriate herbs and formulations tailored to individual health needs.

31) Vedana:
Vedana signifies the sensation or pain experienced by an individual. In Ayurvedic practice, understanding Vedana is essential for diagnosing conditions and prescribing treatments that alleviate discomfort. Effective management of Vedana helps restore health and balance within the body, addressing the subjective experiences of patients during illness.

32) Silver:
Silver refers to a metal used in some Ayurvedic practices for its antimicrobial properties and therapeutic benefits. Its presence in formulations can enhance the effectiveness of certain treatments, particularly in alleviating skin ailments. Silver also carries cultural significance in Ayurveda, utilized traditionally in various medicinal systems.

33) Kandu (Kamdu):
Kandu denotes itching or irritation, often linked to skin disorders. In Ayurveda, conditions that present with Kandu require targeted treatments to relieve discomfort and restore skin health. Herbal formulations with Kandughna properties are particularly effective in addressing this symptom, promoting overall healing and patient well-being.

34) India:
India is the geographical and cultural origin of Ayurveda. Its rich history in herbal medicine and holistic health practices has shaped traditional and contemporary healthcare systems worldwide. The integration of Ayurvedic principles in modern wellness reflects India's influence on global health practices and universal approaches to disease management.

35) Guna:
Guna translates to qualities or attributes characteristic of substances in Ayurveda. The concept of Guna helps practitioners understand the effects and interactions of different herbs and materials used in treatments. This knowledge is pivotal for tailoring therapies that resonate with individual patient needs and specific health conditions.

36) Food:
Food in the Ayurvedic context encompasses dietary elements crucial for health and vitality. Ayurveda emphasizes the significance of nourishing foods that balance the doshas, contributing to overall well-being. Proper nutrition is considered foundational for preventing diseases and supporting bodily functions, illustrating Ayurveda's holistic approach to health.

37) Azadirachta indica:
Azadirachta indica, commonly known as neem, is a vital medicinal plant in Ayurveda recognized for its extensive health benefits. Known for its antibacterial, antifungal, and anti-inflammatory properties, neem is integral in treating a variety of ailments, particularly skin-related issues, and is a staple in many herbal formulations.

38) Kaphavata (Kapha-vata):
Kapha-vata refers to the combination of Kapha and Vata doshas. Understanding this balance is critical in Ayurveda for diagnosing health issues and formulating treatments tailored to an individual's unique constitution. When these doshas are imbalanced, they can lead to various health concerns requiring specific therapeutic interventions.

39) Discussion:
Discussion refers to the analytical exploration of findings within the research. It encompasses evaluating the results, comparing them to existing knowledge, and drawing conclusions about the efficacy and implications of the studied formulations. Effective discussions help in understanding the broader impact of research on Ayurvedic practices and patient care.

40) Flavonoid:
Flavonoid, in a singular form, refers to the class of compounds found in plants known for their beneficial biological activities. Flavonoids contribute to the therapeutic properties of various Ayurvedic formulations, enhancing their ability to combat diseases and support overall health due to their anti-inflammatory and antioxidant properties.

41) Siddhanta (Siddha-anta, Siddhamta):
Siddhanta refers to the principles or established doctrines in Ayurveda. It encompasses the foundational concepts that guide Ayurvedic practice, including theories about health, disease, and treatment modalities. Understanding Siddhanta is crucial for practitioners to apply knowledge effectively in clinical settings.

42) Shothahara (Sothahara, Shotha-hara):
Sothahara signifies the properties of a substance that alleviate swelling or inflammation. Such attributes are especially valued in Ayurvedic treatments aimed at addressing conditions linked to excess dosha activity, thereby promoting healing and restoration of balance in affected areas of the body.

43) Lakshana (Laksana):
Lakshana means characteristics or symptoms in Ayurveda. Identifying Lakshana is critical for diagnosis and treatment within Ayurvedic practice as it pertains to the signs and manifestations of imbalances in the body. Understanding these characteristics aids practitioners in determining the appropriate therapeutic responses to patient needs.

44) Medicine:
Medicine in the Ayurvedic context encompasses a holistic approach to curing and preventing ailments through natural means. This includes the use of herbs, minerals, and lifestyle modifications tailored to restore balance in the body. Ayurveda promotes the use of traditional knowledge fused with modern practices for optimal health outcomes.

45) Science (Scientific):
Sciences, in relation to Ayurveda, signifies the research and empirical methodologies applied to study herbal medicine and health practices. The integration of scientific principles with Ayurvedic traditions aims to validate the efficacy and safety of treatments, fostering an evolving understanding of health and wellness.

46) Vijnana:
Vijnana denotes the body of knowledge or wisdom in Ayurveda. It incorporates the understanding of herbal ingredients, their uses, and the principles guiding effective practice. Vijnana is essential for Ayurvedic practitioners to ensure treatments are founded on sound theoretical frameworks, enhancing their efficacy and relevance in patient care.

47) Medium:
Medium refers to the substances or conditions used to facilitate the preparation of Ayurvedic formulations. This may include water, oils, or other liquids needed to create pastes, decoctions, or tinctures from herbal ingredients. The right medium influences the extraction and bioavailability of therapeutic compounds in the formulations.

48) Field:
Field in this context pertains to the area of study or practice within Ayurveda. It refers to the specific domain where knowledge, research, and application converge, such as herbal medicine, pharmacology, or clinical practice. Expanding one’s knowledge in a specific field enhances the quality of patient care.

49) Rasa (Rasha):
Rasa in Ayurveda refers to the taste and overall essence of herbal substances, which play a crucial role in determining their therapeutic properties. Understanding Rasa is vital for formulating effective remedies, as different tastes can influence digestion, metabolism, and the dosha balance within the body, impacting health.

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Discover the significance of concepts within the article: ‘Study on nimabaaragwadha lepa and nimbaargwadha malahara.’. Further sources in the context of Science might help you critically compare this page with similair documents:

Kshudraroga, Krimighna, Kandughna, Shothahara, Tilataila, Padminikantaka, Chakradatta, Pharmaceutical preparation, Bhaishajya kalpana, Ayurvedic Formulary of India, Dravyaguna Vijnana, Tridosha shamaka, Physico-chemical studies, Analytical lab.

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