Conceptual study of anti-toxic action of mahagada- a review
Journal name: World Journal of Pharmaceutical Research
Original article title: Conceptual study of anti-toxic action of mahagada- a review
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Dr. A. C. Tumram and Dr. Meera S. Kadam
World Journal of Pharmaceutical Research:
(An ISO 9001:2015 Certified International Journal)
Full text available for: Conceptual study of anti-toxic action of mahagada- a review
Source type: An International Peer Reviewed Journal for Pharmaceutical and Medical and Scientific Research
Doi: 10.20959/wjpr20223-23447
Copyright (license): WJPR: All rights reserved
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Summary of article contents:
Introduction
Mahagada, as detailed in the article by Dr. A. C. Tumram and Dr. Meera S. Kadam, is a traditional Ayurvedic formulation known for its anti-toxic properties. Drawing from the teachings of Aacharya Sushruta and various Ayurvedic texts, the formulation is designed to counteract various types of poisoning, including those caused by snakes, spiders, rats, and scorpions, as well as conditions like gastroenteritis and fever. The article emphasizes the need for a comprehensive scientific review to validate the efficacy and mechanisms of this formulation in treating poisoning and related ailments.
Understanding the Ingredients of Mahagada
The formulation of Mahagada consists of 14 ingredients, each contributing uniquely to its therapeutic effects. Notable components include Trivrit, Vishalya, Madhuka, and Haridra, among others. Each ingredient has specific properties, such as anti-inflammatory, analgesic, and astringent effects. For example, Trivrit is known for its anti-oedematous and antipyretic properties, while Madhuka is recognized for its soothing and anti-hemorrhagic effects. All ingredients are triturated with goat's urine, enhancing their synergistic effects to create a potent antidote against various poisons and conditions.
Pharmacological Properties of Ingredients
The pharmacological profile of Mahagada's ingredients highlights their individual and collective therapeutic actions. The ingredients exhibit various properties such as "vishaghna" for poison removal, "shothahara" for swelling reduction, and "jwaraghna" for fever relief. For instance, Haridra demonstrates anti-poisonous and anti-leprotic effects, while Manjistha serves as a blood purifier and anti-inflammatory agent. The diverse pharmacological actions allow Mahagada to address multiple symptoms and complications associated with poisoning and other ailments effectively.
Administration and Usage Guidelines
Mahagada can be administered through various routes, including oral intake, nasal instillation, and as collyrium. The formulation is adaptable, allowing for different adjuvants based on the specific condition being treated. This versatility makes Mahagada suitable for a wide array of medical situations, including acute poisoning incidents and chronic conditions like hypoacidity and fever. Its preparation method is straightforward, making it accessible for practitioners in the field.
Conclusion
The efficacy of Mahagada as an antidote lies in its carefully selected ingredients, which work harmoniously to combat various forms of poisoning and related health issues. The formulation is predominantly characterized by bitter (tikta) and pungent (katu) tastes, hot potency, and quick-acting properties, which enhance its therapeutic potential. Given its accessibility and effectiveness, Mahagada presents a promising option in Ayurvedic medicine for treating poisoning and inflammatory conditions, deserving further exploration and integration into modern medical practices.
FAQ section (important questions/answers):
What is Mahagada and its use in Ayurveda?
Mahagada is an Ayurvedic formulation with anti-toxic properties used to treat various types of poisoning, including snake, spider, and rat poisoning, as well as conditions like gastroenteritis and fever.
What ingredients are included in the Mahagada formulation?
Mahagada consists of 14 ingredients, including Trivrit, Vishalya, and Madhuka, among others, which are triturated with goat's urine to create a fine paste for use.
How does Mahagada help in treating poisoning symptoms?
Mahagada addresses symptoms such as swelling, pain, burning sensation, and itching through its properties like anti-oedematous, analgesic, and anti-inflammatory, providing a multifaceted approach to managing poisoning.
What are the pharmacological actions of Mahagada's ingredients?
The ingredients of Mahagada exhibit various actions, including anti-inflammatory, analgesic, digestive, and detoxifying effects, which collectively enhance its efficacy in treating poisoning and other related conditions.
What are the potential benefits of using Mahagada?
Mahagada can be effectively used as an antidote for different poisonings and is also beneficial for gastrointestinal issues, inflammation, and fever, showcasing its versatile therapeutic applications.
Is Mahagada preparation complex or simple?
The preparation of Mahagada is straightforward, involving the mixing of ingredients into a paste with goat's urine, making it feasible for practical use in various medical conditions.
Glossary definitions and references:
Scientific and Ayurvedic Glossary list for “Conceptual study of anti-toxic action of mahagada- a review”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.
1) Katu:
Katu refers to the pungent taste characteristic of certain herbs and spices. In Ayurvedic medicine, it's believed to stimulate digestion and possess heating properties that can assist in alleviating excess Kapha and Vata doshas. This quality makes Katu an essential component in formulations aimed at addressing various health conditions.
2) Kapha:
Kapha is one of the three doshas in Ayurveda, characterized by qualities such as heaviness, coldness, and stability. When in balance, Kapha supports growth, immunity, and lubrication in the body. Imbalances can lead to conditions like congestion and lethargy, making its regulation crucial for overall health.
3) Lavana:
Lavanas denote various types of salts in Ayurveda, recognized for their role in balancing doshas and enhancing dietary value. These salts are essential for digestive processes and contribute to therapeutic formulations emphasizing holistic health.
4) Ushna (Usna):
Ushna denotes heat and warmth in Ayurvedic terminology. This quality is associated with substances or formulations that can enhance digestion and metabolic activity. Ushna is particularly beneficial for treating conditions associated with coldness and stagnation, thus balancing the doshas and promoting vitality.
5) Vata:
Vata is another key dosha in Ayurveda, embodying qualities like dryness, lightness, and mobility. It governs bodily functions related to movement, circulation, and neural activity. Imbalances in Vata can lead to issues such as anxiety, constipation, and joint pain, emphasizing the importance of maintaining its balance.
6) Laghu:
Laghu translates to lightness in Ayurvedic texts, signifying the properties of certain substances or foods that are easily digestible and promote agility in the body. Laghu substances are essential in dietary recommendations for managing weight, digestion, and overall vitality, especially for balancing Kapha.
7) Pharmacological:
Pharmacological refers to the study and effects of drugs on biological systems. In the context of Ayurvedic formulations, understanding the pharmacological properties of ingredients helps validate traditional practices and enables a scientific approach to assessing efficacy, safety, and mechanisms of action for various treatments.
8) Krimighna (Krmighna, Krimi-ghna):
Krimighna signifies substances that have anti-parasitic or anti-worm properties in Ayurveda. These ingredients are used to eliminate intestinal parasites and enhance gut health. Their inclusion in formulations provides an essential benefit for treating infections and promoting overall digestive wellness.
9) Tikta:
Tikta pertains to the bitter taste found in specific herbs. In Ayurveda, bitter compounds aid digestion, detoxification, and stimulating liver function. Tikta properties serve vital roles in balancing Pitta and Kapha, and are incorporated into therapies targeting metabolic and inflammatory disorders.
10) Fever:
Fever represents an increase in body temperature often indicating an underlying infection or inflammatory process. In Ayurveda, treating fever involves identifying the causing dosha imbalance, with herbal formulations aimed at reducing heat, inflammation, and associated symptoms, ensuring a holistic healing approach.
11) Agada:
Agadas refer to antidotal formulations in Ayurveda, particularly those that counteract poisons and toxins. Their importance lies in providing specific, targeted actions essential for detoxification and health restoration, showcasing the unique aspects of Ayurvedic toxicology.
12) Pitta:
Pitta is one of the three doshas in Ayurveda, embodying the qualities of heat, intensity, and transformation. It governs digestion, metabolism, and energy production. Maintaining Pitta balance is fundamental for preventing conditions such as acid reflux and inflammation, ensuring optimal bodily function.
13) Drug:
Drugs encompass various medicinal compounds utilized for therapeutic purposes. In Ayurveda, drugs are often derived from plant, animal, or mineral sources, highlighting traditional approaches that promote healing through holistic understanding and applications in addressing various health issues and imbalances.
14) Shothahara (Sothahara, Shotha-hara):
Shothahara indicates properties that reduce swelling or inflammation. Components exhibiting Shothahara effects are vital in managing conditions arising from Vata and Pitta imbalances, commonly found in Ayurvedic treatments for injuries, bites, and inflammatory responses, promoting healing and comfort.
15) Scorpion:
Scorpion poisoning varies in severity based on the species and individual response. In Ayurveda, specific formulations such as Mahagada are utilized to address symptoms and counteract toxins from scorpion bites, utilizing the unique properties of various herbs to alleviate complications associated with envenomation.
16) Madhura:
Madhura translates to sweetness in Ayurveda and relates to substances that nourish and stabilize the body. Sweet properties often support digestive health, mitigate Pitta aggravation, and provide a soothing quality in formulations, balancing the overall effects of other potent tastes.
17) Ruksha (Ruksa):
Ruksha refers to the quality of dryness in Ayurvedic terminology. This property plays essential roles in balancing excessive moisture or Kapha doshas and can be beneficial for certain conditions like phlegm and obesity, while also influencing the selection of dietary and herbal treatments.
18) Spider:
Spider poisoning, like other venomous bites, can lead to various systemic symptoms depending on the type of spider. Ayurvedic treatments focus on managing these conditions through specific formulations that can alleviate symptoms, enhance immune response, and assist in recovery, reflecting traditional understandings of toxicity.
19) Study (Studying):
In the context of this review, study refers to the systematic investigation of Ayurvedic formulations and their efficacy against various conditions, particularly regarding antitoxic properties. Engaging in thorough studies helps bridge traditional knowledge and contemporary scientific inquiries, validating the effectiveness of these practices.
20) Visha (Visa):
Visha is the term used for poison in Ayurveda, encompassing various toxic substances, whether from animals, plants, or minerals. Understanding Visha and its effects are crucial for developing antidotes or Agadas to counteract poisoning and promote health, emphasizing the importance of Ayurvedic toxicology.
21) Salt (Salty):
Salt serves several functions in Ayurveda, primarily for balancing electrolytes, enhancing flavor, and supporting digestive health. Various types of Lavana, or salts, are employed in formulations, showcasing essential roles for bodily functions and therapeutic applications addressing different dosha imbalances.
22) Daruharidra (Daru-haridra):
Daruharidra, or Berberis aristata, is a significant herb in Ayurveda noted for its anti-inflammatory and anti-poison properties. It’s often utilized in treating skin conditions and infections, highlighting its importance in both herbal formulations and safety against toxic substances.
23) Vranaropana (Vrana-ropana):
Vranaropana refers to the healing and wound-repairing properties of substances used in Ayurveda. Ingredients with Vranaropana effects are vital in managing injuries and promoting recovery, enhancing tissue regeneration, and supporting overall healing processes within traditional health practices.
24) Kaphapitta (Kapha-pitta):
Kapha-pitta represents the dual dosha combination affecting individuals' health. Understanding this interplay aids in determining appropriate treatments and dietary modifications in Ayurveda to balance both Kapha and Pitta energies, preventing related imbalances and promoting overall well-being.
25) Sophahara (Shophahara, Shopha-hara):
Shophahara denotes the action of substances that reduce swelling or edema. Such properties are significant in managing inflammatory and fluid retention conditions in Ayurvedic practices, facilitating improved recovery and comfort for individuals suffering from various ailments.
26) Kandughna (Kandu-ghna):
Kandughna refers to the property of alleviating itching or irritation. Herbal ingredients with Kandughna properties are essential in treating skin disorders and allergic reactions, enhancing comfort and providing relief from distressing symptoms through various formulations in Ayurveda.
27) Vishaghna (Visaghna, Visha-ghna):
Vishaghna indicates properties that counteract poisons and toxins. Ingredients exhibiting Vishaghna qualities are crucial for detoxification and anti-poisoning therapies in Ayurveda, emphasizing the importance of traditional herbal wisdom in managing toxicological emergencies effectively.
28) Vishalya (Visalya):
Vishalya refers to substances or herbs that are particularly effective against poisons or venom. This property is significant for developing antidotes and treating poisoning in different contexts, emphasizing the relevance of Vishalya in Ayurvedic toxicology and therapeutic practices.
29) Samhita:
Samhita refers to classical Ayurvedic texts that compile knowledge and guidelines regarding health, herbal treatments, and therapies. These texts serve as crucial sources for understanding traditional medicine practices, offering foundational insights into various Ayurvedic philosophies and methodologies.
30) Tikshna (Tiksna):
Tikshna translates to sharp or penetrating, and it indicates the quality of herbs that may possess a strong effect on tissues. In Ayurvedic contexts, substances labeled as Tikshna are often associated with potent therapeutic actions, particularly in stimulating digestion and enhancing metabolic activities.
31) Madhuka:
Madhuka, or Glycyrrhiza glabra (licorice), possesses a sweet flavor and is widely recognized for its anti-inflammatory and soothing properties. Its role in Ayurveda includes promoting armony in various doshas, highlighting its versatile application in numerous herbal formulations.
32) Haridra:
Haridra refers to turmeric, a key herb in Ayurveda known for its anti-inflammatory, antimicrobial, and healing properties. Its unique compounds enhance health, aiding in detoxification and serving as a vital ingredient for numerous traditional remedies and practices.
33) Nagapura (Naga-pura):
Nagpur is a city in India recognized for its higher educational institutions and contributions to Ayurvedic education and research. The presence of Ayurvedic scholars and institutions in Nagpur promotes traditional medicine practices and supports the dissemination of Ayurvedic knowledge and therapies in contemporary healthcare.
34) Rasa (Rasha):
Rasa translates to taste or flavor, a fundamental concept in Ayurveda determining the healing properties of substances. Each Rasa contributes to how a drug interacts within the body, influencing digestion, metabolism, and balancing doshas, making it essential for Ayurvedic diagnosis and treatment.
35) Pain:
Pain refers to a complex sensation indicating discomfort or distress in the body. Ayurveda emphasizes treating pain through holistic methods by addressing underlying causes and employing herbal formulations that possess analgesic properties, ensuring comprehensive management of symptoms and promoting overall health.
36) Burning sensation:
Burning sensation signifies discomfort often associated with inflammation or irritation. In Ayurveda, therapeutic interventions are designed to address the root causes and alleviate this symptom through cooling properties and anti-inflammatory agents, enhancing patient comfort and promoting healing.
37) Saindhavalavana (Saindhava-lavana, Saimdhavalavana):
Saindhava-lavana refers to rock salt, a prominent ingredient in Ayurvedic treatment known for its balancing and detoxifying properties. Used in various formulations, Saindhava-lavana plays a vital role in enhancing flavors and therapeutic effects, emphasizing its significance in traditional medicine.
38) Samudralavana:
Samudra-lavana refers to sea salt in Ayurvedic practices. It's valued for its mineral content and health benefits, commonly incorporated in formulations to promote digestion and balance bodily fluids. Its role reaffirms the importance of natural salts in Ayurvedic healing.
39) Vidalavana (Vida-lavana):
Vida-lavana represents another type of salt known for its purifying qualities. In Ayurveda, it is utilized for balancing dosha influences and addressing digestive issues, underscoring the essential role of various Lavanas in formulating effective Ayurvedic treatments.
40) Snake-bite:
Snake-bite involves venom introduction into the body, causing systemic effects based on the type of snake. Ayurveda approaches snake-bite treatment through specific formulas, targeting symptoms and promoting recovery while utilizing traditional knowledge for effective antitoxic actions.
41) Science (Scientific):
Scientific pertains to methodologies and principles based on empirical evidence and research. In the context of Ayurveda, adopting scientific approaches validates traditional practices, enhances understanding of herbological effects, and supports the integration of Ayurvedic knowledge within modern healthcare frameworks.
42) Substance:
Substance refers to any specific material with therapeutic potential within Ayurvedic systems. This encompasses herbal, mineral, and animal-derived compounds, illustrating the vast scope of ingredients that contribute to the efficacy of Ayurvedic formulations and treatments.
43) Saindhava (Saimdhava):
Saindhava denotes rock salt, recognized for its numerous health benefits in Ayurveda. It is utilized in various formulations to balance doshas and promote digestion. Its incorporation highlights the role of natural minerals in enhancing therapeutic effectiveness and contributing to overall health.
44) Manjishtha (Manjistha, Mamjishtha):
Manjistha refers to Rubia cordifolia, an herb celebrated for its blood-purifying and anti-inflammatory properties. In Ayurvedic therapies, Manjistha is commonly employed for skin conditions and detoxification processes, illustrating its versatility and significance in herbal formulations.
45) Visahara (Vishahara, Visha-hara):
Vishahara indicates properties that counteract poisons and toxins. Ingredients exhibiting Vishahara qualities are essential in formulations targeting poisoning conditions, reaffirming Ayurveda's commitment to holistic approaches in addressing acute and chronic health issues.
46) Ayurveda (Ayus-veda):
Ayurveda is an ancient system of medicine emphasizing balance among body, mind, and spirit. Rooted in holistic principles, it employs natural remedies to treat illnesses, promote health, and enhance well-being, showcasing the rich tradition and comprehensive approach to health care.
47) Vatahara (Vata-ahara):
Vatahara refers to properties that pacify or reduce Vata dosha imbalances. Important for treating conditions caused by excess dryness and mobility, Vatahara ingredients help restore stability and comfort, underscoring the holistic nature of Ayurvedic healing practices.
48) Swelling:
Swelling indicates an accumulation of fluid in tissues, often resulting from injury or inflammation. In Ayurveda, addressing swelling involves using specific formulations that counteract the causes, emphasizing the significance of balancing doshas and promoting healing through targeted therapies.
49) Pippali (Pippalin):
Pippali, or Piper longum, is a significant herb in Ayurvedic medicine prized for its digestive and respiratory benefits. Recognized for enhancing metabolic functions, Pippali aids in detoxification and is often included in formulations for its versatile therapeutic properties.
50) Trivrit (Tri-vrit, Trivrt):
Trivrit represents a key herb, Operculina turpenthum, known for its purgative and detoxifying actions in Ayurveda. Commonly used to address digestive disorders, Trivrit plays a critical role in balancing bodily functions and enhancing overall gastrointestinal health.
51) Samudra:
Samudra refers to the ocean or sea, denoting the source of various minerals and salts used in Ayurveda. The use of Samudra-lavana emphasizes the benefits derived from natural marine resources, showcasing the integration of environmental elements in traditional healing practices.
52) Snigdha:
Snigdha translates to unctuous or oily, describing substances that provide nourishment and moisture. In Ayurveda, Snigdha qualities are essential for balancing dry conditions and promoting healthy skin and bodily functions, emphasizing the significance of incorporating these properties in therapeutic treatments.
53) Anupana:
Anupana refers to adjuvants or substances used alongside primary medicines to enhance efficacy and absorption. In Ayurveda, thoughtfully choosing Anupana is crucial for optimizing treatment outcomes and improving patient experience, ensuring holistic care during therapy.
54) Kashaya (Kasaya):
Kashaya describes the astringent taste, commonly associated with drying effects. Ayurvedic formulations incorporating Kashaya properties are used to treat conditions involving excess moisture and promote healing, highlighting the diverse benefits of various tastes in managing health.
55) Burning (Burn, Burned, Burnt):
Burning relates to unpleasant sensations often stemming from inflammation or irritation. In Ayurveda, addressing burning sensations requires specific formulations designed to cool and soothe the affected areas, mitigating discomfort while restoring balance within the body's systems.
56) Itching:
Itching signifies discomfort often linked to skin irritation, allergies, or infections. In Ayurvedic practices, formulations that relieve itching focus on balancing dosha imbalances, employing soothing and anti-inflammatory ingredients to restore skin comfort.
57) Dravya:
Dravya refers to substances used for therapeutic purposes in Ayurveda. This term encompasses herbs, minerals, and animal-based ingredients, underscoring the diversity of materials available in traditional medicine for treating various health conditions.
58) Hridya (Hrdya):
Hridya translates to heart or cardioprotective qualities in Ayurveda. Ingredients recognized for their Hridya properties are utilized to support cardiovascular health, reflecting the integrative approach in traditional practices focusing on holistic well-being.
59) Vipaka:
Vipaka signifies the post-digestive effect of substances, essential for determining their overall impact on health. Understanding Vipaka helps Ayurveda practitioners select appropriate herbs and foods, aligning treatments with individual needs for effective dosha management.
60) Table:
Table refers to organized data presentation, typically used to summarize or highlight research findings, properties, and effects of Ayurvedic substances. Tables enhance clarity and understanding, facilitating better communication of traditional knowledge and scientific insights.
61) Blood:
Blood is a vital bodily fluid crucial for transporting nutrients, oxygen, and waste products. In Ayurveda, maintaining healthy blood composition and circulation is essential, with certain herbs aimed at purifying and balancing blood properties, underscoring the importance of holistic health.
62) Guru:
Guru translates to heavy in Ayurvedic terms, representing substances that may have dense qualities impacting digestion or elimination. Recognizing the Guru properties of herbs helps practitioners tailor treatments for specific health concerns effectively.
63) Vida:
Vida signifies a type of salt known for its distinctive qualities and therapeutic applications in Ayurveda. It plays a role in digestive health and balancing bodily fluids, enhancing the arsenal of natural ingredients used in traditional healing.
64) Scorpion poison (Scorpion venom):
Scorpion poisoning involves the envenomation from a scorpion sting, leading to a range of symptoms. Ayurvedic formulations often target the specific symptoms and offer comprehensive management strategies to alleviate effects and promote recovery, emphasizing the unique approaches employed in traditional medicine.
65) Berberis aristata:
Berberis aristata, known as Daruharidra in Ayurveda, is recognized for its anti-inflammatory and antimicrobial properties. Used in various formulations, this herb plays an important role in treating infections and supporting overall health through its potent therapeutic applications.
66) Rubia cordifolia:
Rubia cordifolia, or Manjistha, is a widely used herb in Ayurveda known for its blood-purifying and restorative properties. It is often included in formulations aimed at improving skin health and detoxification, reflecting its significance in holistic health practices.
67) Curcuma longa:
Curcuma longa, or turmeric (Haridra), is a fundamental herb in Ayurveda celebrated for its extensive anti-inflammatory, antioxidant, and healing properties. Turmeric's incorporation into traditional formulations emphasizes its vital role in promoting wellness and treating various health conditions.
68) Piper longum:
Piper longum, or Pippali, is an essential herb in Ayurveda, recognized for its warming and digestive properties. This herb is commonly used to enhance respiratory health and support metabolic function, reflecting its importance in Ayurvedic practices.
69) Snake poison (Snake venom):
Snake poison refers to the venom delivered by snakes that can cause severe physiological effects. Ayurveda utilizes specific formulations to combat effects of snake poison, aiming to alleviate symptoms and promote recovery through traditional wisdom and herbal interventions.
70) Ashtangasamgraha (Astangasamgraha, Astangasangraha, Ashtanga-samgraha, Ashtanga-sangraha, Ashtangasangraha):
Astanga-sangraha is one of the classical texts in Ayurveda, compiling diverse knowledge on herbal medicine, treatments, and health principles. This text serves as a foundational resource for practitioners seeking insights into Ayurvedic philosophy and practice.
71) Gloriosa superba:
Gloriosa superba, known as Vishalya, is an herb recognized in Ayurveda for its medicinal properties. The herb is utilized for its potential effects against poisons, emphasizing the diversity of plant-based treatments in traditional healing strategies.
72) Dahaprashamana (Dahaprasamana, Daha-prashamana):
Dahaprashamana indicates the ability to relieve burning sensations or heat-related discomfort. In Ayurveda, substances with Dahaprashamana properties are significant for treating conditions associated with inflammatory or pitta disturbances, providing necessary relief for affected individuals.
73) Kushthaghna (Kusthaghna):
Kushthaghna represents the property of relieving skin diseases or conditions. In Ayurveda, herbs identified as Kushthaghna are essential in formulating treatments for various dermatological issues, underscoring the importance of addressing skin health in holistic practices.
74) Garbhashaya (Garbhasaya, Garbha-ashaya):
Garbhashaya refers to the uterus in Ayurvedic medicine. Understanding its significance is crucial for women’s health, and certain herbs are used to support uterine health, reflecting the importance of reproductive wellness in Ayurvedic practices.
75) Kamalahara (Kamala-hara):
Kamalahara denotes the property of alleviating conditions that resemble or affect the lotus (Kamal) property in Ayurveda. This term often relates to treatment approaches aimed at balancing fluid accumulation and adverse conditions in the body, showcasing specific therapeutic focuses.
[Note: The above list is limited to 75. Total glossary definitions available: 114]
Other Science Concepts:
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