Emergence of epigenetics in ayurvedic preventive cardiology

the long road ahead

| Posted in: Health Sciences Science

Journal name: World Journal of Pharmaceutical Research
Original article title: Emergence of epigenetics in ayurvedic preventive cardiology
The WJPR includes peer-reviewed publications such as scientific research papers, reports, review articles, company news, thesis reports and case studies in areas of Biology, Pharmaceutical industries and Chemical technology while incorporating ancient fields of knowledge such combining Ayurveda with scientific data.
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Subtitle: the long road ahead

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Author:

Nayana B. and Smitha Bhat


World Journal of Pharmaceutical Research:

(An ISO 9001:2015 Certified International Journal)

Full text available for: Emergence of epigenetics in ayurvedic preventive cardiology

Source type: An International Peer Reviewed Journal for Pharmaceutical and Medical and Scientific Research

Doi: 10.20959/wjpr20223-23357

Copyright (license): WJPR: All rights reserved


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Summary of article contents:

Introduction

Cardiovascular diseases (CVD) have increasingly become a major public health concern, particularly in India, where the prevalence of conditions like coronary artery disease is alarmingly high. Traditional preventive strategies have focused on environmental factors, but recent studies emphasize the significance of genetic and epigenetic influences on CVD development. This article reviews the role of epigenetics within the context of Ayurveda and highlights how integrating these perspectives can lead to better preventive cardiology strategies.

The Role of Epigenetics in Cardiovascular Diseases

Epigenetics pertains to the changes in gene expression influenced by environmental factors without altering the DNA sequence itself. Various factors such as lifestyle, diet, stress, and environmental conditions can lead to epigenetic modifications, which in turn affect cardiovascular health. For instance, mechanisms like DNA methylation and histone modification impact how genes associated with cardiovascular diseases are expressed. This understanding bridges the gap between genetic predispositions and environmental influences on health, indicating that lifestyle changes can reverse or mitigate unfavorable epigenetic modifications.

Ayurveda's Contribution to Cardiac Health

Ayurveda, with its holistic approach, emphasizes the significance of Pathya Ahara (conducive diet) and Vihara (lifestyle practices) in maintaining health and preventing diseases, including CVD. Traditional Ayurvedic texts outline personalized dietary and lifestyle recommendations based on an individual's Prakrithi (constitution), which aligns with modern findings that advocate for tailored interventions. Evidence suggests that specific dietary components, such as polyphenols from plants, can induce positive epigenetic changes and promote cardiac health by mitigating the effects of oxidative stress and inflammation.

Personalized Nutrition and Epigenetics

Emerging concepts like Ayurnutrigenomics combine Ayurvedic principles with modern genomic research, paving the way for personalized nutrition strategies. This approach recognizes that individuals’ genetic variations can influence their responses to dietary interventions. By understanding an individual's Prakrithi and integrating it with nutritional practices, personalized diets can be developed to optimize health and prevent CVD. The integration of wellness practices from Ayurveda with scientific knowledge of genetics may lead to more effective public health policies, emphasizing the need for personalized, evidence-based dietetic approaches.

Conclusion

The integration of epigenetic research with Ayurvedic practices presents a comprehensive framework for understanding and combating cardiovascular diseases. This synthesis can improve the efficacy of preventive strategies by promoting personalized nutrition and lifestyle modifications based on genetic predispositions. Encouraging public awareness and government support for research and screening initiatives can empower individuals to make informed health choices, ultimately contributing to a healthier population. The collaboration between Ayurvedic principles and contemporary science evokes a paradigm shift in health maintenance and disease prevention, emphasizing the importance of personalized approaches tailored to individual health profiles.

FAQ section (important questions/answers):

What is the focus of the article on epigenetics and Ayurveda?

The article examines the relevance of epigenetics in understanding Ayurvedic practices for preventive cardiology, emphasizing how genetics and environmental factors influence cardiovascular diseases.

How does epigenetics relate to lifestyle and diet in heart health?

Epigenetics involves how lifestyle and dietary choices can modify gene expression, potentially impacting cardiovascular health by influencing various biological processes related to heart disease.

What connection exists between genetic predisposition and cardiovascular diseases?

The article discusses that genetics play a significant role in the development of cardiovascular diseases, with certain gene polymorphisms associated with higher risks.

How can Ayurvedic practices contribute to preventing heart diseases?

Ayurvedic practices promote a healthy diet and lifestyle modifications that can lead to epigenetic changes, thus potentially reducing the risk factors associated with cardiovascular diseases.

What role does maternal diet play in the prevention of cardiac issues?

Maternal nutrition influences epigenetic modifications in the fetus, affecting long-term cardiovascular health, highlighting the importance of a conducive diet during pregnancy.

What is the importance of personalized nutrition according to genetic makeup?

Personalized nutrition aims to tailor dietary recommendations based on individual genetic profiles and Ayurvedic principles, optimizing health and preventing diseases related to nutrition.

Glossary definitions and references:

Scientific and Ayurvedic Glossary list for “Emergence of epigenetics in ayurvedic preventive cardiology”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.

1) Disease:
Diseases are pathological states resulting from various factors such as genetic predisposition, lifestyle, and environmental influences. The text highlights cardiovascular diseases, which are prevalent globally and increasingly affecting populations, particularly in India. Recognizing genetic determinants and epigenetic interactions is fundamental for creating effective prevention strategies.

2) Diet:
Diet encompasses the foods and beverages consumed by individuals that significantly affect their health outcomes. In the context of cardiovascular disease prevention, a proper diet is highlighted, incorporating Ayurvedic concepts of 'Pathya Ahara', which emphasizes a balanced and nutritious intake that aligns with one’s constitution, or Prakrithi.

3) Ayurveda (Ayus-veda):
Ayurveda is an ancient system of medicine that promotes health through balanced living, including diet, lifestyle, and holistic practices. Its principles advocate harmony between individuals and their environment, providing preventive healthcare strategies, particularly for diseases like cardiovascular disorders, through personalized approaches based on one’s unique constitution.

4) Nayana:
Nayana refers to the lead author of the study discussed in the text. As a second-year postgraduate scholar in Ayurveda, Nayana B. contributes to the exploration of epigenetics within preventive cardiology, underscoring the significance of integrating traditional Ayurvedic principles with modern scientific research for improved health outcomes.

5) Ahara:
Ahara refers to the dietary aspects of Ayurveda, which stresses the importance of food in maintaining health and preventing diseases. It encompasses the selection, preparation, and consumption of nutritious foods aligned with one’s body constitution (Prakrithi), thus playing a crucial role in modifying epigenetic expressions related to health.

6) Study (Studying):
The study referenced in the text aims to explore the role of epigenetics in cardiovascular disease management, integrating Ayurvedic dietary recommendations. It draws from classical Ayurvedic texts and contemporary epigenetic research, highlighting the potential for interdisciplinary approaches in understanding and addressing complex health issues.

7) Activity:
Activity refers to physical or behavioral engagements that can influence health outcomes. In cardiovascular health, regular physical activity or exercise is associated with beneficial epigenetic changes, promoting heart health. Ayurvedic practices advocate for balanced activity aligned with one’s constitution to foster overall well-being.

8) Knowledge:
Knowledge in this context pertains to understanding the relationship between genetics, lifestyle, and disease development. The integration of Ayurvedic wisdom and modern scientific findings on epigenetics highlights the importance of informed health practices, enabling individuals to make better lifestyle choices and effectively manage their health.

9) Dravya:
Dravyas refer to substances utilized in Ayurvedic treatment, including medicinal herbs and foods that possess therapeutic properties. Their role extends to influencing epigenetic mechanisms in disease prevention and management, creating a critical link in applying Ayurveda's holistic approach to health.

10) Science (Scientific):
Sciences refer to systematic fields of study aimed at acquiring knowledge through observation and experimentation. The integration of Ayurvedic principles with modern medical sciences highlights the potential for a unified approach, enhancing understanding of health dynamics and the prevention and treatment of diseases.

11) Vihara:
Vihara refers to lifestyle practices in Ayurveda, including physical, mental, and emotional habits that contribute to health. Emphasizing balanced daily routines is vital in preventing diseases like cardiovascular disorders. Vihara guidelines promote healthy living and can positively impact epigenetic expression.

12) Pitta:
Pitta is one of the three doshas in Ayurveda, representing qualities of heat, transformation, and metabolism. It is crucial in maintaining bodily functions and understanding predispositions to certain health conditions. In the study of epigenetics, pitta may influence metabolic processes linked to cardiovascular health.

13) Field:
Field refers to the domain of study or practice. In this context, it pertains to the interdisciplinary area where epigenetics intersects with Ayurveda, particularly in preventive cardiology, emphasizing a comprehensive approach to understanding health, disease, and individual uniqueness.

14) Vata:
Vata is another dosha in Ayurvedic medicine, symbolizing movement, communication, and change. It plays a crucial role in physiological functions and can influence an individual's predisposition to diseases. Understanding variations in Vata can provide insights into managing cardiovascular health through dietary and lifestyle adjustments.

15) Garbhini:
Garbhini denotes a pregnant woman in Ayurveda. The health and lifestyle choices of a Garbhini significantly impact fetal development and long-term health outcomes. The study underscores the importance of maintaining a healthy environment and practices during pregnancy to prevent epigenetic alterations in the offspring.

16) Jivaniya:
Jivaniya means nutrients or substances that promote life and vitality. Ayurvedic practices emphasize the use of Jivaniya herbs and foods to enhance health and prevent diseases, especially during critical life stages like pregnancy, to support both maternal and fetal well-being.

17) Turmeric:
Turmeric (Curcuma longa) is a widely recognized Ayurvedic herb known for its anti-inflammatory properties. The active compound, curcumin, exhibits potential in modulating epigenetic mechanisms and improving cardiovascular health outcomes by reducing oxidative stress and inflammation.

18) Samhita:
Samhita refers to classic Ayurvedic texts that compile traditional knowledge, including healing practices, principles, and dietary recommendations. The texts serve as foundational references for integrating contemporary science with historical wisdom in preventive medicine and disease management strategies.

19) Haridra:
Haridra is the Sanskrit term for turmeric, valued in Ayurveda for its medicinal properties. Its active compounds are investigated for their potential effects on epigenetic regulation and cardiovascular health, underscoring the importance of incorporating traditional herbs into contemporary health practices.

20) Species:
Species denotes different categories of living organisms, which can be important in studies of genetic inheritance and variances affecting health. Understanding species-specific traits, especially in cardiovascular health, aids in identifying preventive measures tailored to unique genetic profiles.

21) Garbha:
Garbha signifies the fetus or unborn baby in Ayurveda. The term is used in discussions about prenatal health, emphasizing the importance of maternal diet and lifestyle on fetal development and the potential to influence epigenetic outcomes that affect lifelong health.

22) Sthana:
Sthana in Ayurveda refers to a place, condition, or body part that may be scrutinized for its role in health and disease. The study discusses Sthana concerning various physiological states, focusing on how they interact with underlying genetic and epigenetic factors.

23) Indian:
Indian refers to the context arising from the Indian subcontinent, particularly regarding its traditional medical practices, such as Ayurveda. The increase in cardiovascular diseases in Indian populations highlights the relevance of integrating Ayurvedic wisdom with modern medical approaches to preventive cardiology.

24) Kapha:
Kapha is the third dosha in Ayurveda, representing qualities of stability, structure, and nourishment. Its balance is crucial for maintaining health, and understanding Kapha-related variations can aid in identifying individual predispositions to cardiovascular diseases and establishing preventive care tailored to one’s constitution.

25) Mamsa (Mamsha):
Mamsa refers to flesh or meat in Ayurveda and is essential in discussions of nutrition and nourishment for health, particularly in the context of fetal health. It signifies dietary components that may influence epigenetic factors and provide critical nutrients for development and vitality.

26) Death:
Death represents the end of physiological functions in living beings and is a significant concern in health studies. Understanding cardiovascular diseases, their contributors, and prevention strategies is essential for reducing mortality rates, particularly given their prevalence in current population trends.

27) Deha:
Deha refers to the body in Ayurveda, emphasizing its physical representation and health dynamics. The state of one’s Deha is influenced by genetic makeup and environmental factors, playing a crucial role in disease predisposition and the management of health through personalized practices.

28) Yoga:
Yoga encompasses physical, mental, and spiritual practices aimed at achieving holistic well-being. As part of Ayurvedic principles, Yoga is recognized for its potential health benefits, including improvements in cardiovascular health and modifications in gene expression linked to lifestyle changes.

29) Kala:
Kala means time or phase and holds importance in Ayurveda concerning health practices. It relates to appropriate timing in dietary choices and lifestyle adjustments, recognizing that the efficacy of preventative measures may vary with the individual's life stage or condition.

30) Food:
Food encompasses all consumable substances that provide nourishment and sustenance. Within Ayurveda, food choices are tailored based on an individual's constitution, significantly impacting health outcomes and the potential for preventing diseases through careful dietary practices.

31) Drug:
Drugs refer to substances used in treatment to alleviate symptoms or cure diseases. In Ayurveda, drug formulations from natural sources are often employed, focusing on their therapeutic properties to modify disease processes and support health maintenance through holistic approaches.

32) Ashtangahridaya (Astangahrdaya, Ashtanga-hridaya):
Ashtanga-hridaya is one of the classic texts of Ayurveda that provides comprehensive knowledge about the principles of Ayurveda, including preventive and therapeutic measures for various diseases, thus serving as a vital resource for integrating traditional wisdom with modern health practices.

33) Garbhasthapaka (Garbha-sthapaka):
Garbhasthapaka refers to herbs and practices used to nurture and support optimal fetal development during pregnancy. These approaches are crucial in preventing adverse epigenetic changes in the fetus, emphasizing maternal health's impact on long-term offspring well-being.

34) Transformation (Transform, Transforming):
Transformation pertains to the processes by which entities undergo change. In the context of health, it relates to how dietary choices and lifestyle practices can transform genetic expression through epigenetic modifications, thus influencing overall health and the risk of disease.

35) Transmission:
Transmission refers to the transfer of genetic or epigenetic information from one generation to another. The text underscores the imperative for understanding how lifestyle and environmental factors can affect these genetic attributes, highlighting their roles in disease predisposition across generations.

36) Discussion:
Discussion denotes the examined exploration of knowledge or concepts. In this context, it refers to the assessment of the connections between epigenetics, Ayurveda, and cardiovascular health, aiming to foster a deeper understanding of integrative approaches to disease prevention and management.

37) Practising (Practicing):
Practicing refers to the application or implementation of knowledge or skills. In the Ayurvedic context, it signifies the embodiment of health-promoting practices, emphasizing the importance of diligently adhering to prescribed dietary and lifestyle measures for optimal well-being and disease prevention.

38) Mahabhuta (Maha-bhuta):
Mahabhuta refers to the five great elements (earth, water, fire, air, ether) in Ayurveda. They are fundamental in understanding the natural world and body constitution, influencing health outcomes and the manifestation of diseases through their interactions with individual Prakrithi.

39) Vagbhata:
Vagbhata was an eminent ancient physician known for his contributions to Ayurvedic literature. His teachings and texts, including the Ashtanga Samgraha, play a significant role in bridging traditional knowledge with current health practices, particularly in preventive cardiology.

40) Rasayana (Rasa-ayana):
Rasayana refers to the Ayurvedic discipline focused on rejuvenation and promoting longevity. These therapies are aimed at enhancing vitality and optimizing epigenetic expression, thereby potentially reducing the risk of degenerative diseases, including those impacting cardiovascular health.

41) Ashtanga (Astanga, Ashtan-anga):
Ashtanga refers to the eight limbs of yoga and its comprehensive approach to health that combines physical, mental, and spiritual practices. This holistic perspective supports cardiovascular health and encourages individuals to adopt a lifestyle that promotes overall well-being.

42) Pregnant:
Pregnant pertains to the condition of carrying a developing fetus. Understanding the health management of pregnant women is critical, as maternal lifestyle and dietary choices affect not only their health but also the epigenetic landscape of the offspring, influencing their future health.

43) Vitiation (Vitiated):
Vitiated refers to a disrupted or impaired state. In Ayurvedic terms, it indicates an imbalance in doshas, which can lead to health issues. Recognizing vitiated conditions is essential for implementing effective corrective measures in the context of disease prevention and treatment.

44) Indriya (Imdriya):
Indriya, as a singular form, represents a sensory organ within Ayurveda. Its functioning is essential for perceiving health and environmental stimuli, thus influencing the appropriate dietary and lifestyle adjustments necessary for maintaining balance and preventing diseases.

45) Kashyapa (Kasyapa, Kashya-pa):
Kashyapa was a revered sage in Ayurveda known for his contributions to Ayurvedic knowledge, particularly related to health management of children and maternal health. His teachings promote awareness of preventive measures important for sustaining health in individuals and communities.

46) Hridaya (Hrdaya):
Hridaya translates to 'heart' in Ayurveda, emphasizing its central role in emotional and physical health. Understanding the heart's functions and maintaining its health is crucial in the discourse on cardiovascular diseases, aligning with both Ayurvedic and scientific perspectives on prevention.

47) Amalaki:
Amalaki, also known as Indian gooseberry, is revered in Ayurveda for its medicinal properties, particularly as an antioxidant. It is believed to support cardiovascular health and may impact epigenetic factors through its rich polyphenolic content, promoting overall wellness.

48) Vyayama:
Vyayama signifies physical exercise or movement within Ayurveda. It plays a vital role in maintaining health by enhancing bodily functions and promoting epigenetic changes that contribute to reducing the risk of cardiovascular diseases and other health-related issues.

49) Vikara:
Vikara denotes the notion of disease or disorder in Ayurveda. Understanding the nature of Vikara as an imbalance helps inform preventive measures and therapeutics, especially concerning the epigenetic modifications that may arise from lifestyle choices and environmental exposures.

50) Ashaya (Asaya):
Ashaya refers to the receptacles or structures within the body where doshas and dhatus (tissues) reside. Understanding Ashaya is important in Ayurveda for assessing health and disease, emphasizing the need for balance and the prevention of imbalances that can lead to various health issues.

51) Pathya:
Pathya denotes the conducive practices and dietary choices recommended within Ayurveda for maintaining health. Emphasizing Pathya is important for promoting wellness and preventing diseases, particularly through nourishing foods and lifestyle practices aligning with one's constitution and health goals.

52) Nature:
Nature represents the environment and inherent qualities of individuals in Ayurveda. Recognizing how nature influences health outcomes is critical for tailoring preventive strategies that align with an individual's genetic and environmental context, thus promoting overall well-being.

53) Animal:
Animal refers to living organisms, and in the context of Ayurveda, it encompasses the understanding of biological systems and dietary components derived from animals. The role of animal products in health, nutrition, and disease prevention is a significant area of Ayurvedic inquiry.

54) Karma (Karman):
Karma denotes the concept of action and its consequences in both spiritual and physical realms. In Ayurveda, understanding how past and present actions impact health can guide preventive practices and therapeutic approaches, influencing one’s overall health trajectory.

55) Ushna (Usna):
Ushna translates to heat and signifies a quality or property within Ayurveda. Understanding Ushna is essential in assessing health states and determining dietary guidelines and treatments, particularly concerning digestive health and its implications for overall well-being in cardiovascular health.

56) Bhava:
Bhava represents a state of being or emotion. In Ayurveda, it's vital to consider the emotional aspects of health, as mental well-being influences physical health outcomes, particularly concerning cardiovascular diseases and the implications of stress as an epigenetic factor.

57) Svadu:
Svadu signifies the quality of taste, which is essential in Ayurveda for understanding dietary preferences and their effects on health. Taste plays a significant role in promoting proper digestion and nutrient absorption, thus impacting overall health and disease prevention.

58) Grief:
Grief refers to a profound emotional response to loss. In Ayurvedic principles, emotions such as grief can significantly influence health, including cardiovascular health. Managing emotional well-being through practices that promote balance is an essential aspect of holistic health care.

59) Blood:
Blood is a vital bodily fluid that transports nutrients, gases, and waste. In Ayurveda, blood's health is crucial for understanding overall vitality and vitality, and imbalances can lead to various diseases, necessitating a comprehensive view of diet, lifestyle, and health.

60) Anger (Angry):
Anger represents an intense emotional state that can impact physical health. Ayurvedic practices teach that emotional states can lead to imbalances in doshas, which may eventually manifest as diseases, underscoring the importance of emotional regulation for maintaining cardiovascular and overall health.

61) Guna:
Guna, in a singular sense, refers to a specific quality or attribute that influences health conditions. In Ayurveda, recognizing Guna is vital in dietary planning and therapeutic strategies, as they inform how substances may interact with individual health profiles.

62) Hand:
Hand signifies the manual actions taken by individuals to effectuate changes in their health status. In Ayurveda, hands are often involved in therapeutic practices such as massages and herbal application, emphasizing the interplay of touch in holistic healing.

63) Rasa (Rasha):
Rasa translates to taste or essence and is fundamental in Ayurveda for understanding food's properties and effects on health. Each Rasa influences the body's functions and helps determine dietary choices that align with individual health and preventive needs.

64) Dosha (Dosa):
Dosa refers to the three functional energies (Vata, Pitta, Kapha) in Ayurveda that govern physiological processes. Balancing these doshas is crucial for maintaining health and preventing diseases, particularly in the context of its implications on epigenetic expressions affecting cardiovascular health.

65) Bija:
Bija means seed, symbolizing the source or origin that carries potential. In Ayurveda, understanding Bija emphasizes the genetic basis of health, signifying how genetic predispositions contribute to health outcomes and influence the efficacy of preventive measures.

66) Atman (Atma):
Atma denotes the soul or self in Ayurvedic philosophy. It represents the core of an individual, influencing health and well-being. Acknowledging the relationship between Atma, mental health, and physical health is essential for holistic approaches to treatment and prevention of diseases.

67) Trina (Tri-na, Trna):
Trna refers mainly to transfer RNA, which is involved in protein synthesis. While it's a biological term, in the Ayurvedic context, understanding the correlation of genetic encoding and epigenetic modifications reflects the integration of modern biological concepts with traditional health practices.

68) Jala:
Jala means water in Ayurveda, essential for sustaining life and maintaining bodily functions. The quality and nature of water influence health outcomes, emphasizing the importance of clean and balanced hydration in preventive health strategies.

69) Fear:
Fear denotes a powerful emotional response that can significantly impact health. In Ayurveda, emotional balance is essential for maintaining physical health, with chronic fear potentially leading to doshic imbalances and a higher risk of stress-related diseases like cardiovascular disorders.

70) Road:
Road represents the journey or path towards health and wellness. The concept signifies the importance of guiding principles in both Ayurveda and modern science towards disease prevention and the significance of making informed choices in personal health management.

71) Line:
Line in this context could refer to genetic lines or familial connections, highlighting how hereditary traits influence health outcomes. Understanding these connections is vital in exploring the role of genetics and epigenetics in disease prevention and management strategies.

72) Milk:
Milk is regarded as a nourishing food in Ayurveda, rich in essential nutrients vital for health. It plays a crucial role in maternal health and fetal development, being a significant element in dietary practices aimed at supporting cardiovascular well-being.

73) Life:
Life embodies the experience of existence and the holistic view of being in Ayurveda. Understanding the elements of life, including physical, mental, and spiritual components, is essential for promoting health, longevity, and preventing diseases while fostering an integrative approach to well-being.

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