22 Factorial Design in Sunscreen with Zinc Oxide and Polypodium.

| Posted in: Health Sciences Science Journals

Journal name: World Journal of Pharmaceutical Research
Original article title: Application of 22 factoiral design in the formulation and evaluation of sunscreen containing non nano zinc oxide and polypodium leucotomos
The WJPR includes peer-reviewed publications such as scientific research papers, reports, review articles, company news, thesis reports and case studies in areas of Biology, Pharmaceutical industries and Chemical technology while incorporating ancient fields of knowledge such combining Ayurveda with scientific data.
This page presents a generated summary with additional references; See source (below) for actual content.

Original source:

This page is merely a summary which is automatically generated hence you should visit the source to read the original article which includes the author, publication date, notes and references.

Author:

R. Ramya, Dr. G. Mariyappan, M. Venkatesan, R. Rajadurai, K. Vidhya and M. Prem Kumar


Download the PDF file of the original publication


World Journal of Pharmaceutical Research:

(An ISO 9001:2015 Certified International Journal)

Full text available for: Application of 22 factoiral design in the formulation and evaluation of sunscreen containing non nano zinc oxide and polypodium leucotomos

Source type: An International Peer Reviewed Journal for Pharmaceutical and Medical and Scientific Research

Doi: 10.20959/wjpr20223-23302

Copyright (license): WJPR: All rights reserved


Summary of article contents:

Introduction

The research presented focuses on the formulation and evaluation of a sunscreen containing non-nano zinc oxide and Polypodium leucotomos. Sun exposure poses risks such as skin cancer and photoaging due to harmful ultraviolet (UV) radiation. Thus, effective sun protection is paramount, and the incorporation of chemical and physical UV filters is essential. This study aims to enhance the Sun Protection Factor (SPF) value by utilizing natural ingredients without introducing toxicity, thereby improving the safety and efficacy of sunscreen formulations.

Role of Polypodium Leucotomos as a Natural UV Filter

Polypodium leucotomos, a tropical plant found in Central and South America, is identified for its potent antioxidant properties. Its extracts, which include compounds like P-Coumaric acid and ferulic acid, exhibit significant photoprotective effects. The study emphasizes the dual utility of Polypodium leucotomos—not only does it serve as a natural UV filter, but it also contributes to the stabilization of sunscreen formulations. This is particularly valuable in cosmetic applications, where user safety is a priority, especially for those with sensitive skin types.

Formulation and Evaluation Using Factorial Design

The formulation process involved a systematic approach using a 2x2 factorial design to ascertain the effects of varying concentrations of non-nano zinc oxide and Polypodium leucotomos on the SPF. By focusing on the main and interaction effects, the study illustrated how different percentages of these ingredients impact the sunscreen's protective qualities. The factorial design methodology allowed researchers to determine that higher concentrations of both components led to enhanced SPF, identifying a synergistic effect that maximizes sun protection.

Absorbance Properties and Preformulation Studies

Preformulation studies established essential physicochemical characteristics of the selected ingredients. The absorption maxima for non-nano zinc oxide and Polypodium leucotomos were determined using UV spectrophotometry, demonstrating their effectiveness as UV filters across the relevant spectral range. Furthermore, the properties such as particle size, solubility, hydroscopicity, and flow characteristics were assessed, providing a comprehensive understanding of how each component would behave within the final formulation. These studies laid the groundwork for creating a stable and effective sunscreen.

Conclusion

The research successfully formulates a sunscreen that exhibits a 93.3% potency against UVB rays, as represented by an SPF value of 14.7. The findings highlight the effectiveness of using non-nano zinc oxide in combination with Polypodium leucotomos to enhance the overall protective capabilities of sunscreen. Additionally, the formulation was noted for its good physical parameters, including stability and lack of skin irritation. The study advocates for the continued exploration of natural ingredients in cosmetic formulations, emphasizing their potential in improving sun protection without compromising skin health.

FAQ section (important questions/answers):

What ingredients were used in the formulated sunscreen cream?

The sunscreen cream was formulated with non-nano zinc oxide, polypodium leucotomos, sweet almond oil, cocoa butter, shea butter, stearic acid, glycerin, sodium benzoate, sorbitan monostearate, deionized water, and Tween 80.

What was the main objective of this sunscreen research?

The main objective was to formulate and evaluate a sunscreen containing non-nano zinc oxide and polypodium leucotomos using a 2x2 factorial design. This aimed to enhance SPF without increasing toxicity.

How was the SPF of sunscreen determined in the study?

The in vitro SPF was determined using UV spectrophotometry based on absorbance characteristics of the sunscreen. The SPF values were calculated from the ratio of UV energy needed for minimal erythema dose on protected versus unprotected skin.

What were the results regarding the SPF values of the formulations?

Formulation F1 had an SPF of 6.7, F2 had 14.7, F3 had 7.8, and F4 had 4.8. F2 offered the highest protection of approximately 93.3% against UV rays.

What were the findings about the physical properties of the cream?

The cream was found to be uniform and homogeneous, with a pH of 7.03. It exhibited good viscosity and did not show phase separation in centrifugation tests, indicating stability.

What is the significance of using polypodium leucotomos in sunscreen?

Polypodium leucotomos has potent antioxidant and photoprotective properties, making it beneficial for enhancing the effectiveness of sunscreens while minimizing toxicity associated with chemical filters.

Glossary definitions and references:

Scientific and Ayurvedic Glossary list for “22 Factorial Design in Sunscreen with Zinc Oxide and Polypodium.”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.

1) Water:
Water is a crucial solvent in many chemical and biological processes. In the context of this study, it is used as a medium to dissolve certain materials, such as polypodium leucotomos, for analyzing absorbance characteristics vital for sunscreen formulation. Proper solubility in water ensures effective ingredient dispersion.

2) Ramya:
Ramya refers to the lead author of the research article, indicating the individual’s contribution to the study. Their name represents a significant personal and professional investment in the research surrounding sunscreen formulations, particularly those involving non-nano zinc oxide and polypodium leucotomos for skincare applications.

3) Table:
In academic research, tables are vital for presenting data succinctly. The tables in this study provide organized information on materials, equipment, and experimental results, making complex data more accessible for researchers to interpret findings, compare different formulations, and understand the parameters affecting sun protection factor (SPF).

4) Study (Studying):
Study denotes the systematic investigation conducted by the authors. This research aims to evaluate the formulation and efficacy of a sunscreen product containing non-nano zinc oxide and polypodium leucotomos. It emphasizes the importance of evaluating protective properties against UV radiation for skin health and cosmetic applications.

5) Surface:
In the context of this research, surface refers to the layer of the skin that interacts with the sunscreen formulation. The surface properties of the product, measured through various tests, are crucial to assess its performance, user experience, and overall effectiveness in providing UV protection.

6) Glass:
Glass is referenced regarding laboratory equipment like the glass slides used to test spreadability or the containers for measuring solutions. The use of glassware is standard in scientific experiments due to its inert nature, allowing precise observation of chemical reactions without contamination affecting results.

7) Observation:
Observations pertain to the notes and data collected during experimentation. Documenting these observations systematically allows researchers to analyze trends, confirm hypotheses, and make informed decisions about formulation adjustments and their resultant effects on SPF and stability.

8) Cancer:
Cancer is a significant concern related to UV exposure, with the study highlighting the need for effective sun protection to prevent its onset. Formulating sunscreens with protective agents aims to mitigate risks linked to skin cancer by blocking harmful UV radiation that leads to cellular damage.

9) Powder:
In this research, 'powder' primarily refers to the physical state of active ingredients like non-nano zinc oxide used in sunscreen formulations. The fineness of the powder is essential for homogenous mixing and development of stable emulsions, directly impacting the product's application and effectiveness.

10) Irritation:
Irritation refers to the potential adverse skin reactions that formulations may cause upon application. The study includes tests to determine whether the formulated sunscreen induces irritation or allergic responses. Understanding irritation potential is vital for developing safe and effective skincare products suitable for all skin types.

11) Medium:
Medium is associated with the substances used to dissolve or deliver active ingredients, such as deionized water or solvents. Choosing the right medium is critical for the solubility and efficacious delivery of active components in cosmetic formulations, affecting their stability and protective capacity.

12) Line:
Line refers to graphical representations used in data analysis, particularly in factorial designs. In this research, lines depict the interactions between different variables affecting SPF, providing insights into how varying concentrations of the active ingredients influence the sunscreen's effectiveness and behaviors.

13) Transmission:
Transmission refers to the passage of UV radiation through the sunscreen product. The study evaluates how well the formulated creams absorb or scatter UV light, which is crucial for determining their effectiveness in providing sun protection and preventing skin damage from harmful rays.

14) Kancipura (Kancipuram, Kanchipuram, Kamcipura, Kanci-pura, Kamci-pura):
Kanchipuram is the geographic location associated with the institute where the research was conducted. This context provides insights into the regional focus of the study, reflecting local practices in pharmaceutical and skincare formulation, and contributing to knowledge on indigenous ingredients in cosmetics.

15) Substance:
Substances refer to the individual chemical entities used in the formulation of the sunscreen. Understanding the properties of these substances, such as solubility and reactivity, is crucial for creating an effective and safe product while meeting regulatory requirements.

16) Toxicity:
Toxicity indicates the potential harmful effects that certain formulations or ingredients may have on human health. The study underscores the need to balance efficacy in sun protection while minimizing toxicity risks associated with chemical sunscreens to ensure consumer safety and product acceptance.

17) Quality:
Quality relates to the standards of the formulated sunscreen in terms of safety, effectiveness, and stability. The study adopts various evaluation methods to ensure the final product meets quality criteria for formulation, application, and protective capacity against UV radiation.

18) Cina:
China is referenced in terms of using china dishes for hygroscopicity testing or other laboratory practices. The choice of using specific dishes for weighing samples underlines the importance of using appropriate laboratory equipment to obtain accurate and reproducible results in scientific research.

19) Food:
Food relates to potential flavor agents, such as lavender oil, used in formulations. These agents enhance the sensory experience of the cosmetic product. It emphasizes the importance of organoleptic properties in consumer products, where scent can significantly influence consumer acceptability and satisfaction.

20) Hand:
Hand signifies the area where the sunscreen is typically applied and tested, particularly regarding water resistance and application spreadability. Studying its performance on human skin is vital for evaluating the product's real-world applicability and effectiveness in providing adequate protection.

21) Pur:
Poor refers to the classification of flow properties or behavior of the powdered ingredients. Products rated as poor may indicate issues with texture, mixing, and application efficiency. Understanding these properties is crucial for optimizing formulations for user comfort and effectiveness.

22) Dish (Dis):
Dish signifies laboratory equipment, such as petri dishes or weighing dishes, used in experiments. The choice of a dish for various laboratory activities highlights the importance of proper lab practices, ensuring accurate measurements and containment of substances during testing.

23) Calculation:
Calculation refers to quantitative measurements and analyses performed in the study. This includes determining SPF values and solubility, which require accurate data processing to arrive at definitive conclusions about product efficacy and performance metrics.

24) Surrounding:
Surrounding relates to environmental factors or conditions affecting the performance of sunscreen formulations. Factors such as temperature and humidity can impact the stability and effectiveness of the product, making surrounding conditions an important consideration during formulation and application.

25) Measurement:
Measurement encompasses the various techniques used to quantify physical and chemical properties of the sunscreen preparations. Accurate measurements are essential for quality control and ensuring that formulations meet specified standards for efficacy and safety for consumer use.

26) Discussion:
Discussion refers to the analytical portion of the research reporting where authors interpret the results, providing insights into formulations' effectiveness and relevance with regard to scientific literature, comparative analysis, and implications for future research.

27) Activity:
Activity in this context refers to the functional capabilities of the active ingredients in the formulation. Higher activity levels are likely to result in better UV protection, emphasizing the importance of selecting and evaluating ingredients based on their demonstrated efficacy in sunscreen applications.

28) Relative:
Relative refers to comparative measurements or the interactions between different variables within the study, such as the relationship of ingredient concentrations to SPF. Understanding these relative influences allows for optimized formulation development to ensure maximum efficacy and safety.

29) Disease:
Disease refers to singular health conditions resulting from prolonged UV exposure, such as skin cancer. Highlighting disease underscores the critical importance of the developed sunscreen formulations, which serve to protect against harmful UV radiation that can lead to severe health outcomes.

30) Family:
Family in this context refers to the classification of polypodium leucotomos within the plant taxonomy, indicating its broader contextual relevance. Understanding the botanical family helps inform researchers about potential benefits and applications derived from similar plants within the family.

31) Nature:
Nature usually refers to the intrinsic characteristics of ingredients used in cosmetic formulations. The study emphasizes the use of natural components in sunscreen to assure safety, effectiveness, and minimize adverse reactions, appealing to a growing demand for natural skincare products.

32) Reason:
Reason represents justifications for the study's design choices and ingredient selections. Each aspect, from material choice to testing protocols, is intended to reveal insights about efficacy and safety, driving the overarching research objectives toward successful skincare formulations.

33) Trader:
Trader denotes the suppliers or commercial entities from whom raw ingredients were procured. Understanding the source of substances can inform product development about ingredient quality and reliability, ultimately impacting the final formulation's safety and effectiveness.

34) Kumar:
Kumar is one of the co-authors in the research paper, denoting the collaborative effort in the study. His contributions to the research underline the collective expertise and teamwork necessary in scientific inquiry leading to impactful findings on sunscreen formulation.

35) Edema (Oedema):
Edema refers to swelling often studied in irritation tests to assess the safety of topical formulations. Monitoring for edema after product application ensures that formulations are safe and do not induce adverse reactions, contributing to overall consumer safety.

36) Field:
Field represents the area of study or discipline in which this research is situated, namely pharmaceuticals and cosmetics. The field dictates the methodologies, regulatory considerations, and consumer expectations that guide the research process and product development.

37) Drug:
Drug refers to individual active chemical components within formulations, similar to substances, highlighting their functional roles. The distinction emphasizes the need for thorough evaluation of each drug's properties so that formulations achieve the intended protective effects effectively.

Other Science Concepts:

[back to top]

Discover the significance of concepts within the article: ‘22 Factorial Design in Sunscreen with Zinc Oxide and Polypodium.’. Further sources in the context of Science might help you critically compare this page with similair documents:

Microscopic observation, Main effect, Antioxidant activity, Viscosity measurement, Hygroscopicity, Factorial design, Particle size determination, Spreadability test, Sun Protection Factor, Solubility analysis, Preformulation study, Centrifugation test, Irritancy test, Surface Plot, Yield calculation, Water resistance test, Polypodium Leucotomos, UV Filter, Interaction Effect.

Let's grow together!

I humbly request your help to keep doing what I do best: provide the world with unbiased sources, definitions and images. Your donation direclty influences the quality and quantity of knowledge, wisdom and spiritual insight the world is exposed to.

Let's make the world a better place together!

Like what you read? Help to become even better: