Polybion protects against radiation and cadmium in mouse liver.

| Posted in: Science

Journal name: World Journal of Pharmaceutical Research
Original article title: Protective effect of polybion against radiation and cadmium induced changes in total proteins and cholesterol content in the liver of swiss albino mice
The WJPR includes peer-reviewed publications such as scientific research papers, reports, review articles, company news, thesis reports and case studies in areas of Biology, Pharmaceutical industries and Chemical technology while incorporating ancient fields of knowledge such combining Ayurveda with scientific data.
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Author:

Ramesh Kumar Purohit


World Journal of Pharmaceutical Research:

(An ISO 9001:2015 Certified International Journal)

Full text available for: Protective effect of polybion against radiation and cadmium induced changes in total proteins and cholesterol content in the liver of swiss albino mice

Source type: An International Peer Reviewed Journal for Pharmaceutical and Medical and Scientific Research

Doi: 10.20959/wjpr20225-22930

Copyright (license): WJPR: All rights reserved


Summary of article contents:

Introduction

The increasing utilization of radiation in various fields poses significant risks of acute and chronic health issues, exacerbated by toxic elements such as heavy metals in the environment. This study investigates the impact of radiation and cadmium chloride on liver function in male Swiss albino mice, specifically evaluating the total protein and cholesterol content. These elements, when combined, can have synergistic negative effects, highlighting the necessity for protective agents. The study explores the protective role of Polybion, a natural extract, against these challenges to liver health.

Synergistic Effects of Radiation and Cadmium

The exploration of the combined effects of gamma radiation and cadmium chloride reveal the severe health implications of their interaction. Specifically, it was found that both agents act on sulfhydryl (-SH) groups of proteins, leading to a pronounced decrease in total protein levels. Mice exposed to cadmium chloride and radiation exhibited significantly reduced protein synthesis due to disrupted metabolic processes. Additionally, the severity of liver damage was correlated with the dosage of radiation and cadmium, indicating that their combined presence leads to a deterioration of liver function at both biochemical and histological levels.

The Protective Role of Polybion

Polybion demonstrates a protective effect against the detrimental changes induced by radiation and cadmium exposure. Mice treated with Polybion showed less severe reductions in total protein and cholesterol compared to untreated groups. The administration of Polybion facilitated a faster recovery of protein levels in the liver, which suggests its potential as an effective antioxidant. Its properties may help mitigate oxidative stress and support the regulation of metabolic functions, highlighting the importance of antioxidants in protecting against environmental pollutants.

Biochemical Alterations in Liver Function

The study's findings indicate significant biochemical alterations in liver function due to exposure to gamma radiation and cadmium chloride. Cholesterol levels declined in treated groups, with the most substantial decreases observed within specific time-frames post-treatment. The liver responded to combined stressors with complex changes in metabolic processes, often exacerbating the damage observed. Moreover, the levels of total proteins and cholesterol serve as critical indicators of liver health, and the affected groups display the inherent vulnerability of liver tissues to environmental toxicities.

Conclusion

This study concludes that both radiation and cadmium chloride significantly impact liver health in Swiss albino mice, leading to combined detrimental effects on protein and cholesterol levels. Polybion emerges as a promising protective agent, demonstrating its ability to safeguard liver function by reducing oxidative damage and supporting metabolic recovery. Given its multifaceted properties, Polybion holds potential for clinical applications, particularly in mitigating the adverse effects of radiation therapy in cancer patients. Further research is warranted to explore the therapeutic implications of Polybion in protecting against environmental and treatment-related toxicities.

FAQ section (important questions/answers):

What is the focus of Ramesh Kumar Purohit's study?

The study investigates the protective effects of Polybion against radiation and cadmium-induced changes in total proteins and cholesterol content in the liver of Swiss albino mice.

How were the Swiss albino mice treated in the study?

The mice were divided into groups, some receiving cadmium chloride and/or radiation treatment, while others were administered Polybion to evaluate its protective effects against induced changes.

What were the main findings regarding total protein content?

Total protein content decreased in untreated mice exposed to radiation and cadmium. In Polybion-treated groups, a faster recovery of protein levels was observed.

What impacts did cadmium chloride have on cholesterol levels?

Cholesterol content initially declined in cadmium-treated groups, followed by increases, while Polybion-treated groups showed less severe variations, indicating protective effects.

What mechanisms are suggested for Polybion's protective effects?

Polybion may exhibit antioxidant properties, inhibit carcinogenic activity, and enhance levels of protective compounds like GSH, offering multiple mechanisms of action against radiation damage.

What conclusion does the study reach about Polybion?

Polybion appears to provide significant radioprotection to the liver and may be beneficial for cancer patients undergoing radiotherapy to mitigate adverse effects.

Glossary definitions and references:

Scientific and Ayurvedic Glossary list for “Polybion protects against radiation and cadmium in mouse liver.”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.

1) Animal:
This word underscores the variety of living organisms involved in the experimentation. Here, it emphasizes the use of multiple mice for reliable statistical analysis. It highlights the broader role of animals in research to simulate human responses to environmental and chemical stressors, contributing to scientific knowledge.

2) Water:
Water is an essential medium in the study since cadmium chloride was dissolved in it for administration to the mice. The study outlines the significance of hydration in laboratory experiments and highlights how solutions are formulated for providing dosages of substances like cadmium essential for evaluating biological responses.

3) Post:
The term 'post' refers to the period following the treatment intervals in which the autopsies were conducted. It indicates the timeline for assessing the effects of radiation and cadmium chloride on liver functions, relevant for understanding longevity and recovery rates post-treatment and the general dynamics of biological responses.

4) Drug:
The term 'drug' specifically relates to Polybion, the substance administered to the mice. Its relevance lies in its ability to provide potential protection against the harmful effects of radiation and cadmium toxicity, representing the broader role of pharmacological agents in therapeutic and preventive measures in biological research.

5) Study (Studying):
The term 'study' denotes the systematic investigation of the effects of radiation and cadmium chloride on liver health in mice. This relevance highlights the structured approach in scientific research, emphasizing methodology, data collection, and analysis to derive conclusions about health implications and potential protective strategies.

6) Activity:
In this context, 'activity' refers to the biological processes and metabolic functions observed in the mice during the experiment. The term emphasizes the relationship between exposure to harmful agents such as radiation and cadmium and the resulting physiological changes that are crucial for understanding various health outcomes.

7) India:
India is mentioned as the geographical context of the study, which is vital in terms of locational environmental impact. It reflects the relevance of studying local pollution sources like cadmium and radiation exposure in Indian settings, contributing to global knowledge about industrial and agricultural impacts on health.

8) Sah:
Shah refers to a researcher whose findings are cited in the discussion, contributing to the credibility and background of the study. It illustrates the importance of referencing existing literature to situate new research within the broader scientific discourse and validate its findings through established studies.

9) Radiotherapy:
Radiotherapy is a medical treatment using ionizing radiation, relevant to understanding its health implications and effects on living tissue. This term draws attention to radiotherapy as a common practice in cancer treatment, and the study investigates how protective agents can mitigate its adverse side effects on healthy tissues.

10) Disease:
Diseases refer to broad pathological conditions induced by various external and internal factors. This term is relevant as it encapsulates the overarching theme of the study, emphasizing how radiation and toxins like cadmium can lead to health detriments, underlining the importance of protective measures.

11) Cancer:
Cancer is a primary concern addressed in the study due to its association with radiation exposure. The term underscores the relevance of exploring protective agents against the side effects of therapies designed to treat cancer, indicating the ongoing need for effective cancer treatment strategies.

12) Kumar:
Kumar is the last name of the primary author of this research, reflecting individual contribution in the scientific community. Its mention connects the study to its authorial credibility, emphasizing the background and expertise of researchers involved in exploring complex interactions between environmental and biological factors.

13) Glass:
Glass refers to a material used in the context of containers or experimental setups. Its relevance in laboratory settings generally highlights how various materials are utilized in scientific research for safely housing solutions, ensuring control of experimental conditions, and containing substances vital to the study.

14) Field:
Fields refer to areas of study or disciplines. In this context, it underscores the diverse scientific arenas from which insights are drawn, showcasing the interdisciplinary approach necessary to address complex public health challenges brought on by environmental exposures.

15) Blood:
Blood refers to the essential bodily fluid responsible for transportation of nutrients, oxygen, and waste products. In the context of this study, it may hint at the biochemical analysis of liver impacts, signifying overall health assessment and the systemic effect of the exposures outlined in the research.

16) Sam (Sham):
The term 'sham' refers to the control group in the experiment that did not receive radiation or cadmium treatment. This relevance is critical for comparative analysis, allowing researchers to understand the baseline physiological and biochemical parameters to juxtapose against treated groups effectively.

17) Science (Scientific):
The term 'science' encapsulates the rigorous methodology employed in the study. Its importance is underscored by the emphasis on empirical evidence, hypothesis testing, and a systematic approach to investigating the effects of harmful exposures on biological systems and potential mitigative strategies.

18) Medicine:
Medicine symbolizes the field related to health sciences that involves diagnosis, treatment, and prevention of diseases. Its relevance in this context relates to exploring Polybion's potential benefits in alleviating radiation-induced damage, contributing to therapeutic strategies in clinical settings.

19) Zoology:
Zoology is the biological discipline that studies animal life. Its relevance is underscored by the study's focus on Swiss albino mice as model organisms, showcasing the critical role of zoological research in understanding physiological responses and therapeutic interventions for health issues caused by toxic exposures.

20) Reason:
Reason pertains to the rationale behind the study's design, methodology, and focus. It underscores the importance of investigating both radiation and cadmium's impact on health as a relevant concern, especially in light of environmental pollution and radiation exposure prevalent in modern societies.

21) Cage:
The word 'cage' is similar to 'cages' but relates to individual housing units for animals. Its relevance emphasizes the importance of appropriate animal housing in research settings, ensuring animal welfare and minimizing stress during experimentation to achieve reliable results.

22) Male:
The term 'male' specifies the gender of the Swiss albino mice used in the experiments, which is relevant for understanding sex-based biological differences in response to radiation and cadmium, illustrating the importance of gender considerations in experimental design and outcomes.

23) Accumulation (Accumulating, Accumulate):
Accumulation refers to the buildup of substances, such as fatty deposits or toxic elements within tissues. Its relevance in the study indicates the potential biochemical sequelae of cadmium exposure or radiation and how protective agents might mitigate these harmful changes within biological systems.

24) Agriculture:
Agriculture signifies the connection between environmental practices and potential exposures to heavy metals like cadmium. Its relevance emphasizes the vital role of studying agricultural impacts on health, especially as these practices might introduce pollutants into the food chain and affect animal and human health.

25) Discussion:
Discussion refers to the section in scientific papers where findings are interpreted and contextualized. Its relevance in the study encompasses deriving meanings from the experimental results, linking findings with existing literature, and understanding the implications of across various biological and environmental paradigms.

26) Depression:
Depression in this context may refer to reduced levels or availability of proteins or biochemical substances in the study subjects due to stressors like radiation. Its relevance shows how external factors can impact physiological conditions and alters health outcomes in experimental models.

27) Substance:
The term 'substance' generally relates to any chemical compound or agent being studied. In this context, it highlights the importance of identifying individual elements like Polybion involved in the experimental design, focusing on their roles in health protection against detrimental agents.

28) Rajasthan:
Rajasthan represents the geographical context of the study, emphasizing local environmental factors. Its significance underscores how specific regional traits may influence exposure levels to pollutants like cadmium, enhancing understanding of localized health impacts on organisms.

29) Stiffness:
Stiffness references a condition associated with certain diseases, possibly due to heavy metal toxicity or radiation exposure leading to joint pain, indicative of broader systemic effects. Its relevance illustrates how such conditions can arise from environmental exposures, necessitating research on preventive measures.

30) Toxicity:
Toxicity pertains to the degree to which a substance can cause harm to organisms. In this study, it signifies the health threats posed by cadmium and radiation, emphasizing the importance of exploring protective substances like Polybion to mitigate adverse health effects.

31) Mutation:
Mutation represents alterations in the genetic material of organisms. The study's context discusses how radiation can induce mutations, indicating potential long-term genetic risks, thus highlighting the importance of investigating protective agents to reduce such genetic damage.

32) Vomiting:
Vomiting signifies a severe gastrointestinal response often associated with toxicity. In the context of cadmium exposure, it indicates adverse health effects on living organisms, underscoring the necessity of research focused on minimizing such responses with protective treatments.

33) Chennai:
Chennai is mentioned as a location significant for ethical standards in animal experimentation. Its relevance emphasizes the importance of adhering to regulated protocols in biological research, thereby ensuring animal welfare and the integrity of experimental outcomes.

34) Repair:
Repair denotes the biological processes activated in response to cellular damage from radiation or toxins. In this study, it highlights the mechanisms through which organisms attempt to restore health, revealing the significance of protective agents in aiding these restorative functions.

35) Powder:
Powder relates to the form of Polybion used in the study, emphasizing the method of administration. The relevance indicates the preparation processes involved in utilizing natural substances for biological studies, impacting the delivery methods and actions of the compounds being tested.

36) Pigeon:
Pigeon serves as a reference species in comparative studies. Its mention highlights the relevance of studying various animals to understand biological responses and the consequences of radiation, indicating how diverse animal models can offer insights into human health.

37) Ulcer:
Ulcer refers to lesions that can arise as a consequence of exposure to harmful toxins like cadmium. Its significance in the study lies in illustrating the adverse health effects that these substances can induce, strengthening the need for preventive strategies.

38) Gupta:
Gupta refers to a researcher whose work provides context or background to the study. Its mention adds credibility and supports the legitimacy of the research findings by situating them within the broader scope of established literature.

39) Mazia:
Mazia refers to a researcher cited in the study, highlighting previous work related to the effects of radiation on biological processes. Including such references emphasizes the cumulative knowledge in the field and illustrates how past research informs new investigations.

40) Edema (Oedema):
Edema refers to swelling caused by fluid accumulation. In this study, it may relate to effects from cadmium exposure, underlining the physiological disruptions that pollutants can cause in living organisms, stressing the importance of protective agents.

41) Death:
Death signifies the ultimate outcome of severe physiological distress or toxicity. The term is relevant in emphasizing the critical need for research into protective measures that can mitigate life-threatening exposures due to environmental pollutants.

42) Lamp:
Lamp, a singular form, reflects the industrial sources of cadmium exposure. Its mention underscores the need for awareness and safety measures concerning environmental pollutants that can come from everyday items like lamps and how they can impact health.

43) Hari (Harin):
Hari refers to a researcher mentioned within the broader scientific discourse. Including such citations connects the current findings to established scientific knowledge, reflecting collaborative progress in the understanding of protective strategies against toxic exposures.

44) Amla:
Amla, known for its medicinal properties, relates to the study as the source material for Polybion. Its mention underscores the relevance of natural substances in health protection research and emphasizes the potential for dietary supplements to mitigate biochemical damage from toxins.

45) Food:
Food denotes the sustenance necessary for organisms, in this case, the diet provided to experimental animals. Its relevance emphasizes the role that nutrition plays in health responses and how certain diets can influence the bioavailability of protective compounds.

46) Diet:
Diet refers to the overall nutritional intake of the experimental animals. Its relevance illustrates the significance of incorporating protective agents in diets, suggesting potential preventive strategies against the adverse effects of pollution and toxic substance exposure.

47) Pain:
Pain signifies the discomfort that can result from toxic exposure, indicating adverse health effects linked to radiation and cadmium. Its relevance points to the critical need for protective measures that can alleviate suffering associated with environmental hazards.

48) Salt (Salty):
Salt, in this context, refers to cadmium chloride as the substance used in the study. Its relevance highlights how certain compounds, although common, can cause significant health issues when they contaminate food and water supplies.

49) Viru:
Viru may refer to a specific researcher or a concept referenced in the study. Its mention adds credibility and helps ground the findings in a broader scientific context, strengthening the narrative established in the research.

50) Life:
Life refers to the biological state of living organisms examined in the study. Its relevance underscores the overarching theme of understanding how environmental toxins affect health and the importance of exploring ways to protect and promote well-being in living systems.

Other Science Concepts:

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Discover the significance of concepts within the article: ‘Polybion protects against radiation and cadmium in mouse liver.’. Further sources in the context of Science might help you critically compare this page with similair documents:

Antioxidant activity, Experimental group, Institutional animal ethics committee, Synergistic effect, Swiss albino mice, Biochemical investigation, Gamma radiation, Total protein, Radiation hazards, Cadmium chloride, Cholesterol content, Histological changes, GSH LEVEL, Radiotherapy department.

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