Polybion's protective effect on liver proteins and cholesterol in mice
Journal name: World Journal of Pharmaceutical Research
Original article title: Protective effect of polybion against radiation and cadmium induced changes in total proteins and cholesterol content in the liver of swiss albino mice
The WJPR includes peer-reviewed publications such as scientific research papers, reports, review articles, company news, thesis reports and case studies in areas of Biology, Pharmaceutical industries and Chemical technology while incorporating ancient fields of knowledge such combining Ayurveda with scientific data.
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Ramesh Kumar Purohit
World Journal of Pharmaceutical Research:
(An ISO 9001:2015 Certified International Journal)
Full text available for: Protective effect of polybion against radiation and cadmium induced changes in total proteins and cholesterol content in the liver of swiss albino mice
Source type: An International Peer Reviewed Journal for Pharmaceutical and Medical and Scientific Research
Doi: 10.20959/wjpr20225-22930
Copyright (license): WJPR: All rights reserved
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Summary of article contents:
Introduction
The increasing use of radiation in various fields has raised concerns regarding its acute and prolonged effects on health. This study investigates the protective effects of Polybion against changes induced in total proteins and cholesterol content in the liver of Swiss albino mice exposed to radiation and cadmium chloride. The research highlights the synergistic effects of these agents on liver health and emphasizes the potential benefits of Polybion as a protective treatment.
Synergistic Effects of Radiation and Cadmium
Radiation exposure and cadmium toxicity can lead to severe health implications, particularly affecting the liver. The study showed that both factors resulted in significant decreases in total protein content in liver tissues. When subjected to combined treatment, the detrimental effects were exacerbated, indicating a synergistic interaction that severely compromised liver function. This finding underscores the need to explore protective agents like Polybion in mitigating these harmful impacts.
Protective Role of Polybion
Polybion was administered to various groups of mice prior to exposure to radiation and cadmium chloride. The results indicated a noticeable reduction in the severity of biochemical changes, particularly in total proteins and cholesterol content among the Polybion-treated groups. This suggests that Polybion provides protective effects against radiation-induced damage, promoting faster recovery in liver biochemical parameters compared to the non-drug treated groups. The antioxidant properties of Polybion likely play a critical role in this protection.
Biochemical Changes in Liver Function
The investigation revealed that, while both radiation and cadmium chloride adversely affected total proteins and cholesterol levels, the presence of Polybion mitigated these declines. The study observed an early recovery in protein content following Polybion treatment, alongside less severe changes in cholesterol levels. This indicates that Polybion not only protects against immediate damage caused by radiation and cadmium exposure but also aids in restoring liver function over time.
Conclusion
In summary, the study demonstrates that the liver undergoes significant biochemical alterations when subjected to radiation and cadmium chloride, with compounded effects when both are present. Polybion emerges as a promising protective agent, showing the ability to alleviate adverse biochemical changes and promoting recovery in treated mice. These findings suggest that Polybion could be beneficial for patients undergoing radiotherapy, offering a potential strategy to minimize radiation's harmful effects. Further research could solidify its role as a safe adjunct treatment during cancer therapy.
FAQ section (important questions/answers):
What is the study about regarding Polybion's effect on mice?
The study investigates the protective effect of Polybion against radiation and cadmium-induced changes in liver proteins and cholesterol content in Swiss albino mice.
How were the experimental groups of mice treated in the study?
Groups of mice were treated with cadmium chloride, gamma radiation, and Polybion. Different groups received combinations of these treatments to assess the biochemical effects.
What findings were observed regarding total protein content in mice?
Total protein content decreased in non-drug treated groups and slightly less in Polybion treated groups, indicating protective effects of Polybion against radiation and cadmium.
How did cholesterol levels change during the experiment?
Cholesterol levels initially declined in cadmium treated groups but increased on subsequent days, with Polybion treated groups showing less severe declines, indicating protective effects.
What potential mechanisms does Polybion use for protection?
Polybion may provide protection by reducing oxidative damage, inhibiting mutagenesis, and increasing antioxidant levels, which helps mitigate negative effects from radiation exposure.
What is the conclusion of this study regarding Polybion's efficacy?
Polybion significantly protects the liver from radiation and cadmium-induced damage, promoting faster recovery and potentially reducing adverse effects for cancer patients undergoing radiotherapy.
Glossary definitions and references:
Scientific and Ayurvedic Glossary list for “Polybion's protective effect on liver proteins and cholesterol in mice”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.
1) Animal:
This plural form of 'animal' emphasizes the collective use of multiple test subjects in research. A diverse range of animals improves the reliability and validity of results, allowing researchers to observe variations across species and facilitating the development of treatments applicable to humans in medical contexts.
2) Water:
Water is a crucial medium involved in the administration of cadmium chloride to test animals. It serves as a solvent for diluting drugs and solutes, facilitating their absorption and systemic distribution, which is essential for accurately assessing the biochemical effects of substances administered to test subjects.
3) Post:
The term 'post' refers to the time following an event, particularly the treatment or exposure of animals. In this study, post-treatment intervals are critical for evaluating the duration and extent of effects, such as changes in total proteins and cholesterol levels in the liver.
4) Drug:
In this context, 'drug' refers to Polybion, a dietary supplement used to assess potential protective effects against radiation and cadmium-induced toxicity. Understanding the impact of drugs on health is vital in pharmacology and therapy, especially in mitigating adverse reactions in subjects exposed to harmful agents.
5) Study (Studying):
The study constitutes a systematic investigation assessing the effects of radiation and cadmium on liver biochemistry in mice. It aims to explore protective measures utilizing Polybion, highlighting the importance of scientific experimentation in advancing knowledge and developing strategies to counteract environmental and chemical hazards.
6) Activity:
Activity in this research context likely pertains to biological processes or reactions occurring in response to external stimuli, such as radiation or drug treatment. Monitoring such activities is crucial for discerning the mechanisms of action and the overall effects of exposure on living organisms.
7) India:
India is the geographical context of the study, where the experiments were conducted using native species like Swiss albino mice. The country provides a rich avenue for research involving environmental impacts of pollution and heavy metals, which are critical issues faced by many developing nations.
8) Sah:
Shah likely refers to a researcher cited in the study that discusses various biochemical effects related to irradiation, allowing deeper insights into the consequences of experimental findings. Citing previous works supports the relevance of the current research by building on established scientific literature.
9) Radiotherapy:
Radiotherapy represents a medical treatment using ionizing radiation to eliminate cancer cells. The study addresses the potential protective roles of substances like Polybion in reducing the detrimental impacts of radiation, vital for developing strategies to enhance the efficacy and safety of cancer therapies.
10) Disease:
Diseases refer to pathological conditions arising from diverse factors, including environmental toxins. Understanding their biochemical impacts, particularly in the context of this research, is crucial for developing preventive strategies and treatments that improve human health outcomes.
11) Cancer:
Cancer is a potential outcome of prolonged exposure to harmful agents, including radiation and heavy metals. The study examines biological responses to such exposures and determines if Polybion can mitigate the associated risks, thereby contributing to cancer prevention and treatment strategies.
12) Kumar:
Kumar is the last name of the primary author of the study, indicating their significant role in this research. The presence of an author’s name highlights the importance of individual contributions in scientific investigation and the dissemination of findings through publications.
13) Glass:
Glass production is one of the industries associated with cadmium exposure. Understanding the implications of heavy metals in industrial processes is essential for addressing occupational hazards, thereby informing regulatory frameworks aimed at protecting workers and mitigating environmental impacts.
14) Field:
This plural form of 'field' may imply various areas of inquiry relevant to the study, highlighting the interdisciplinary approach required to understand complex health issues linked to environmental exposures and the efficacy of protective measures.
15) Blood:
Blood serves as a crucial biological fluid transporting nutrients and waste products within organisms. The study may explore how exposure to radiation and cadmium alters blood chemistry, thereby affecting overall health and biological responses in experimental subjects.
16) Sam (Sham):
Sham refers to a control procedure where animals undergo similar conditions as experimental groups without actual treatment, ensuring valid comparisons. Such controls are essential in scientific research, helping isolate the effects of specific treatments, such as radiation or toxic substances.
17) Science (Scientific):
Science represents the systematic study of the natural world through observation and experimentation. This research exemplifies the scientific method and aims to contribute valuable knowledge regarding the effects of radiation and heavy metals on health.
18) Medicine:
Medicine encompasses the science and practice of human health care, including disease diagnosis and treatment. Research findings can contribute to advance medical practices, particularly in understanding the protective roles of supplements against radiation and toxicity inherent in certain therapeutic interventions.
19) Zoology:
Zoology is the scientific study of animals, which is foundational to understanding biological systems in this research. Utilizing Swiss albino mice allows insights into mammalian biology, facilitating apportionment of findings to broader biological and medical contexts.
20) Reason:
The term 'reason' underlines the rationale behind conducting the study, focused on evaluating the interactions between radiation, cadmium, and biological responses. Identifying underlying causes and mechanisms allows scientists to develop better strategies for mitigating health risks.
21) Cage:
Singular form of 'cages,' referring to an individual space where a test animal is housed. A well-structured cage is fundamental to providing a stable environment for animal research, impacting the quality and reproducibility of experimental results.
22) Male:
Male refers to the specific gender of the Swiss albino mice used in the study. Gender can influence biological responses and variability in results; thus, its specification ensures accuracy in interpreting how treatments affect different sexes in research contexts.
23) Accumulation (Accumulating, Accumulate):
Accumulation emphasizes the buildup of substances, such as cholesterol or cadmium, within biological systems. Understanding accumulation patterns can elucidate the toxicological profiles and therapeutic potentials of compounds like Polybion in managing exposure to harmful agents.
24) Agriculture:
Agriculture represents an area where environmental pollutants, including heavy metals, can adversely impact health. Investigating drugs like Polybion in agricultural contexts is crucial for finding solutions that safeguard food supply and public health from chemical exposure.
25) Discussion:
The discussion section of the study interprets findings, correlating them with existing research. It critically assesses results, exploring implications and rationales for observed biochemical changes, and guiding future research directions.
26) Depression:
In this context, depression may refer to reduced biochemical parameters, such as protein concentrations post-exposure to harmful agents. Understanding the extent of such depression helps evaluate potential recovery mechanisms and protective strategies.
27) Substance:
Substance refers to individual chemicals or compounds examined in the study, particularly those contributing to toxicity like cadmium. Their effects on living organisms highlight the need for research on protective measures against environmental hazards.
28) Rajasthan:
Rajasthan is a state in India where the study was conducted, relevant for understanding local environmental impacts. Studying local issues allows the research to address specific health concerns faced by populations in particular regions.
29) Stiffness:
Stiffness denotes physical reactions associated with cadmium exposure, which can manifest as joint pain or movement restrictions in affected populations. Understanding such symptoms is critical in evaluating the full implications of heavy metal toxicity on health.
30) Toxicity:
Toxicity refers to the degree to which a substance can harm living organisms. Understanding the toxicity of substances like cadmium is central to the study's aim of assessing protective measures against hazardous exposures.
31) Mutation:
Mutation involves changes in DNA that can lead to abnormal cell behavior, including cancer. Understanding the role of radiation in inducing mutations is important for developing treatments that minimize genetic damage from environmental exposures.
32) Vomiting:
Vomiting represents a physiological response often associated with cadmium poisoning. Studying symptoms like vomiting is crucial for characterizing the broader health effects of toxic exposures on animal models, informing safety guidelines.
33) Chennai:
Chennai, a city in India, is mentioned as the location of the registration body for animal ethics, underscoring the importance of ethical considerations in experimental research. Compliance with animal welfare regulations is essential for credibility and ethical integrity in scientific studies.
34) Repair:
Repair refers to biological processes aimed at restoring normal function following damage from radiation or toxins. Understanding these repair mechanisms is essential for developing therapeutic interventions that can enhance recovery in affected individuals.
35) Powder:
Powder refers to the dried and processed form of Polybion used in the study. The method of preparation signifies the importance of dosage forms in ensuring effective administration and absorption of potential therapeutic agents.
36) Pigeon:
Pigeon may be referenced concerning prior studies that indicate effects of radiation on various species. Utilizing such comparative studies helps broaden understanding of physiological responses across different animal models during research.
37) Ulcer:
This singular form of 'ulcers' highlights specific instances of tissue damage that the study aims to protect against using Polybion. Researching such protective strategies is valuable in developing therapeutic options for affected individuals.
38) Gupta:
Gupta likely refers to a researcher whose work contributed to the understanding of heavy metals and their impact on health. Citing prior studies solidifies the foundation of the current research by linking it with established scientific knowledge.
39) Mazia:
Mazia is likely a researcher whose findings are referenced in the discussion of how radiation affects biological processes. Citing such studies bolsters the credibility of the research and helps understand the implications of results.
40) Edema (Oedema):
Edema points to a swelling caused by the accumulation of fluid in tissues, potentially related to cadmium exposure. Understanding symptoms like edema provides insight into the physiological effects of toxic substances and informs health interventions.
41) Death:
Death indicates the extreme end result of toxicity or disease progression, representing the finality of the detrimental health impacts studied. Assessing mortality risks associated with radiation and heavy metals underpins the importance of preventive measures.
42) Lamp:
Singular form of 'lamps,' emphasizing specific devices associated with cadmium, relevant in discussing industrial exposure. Understanding exposure sources assists in risk assessment and determining safety measures for workers and consumers.
43) Hari (Harin):
Hari likely refers to an author cited for research supporting the protective efficacy of substances like Polybion against radiation effects. Attribution to specific researchers contributes to acknowledging contributions within scientific discourse.
44) Amla:
Amla, known scientifically as Emblica officinalis, is part of the Polybion formulation and recognized for its health benefits, particularly in traditional medicine. Investigating its role in mitigating oxidative damage situates the study within complementary and alternative medicine contexts.
45) Food:
Food plays a central role in health and nutrition, impacting overall biochemical processes in organisms. The study's findings on cholesterol and proteins relate to how dietary substances affect animal health amidst environmental stressors.
46) Diet:
Diet refers to the nutritional intake influencing the health and biochemistry of experimental animals. Changes in liver parameters in response to radiation and cadmium underline the significance of dietary components in health research.
47) Pain:
Pain signifies a possible health effect due to cadmium exposure, focusing on physiological responses elicited amidst toxic interactions. Assessing pain responses helps factor in quality of life considerations in therapeutic interventions.
48) Salt (Salty):
Salt in this context likely refers to cadmium chloride, the specific compound used in administering cadmium to animals. Understanding its properties and effects is paramount to the study's focus on toxicity and protective measures.
49) Viru:
Viru does not have a clear connection within the study text. Its mention may represent an unrelated term or misunderstanding; clarification may be needed to understand its relevance in the context provided.
50) Life:
Life symbolizes the broad scope of biological study, emphasizing the significance of understanding living organisms' health and responses. Evaluating how harmful substances affect life forms provides a foundation for improving health strategies.
Other Science Concepts:
Discover the significance of concepts within the article: ‘Polybion's protective effect on liver proteins and cholesterol in mice’. Further sources in the context of Science might help you critically compare this page with similair documents:
Control group, Gamma ray, Antioxidant activity, Experimental group, Extracellular matrix, Institutional animal ethics committee, Synergistic effect, Swiss albino mice, Vitamin C content, Biochemical investigation, Total protein, Radiation hazards, Histological structure, Liver enzyme, Cholesterol content, Mucosal damage, Dose rate, Radiotherapy department.