Formulation and evaluation of polyherbal cream
Journal name: World Journal of Pharmaceutical Research
Original article title: Formulation and evaluation of polyherbal cream
The WJPR includes peer-reviewed publications such as scientific research papers, reports, review articles, company news, thesis reports and case studies in areas of Biology, Pharmaceutical industries and Chemical technology while incorporating ancient fields of knowledge such combining Ayurveda with scientific data.
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Raja Babu, Amit Semwal, Shilpa Sharma, Sachin Kumar and Arif Khan
World Journal of Pharmaceutical Research:
(An ISO 9001:2015 Certified International Journal)
Full text available for: Formulation and evaluation of polyherbal cream
Source type: An International Peer Reviewed Journal for Pharmaceutical and Medical and Scientific Research
Doi: 10.20959/wjpr20228-24274
Download the PDF file of the original publication
Summary of article contents:
Introduction
The research conducted by Babu et al. focuses on the formulation and evaluation of a polyherbal cream designed to address skin conditions, particularly psoriasis. The cream incorporates various medicinal plants traditionally used in herbal medicinal systems, including Equisetum arvense, Azadirachta indica, Emblica officinalis, Syzygium aromaticum, Trigonella foenum-graecum, Curcuma longa, and Aloe vera. These plants are recognized for their anti-inflammatory and analgesic properties, making the cream a potential treatment option for patients suffering from skin ailments. The study highlights not only the formulation process but also the evaluation of the cream through various physical and chemical parameters.
Efficacy of Herbal Ingredients
One of the significant concepts addressed in the study is the efficacy of the individual herbal ingredients used in the cream formulation. Equisetum arvense, commonly known as horsetail, is lauded for its high silica content, which supports skin health and promotes collagen production. It is known to offer soothing effects for acne and eczema while also combating signs of premature aging. Similarly, Azadirachta indica (neem) is recognized as a powerful antioxidant with broad therapeutic applications in traditional medicine. Its various constituents help in neutralizing free radicals and managing disease pathogenesis, making it highly relevant for treating skin disorders. This combination of herbal components aims to leverage their combined beneficial effects, enhancing the cream's overall effectiveness.
Importance of Cream Formulation
Another crucial aspect of the research is the meticulous process of cream formulation. The study emphasizes the use of the slab method for preparing the polyherbal cream, focusing on achieving optimal consistency and stability. The cream was formulated as an oil-in-water (O/W) emulsion, which is advantageous for ease of application and washability. Key evaluation parameters such as color, odor, consistency, pH, spreadability, and viscosity were measured to ensure the cream's quality and suitability for topical use. Results indicated the cream had a pleasing appearance, a pH close to the natural skin level, and excellent spreadability, which are critical factors for user acceptance and effectiveness.
Safety and Non-Irritancy
The study also highlights the safety and non-irritant nature of the formulated cream, which is important for skincare products, especially those intended for sensitive skin conditions like psoriasis. The non-irritancy test showed no adverse reactions on the skin, indicating that the cream is safe for regular use. This aspect contributes to user compliance, as patients are more likely to consistently use a product that does not cause irritation or discomfort. The absence of phase separation during storage further demonstrates the formulation's stability, adding to its appeal as a reliable therapeutic option.
Conclusion
In conclusion, the formulation and evaluation of the polyherbal cream demonstrate promising results for addressing psoriasis and potentially other skin conditions. The combination of effective herbal ingredients, careful formulation techniques, and strong safety profiles positions this cream as a viable alternative to synthetic treatments. The growing demand for herbal cosmetics reflects a broader trend towards natural remedies perceived as safer and more acceptable to consumers. The findings suggest that such herbal formulations not only have therapeutic potential but also enhance patient compliance, making them a critical consideration in contemporary skincare solutions.
FAQ section (important questions/answers):
What is the main focus of this research on polyherbal cream?
The research aims to formulate and evaluate a polyherbal cream to treat skin lesions, particularly in psoriasis, using various medicinal plants known for their anti-inflammatory and analgesic properties.
Which medicinal plants are included in the cream formulation?
The cream includes Equisetum arvense, Azadirachta indica, Emblica officinalis, Eugenia caryophyllus, Zingiber officinale, Trigonella foenum-graecum, and Aloe vera, all recognized for their therapeutic benefits.
What are the physical characteristics of the formulated cream?
The cream is slightly pale yellow, has a characteristic odor, smooth consistency, and a semisolid state. Its pH measures 6.5, making it suitable for skin application.
How effective is the cream regarding spreadability and washability?
The newly formulated cream demonstrated good spreadability at 7.4 g.cm/sec and is easily washable with plain water, ensuring convenience in application and removal.
Is the formulated polyherbal cream safe for skin use?
Yes, the cream is non-irritant, showing no redness or inflammation during testing, and its herbal composition is considered safer compared to synthetic alternatives.
What are the expected benefits of using this polyherbal cream?
This cream is expected to relieve pain associated with psoriasis, promote healing, and offer a natural, effective treatment option with fewer side effects than conventional synthetic medications.
Glossary definitions and references:
Scientific and Ayurvedic Glossary list for “Formulation and evaluation of polyherbal cream”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.
1) Disease:
Diseases encompass a wide array of health conditions that impact the well-being of individuals. This research specifically focuses on skin diseases like psoriasis, aiming to explore herbal treatment options that can effectively manage symptoms and improve the quality of life for those affected.
2) Babu:
Babu is the surname of one of the authors of the research article. Raja Babu, along with his colleagues, contributed to the study on the formulation and evaluation of polyherbal cream, demonstrating the importance of individual researchers in advancing medicinal and pharmaceutical knowledge.
3) Water:
Water is a vital solvent used in the extraction and formulation processes of herbal medicines. In the context of the study, water is utilized to extract active compounds from medicinal plants, playing a quintessential role in creating effective topical applications like the polyherbal cream.
4) Emblica officinalis:
Emblica officinalis, commonly known as amla, is a medicinal plant with potent health benefits. It is rich in vitamin C and known for its rejuvenative and antioxidant properties, making it integral to the formulation of the polyherbal cream aimed at treating skin ailments, including psoriasis.
5) Azadirachta indica:
Azadirachta indica, or neem, is a tree known for its therapeutic properties. Rich in antioxidants, it is commonly used in traditional medicine for various conditions, including skin disorders. Its inclusion in the polyherbal cream formulation supports its efficacy against inflammation and infection.
6) Pain:
Pain is a crucial aspect that reflects the discomfort experienced during diseases like psoriasis. The study emphasizes the pain-relieving properties of the ingredients in the polyherbal cream, indicating its potential to alleviate symptoms for those suffering from inflammatory skin conditions.
7) Trigonella foenum-graecum:
Trigonella foenum-graecum, commonly known as fenugreek, is another herbal ingredient in the cream. Recognized for its anti-inflammatory and skin healing properties, fenugreek enhances the cream’s ability to provide relief from irritation and promote skin health, thus supporting traditional healing practices.
8) Amla:
Amla, derived from the fruit of Emblica officinalis, is noted for its high vitamin C content and powerful antioxidant properties. It is traditionally used in Ayurvedic medicine for skin rejuvenation and healing, making it a valuable ingredient in the polyherbal cream aimed at enhancing skin quality.
9) Hair:
Hair is mentioned in the context of traditional remedies provided by the herbal ingredients used in the cream. Several ingredients, such as amla and neem, are beneficial not only for skin but also for hair health, highlighting their holistic applications in cosmetic formulations.
10) Zingiber officinale:
Zingiber officinale, known as ginger, is recognized for its anti-inflammatory, antimicrobial, and antioxidant properties. Its inclusion in the cream formulation contributes to the overall therapeutic effects aimed at relieving symptoms of skin ailments and enhancing skin nourishment in topical applications.
11) Medicine:
Medicines encompass a wide variety of substances used for therapeutic purposes. This research emphasizes herbal medicines as viable alternatives to synthetic options, promoting natural remedies with fewer side effects for treating skin and hair ailments effectively.
12) Activity:
Activity refers to the functional effects of the herbal components being investigated. In this research, the biological activity of selected plant extracts is evaluated for their potential in treating psoriasis, thereby providing evidence of their beneficial roles in therapeutic applications.
13) Table:
Table refers to a structured arrangement of data summarizing the findings of the research. The use of tables in the study aids in clearly communicating the results of various evaluations conducted on the formulated cream, enhancing the reader's understanding of its efficacy.
14) Food:
Food is briefly alluded to concerning the nutritional background of herbal ingredients used in the formulation. Many plants involved in the study have dual roles as both food and medicine, showcasing the integral connection between diet and health in traditional practices.
15) Inflammation:
Inflammation is the body's immune response to injury or disease and is particularly relevant in conditions like psoriasis. The study aims to address inflammation through the formulation of the cream, highlighting the anti-inflammatory properties of various herbal extracts included in the mix.
16) Substance:
Substances refer to the distinct active compounds extracted from the medicinal plants used in the formulation of the cream. The presence of these herbal substances is crucial for their efficacy in treating skin conditions and enhancing the therapeutic profile of the cream.
17) Family:
Family, in botanical terms, refers to the classification grouping of related plants. Many of the herbs used, such as neem and ginger, belong to specific families, which is relevant for understanding their medicinal properties and therapeutic applications in formulations.
18) Neem:
Neem is a versatile plant recognized for its health-promoting properties, particularly its antibacterial and anti-inflammatory effects. Its use in the cream emphasizes traditional practices in herbal medicine aimed at treating various skin conditions, ensuring holistic well-being.
19) Fenugreek:
Fenugreek, known as Trigonella foenum-graecum, is highlighted for its multifaceted health benefits, including skin healing and anti-inflammatory properties. Its inclusion in the polyherbal cream supports cultural practices of utilizing food plants for medicinal purposes, promoting skin health.
20) Indian:
Indian refers to the cultural and geographical origin of many herbs used in the study, particularly reflecting traditional medicine systems like Ayurveda. The research signifies the role of Indian herbal practices in modern therapeutic applications, advocating for the efficacy of indigenous knowledge.
21) Study (Studying):
Study refers to the systematic investigation presented in the research article, aimed at formulating and evaluating a polyherbal cream. This study underscores the continued relevance of traditional herbal remedies in addressing modern health challenges, particularly skin diseases.
22) Rich (Rch):
Rich indicates the abundance of beneficial compounds found within the herbal ingredients. Many of the plants utilized are rich in vitamins, antioxidants, and therapeutic properties, thereby contributing significantly to the efficacy of the formulated cream in treating various ailments.
23) Life:
Life refers to the health and wellness of individuals, which is impacted by diseases like psoriasis. The development of effective herbal treatments aims to enhance life quality, alleviating symptoms and promoting better overall health outcomes for individuals with skin diseases.
24) Oil:
Oils derived from various plants serve as vital components in the cream formulation, contributing moisturizing and therapeutic properties. These oils enhance skin nourishment and support the cream's efficacy in treating skin conditions commonly associated with dryness and irritation.
25) Curcuma longa:
Curcuma longa, or turmeric, is an important herbal ingredient known for its anti-inflammatory and antioxidant properties. Its role in the cream formulation emphasizes the use of turmeric in traditional medicine to alleviate various skin issues and enhance overall skin health.
26) Antibiotic (Antibacterial):
Antibacterial properties are crucial in formulations aimed at treating skin diseases. The cream's efficacy is supported by the antibacterial effects of several included ingredients, helping to prevent infections and promote a healthier skin environment for healing.
27) Irritation:
Irritation refers to the skin's response to certain substances, which can cause discomfort. The research emphasizes the non-irritating nature of the cream formulated from herbal extracts, making it suitable for sensitive skin, particularly in individuals suffering from psoriasis.
28) Flavonoid:
Flavonoid, as a classification of compounds, represents the various beneficial chemicals present in the study's herbal ingredients. These compounds play a significant role in enhancing health benefits and therapeutic functions of the formulations used for skin treatment.
29) Cleansing:
Cleansing refers to the process of removing impurities and promoting skin health. The formulated cream, enriched with herbal extracts, supports the cleansing properties that enhance skin condition, making it a valuable addition to skincare routines aimed at treating ailments like psoriasis.
30) Science (Scientific):
Science, in this context, underscores the rigorous methodology applied in the research. The study utilizes scientific principles to evaluate the efficacy of polyherbal creams, bridging traditional knowledge with modern understanding in the treatment of skin conditions.
31) Methi:
Methi, another name for fenugreek (Trigonella foenum-graecum), is an integral part of traditional medicine used for its beneficial effects. The research highlights its multi-purpose applications in skin treatments, exemplifying the plant's importance in herbal formulations for health enhancement.
32) Field:
Field refers to the area of study or application that the research pertains to. In this case, it involves pharmacognosy, a field that emphasizes the relationships between medicinal plants and their therapeutic applications, vital for advancing modern herbal medicine.
33) Borax:
Borax is a mineral used in the preparation of the cream as an emulsifying agent. Its inclusion facilitates the stability and texture of the formulation, showcasing the importance of various compounds in creating effective topical treatments derived from natural sources.
34) Raja:
Raja refers to the first name of the corresponding author, Raja Babu, whose contribution in formulating and studying the polyherbal cream is critical. Such authors bring attention to the collaborative nature of research and the importance of individual expertise in scientific endeavors.
35) Hand:
Hand signifies the practical application and sensory perception of the formulated cream during evaluations. Assessing texture, consistency, and spreadability are crucial for determining user satisfaction and the cream's efficacy in providing skin relief and nourishment.
36) Phytochemical:
Phytochemical refers to specific chemical compounds derived from plants that exhibit beneficial health effects. The study underscores the role of these compounds in the cream formulation and their importance in fostering natural healing and supporting skin health.
37) Tuberculosis:
Tuberculosis is a serious infectious disease that can affect various body parts, including the skin. While the study primarily focuses on skin conditions, mentioning tuberculosis accentuates the broader therapeutic potential of the herbal ingredients utilized in the formulation.
38) Observation:
Observation is an integral part of the scientific method, employed throughout the study to assess the physical and chemical properties of the formulated cream. Accurate recording of observations ensures the reliability and credibility of the research findings.
39) Anti-aging:
Anti-aging refers to properties that help reduce the visible signs of aging, such as wrinkles and fine lines. The research acknowledges the role of certain herbal components, especially horsetail, known for its anti-aging effects, in enhancing the cream's formulation.
40) Discussion:
Discussion in research refers to the section where authors interpret results and implications. In this study, the discussion elucidates how findings support traditional remedies’ effectiveness, bridging gaps between ancient knowledge and contemporary application in treating skin diseases.
41) Developing:
Developing refers to the continuous process of creating and enhancing products based on research findings. In this context, it points to formulating effective herbal preparations that can treat skin diseases, emphasizing innovation in the field of herbal medicine.
42) Depression:
Depression, a common comorbidity in many chronic diseases, is included to highlight the multifaceted impact of conditions like psoriasis on mental health. This context implies the holistic approach needed in treatment strategies that consider both physical and psychological well-being.
43) Container:
Container refers to the vessel used for storing the formulated cream. Proper container choice is crucial for maintaining product integrity and ensuring stability, thus enhancing the shelf life and effectiveness of the herbal preparation applied to the skin.
44) Relative:
Relative highlights the connection or similarity among substances, particularly in the context of medicinal plants. Understanding the relationship between various herbs is essential for improving formulation strategies and enhancing the therapeutic effects of combined herbal treatments.
45) Ayurveda (Ayus-veda):
Ayurveda is an ancient Indian system of medicine that emphasizes a holistic approach to health. The study integrates principles from Ayurveda in utilizing herbal formulations, aiming to promote healing and wellness through natural means, aligning with traditional practices.
46) Toxicity:
Toxicity denotes the degree to which substances can harm living organisms. The formulation aims to be non-toxic, favoring the use of herbal ingredients to mitigate adverse effects often associated with synthetic drugs in treating skin conditions.
47) Swelling:
Swelling refers to the inflammatory response manifested in various skin conditions. The research emphasizes the anti-inflammatory properties of the herbal ingredients in the cream, aimed at reducing swelling and promoting healing in affected skin areas.
48) Mineral:
Mineral refers to the individual inorganic substances that play a pivotal role in bodily functions. Their presence in herbal ingredients enhances the nutritional value and therapeutic potential of the cream formulated for skin disorders.
49) Quality:
Quality signifies the standard of the formulated products, emphasizing efficacy, safety, and user acceptance. The research framework strives to achieve high-quality formulations through rigorous evaluation of herbal components and adherence to established pharmaceutical practices.
50) Heating:
Heating is a critical process in the formulation of creams, ensuring proper incorporation of ingredients. The study demonstrates the importance of controlled heating techniques in achieving the right consistency and texture for effective topical applications.
51) Coconut (Cocoanut):
Coconut, often used for its oil, is appreciated for its moisturizing properties. The study may reference coconut oil's role in enhancing skin hydration and nourishment within formulations, indicating its importance in creating effective skincare products.
52) Surface:
Surface implies the outer layer of the skin that the formulated cream interacts with upon application. Understanding surface properties is crucial for determining the absorption and effectiveness of topical treatments in alleviating skin conditions.
53) Siddha:
Siddha is another traditional Indian medicine system, closely related to Ayurveda, focusing on holistic healing through natural remedies. The study recognizes these traditional knowledge systems' significance in the formulation of the polyherbal cream and herbal treatments.
54) Cancer:
Cancer, as a serious illness, is included to underscore the potential therapeutic properties of active compounds derived from the herbal ingredients. Many of the plants studied boast anti-cancer properties, showcasing their multi-faceted health benefits beyond skin health.
55) Nausea:
Nausea denotes an uncomfortable sensation that can accompany various health conditions. While the main focus is skin diseases, the mention of nausea emphasizes the comprehensive approach needed for treating multi-symptomatic issues in patient care.
56) Sharman (Sarma, Sharma, Sarman):
Sharma is another contributing author's surname in the research. It underscores the collaborative effort in academic research, drawing upon diverse expertise to enhance the investigation’s integrity and depth in studying the polyherbal cream.
57) Nature:
Nature refers to the natural origins of the herbal ingredients used in the formulation. This emphasizes the movement towards utilizing eco-friendly, plant-derived substances in medicine, reflecting a growing trend in preferring natural remedies over synthetic alternatives.
58) Powder:
Powder denotes the physical form in which some herbal ingredients are prepared for extraction. The process of grinding herbs into powder maximizes surface area for extraction, ensuring that the cream contains concentrated beneficial properties of the plants.
59) Ulcer:
Ulcer refers to a sore or open lesion on the skin or mucous membrane. The research emphasizes the need for effective treatments targeting such conditions, showcasing how the formulated cream can alleviate symptoms associated with ulcers and promote healing.
60) India:
India is the geographical origin of many traditional medicinal practices, including Ayurveda. The mention of India in this context highlights the cultural significance of plant-based medicine and the relevance of indigenous knowledge in contemporary health practices.
61) Kumar:
Kumar, another contributing author's surname, represents the collective effort of multiple researchers in this study. The collaboration among these authors showcases the importance of sharing knowledge and expertise in advancing research on herbal medicine.
62) Aroma (A-roma):
Aroma pertains to the characteristic smell of herbal ingredients, which can enhance user experience with the product. The pleasant natural aroma of the polyherbal cream plays a role in consumer acceptance and satisfaction during application.
63) Glass:
Glass refers to the material of the containers used for the storage or application of the cream. The choice of glass can help maintain product purity and prevent interactions that might diminish the cream's effectiveness over time.
64) Edema (Oedema):
Edema refers to swelling caused by excess fluids in tissues, often associated with inflammation. The study addresses the anti-inflammatory properties of the formulated cream, presenting an approach to reduce symptoms like edema in skin diseases.
65) Fever:
Fever is a systemic response indicating infection or illness. By highlighting fever, the study implications extend to systemic health challenges linked with skin diseases, advocating for a comprehensive understanding of patient care in herbal medicine.
66) Fainting (Fainted):
Faint denotes a light or subtle quality, often relating to sensory experiences. In the context of the study, it might be linked to the subtle effectiveness of certain herbal components in achieving desired therapeutic outcomes without overwhelming side effects.
67) Burning (Burn, Burned, Burnt):
Burn, in a skin-care context, refers to damage to the skin. The properties of the herbal cream are aimed at soothing burns and promoting recovery, indicating its multifunctionality beyond merely treating psoriasis and other skin ailments.
68) Drug:
Drug signifies any substance used for therapeutic effects. This highlights the transition in discussions towards integrating herbal compounds as alternatives to conventional drugs in treating skin diseases, emphasizing their lower toxicity and broader acceptance.
69) Tree:
Tree refers to the greater plant family from which certain medicinal ingredients are sourced. Many herbs studied, including neem, originate from trees, showcasing the botanical diversity utilized in traditional and modern medicinal applications.
70) Sign:
Sign represents indicators of health conditions or diseases observable during evaluations. In the study, observing specific signs of effectiveness or side effects helps gauge the success of the formulated polyherbal cream in treating skin disorders.
71) Pur:
Poor describes a state of inadequacy, often referring to health status or access to effective treatments. In the research context, it underscores the need for affordable, safe, and effective remedies for individuals suffering from various skin diseases, promoting equitable healthcare.
Other Science Concepts:
Discover the significance of concepts within the article: ‘Formulation and evaluation of polyherbal cream’. Further sources in the context of Science might help you critically compare this page with similair documents:
Azadirachta indica, Zingiber officinale, Trigonella foenum-graecum, Emblica officinalis, Aloe vera, Saponification value, Viscosity, Health-related quality of life, Acid value, Soxhlet Apparatus, Dye test, Topical treatment, Spreadability test, Maceration, Evaluation parameter, Polyherbal cream, Cream formulation.