Antimicrobial resistance (amr) in kaumarbhritya

an ayurvedic view

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Journal name: World Journal of Pharmaceutical Research
Original article title: Antimicrobial resistance (amr) in kaumarbhritya
The WJPR includes peer-reviewed publications such as scientific research papers, reports, review articles, company news, thesis reports and case studies in areas of Biology, Pharmaceutical industries and Chemical technology while incorporating ancient fields of knowledge such combining Ayurveda with scientific data.
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Subtitle: an ayurvedic view

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Author:

Karuna S. Ratnaparkhi and Ruchira B. Gaikwad


World Journal of Pharmaceutical Research:

(An ISO 9001:2015 Certified International Journal)

Full text available for: Antimicrobial resistance (amr) in kaumarbhritya

Source type: An International Peer Reviewed Journal for Pharmaceutical and Medical and Scientific Research

Doi: 10.20959/wjpr20229-23895

Copyright (license): WJPR: All rights reserved


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Summary of article contents:

Introduction

Antimicrobial resistance (AMR) poses a significant global health threat, with resistant microorganisms, commonly termed “superbugs,” leading to increased morbidity, mortality, and healthcare costs. While AMR is a natural phenomenon, its acceleration can be attributed to the inappropriate use of antimicrobials. Ayurveda, the ancient healthcare system, although lacking a direct reference to antibiotics, contains extensive literature on the effects of microorganisms (krimi) and various Ayurvedic treatments aimed at combating them. This paper highlights Ayurvedic concepts and practices that can be employed to prevent and treat bacterial infections amid the growing concern about AMR.

The Concept of Krimi in Ayurveda

Ayurvedic texts provide an understanding of disease causation attributed to various organisms, which can be classified as krimi, including pathogenic microorganisms. The ancient scriptures, such as the Rigveda and Atharvaveda, mention these entities as invisible life forms with unique characteristics. The Charak Samhita classifies microorganisms into normal and pathogenic types, emphasizing the importance of immunity and prevention. Ayurveda historically stresses not only the destruction of pathogenic microbes but also the enhancement of the body's resistance to prevent disease recurrence. Traditional dietary and therapeutic approaches are used to create an unfavorable environment for these harmful organisms.

Prevention of Antimicrobial Resistance

Prevention strategies within the Ayurvedic framework focus on holistic health practices that maintain well-being and reduce the risk of infection. Important aspects include adhering to daily and seasonal regimens, known as Dincharya and Ritucharya, and ensuring proper cleaning and cleansing methods. The Ayurvedic approach promotes healthy habits that encompass physical, mental, and spiritual dimensions, thereby fostering overall immunity. Emphasis is also placed on non-retaining natural urges, dietary management, and the use of Rasayanas, both to prevent infections and to enhance the body’s defense mechanisms against them.

Curative Approaches in Ayurveda

The Ayurvedic treatment modalities for addressing infections are multifaceted, incorporating detoxification, herbal remedies, and preventative care. Treatments are categorized into methods that eliminate pathogens (aprokarshana), restore balance (prakrtivighata), and avoid disease triggers (nidana-parivarjana). Specific herbal formulations, such as Mahakashayas, are employed for their anti-pathogenic properties, aiming to directly counter infections and reduce symptoms. Additionally, Ayurvedic herbs like Haridra (turmeric), Neem, and Guggul possess recognized antimicrobial activities that can safely aid in treating infections while minimizing side effects compared to conventional antibiotics.

Conclusion

In summary, Ayurveda provides a comprehensive framework for both prevention and treatment of bacterial diseases, particularly in the context of the rising challenge of AMR. By integrating holistic health practices, dietary measures, and the use of effective herbal remedies, Ayurvedic interventions can play a critical role in enhancing immunity and combating infections. While the efficacy of many Ayurvedic preparations warrant further research, their traditional application and safety represent a promising avenue for addressing the public health crisis posed by antimicrobial resistance. As the global healthcare landscape evolves, the inclusion of these ancient practices offers substantial potential in managing infections harmoniously with modern medical approaches.

FAQ section (important questions/answers):

What is antimicrobial resistance (AMR) and why is it a concern?

Antimicrobial resistance (AMR) occurs when microorganisms become resistant to most antimicrobials, leading to 'superbugs.' It is a global health concern because AMR results in increased morbidity, mortality, and healthcare costs, making infections harder to treat.

How does Ayurvedic medicine approach the treatment of microbial infections?

Ayurvedic medicine emphasizes using natural remedies mentioned in its classics, targeting microorganisms (krimi). It includes dietary changes, herbal preparations, and specific treatments aimed at enhancing immunity and eliminating pathogens.

What preventive strategies does Ayurveda recommend to combat diseases?

Ayurveda recommends practices like daily regimen (Dincharya), seasonal cleansing (Samshodhana), and promoting mental strength through Yoga to enhance immunity and prevent diseases.

What are some Ayurvedic herbs with antibacterial properties?

Ayurvedic herbs with antibacterial properties include Turmeric (Haridra), Holy Basil (Tulsi), and Neem (Azadirachta indica), which have proven effective against various pathogens.

How does the concept of microbiology appear in Ayurvedic texts?

Ayurvedic texts refer to microorganisms (krimi) and mention methods to destroy them. Classics like Charak Samhita categorize them and emphasize enhancing the body's resistance against infections.

What is the role of Panchakarma in Ayurvedic treatment of infections?

Panchakarma, a cleansing therapy in Ayurveda, removes toxins and enhances health. It's suggested for the treatment of infectious diseases through methods like therapeutic vomiting and purging.

Glossary definitions and references:

Scientific and Ayurvedic Glossary list for “Antimicrobial resistance (amr) in kaumarbhritya”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.

1) Drug:
Drugs are chemical substances that cause changes in physiological or psychological processes in the body. They can be natural or synthetic and are used for various therapeutic purposes. In Ayurveda, the focus is on herbal and natural formulations to achieve healing and maintain health.

2) Antibiotic (Antibacterial):
Antibacterial denotes properties effective against bacteria, playing a critical role in both traditional and modern medicine. In Ayurveda, numerous herbs exhibit antibacterial activities, showcasing the system's potential in providing alternatives to synthetic antibiotics in treating infections.

3) Disease:
Diseases encompass various pathological conditions that disrupt normal biological functions. They can be acute or chronic, affecting individuals’ health and well-being. Ayurveda’s extensive knowledge allows for tailored treatments, focusing on the root cause and employing natural substances to restore health and balance.

4) Ayurveda (Ayus-veda):
Ayurveda is an ancient Indian system of medicine that emphasizes holistic health and wellness through natural remedies. It incorporates principles of balance between body, mind, and environment. Ayurveda offers various methods for disease prevention and treatment without adversely affecting health, making it relevant in combating AMR.

5) Activity:
Activity refers to the physiological or biological effect induced by a substance or organism, particularly in the context of pharmacology, where it denotes the effectiveness of drugs. Understanding activity helps assess the therapeutic potential of Ayurvedic herbs against pathogens, contributing to holistic health.

6) Krimi (Krmi):
Krimi is a Sanskrit term used in Ayurveda to denote microorganisms or parasites, often linked to diseases. The concepts surrounding krimi are foundational, illustrating how ancient texts identify and describe infectious agents, laying the groundwork for Ayurvedic treatments against various ailments.

7) Mahakashaya (Maha-kashaya, Mahakasaya):
Mahakashayas are plural formulations of potent herbal mixtures in Ayurveda. They are recognized for their multifaceted therapeutic properties, targeting various ailments through the synergistic action of included herbs, showcasing the traditional wisdom ingrained in Ayurvedic healing practices.

8) Samhita:
Samhita refers to an ancient collection or compilation of texts in Ayurveda, containing knowledge on health, medicine, and healing practices. These foundational texts serve as a reference for practitioners, ensuring the preservation of traditional knowledge and practices in contemporary Ayurvedic medicine.

9) Viru:
Viru generally refers to viruses that cause diseases in living organisms, contributing to a significant public health burden. While Ayurveda predominantly focuses on bacterial pathogens, understanding viral diseases allows practitioners to explore holistic remedies that may boost the immune system and promote recovery.

10) Bhumyamalaki (Bhumi-amalaki):
Bhumyamalaki, known as Phyllanthus niruri, is an Ayurvedic herb recognized for its efficacy in treating liver disorders and viral infections, particularly hepatitis B. Its use showcases the importance of specific plants within Ayurveda, emphasizing the role of natural remedies in combating prevalent health issues.

11) Substance:
Substances refer to any matter or material with defined compositions and properties. In Ayurveda, various natural substances are sourced for therapeutic use, emphasizing holistic healing and comprehensive treatment modalities that align with the body's innate healing processes.

12) Species:
Species refers to distinct biological classifications of organisms that are capable of interbreeding. In the context of herbal medicine, understanding species is vital for accurately identifying and utilizing plants in Ayurvedic practices, ensuring therapeutic efficacy and safety.

13) Aureus:
Aureus, particularly Staphylococcus aureus, is a significant bacterial pathogen known for causing various infections, notably in healthcare settings. Understanding its pathogenicity and resistance mechanisms is crucial for developing effective treatments, including explorations of Ayurvedic remedies to address infections.

14) Kalpa:
Kalpas denote the methods of preparation of Ayurvedic medicines, focusing on the formulation of herbal compounds for therapeutic use. This term reflects the meticulous process of curating effective herbal treatments to ensure optimal health benefits.

15) Life:
Life refers to the condition of living organisms characterized by growth, reproduction, and response to stimuli. In Ayurvedic philosophy, life is seen as a balance of body, mind, and spirit, guiding the principles of treatment and health maintenance toward holistic well-being.

16) Krimighna (Krmighna, Krimi-ghna):
Krimighna refers to formulations in Ayurveda specifically aimed at destroying or mitigating the harmful effects of microorganisms. These remedies highlight Ayurveda's approach to infection management by employing natural ingredients effective against pathogens, thereby enhancing treatment outcomes.

17) Jvarahara (Jvara-hara):
Jvarahara refers to Ayurvedic treatments focused on reducing fever. These formulations employ various herbs and methods designed to bring down body temperature while addressing underlying imbalances, showcasing Ayurveda's holistic methodology in managing symptomatic conditions.

18) Education:
Education in the context of Ayurveda refers to the dissemination of knowledge relating to health, treatments, and preventive care. Promoting health education fosters awareness and adherence to Ayurvedic principles, encouraging individuals to take proactive steps in managing their well-being.

19) Rasayana (Rasa-ayana):
Rasayana is a branch of Ayurveda focusing on rejuvenating therapies and substances that promote health and longevity. It emphasizes improving body functions and enhancing mental clarity, providing a comprehensive approach to wellness and disease prevention.

20) Family:
Family refers to a category in biological classification, typically encompassing related organisms. In Ayurveda, understanding plant families can help practitioners identify and utilize medicinal herbs effectively, selecting those most suitable for specific health concerns based on their properties.

21) Azadirachta indica:
Azadirachta indica, commonly known as neem, is an important medicinal plant in Ayurveda recognized for its anti-bacterial, anti-inflammatory, and antifungal properties. Its extensive use emphasizes Ayurveda's reliance on natural remedies to combat infections and promote healing in various diseases.

22) Commiphora wightii:
Commiphora wightii, known as guggul, is an Ayurvedic herb praised for its varied health benefits, including anti-inflammatory and antimicrobial properties. Its importance in Ayurvedic formulations showcases the diversity of natural resources utilized for therapeutic purposes.

23) Burning sensation:
Burning sensation is a common symptom experienced in various infections and inflammatory conditions. In Ayurveda, understanding this symptom aids in diagnosing underlying issues and selecting appropriate herbal remedies that can effectively soothe and address the discomfort.

24) Ocimum sanctum:
Ocimum sanctum, or holy basil, is revered in Ayurveda for its numerous health benefits, including antimicrobial and adaptogenic properties. Its use signifies the incorporation of sacred plants in traditional medicine, enhancing overall health while ensuring spiritual well-being.

25) Ashtangahridaya (Ashtanga-hridaya, Astangahrdaya):
Ashtanga-hridaya is a classic text in Ayurveda representing a compilation of knowledge on the medical science and practice. It serves as a valuable resource for practitioners seeking to understand Ayurvedic principles and therapeutic methodologies across various health conditions.

26) Commiphora mukul:
Commiphora mukul, commonly known as guggul, is used in Ayurvedic medicine for its metabolic and anti-inflammatory properties. Its therapeutic potential underscores the significance of specific plants in addressing health issues and promoting holistic wellness.

27) Sushruta-samhita (Susruta-samhita):
Susruta-samhita is an ancient Ayurvedic text focusing on surgical practices and medical ethics. It is a foundational work that contributes to the understanding of holistic care, highlighting the significance of integrating surgical and non-surgical treatments in Ayurvedic healing.

28) Shitaprashamana (Shita-prashamana, Sitaprasamana):
Sitaprasamana refers to specific Ayurvedic formulations that aim to balance the body's heat and cold elements. Such treatments are integral for addressing conditions characterized by disbalance in these elements, emphasizing Ayurveda's comprehensive approach to health.

29) Shirovirecana (Shiras-virecana, Sirovirecana):
Sirovirecana is an Ayurvedic treatment involving therapeutic purgation through the head, primarily targeting mental health imbalances. This treatment highlights Ayurveda's intricate understanding of bodily connections and the role of the mind in overall health.

30) Vranashodhana (Vranasodhana, Vrana-shodhana):
Vranasodhana refers to Ayurvedic procedures aimed at cleansing wounds or infected areas. It emphasizes the importance of maintaining hygiene and promoting healing through specific herbs and techniques, aligning with Ayurveda’s holistic methodologies in treatment.

31) Atharvaveda (Atharva-Veda):
Atharvaveda is one of the four Vedas in Hindu philosophy, rich in information about health, healing, and medicinal practices. It provides a spiritual context to Ayurvedic principles, emphasizing the interconnectedness of body, mind, and the natural world in health maintenance.

32) Kushthaghna (Kusthaghna):
Kushthaghna refers to Ayurvedic formulations specifically aimed at treating skin ailments, including leprosy. This highlights Ayurveda's targeted approach to addressing specific health conditions through carefully selected herbal remedies, ensuring effective treatment outcomes.

33) Samshodhana (Samsodhana):
Samshodhana is the Ayurvedic process of detoxification and purification of the body, using various techniques and therapies. This practice is essential for achieving balance, promoting health, and preparing the body for more intensive Ayurvedic treatments.

34) Vranaropana (Vrana-ropana):
Vranaropana denotes the process of wound healing in Ayurveda, incorporating herbal treatments and therapies aimed at facilitating recovery. This practice underscores the significance of natural remedies in promoting repair and restoration in the body.

35) Rakshoghna (Raksoghna, Rakshas-ghna):
Rakshoghna refers to substances or treatments in Ayurveda that protect against harmful agents, notably infections. This concept reflects the essential role of preventive medicine in Ayurveda, aiming to bolster natural defenses and maintain health.

36) Salasaradi (Salasara-adi):
Salasaradi is a set of Ayurvedic formulations designed to address skin infections and diseases. These remedies exemplify Ayurveda's approach to targeted treatment based on symptomatology and specific health needs.

37) Asthapana:
Asthapana refers to an Ayurvedic enema therapy focused on detoxifying the body through the rectal route. This method is significant for treating digestive disorders and promoting overall health, demonstrating a detailed understanding of bodily detoxification processes.

38) Kandughna (Kandu-ghna):
Kandughna signifies Ayurvedic treatments and formulations aimed at alleviating itching and skin irritations. Such targeted approaches exemplify Ayurveda's focus on addressing specific symptoms and enhancing patient comfort in disease management.

39) Haridradi (Haridra-adi):
Haridradi refers to a group of Ayurvedic formulations derived from turmeric (Haridra) and other herbs, celebrated for their anti-inflammatory and therapeutic properties. These blends underscore the efficacy of natural remedies in Holm holistic approaches to health and wellness.

40) Shvasahara (Svasahara, Shvasa-hara):
Svasahara denotes Ayurvedic remedies aimed at enhancing respiratory health. These formulations are crucial for managing respiratory diseases and aligning with Ayurveda’s philosophy of maintaining balance in bodily functions.

41) Shothahara (Shotha-hara, Sothahara):
Sothahara refers to Ayurvedic treatments focused on reducing swelling or edema in the body. This concept reveals Ayurveda's detailed strategies for addressing various symptoms and maintaining health through targeted interventions.

42) Furniture:
Furniture, in the context of Ayurvedic principles, may require regular cleansing and fumigation to maintain a healthy environment, particularly for children. This practice reflects Ayurveda’s attention to hygiene and the prevention of disease through environmental management.

43) Cleansing:
Cleansing in Ayurveda refers to the processes used to purify the body and remove toxins. This foundational practice encourages holistic health and balance, essential for effective treatment and overall well-being.

44) Epidemic:
Epidemic denotes a rapid onset of disease affecting many individuals within a population. Addressing epidemics through preventive health education, hygiene practices, and Ayurvedic principles highlights the urgent need for holistic solutions in public health.

45) Virecana:
Virecana is an Ayurvedic therapeutic procedure involving purgation to eliminate toxins and balance bodily doshas. This method is integral to detoxifying and preparing the body for healing, showcasing Ayurveda's systematic approach to health management.

46) Tamalaki:
Tamalaki is an Ayurvedic herb and a significant component of several formulations aimed at enhancing immunity and detoxification. Its use highlights Ayurveda’s reliance on nature to provide health solutions, aiding against various diseases.

47) Varunadi (Varuna-adi):
Varunadi refers to Ayurvedic formulations effective in treating urinary tract infections and related disturbances. This reflects the targeted nature of Ayurvedic remedies, focusing on specific ailments with supportive herbal combinations.

48) Surasadi (Surasa-adi):
Surasadi is an Ayurvedic herbal grouping aimed at respiratory health, addressing various respiratory conditions. Its application showcases the breadth of Ayurvedic treatments available for improving health and alleviating specific symptoms.

49) Vishaghna (Visaghna, Visha-ghna):
Visaghna signifies therapies in Ayurveda designed to counteract or eliminate toxic substances from the body. This philosophy underpins the detoxification processes integral to Ayurveda, supporting health and disease prevention.

50) Ashtanga (Astanga, Ashtan-anga):
Ashtanga refers to the foundational system of Ayurveda, encompassing eight branches of knowledge. It guides practitioners in diagnosing and treating various health conditions, promoting a comprehensive understanding of holistic healthcare within the Ayurvedic tradition.

51) Medicine:
Medicine refers to the science and practice of diagnosing, treating, and preventing illness. Ayurveda exemplifies a holistic approach to medicine, integrating natural remedies and traditional practices to achieve optimal health.

52) Mutation:
Mutation refers to changes occurring in the genetic material of microorganisms, often leading to antibiotic resistance. Understanding mutation is critical in both modern medicine and Ayurveda, as it influences the effectiveness of treatments and highlights the need for alternative therapeutic approaches.

53) Turmeric:
Turmeric, known as Haridra in Ayurveda, is a powerful herb renowned for its anti-inflammatory and antimicrobial properties. Its use in traditional medicine underscores the importance of natural ingredients in effective herbal treatments and wellness practices.

54) Sukshma (Suksma, Shukshma):
Sukshma translates to 'subtle' in Sanskrit, often referring to the invisible or microscopic entities like microorganisms. In Ayurveda, this concept underscores the significance of understanding subtle forces impacting health and advocating for interventions targeting these agents.

55) Hridaya (Hrdaya):
Hridaya, meaning 'heart' in Sanskrit, carries both anatomical and metaphorical significance in Ayurveda, representing the seat of emotions and consciousness. The holistic focus on hridaya exemplifies Ayurveda’s approach to treating physical and psychological well-being as interconnected.

56) Amalaki:
Amalaki, or Indian gooseberry, is a revered fruit in Ayurveda known for its health-promoting properties, especially its high vitamin C content. Its attributes highlight the importance of incorporating nutrient-rich plants in Ayurvedic remedies for immunity and wellness.

57) Shodhana (Sodhana):
Sodhana refers to the purifying processes in Ayurveda aimed at detoxifying the body from accumulated toxins and promoting health. This foundational practice enhances the overall efficacy of Ayurvedic treatments, ensuring a balanced and harmonized state.

58) Haridra:
Haridra or turmeric is essential in Ayurveda due to its extensive health benefits, including its anti-inflammatory and antimicrobial effects. Its culinary and medicinal uses exemplify Ayurveda's reliance on nature for healing and maintaining health.

59) Kashaya (Kasaya):
Kashaya refers to the bitter or astringent taste in Ayurveda, associated with certain herbs and formulations. Its properties play a crucial role in managing conditions and restoring balance, highlighting the diverse application of taste in Ayurvedic practices.

60) Burning (Burn, Burned, Burnt):
Burning sensations often signify inflammation or irritation in the body. Ayurveda's understanding of this symptom helps guide treatment approaches, employing soothing herbs to alleviate discomfort while addressing underlying issues.

61) Itching:
Itching is a common sensation associated with skin conditions and infections. In Ayurveda, understanding the causes of itching enables practitioners to prescribe targeted treatments to relieve discomfort and restore skin health.

62) Surface:
Surface in a health context may refer to the outer layer of the body or skin affected by diseases or infections. Ayurveda emphasizes addressing both superficial and internal health issues, ensuring comprehensive care.

63) Dravya:
Dravya is an equivalent term to dravyas in Ayurveda, emphasizing the significance of used substances in herbal medicine. These materials provide medicinal properties crucial for formulating effective Ayurvedic treatments.

64) Sahaja (Saha-ja):
Sahaja refers to inherent or natural conditions or qualities. In Ayurveda, saha signifies the body's natural state of balance and health, which treatments aim to restore by addressing diseases and imbalances.

65) Dhyana:
Dhyana, or meditation, is a vital practice in Ayurveda that promotes mental clarity, reduces stress, and aids the healing process. Integrating dhyana into treatment plans exemplifies Ayurveda's holistic approach to health encompassing both body and mind.

66) Agantu (Agamtu):
Agantu refers to external factors or agents causing disease, as categorized in Ayurveda. This concept helps practitioners understand the origins of health conditions, enabling them to prescribe targeted treatment strategies.

67) Vamana:
Vamana is an Ayurvedic therapeutic practice involving induced vomiting for detoxification. This procedure is essential for removing excess doshas from the body, reinforcing Ayurveda's emphasis on cleansing and balance for promoting health.

68) Karuna:
Karuna, meaning compassion, plays a vital role in Ayurvedic philosophy, guiding practitioners to approach treatment with empathy and understanding. This ethical consideration is integral for fostering healing relationships between practitioners and patients.

69) Nidana:
Nidana refers to the root cause or diagnosis of a disease in Ayurveda. Identifying nidana is crucial for determining appropriate treatment plans, promoting effective healing based on the understanding of underlying imbalances.

70) Arkadi (Arka-adi):
Arkadi denotes Ayurvedic formulations utilizing specific plants and herbs, emphasizing the variety of natural remedies available within the system. Each formulation is tailored to target particular health concerns, highlighting the significance of plant-based medicine.

71) Vacadi (Vaca-adi):
Vacadi refers to specific herbal combinations in Ayurveda intended to manage particular health issues. Appropriately identified and utilized, these formulations underscore Ayurveda's commitment to treating illnesses with natural solutions.

72) Labour (Labor):
Labour refers to the process of childbirth, during which Ayurvedic practices can offer support for both mother and infant. Understanding labour within Ayurveda emphasizes the importance of holistic care and ancestral knowledge in maternal health.

73) Insect:
Insects, in the context of Ayurveda, may refer to carriers or harbingers of disease or infection. Recognizing the role of insects underscores the importance of hygiene and preventive measures in maintaining health.

74) Ahara:
Ahara encompasses the concepts of diet and nutrition in Ayurveda, highlighting the significance of food choices in maintaining health and preventing diseases. Proper ahara is among the fundamental aspects of achieving balance and wellness.

75) Kapha:
Kapha is one of the three doshas in Ayurveda, representing the water and earth elements. It governs structure and stability in the body, and maintaining its balance is key to preventing diseases associated with excess kapha.

[Note: The above list is limited to 75. Total glossary definitions available: 100]

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