Pharmacological properties of neem – a review

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Journal name: World Journal of Pharmaceutical Research
Original article title: Pharmacological properties of neem – a review
The WJPR includes peer-reviewed publications such as scientific research papers, reports, review articles, company news, thesis reports and case studies in areas of Biology, Pharmaceutical industries and Chemical technology while incorporating ancient fields of knowledge such combining Ayurveda with scientific data.
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Author:

Saman Moin, Hafsa Khan, Ramit Yadav, Mohd. Asif, Nadeem Ahamad, Mohd. Danish and Preeti Biswas


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World Journal of Pharmaceutical Research:

(An ISO 9001:2015 Certified International Journal)

Full text available for: Pharmacological properties of neem – a review

Source type: An International Peer Reviewed Journal for Pharmaceutical and Medical and Scientific Research

Doi: 10.20959/wjpr202210-24862

Copyright (license): WJPR: All rights reserved


Summary of article contents:

Introduction

Neem (Azadirachta indica) has been revered in India for centuries as a versatile medicinal tree with numerous health benefits. Known for its wide-ranging pharmacological properties, neem is utilized in traditional Ayurvedic and Unani medicine systems, addressing various ailments. This summary delves into the medicinal properties of neem, highlighting its therapeutic applications and the active compounds that contribute to its efficacy.

Antimicrobial Properties of Neem

One of the key benefits of neem is its potent antimicrobial properties. Compounds such as nimbidin, nimbolide, and azadirachtin exhibit significant antibacterial, antifungal, and antiviral activities. Neem extracts have shown effectiveness in treating skin diseases like acne, psoriasis, and eczema, as well as underlying infections. Traditional practices involve using neem leaves, oil, or twigs for skin applications, emphasizing neem's role in promoting skin health. Additionally, neem is recognized for its ability to inhibit the growth of various pathogens, making it a valuable natural remedy against infections.

Anti-inflammatory and Antioxidant Effects

Neem is also celebrated for its anti-inflammatory and antioxidant effects, making it beneficial for a range of conditions, including arthritis and other inflammatory diseases. The presence of nimbidin and other related compounds contributes to its efficacy in reducing inflammation. Studies have indicated that neem extracts help regulate oxidative stress in the body, supporting overall health by protecting cells from damage caused by free radicals. As a result, neem is often utilized to support the immune system and maintain health, particularly among populations reliant on traditional medicine.

Antidiabetic and Hepatoprotective Benefits

Another critical aspect of neem's therapeutic potential is its antidiabetic properties. Research demonstrates that neem extracts can significantly lower blood glucose levels in diabetic models, making it a promising supplement for managing diabetes. Furthermore, neem exhibits hepatoprotective effects, protecting the liver from toxins and promoting overall liver health by enhancing detoxification processes. These attributes underline neem's importance in traditional and modern medicine, notably for its role in disease prevention and management.

Conclusion

The extensive medicinal applications of neem, supported by both traditional practices and scientific research, highlight its significance as a natural remedy. With its antimicrobial, anti-inflammatory, antidiabetic, and hepatoprotective properties, neem continues to be a vital component in herbal medicine. As awareness of natural health trends grows globally, the need for further research into neem's potential benefits and applications remains imperative, ensuring its continued role in promoting health and well-being. There is an opportunity to integrate neem into modern therapeutic strategies, reinforcing its status as a remarkable “wonder tree” for health.

FAQ section (important questions/answers):

What are the traditional uses of Neem in medicine?

Neem (Azadirachta indica) has been used traditionally in Ayurveda and Unani systems for treating various ailments. Its parts, including leaves, bark, and oil, serve medicinal purposes for skin diseases, infections, and as a natural remedy for fevers and digestive issues.

What are the key health benefits of Neem?

Neem exhibits several health benefits, including antibacterial, antifungal, antiviral, and anti-inflammatory properties. It is used for treating skin disorders, digestive issues, and even as a natural insect repellent, promoting overall health and well-being.

How does Neem contribute to skin health?

Neem supports skin health by treating conditions like acne, psoriasis, and eczema. Its antibacterial properties help reduce skin infections, while topical applications of Neem oil can alleviate itching and inflammation, promoting clearer skin.

What chemical compounds are found in Neem?

Neem contains bioactive compounds such as azadirachtin, nimbidin, and nimbin, which are responsible for its various pharmacological properties. These compounds contribute to its effects as an antibacterial, antifungal, and anti-inflammatory agent, among others.

Can Neem be used for dental hygiene?

Yes, Neem twigs have been traditionally used as natural toothbrushes to maintain dental hygiene. They contain anti-inflammatory and antibacterial properties that help prevent tooth decay, gingivitis, and maintain overall oral health.

Is Neem effective in agricultural applications?

Neem is widely used in agriculture as a natural pesticide and fertilizer. Its extracts can effectively control various pests and enhance soil fertility, making it an eco-friendly alternative to chemical pesticides.

Glossary definitions and references:

Scientific and Ayurvedic Glossary list for “Pharmacological properties of neem – a review”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.

1) Neem:
Neem is a medicinal tree known for its wide range of therapeutic properties. Each part of the neem tree, including leaves, seeds, and bark, contains compounds beneficial for treating various ailments, reflecting its importance in traditional medicine systems like Ayurveda and Unani. Its versatility makes it a vital plant in natural health practices.

2) Tree:
Trees play a vital role in ecosystems, providing oxygen and habitat. Neem trees specifically aid in ecological restoration, pest management, and providing medicinal resources, highlighting their importance for both environmental health and human well-being.

3) Azadirachta indica:
Azadirachta indica is the scientific name for the neem tree. This taxonomy identifies it within the Meliaceae family and highlights its recognition in botanical classifications. The name reflects both its Indian origin and its role as a source of bioactive compounds with therapeutic potential, thus indicating its global importance in traditional medicine.

4) Neem tree:
The neem tree is renowned for its numerous health benefits and ecological value. Traditionally revered in India, it is used widely in practices like Ayurveda for its properties against various diseases. Its components, including leaves and oil, are utilized in pharmaceuticals, agriculture, and personal care products, showcasing its diverse applications.

5) India:
India is the native region of the neem tree, where it has been utilized for thousands of years in traditional medicine. The country's rich biodiversity provides a suitable environment for neem to thrive and become an integral part of India's cultural heritage, particularly within indigenous healing systems.

6) Indian:
Indians refers to the people of India who have historically utilized neem for its medicinal properties. Their traditional knowledge and cultural practices contribute to the comprehensive understanding and growth of herbal medicine around neem.

7) Ulcer:
Ulcers are open sores that can occur in the stomach lining, mouth, or on the skin. Neem extracts have been studied for their healing properties concerning ulcers, showcasing their potential in natural treatments for gastrointestinal discomfort and skin conditions associated with ulceration.

8) Pharmacological:
Pharmacological relates to the study of drug action and the effects of medicinal compounds in the body. The extensive pharmacological properties of neem, including its antibacterial, antifungal, anti-inflammatory, and antidiabetic effects, underscore its potential as a natural resource in drug development and therapeutic applications.

9) Antibiotic (Antibacterial):
Antibacterial refers to substances that prevent bacterial growth or kill bacteria. Neem has demonstrated strong antibacterial properties, making it effective in treating skin disorders and infections. Its use highlights the plant's significance in natural medicine as a safeguard against bacterial diseases.

10) Disease:
Diseases are pathological conditions affecting bodily functions, often requiring treatment. Neem's efficacy in combating various diseases underscores its relevance in both traditional and contemporary healing modalities, making it an essential resource in healthcare.

11) Soil:
Soil is the upper layer of earth where plants grow, crucial for agriculture. Neem trees improve soil health by preventing erosion and enhancing fertility through their deep root systems. They also have unique properties that allow them to thrive in poor soil conditions, facilitating sustainable land use.

12) Water:
Water is vital for all forms of life, and its availability significantly affects plant growth. Neem trees can survive in low-water conditions, making them environmentally adaptable. This quality contributes to their resilience in areas with limited water resources, ensuring their potential in arid regions.

13) Fever:
Fever is a common body response to infection or illness. Neem is traditionally used to manage fevers due to its anti-inflammatory and antipyretic properties. Its use in various cultures as a natural remedy for fever highlights its importance in traditional healing practices.

14) Drug:
Drugs are substances used in the treatment, prevention, or diagnosis of disease. Neem contains various compounds that can be formulated into drugs, reinforcing its medicinal significance and potential in pharmaceutical development.

15) Activity:
Activity refers to the behavior or effects of a substance in a biological context. The diverse activities of neem compounds—from antibacterial to anti-inflammatory—underscore their potential in pharmacological research and therapeutic applications across medicine and ecology.

16) Nature:
Nature encompasses the physical world and all living organisms. Neem exemplifies natural medicine, reinforcing the significance of botanical resources in health and sustainability. Its multifaceted utility in traditional remedies emphasizes the wisdom found in natural systems.

17) Blood:
Blood is crucial for transporting nutrients and oxygen throughout the body. Neem is known for its detoxifying properties and potential to support blood health, particularly through its effects on blood circulation and purity, making it significant in both traditional and modern medicine.

18) Worm:
Worms, particularly parasitic ones, can lead to significant health issues in humans. Neem has been traditionally employed as an effective agent against parasitic infections, indicating its historical role in maintaining health and wellness in various cultures.

19) Arrangement:
Arrangements refer to the systematic organization of elements. The study of arrangements in neem extracts focuses on their active compounds, which are essential for determining the therapeutic efficacy in medicinal applications.

20) Measurement:
Measurements involve quantifying aspects of substances. Accurate measurements of neem extracts are vital for evaluating their potency and biological effects, underscoring the need for precision in herbal pharmacology studies.

21) Field:
Fields refer to areas of land or areas of study. In agriculture, neem is crucial for sustainable agriculture practices, while in academic research, it represents the interdisciplinary study of neem's medicinal and ecological importance.

22) Study (Studying):
Study refers to the systematic investigation into a subject. Numerous studies have explored neem's biological activities and therapeutic applications, contributing to the growing body of scientific literature validating traditional claims and informing modern medicine.

23) Pesticide:
Pesticides are chemicals used to eliminate pests. Neem's extract serves as a natural pesticide, contributing to sustainable agricultural practices while mitigating harm to the environment, which underscores its ecological importance.

24) Ayurveda (Ayus-veda):
Ayurveda is a traditional Indian system of medicine that emphasizes holistic healing through natural remedies. Neem holds a significant position in Ayurveda, where it is utilized for its numerous health benefits, affirming its integration into ancient health practices and modern herbal medicine.

25) Margosa:
Margosa is another name for the neem tree, derived from its local nomenclature in various cultures. The term is often used interchangeably with neem and signifies the tree's widespread recognition and importance across different regions and traditions.

26) Science (Scientific):
Sciences refer to systematic fields of study. Research into neem spans multiple scientific disciplines, from pharmacology to botany, underlining its diverse applications and importance in various domains of knowledge.

27) Inflammation:
Inflammation is the body's response to injury or infection, often causing redness, swelling, and pain. Neem's anti-inflammatory properties position it as a natural remedy for various inflammatory conditions, reflecting its therapeutic importance in traditional and modern medicine.

28) Sanskrit:
Sanskrit is an ancient language of India, historically used in religious and medical texts. Traditional writings refer to neem's medicinal qualities, highlighting its cultural significance and historical roots in India, particularly within Ayurvedic practices.

29) Account:
Account refers to a narrative or record of events. In the context of neem, historical accounts document its various applications in traditional medicine, providing insights into its cultural relevance and the evolution of herbal practices over time.

30) Jauhar:
Jauhar refers to Mohammad Ali Jauhar University, where research on neem and its properties is conducted. The institution highlights the academic effort to document and validate the medicinal applications of neem, thus bridging traditional knowledge with modern scientific research.

31) Reason:
Reason refers to the underlying justification or cause for something. The reasons for neem's widespread use in traditional medicine stem from its various health benefits, making it a valuable plant in addressing numerous ailments.

32) Powder:
Powder refers to the fine particle form of a substance. Neem powder, obtained from the dried leaves or bark, is often used in herbal formulations and remedies. Its application emphasizes the versatility of neem in natural medicine.

33) Irritation:
Irritation refers to inflammation or discomfort in tissues. Neem's medicinal properties include soothing irritated skin and alleviating symptoms of irritation, emphasizing its role in treating dermal and inflammatory conditions in traditional healthcare.

34) Gathering:
Gathering refers to the act of collecting or assembling. In the context of neem, gathering knowledge about its uses and benefits forms the basis of both traditional practices and modern scientific inquiry, highlighting its multifaceted applications.

35) Writing:
Writing refers to the act of recording information. Texts on neem document its benefits and uses, showcasing the importance of knowledge transmission across generations, preserving traditional medicine and informing contemporary practices.

36) Cancer:
Cancer is a significant global health concern characterized by uncontrolled cell growth. Neem has been studied for its potential antitumor properties, showcasing its relevance in cancer research and natural therapeutic interventions.

37) Timber:
Timber refers to wood that has been processed for construction or other uses. The neem tree provides durable timber, adding economic value and highlighting the tree's multifaceted importance beyond its medicinal properties.

38) Animal:
Animals indicate non-human living organisms that may benefit from medicinal treatments. Neem is employed in veterinary practices to promote health in animals, highlighting the versatility of its applications beyond human medicine.

39) Manure:
Manure is organic matter used as fertilizer for soil enrichment. Neem cake, a byproduct of neem oil extraction, is utilized as a natural manure, promoting soil health and sustainable agricultural practices.

40) Hela (Helá):
Hela refers to HeLa cells, a line of human cervical cancer cells used for scientific research. Studies on neem's effects on HeLa cells contribute to understanding its potential therapeutic implications in cancer treatment.

41) Hair:
Hair refers to strands of protein filaments that grow from follicles on the skin. Neem is often used in hair care products due to its antifungal and antibacterial properties, highlighting its relevance in cosmetic applications.

42) Line:
Line refers to a series or sequence. In botanical and medicinal research, a line of inquiry into neem’s properties can help elucidate the potential therapeutic benefits derived from its various compounds.

43) Pain:
Pain refers to physical discomfort or suffering. Neem's analgesic properties allow it to be used in managing pain, reflecting its historical use in traditional medicine as a natural remedy for relief.

44) Hand:
Hands refer to the appendages used in various tasks. In traditional medicinal practices, using hands to prepare neem extracts or poultices emphasizes the tactile and manual engagement in herbal medicine.

45) Post:
Post can refer to the position after an event or the publishing of information. In research, posting findings about neem could contribute to the broader conversation surrounding its medicinal uses and applications.

46) Pharmacotherapeutics:
Pharmacotherapeutics is the study of drugs and their clinical applications. The exploration of neem compounds within this field highlights their potential in developing effective natural therapies for various health conditions.

47) Substance:
Substance refers to a particular kind of matter. In the context of neem, the active substances derived from various parts of the tree are critical in determining its therapeutic properties and applications.

48) Fragrance:
Fragrance refers to a pleasant scent. Neem oil possesses a natural fragrance, which is often utilized in cosmetic and personal care products, reflecting its appeal in enhancing product quality in cosmetics.

49) Medicine:
Medicine pertains to the science and practice of diagnosing, treating, and preventing illness. Neem's traditional and modern medicinal applications underscore its significance as a natural remedy, contributing to health and wellness.

50) Fixation:
Fixation refers to the process of making a substance stable or concentrated. In the context of neem, fixation can pertain to the extraction process that retains the bioactive compounds for use in medicinal products.

51) Vitiation (Vitiated):
Vitiated refers to something that is impaired or corrupted. In traditional Ayurvedic medicine, vitiation may describe a state of imbalance within the body that neem is thought to help correct through its healing properties.

52) Quality:
Quality refers to the standard of something. The quality of neem extracts is essential in determining their efficacy as medicinal agents, underscoring the importance of sourcing and processing in herbal medicine.

53) Rampur:
Rampur refers to the location of Mohammad Ali Jauhar University, where research on neem and its properties takes place. The locality signifies the intersection of traditional knowledge and academic inquiry into neem's benefits.

54) Family:
Family, in a biological context, refers to a group of related plants. Neem belongs to the Meliaceae family, indicating its botanical classification and relationship with other species that may share similar properties.

55) Bitter:
Bitter describes a taste profile that is sharp and pungent. Neem has a naturally bitter taste due to its bioactive constituents, which is often part of its therapeutic efficacy in traditional remedies.

56) Sharman (Sarma, Sharma, Sarman):
Sharma is likely a reference to an author or a contributor to the body of research surrounding neem and its properties. It represents the academic efforts to validate traditional uses through scientific inquiry.

57) Kapha:
Kapha is a concept in Ayurveda representing one of the three doshas that govern bodily functions. Neem is believed to influence Kapha disorders, underscoring its role in balancing bodily elements in traditional medicine.

58) Pulse:
Pulse refers to the rhythmic contraction and expansion of blood vessels, signifying circulation. Neem's potential benefits in blood purification might correlate with enhancing overall cardiovascular health, showcasing its importance in traditional practices.

59) Money:
Money refers to currency or a medium of exchange. The economic aspects of neem, including its applications in agriculture and medicine, illustrate its potential financial benefits for those involved in its cultivation and use.

60) Crop:
A crop denotes a cultivated plant, often for food production. Neem's role in agriculture, particularly as a natural pesticide, emphasizes its importance for sustainable farming practices, which can enhance crop viability and yield.

61) Nakar:
Nagar refers to a locality or urban area and may denote the location of Mohammad Ali Jauhar University. The context reinforces the academic focus on neem and its applications in the surrounding fabric of local traditional practices.

62) Food:
Food encompasses all substances consumed for nourishment. Neem may be incorporated in dietary practices due to its health benefits, connecting traditional uses with nutritional therapies prevalent in various cultures.

63) Rice (Rce):
Rice is a staple food in many cultures. The use of neem in agriculture can enhance crop yield and quality, indicating its significance in food security and sustainable practices for crucial food sources like rice.

64) Sign:
Sign conveys an indication or symbol. In the context of neem, signs of its effectiveness are reflected in its historical usage and the growing body of research confirming its medicinal properties.

65) Rich (Rch):
Rich often denotes abundance or wealth. In reference to neem, it indicates the richness of bioactive compounds found in the plant, which contribute to its diverse therapeutic effects and ecological benefits.

66) Wind:
Wind signifies air movement, which plays a role in seed dispersal and ecological balance. Neem's adaptability allows it to flourish in various environmental conditions, demonstrating its resilience against elements like wind.

67) Oil:
Oils refer to lipid substances extracted from plants. Neem oil is celebrated for its therapeutic properties, including antibacterial and antifungal effects, making it a popular ingredient in various pharmaceutical and cosmetic products.

68) Nerium indicum:
Nerium indicum refers to a different plant known for its medicinal properties. In discussions around neem, referring to other plants like Nerium indicum underlines the comparative studies of multiple botanicals in traditional medicine.

69) Curcuma longa:
Curcuma longa, known as turmeric, is celebrated for its health benefits. Mentioning turmeric alongside neem emphasizes the importance of traditional herbs that offer complementary therapeutic effects in natural remedies.

70) Human body:
The human body is a complex system requiring various nutrients and care. Neem's therapeutic applications target various bodily functions, showcasing its role in maintaining health and preventing diseases.

71) Invulnerability:
Invulnerability refers to immunity or resistance to disease. Neem is traditionally believed to enhance immune functions, reinforcing its use as a natural remedy for promoting overall health and preventing illnesses.

72) Phytochemical:
Phytochemical refers to biologically active compounds derived from plants. Neem is rich in various phytochemicals, laying the foundation for its numerous therapeutic effects and underlining the significance of plant-derived medicines in healthcare.

73) Civilization:
Civilization refers to advanced human social development. Neem's historical use throughout various civilizations highlights its long-standing significance in traditional medicine and agriculture, showing its integral role in human development.

74) Tuberculosis:
Tuberculosis is a serious infectious disease primarily affecting the lungs. Neem has been studied for its potential effects on TB, emphasizing its relevance in combating major infectious diseases in traditional health practices.

75) Prosperity:
Prosperity refers to a state of success or flourishing. Neem’s diverse applications in medicine and agriculture contribute towards societal health and well-being, reinforcing its potential role in enhancing the quality of life.

[Note: The above list is limited to 75. Total glossary definitions available: 113]

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Discover the significance of concepts within the article: ‘Pharmacological properties of neem – a review’. Further sources in the context of Science might help you critically compare this page with similair documents:

Neem tree, Research findings, Therapeutic application, Traditional medicine, Ayurvedic medicine, Pharmacological properties, Clinical investigation, Anti-inflammatory, Antimicrobial properties, Skin ailments, Dental care, Glycemic control, Immunomodulatory, Active constituent, Neuroprotective effect, Natural remedy, Skin disorder, Antifungal properties, Ethno medicinal knowledge, Environmental sustainability, Anti-HIV properties, Anti-tumor effect, Biologically active principles, Mosquito repellent, Natural contraceptive.

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