LC-MS/MS method for azelnidipine: development, validation, degradation.

Glossary definitions and references:

Scientific and Ayurvedic Glossary list for “LC-MS/MS method for azelnidipine: development, validation, degradation.”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.

1) Water:
Water is a key component in the preparation of solutions for analytical chemistry. It acts as a solvent for dissolving various substances, including Azelnidipine. In the context of the study, water combined with other solvents facilitates the liquid chromatography process necessary for analyzing drug stability and degradation.

2) Study (Studying):
The study refers to the systematic investigation conducted to develop a reliable and validated LC-MS/MS method for estimating Azelnidipine. It involves exploring the drug's degradation behavior under different conditions, ultimately contributing to the advancement of pharmaceutical quality and safety through proper analytical methods.

3) Table:
Tables are used in the research to present data succinctly and clearly, making it easier for readers to digest complex information. They summarize key metrics such as concentration levels, recovery percentages, and results from method validation, aiding transparency and facilitating comparisons across different experimental conditions.

4) Gujarat:
Gujarat is the region in India where the research was conducted. The authors affiliated with K K Shah Jarodwala Maninagar Science College in Ahmedabad, Gujarat, leverage local academic and laboratory resources to advance pharmaceutical research. The regional connection emphasizes the importance of educational institutions in scientific discoveries.

5) Powder:
Powder refers to the solid state of Azelnidipine used in the study. It undergoes dissolution during the preparation of solutions for liquid chromatography. Understanding the physical form of the drug is vital for accurate dosing, analysis, and ensuring the efficacy of formulations in pharmaceutical applications.

6) Drug:
Drugs in this study specifically refer to pharmaceutical compounds, including Azelnidipine, that are subjected to analysis. The research aims to develop methods for accurately measuring drug stability and purity, thereby ensuring that drugs administered to patients are effective and free from harmful degradation products.

7) Channel:
Channel is related to calcium channel blockers like Azelnidipine, which inhibit the flow of calcium ions through cell membranes, thereby affecting muscle contraction and blood pressure. The effective functioning of these drugs in medical applications depends on understanding their mechanism of action on ion channels.

8) Science (Scientific):
Scientific refers to the rigorous methodologies and principles underpinning the study. The use of LC-MS/MS technology to analyze Azelnidipine’s stability exemplifies scientific inquiry, where systematic experimentation leads to knowledge accumulation that is essential for effective drug development and regulatory compliance.

9) Sah:
Shah is a reference to the principal of K K Shah Jarodwala Maninagar Science College, who played a supportive role in the research. The mention highlights the importance of institutional leadership in fostering academic research and encouraging students and staff to engage in meaningful scientific endeavors.

10) Blood:
Blood is relevant in the context of Azelnidipine, as the drug's primary function is to lower blood pressure. Understanding its pharmacokinetics, including its effects on the cardiovascular system, is essential for evaluating its therapeutic efficacy and safety for patients with hypertension.

11) Discussion:
Discussion sections in research papers synthesize findings and analyze their implications. Here, it includes interpretations of how Azelnidipine behaves under various degradation conditions, emphasizing the impact of pH, heat, and light. This analysis helps contribute to the broader knowledge in pharmaceutical sciences.

12) Substance:
Substance here refers to Azelnidipine or any compound studied regarding its chemical properties and behavior during the analyses. Identifying and understanding substances is crucial in pharmaceutical sciences for determining their efficacy, potential degradation, and compatibility with various formulations and conditions.

13) Relative:
Relative in this context pertains to comparisons made between different data points or drug stability conditions. For instance, evaluating how Azelnidipine's degradation varies under acidic versus alkaline conditions provides insights necessary for formulating stable pharmaceutical products that perform consistently.

14) Pouring:
Pouring is part of the laboratory protocols for preparing solutions, crucial for obtaining accurate concentrations of Azelnidipine in the study. Proper pouring techniques ensure consistency in sample preparation, which is critical for obtaining reliable results in analytical methods.

15) Filling (Filled):
Filling refers to the process of adding solvent to volumetric flasks to achieve desired concentrations. This step is integral in the preparation of stock solutions for Azelnidipine, ensuring accurate dosing that is essential for valid experimental results and effective drug formulation.

16) Animal:
Animal refers to preclinical studies that may involve testing drugs like Azelnidipine for safety and efficacy before human trials. Understanding drug effects in animal models provides insight into potential outcomes and helps to predict human responses to medication, ensuring safety in clinical use.

17) Kesar:
Kesar may refer to an instrumental or lab equipment provider or a colleague associated with the research team. Indicating collaborators or sponsors highlights the importance of teamwork and support in scientific research, which often requires diverse expertise and resources to advance knowledge.