Study comparing efficacy of twageladi and bruhatsharkarasama in kaphaja kasa.

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Journal name: World Journal of Pharmaceutical Research
Original article title: A randomized clinical study to evaluate and compare the efficacy of twageladi churna and bruhatsharkarasama churna in kaphaja kasa
The WJPR includes peer-reviewed publications such as scientific research papers, reports, review articles, company news, thesis reports and case studies in areas of Biology, Pharmaceutical industries and Chemical technology while incorporating ancient fields of knowledge such combining Ayurveda with scientific data.
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Author:

Ayana K. T. and Surekha Pai


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World Journal of Pharmaceutical Research:

(An ISO 9001:2015 Certified International Journal)

Full text available for: A randomized clinical study to evaluate and compare the efficacy of twageladi churna and bruhatsharkarasama churna in kaphaja kasa

Source type: An International Peer Reviewed Journal for Pharmaceutical and Medical and Scientific Research

Doi: 10.20959/wjpr202210-24723

Copyright (license): WJPR: All rights reserved


Summary of article contents:

Introduction

The study presented in this paper, published in the World Journal of Pharmaceutical Research, examines the efficacy of two Ayurvedic formulations—Twageladi Churna and Bruhatsharkarasama Churna—in treating Kaphaja Kasa, a condition analogous to chronic bronchitis characterized by excessive mucus production and cough. The research involved a clinical trial with 60 participants, who were randomly divided into two groups, each receiving one of the formulations for a duration of 14 days. The objective was to evaluate the therapeutic effects of these treatments individually and comparatively.

Concept of Kaphaja Kasa and its Relevance

Kaphaja Kasa, classified among the five types of Kasa in Ayurveda, is characterized by a cough associated with an abundance of thick Kapha mucus. If untreated or mismanaged, this condition can lead to severe complications like Kshaya and Shwasa, which are difficult to treat. In contemporary medical terms, Kaphaja Kasa has been correlated with chronic bronchitis, a condition prevalent across populations, with estimates suggesting that around 9.5 million individuals in the U.S. are diagnosed with it. Effective management of Kaphaja Kasa necessitates treatments that possess properties to reduce Kapha and Vata doshas, highlighting the significance of appropriate herbal formulations.

The Role of Twageladi Churna

Twageladi Churna is an Ayurvedic preparation utilized in managing respiratory conditions due to its properties that counter Kapha dosha. The formulation comprises several key ingredients, including Twak, Ela, Pippali, Tugaksheeri, and Sharkara. Each of these components is recognized for its therapeutic potential—in particular, Twak and Pippali are known for their heating qualities and ability to alleviate symptoms associated with excessive mucus. The study indicated that Twageladi Churna provided significant relief in symptoms such as Kasa (cough), Kapha nishteevana, and other related parameters after treatment, demonstrating its therapeutic utility.

Efficacy of Bruhatsharkarasama Churna

On the other hand, Bruhatsharkarasama Churna, another Ayurvedic formulation examined in the study, is derived from ingredients such as Lavanga, Jatiphala, and Shunti. These components work together to enhance expectoration and alleviate respiratory distress by promoting digestive health and reducing Kapha dosha. Notably, while both treatments were statistically effective, Bruhatsharkarasama Churna showed clinically better performance in reducing symptoms of Kaphaja Kasa, suggesting a potential preference for this formulation in practice. This aspect highlights the diversity and potency of Ayurvedic remedies in addressing chronic respiratory conditions.

Conclusion

In conclusion, the study validated the significance of both Twageladi Churna and Bruhatsharkarasama Churna in treating Kaphaja Kasa, with statistically significant improvements in symptoms observed in both groups. Although there was no significant difference between the two treatments in the statistical analysis, Bruhatsharkarasama Churna exhibited better clinical outcomes and reduced recurrence of symptoms, showcasing the need for further exploration of its efficacy. The findings underscore the enduring importance of Ayurvedic formulations in managing complex health conditions and the potential for integration into contemporary healthcare practices.

FAQ section (important questions/answers):

What are the primary objectives of the study?

The study aimed to evaluate the individual therapeutic effects of Twageladi churna and Bruhatsharkarasama churna in treating Kaphaja Kasa, as well as to compare their therapeutic effects.

What conditions are associated with Kaphaja Kasa?

Kaphaja Kasa is correlated with chronic bronchitis and may lead to serious disorders like kshaya and shwasa if untreated. It involves symptoms like a cough associated with excessive mucus.

What were the main results of the study?

Both treatments showed statistically significant improvements in symptoms of Kaphaja Kasa, with no significant difference between them. Clinically, Bruhatsharkarasama churna appeared to perform slightly better.

How many patients were involved in the study?

The study involved 60 patients diagnosed with Kaphaja Kasa, who were randomly assigned to two treatment groups.

What statistical methods were used in the research?

The Wilcoxon Signed Rank Test was used for within-group analysis, while the Mann-Whitney Rank Sum Test compared effects between the two groups.

What ingredients are in Twageladi churna and Bruhatsharkarasama churna?

Twageladi churna contains Twak, Ela, Pippali, Tugaksheeri, and Sharkara, while Bruhatsharkarasama churna includes Lavanga, Jatiphala, Pippali, Maricha, Shunti, and Sharkara.

Glossary definitions and references:

Scientific and Ayurvedic Glossary list for “Study comparing efficacy of twageladi and bruhatsharkarasama in kaphaja kasa.”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.

1) Kasa (Kasha):
Kasa refers to coughing in Ayurveda, a symptom that can indicate respiratory issues such as chronic bronchitis. Recognizing Kasa's significance is crucial in Ayurveda, as it can evolve from mild to severe infections if not treated properly. Ayurveda aims to mitigate Kasa by restoring balance through various natural treatments.

2) Kapha:
Kapha is one of the three doshas in Ayurveda, representing earth and water elements. It governs structure, stability, and moisture in the body. An imbalance in Kapha can lead to conditions like congestive disorders, allergies, and respiratory issues. Treatments aim to balance Kapha by using herbs and lifestyle adjustments.

3) Kaphaja:
Kaphaja refers to conditions that are primarily influenced by an imbalance in Kapha dosha. In Ayurveda, Kaphaja Kasa indicates a cough characterized by thick mucus production. Understanding Kaphaja helps in tailoring treatments that specifically address excess Kapha through dietary and herbal interventions.

4) Study (Studying):
The study refers to the clinical research conducted to evaluate the efficacy and compare two Ayurvedic formulations for treating Kaphaja Kasa. The results derived from this study contribute valuable insights into alternative medical practice and promote evidence-based approaches within Ayurveda, enhancing treatment methodologies for respiratory health.

5) Ayana:
Ayana is the first author's name and is indicative of the researchers involved in the study. In academic publications, authors' names allow readers to trace back the credibility and expertise of individuals conducting clinical research, establishing trust in the findings presented in the journal.

6) Drug:
Drugs, in the plural form, encompass a range of medicinal preparations utilized to treat specific health conditions. The use of various Ayurvedic drugs in the study highlights the importance of individualized treatments based on dosha imbalances, focusing on achieving holistic wellness.

7) Aruci:
Aruchi refers to a loss of appetite in Ayurvedic terms. It is an important symptom associated with many illnesses, including Kaphaja Kasa. Identifying Aruchi allows Ayurvedic practitioners to adopt appropriate treatment strategies that stimulate appetite and improve overall health in patients.

8) Pippali (Pippalin):
Pippali, or long pepper, is a revered herb in Ayurveda known for its warming properties and ability to support respiratory health. It is valued for its expectorant qualities, making it particularly effective in treating Kaphaja disorders by enhancing digestion and promoting mucus clearance.

9) Disease:
Diseases refer to disorders affecting normal physiological function, which Ayurveda seeks to address holistically. Understanding the range of diseases allows practitioners to tailor treatments based on individual constitution and the specific dosha imbalances contributing to the illness.

10) Vata:
Vata is one of the three doshas in Ayurveda, representing air and space. It governs movement and communication in the body. An imbalance in Vata can lead to various health issues, including respiratory disorders. Treatments focus on grounding and stabilizing Vata through dietary, lifestyle, and herbal interventions.

11) Utklesha (Utklesa):
Utklesha refers to a feeling of heaviness or oppression in the chest, often associated with respiratory ailments like cough and asthma. This symptom is pivotal in the diagnosis and treatment of Kaphaja Kasa, guiding practitioners to select appropriate therapeutic measures.

12) Lakshana (Laksana):
Lakshanas refers to the signs and symptoms associated with a disease, essential for diagnosis and treatment in Ayurveda. Identifying Lakshanas helps clinicians create tailored treatment plans for conditions like Kaphaja Kasa, ensuring effective management of symptoms.

13) Ayurveda (Ayus-veda):
Ayurveda is an ancient system of medicine originating from India, emphasizing holistic health and balance among body, mind, and spirit. Its principles guide the understanding of diseases and treatment methodologies, employing natural remedies to restore health and prevent illness.

14) Medicine:
Medicines in Ayurveda encompass a range of natural remedies used to treat various ailments. Their formulations are based on an understanding of the body's constitution and dosha imbalances, leading to effective interventions for conditions like Kaphaja Kasa.

15) Lavanga (Lavamga):
Lavanga, or clove, is an aromatic spice used in Ayurveda for its medicinal properties, including its capacity to enhance digestion and alleviate cough. It is often included in formulations for Kaphaja disorders due to its warming and stimulating effects on the respiratory system.

16) Madhu:
Madhu refers to honey in Ayurveda, often used as an Anupana or an accompanying substance for medicine. It possesses Tridoshahara properties, aiding in the absorption of herbal remedies and enhancing their effectiveness while supporting overall health during treatment.

17) Table:
Tables in scientific studies serve as a visual representation of data, summarizing results, and facilitating easy comparison and analysis. They play a critical role in presenting research findings clearly, making complex information accessible for readers and practitioners alike.

18) Vega:
Vega is a term used to describe the urgency or intensity of symptoms in Ayurveda, often relating to the individual's response to a disease. Recognizing vega is essential for understanding the severity of conditions like Kaphaja Kasa and tailoring appropriate treatments.

19) Diet:
Diet plays a significant role in Ayurveda, impacting health and disease management. In the context of Kaphaja Kasa, dietary choices can either exacerbate or alleviate symptoms, guiding practitioners in advising appropriate food selections that balance doshas and support recovery.

20) Karnataka:
Karnataka is a state in India where the study and its clinical trials were conducted. The region's cultural context and population demographics may influence dietary practices, health conditions, and responses to Ayurvedic treatments, necessitating local adaptations of herbal formulations.

21) Jatiphala (Jati-phala):
Jatiphala, or nutmeg, is a spice renowned for its warming properties in Ayurveda. It is used in formulations to manage respiratory and digestive issues due to its therapeutic benefits. Incorporating Jatiphala enhances the efficacy of treatments aimed at clearing excess Kapha.

22) Sharkara (Sarkara):
Sharkara refers to sugar or jaggery, often included in Ayurvedic formulations for its sweet taste and health benefits. It aids in balancing doshas and enhancing the palatability of herbal medicines, promoting ease of consumption while facilitating effective absorption.

23) Anupana:
Anupana refers to the substance taken along with Ayurvedic medicines to enhance their absorption and efficacy. The choice of Anupana, such as Madhu, is crucial in Ayurveda for maximizing the therapeutic effects of treatments for conditions like Kaphaja Kasa.

24) Nidana:
Nidana refers to the causes or factors contributing to a disease's onset in Ayurveda. Understanding Nidana for Kaphaja Kasa allows practitioners to identify and address underlying issues, facilitating a comprehensive approach to treatment and long-term health management.

25) Dosha (Dosa):
Dosha refers to the three basic biological energies in Ayurveda: Vata, Pitta, and Kapha. Each individual has a unique dosha combination that influences their health. Understanding doshas is essential for effective treatment and disease prevention, particularly in respiratory conditions like Kaphaja Kasa.

26) India:
India is the birthplace of Ayurveda and serves as the cultural and historical context for all practices related to this ancient system of medicine. The diverse population in India gives rise to varied health issues, requiring localized and culturally sensitive Ayurvedic treatments.

27) Katu:
Katu refers to the pungent taste, which is significant in Ayurveda for its stimulating and digestive properties. Foods and herbs with Katu rasa help alleviate congestion and are often used in treatments for Kaphaja conditions, promoting respiratory health and clearing mucus.

28) Rasa (Rasha):
Rasa translates to the essence or taste of a substance in Ayurveda, playing a crucial role in determining its therapeutic properties and effects. Understanding rasa, such as Katu or Madhura, aids practitioners in designing effective treatment plans tailored to individual needs.

29) Guna:
Guna refers to the inherent qualities or attributes of substances in Ayurveda, such as light, heavy, dry, or moist. Understanding the Guna of herbs helps practitioners select appropriate treatments based on their patients' specific conditions and the dosha imbalances present.

30) Observation:
Observation involves monitoring patients' responses and symptoms during treatment, which is essential in clinical studies. This process helps assess the effectiveness of treatments and informs future patient care strategies, particularly in managing chronic conditions like Kaphaja Kasa.

31) Anubandha (Anubamdha):
Anubandha refers to the secondary conditions or symptoms associated with a primary disease in Ayurveda. Understanding Anubandha allows for the identification of comprehensive treatment strategies that address not just the main condition, like Kaphaja Kasa, but also its accompanying effects.

32) Samprapti:
Samprapti refers to the pathological process or progression of disease in Ayurveda. Understanding the Samprapti of Kaphaja Kasa provides insights into the underlying mechanisms of the disease, thereby guiding treatment strategies focused on reversing or mitigating the condition.

33) Prabhuta:
Prabhuta indicates abundance or excess in Ayurveda, often relating to the severity of Kapha-related conditions. In the context of Kaphaja Kasa, recognizing Prabhuta helps inform treatment decisions, aiming to reduce the excessive mucus or heaviness associated with the condition.

34) Chedana:
Chedana refers to the therapeutic action aimed at cutting or breaking down unwanted formations (like mucus) in the body. In managing Kaphaja Kasa, Chedana actions are vital for clearing excess Kapha and alleviating respiratory symptoms effectively.

35) Sandra (Samdra):
Sandra refers to thickness or heaviness, often describing the quality of Kapha-related issues, such as mucus in respiratory conditions like Kaphaja Kasa. Recognizing Sandra can guide treatment options focusing on reducing thickened bodily substances for better health.

36) Kshaya (Ksaya):
Kshaya denotes a condition of wasting or depletion in Ayurveda. Understanding Kshaya in relation to kapha imbalances helps practitioners formulate treatments that strengthen the patient's health, preventing the degradation of bodily tissues and overall vitality.

37) Bahula:
Bahula means abundant or excessive, particularly used to describe conditions with notable symptom severity, such as excessive mucus in Kaphaja Kasa. Identifying Bahula symptoms allows Ayurveda practitioners to create targeted treatment plans aimed at alleviating the condition.

38) Ushna (Usna):
Ushna translates to hot or warm, a quality associated with certain herbs or treatments in Ayurveda. When dealing with cold types of illness, such as Kaphaja Kasa, Ushna substances are often used to counteract the coldness associated with excess Kapha.

39) House:
House refers to the domestic environment where individuals might be exposed to allergens or irritants that could trigger respiratory issues. In Ayurveda, understanding the role of the household environment can help identify contributing factors to health problems like Kaphaja Kasa.

40) Kasacikitsa (Kasa-cikitsa):
Kasa-chikitsa is the branch of Ayurveda dedicated to the management of coughs and respiratory disorders. This field provides guidance on distinguishing types of cough and appropriate treatments, enhancing the overall effectiveness of Ayurvedic practice in addressing respiratory health.

41) Tridoshahara (Tridosahara, Tridosha-hara):
Tridoshahara refers to substances or therapies that pacify the three doshas—Vata, Pitta, and Kapha—in Ayurveda. Utilizing Tridoshahara properties is essential for creating balanced treatments that support overall health and restore equilibrium across dosha dynamics in patients.

42) Tuberculosis:
Tuberculosis is a severe infectious disease affecting the lungs. Understanding its clinical implications is critical in Ayurveda to differentiate it from conditions like Kaphaja Kasa, ensuring that practitioners avoid misdiagnosis and provide appropriate treatments.

43) Abhishyandi (Abhisyandi):
Abhishyandi refers to substances that cause accumulation or obstruction, particularly of Kapha-related attributes. These qualities can exacerbate respiratory issues, making them essential considerations in treatment planning for conditions such as Kaphaja Kasa, where clearing obstructions is necessary.

44) Vatadosha (Vatadosa, Vata-dosha):
Vata-dosha represents the air element in Ayurvedic classification, influencing movement and communication in the body. An imbalance can result in health conditions, including respiratory disorders. Treatment strategies in Ayurveda focus on restoring Vata balance through dietary and lifestyle modifications.

45) Kaphadosha (Kapha-dosha, Kaphadosa):
Kaphadosha is the Ayurvedic term for the Kapha dosha, which influences bodily structure and fluid balance. Understanding Kaphadosha is critical for managing diseases like Kaphaja Kasa, since excess Kapha leads to various health challenges, including respiratory troubles.

46) Kaphavata (Kapha-vata):
Kapha-vata refers to the combined influence of both Kapha and Vata doshas in an individual's health. Understanding their balance is essential in Ayurveda, particularly in managing respiratory conditions like Kaphaja Kasa, as both doshas can significantly affect respiratory function.

47) Discussion:
Discussion refers to the section of a scientific study where findings are interpreted, implications are analyzed, and conclusions are drawn. This part is critical for synthesizing data regarding the efficacy of treatments and refining future research directions in Ayurveda.

48) Vatahara (Vata-ahara):
Vatahara refers to substances capable of pacifying Vata dosha. In patients with respiratory issues associated with Vata imbalance, utilizing Vatahara remedies can greatly facilitate recovery and restore normal bodily functions in a holistic manner.

49) Muhurmuhuh (Muhur-muhu, Muhur-muhur, Muhurmuhu, Muhurmuhur):
Muhurmuhu means frequently or repeatedly in Ayurvedic context, particularly regarding the administration of medicine. This principle emphasizes that consistent dosing can lead to better absorption and effectiveness of treatments, especially in acute or chronic respiratory conditions like Kaphaja Kasa.

50) Katurasa (Katu-rasa):
Katu-rasa refers to the hot, pungent taste associated with certain foods and medicines in Ayurveda. It is thought to stimulate digestion and is particularly valuable in treating Kaphaja Kasa, as it helps to cut through excess mucus and congestion.

51) Activity:
Activity refers to any physical or functional action carried out by an individual. In the context of health, the level of daily activity impacts overall well-being and can influence the severity of conditions like Kaphaja Kasa, making them essential to consider in treatment planning.

52) Pregnant:
Pregnant refers to women who are expecting or carrying a developing fetus. In Ayurveda, special care is required when treating pregnant women, as certain treatments and herbs can affect both maternal and fetal health, particularly in respiratory conditions.

53) Vitiation (Vitiated):
Vitiated refers to an imbalance or pathological state of the doshas in Ayurveda. Recognizing vitiated conditions, like Kaphaja, assists practitioners in tailoring treatments that restore health by addressing the underlying causes of the imbalance.

54) Yogavahin (Yogavahi, Yoga-vahi, Yoga-vahin):
Yogavahi refers to substances that facilitate the absorption and potency of medicinal formulations in Ayurveda. Using Yogavahi components enhances the effectiveness of treatments by ensuring that active ingredients are more readily available for the body to utilize.

55) Kalpana:
Kalpana is a term for the preparation and formulation of medicinal herbs and materials in Ayurveda. Different Kalpanas are designed to treat specific conditions, influencing their effectiveness based on individual patient needs and the nature of their ailments.

56) Lekhana:
Lekhana refers to the action of scraping or purifying, especially in Ayurvedic treatments aimed at clearing excess dosha accumulation, such as Kapha. Lekhana techniques are important for managing respiratory health by helping clear mucus and facilitating easier breathing.

57) Sukshma (Suksma, Shukshma):
Sukshma means subtle or micro-sized, particularly in the context of herb formulations. Smaller particle sizes in medicines enhance absorption and efficacy, crucial for effectively addressing health issues like Kaphaja Kasa, where rapid therapeutic action is desired.

58) Utpatti:
Utpatti refers to the emergence or creation of health issues or dosha imbalances. Understanding Utpatti is essential in Ayurveda for early diagnosis and intervention, aiding practitioners in preventing chronic conditions by managing their root causes effectively.

59) Vikara:
Vikara denotes the concept of pathological changes or disorders within the body in Ayurveda. Understanding Vikara is crucial for diagnosing conditions and guiding treatment strategies that are aimed at restoring balance and health.

60) Ruksha (Ruksa):
Ruksha signifies dry or astringent qualities associated with certain herbs and treatments in Ayurveda. Ruksha properties can be beneficial for managing Kapha-related conditions, where excess moisture or phlegm needs to be reduced to alleviate respiratory symptoms.

61) Reason:
Reason refers to the rationale behind clinical decisions and treatment choices in Ayurveda. Identifying the underlying reasons for health conditions like Kaphaja Kasa assists practitioners in providing personalized and effective therapeutic strategies aimed at restoring balance.

62) Cotton:
Cotton, as an industrial material, may be linked to occupational health concerns, particularly in respiratory diseases among workers. Understanding the context of cotton exposure helps Ayurveda practitioners assess environmental health risks and tailor interventions accordingly.

63) Ghana:
Ghana indicates compactness or density, especially concerning Kapha-related issues in Ayurveda. Recognizing Ghana characteristics in bodily substances like mucus informs treatment choices that aim to ease heaviness and promote normal respiratory function.

64) Sugar:
Sugar, while a common dietary ingredient, can influence health negatively when consumed excessively. In Ayurveda, regulating sugar intake supports overall wellness, particularly for patients with respiratory conditions like Kaphaja Kasa, where excess sweetness could aggravate congestion.

65) Blood:
Blood is an essential fluid in Ayurveda, representing the quality and vitality of the body. Monitoring blood parameters helps practitioners assess overall health and diagnose underlying conditions, including those related to Kaphaja Kasa and other respiratory issues.

66) Guru:
Guru indicates heavy or dense qualities in Ayurvedic terms. Foods or substances that are Guru can contribute to Kapha imbalances, leading to health challenges. Recognizing Guru properties helps guide dietary recommendations for managing conditions like Kaphaja Kasa.

67) Hara:
Hara denotes a quality of alleviating or reducing the impact of diseases. In Ayurvedic practice, treatments aimed at Hara focus on restoring balance and promoting health, particularly for conditions like Kaphaja Kasa involving excess doshas.

68) Agni:
Agni, referring to digestive fire in Ayurveda, is vital for overall health. A well-functioning Agni ensures proper digestion, metabolism, and nutrient absorption, impacting respiratory conditions like Kaphaja Kasa. Enhancing Agni is essential for effective treatment protocols.

69) Yoga:
Yoga, in the context of Ayurvedic medicine, refers to the union of body, mind, and spirit through physical postures, breathing techniques, and meditation. It plays an essential role in holistic health, enhancing the therapeutic impact of Ayurvedic treatments.

70) Kala:
Kala indicates time or period, particularly concerning the administration of medicines and their effects in Ayurveda. Acknowledging the significance of time in treatment strategies influences the overall management of health conditions, particularly in chronic issues like Kaphaja Kasa.

71) Tree:
Tree refers metaphorically to the interconnectedness of various elements in Ayurveda, including health, environment, and the body's ecosystem. Trees symbolize balance and vitality, serving as reminders of nature's role in health and medicinal resources.

72) Meat:
Meat is a dietary component that can be heavy and potentially aggravate Kapha. In Ayurveda, moderation and balance are key; thus, understanding the impact of meat consumption assists practitioners in providing tailored dietary advice in the management of Kaphaja Kasa.

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Ushnavirya, Katurasa, Therapeutic effect, Kaphaja Kasa, Ayurvedic literature, Inclusion criteria, Exclusion criteria, Sample size, Clinical trial, Research article, Chronic Bronchitis, Kasa treatment, Statistical comparison, Kasa vega, Respiratory disease, Sublingual absorption, Mucus secretion, Statistical test of significance, Bio-availability of drug.

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