Antifungal potential of argemone mexicana l

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Journal name: World Journal of Pharmaceutical Research
Original article title: Antifungal potential of argemone mexicana l
The WJPR includes peer-reviewed publications such as scientific research papers, reports, review articles, company news, thesis reports and case studies in areas of Biology, Pharmaceutical industries and Chemical technology while incorporating ancient fields of knowledge such combining Ayurveda with scientific data.
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Author:

Ravi Kaushik, Chandan Singh and Manoj Adlakha


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World Journal of Pharmaceutical Research:

(An ISO 9001:2015 Certified International Journal)

Full text available for: Antifungal potential of argemone mexicana l

Source type: An International Peer Reviewed Journal for Pharmaceutical and Medical and Scientific Research

Doi: 10.20959/wjpr202211-25126

Copyright (license): WJPR: All rights reserved


Summary of article contents:

Introduction

The increasing prevalence of infectious diseases caused by various microorganisms remains a significant global health concern. While synthetic antimicrobial agents provide effective treatments, their efficacy is often hampered by the development of microbial resistance and associated side effects. Consequently, there is a growing demand for natural antimicrobial alternatives, particularly from medicinal plants with historical usage in traditional health systems like Ayurveda. This study focuses on the evaluation of the antifungal potential of Argemone mexicana L., a plant recognized in Ayurveda for its medicinal properties.

Antifungal Efficacy of Argemone mexicana

The research conducted assessed the antifungal activities of both methanol and aqueous extracts from the leaves of Argemone mexicana against common dermatophytes: Trichophyton rubrum, Epidermophyton floccosum, and Microsporum canis. Using the agar well diffusion method, both types of extracts demonstrated significant inhibition of fungal growth, comparable to the antifungal agent ketoconazole. This indicates that A. mexicana could serve as a natural alternative or supplement to synthetic antifungal treatments.

Methodology for Extract Preparation

To investigate the antifungal properties, methanolic and aqueous extracts were prepared from the leaves of A. mexicana. Leaves collected in Rajasthan were dried, ground, and then subjected to extraction processes using methanol and sterile distilled water. The resulting extracts underwent filtration, concentration, and sterilization before being tested against selected fungal cultures. This systematic method ensured that the extracts were viable for studying their antifungal effects effectively.

Sensitivity Analysis of Fungal Strains

The study utilized a scale to assess the sensitivity of the fungal strains to the extracted compounds, revealing varied responses based on the extract and concentration. For instance, Trichophyton rubrum exhibited increased sensitivity with higher doses of both extracts, while Microsporum canis displayed high sensitivity across all tested doses. Notably, methanol extracts performed better than aqueous extracts in terms of antifungal activity, emphasizing the potential of phytochemical compounds in A. mexicana for combating fungal infections.

Conclusion

In summary, the findings underscore Argemone mexicana L. as a promising candidate for developing natural antifungal agents. The study highlights the substantial antifungal activity demonstrated by both methanolic and aqueous extracts against selected dermatophytes. Further research is warranted to isolate specific antifungal compounds within A. mexicana and elucidate their mechanisms of action. This exploration may pave the way for innovative treatments that mitigate the limitations of conventional antifungal medications.

FAQ section (important questions/answers):

What is the antifungal potential of Argemone mexicana?

The study demonstrated that both methanolic and aqueous extracts of Argemone mexicana leaves exhibited significant antifungal activity against Trichophyton rubrum, Epidermophyton floccosum, and Microsporum canis, comparable to the antifungal agent ketoconazole.

What method was used to test the antifungal activity?

The researchers used the agar well diffusion method to test the antifungal activity of the extracts. They measured the zones of inhibition around the wells filled with the extracts after 72 hours of incubation.

Which fungal strains were tested in this study?

The study tested three dermatophyte fungal strains: Trichophyton rubrum, Epidermophyton floccosum, and Microsporum canis, which are known to cause ringworm infections.

What types of extracts were prepared from Argemone mexicana?

The researchers prepared two types of extracts from Argemone mexicana leaves: methanolic and aqueous extracts, to evaluate their antifungal properties.

What were the results of the antifungal activity tests?

The results indicated that both extracts inhibited fungal growth, with methanolic extract showing slightly higher antifungal activity compared to aqueous extract against all tested fungal strains.

What phytochemical compounds contribute to the antifungal activity?

Phytochemical compounds, particularly alkaloids like dehydrocorydalmine and oxyberberine, found in Argemone mexicana are suggested to be responsible for its antifungal properties.

Glossary definitions and references:

Scientific and Ayurvedic Glossary list for “Antifungal potential of argemone mexicana l”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.

1) Activity:
Activity refers to the biological interactions of the methanol and aqueous extracts from Argemone mexicana leaves in inhibiting fungal growth. The study evaluates how these extracts perform against specific fungal strains, demonstrating their potential as natural antifungal agents, relevant for medicinal applications in treating infections caused by fungi.

2) Study (Studying):
Study signifies the systematic investigation conducted to assess the antifungal potential of Argemone mexicana. It outlines the methods used, such as the agar well diffusion technique and specifies the observed results regarding antifungal activity. Such studies are crucial for substantiating natural substances' roles in modern medicinal practices.

3) Disease:
Diseases refer to a broader category of health conditions caused by various pathogens. The document outlines how these illnesses impact human health and emphasizes the growing concern of antimicrobial resistance, thereby necessitating research on natural compounds like those derived from Argemone mexicana to combat such diseases effectively.

4) India:
India is the geographic context of the study, being the native region for Argemone mexicana. The traditional medicinal practices in India, especially Ayurveda, highlight the significance of researching local plants for their pharmacological benefits, demonstrating the cultural and scientific intersections present in the study.

5) Water:
Water is crucial in this study, particularly with respect to extracting the active antifungal compounds from Argemone mexicana leaves. The aqueous extract is important as it represents a natural solvent approach to herbal extraction, which aligns with traditional herbal medicine practices and enhances the therapeutic relevance of the study.

6) Drug:
Drug in this context refers to the compounds derived from Argemone mexicana that exhibit antifungal properties. The study investigates natural alternatives to synthetic drugs, arguing for the potential role of these natural extracts in modern medicine as viable treatments for fungal infections, thus promoting health and wellbeing.

7) Rajasthan:
Rajasthan is the specific location in India where the Argemone mexicana leaves were collected for research purposes. It contextualizes the natural habitat of the plant and corroborates the environmental and ecological relevance of using locally sourced plants for their medicinal properties in Ayurvedic practices.

8) Cani:
Cani likely refers to the fungal species Microsporum canis included in the study. Understanding specific pathogens like M. canis is critical for evaluating the efficacy of these antifungal extracts, as it allows for targeted research to combat well-known dermatophytes and skin infections in humans.

9) Phytochemical:
Phytochemicals, as previously mentioned, are biologically active compounds derived from plants. They are fundamental to this research because they are responsible for the antifungal effects observed when testing Argemone mexicana extracts. Understanding their chemical nature is essential for validating traditional uses and discovering new treatments.

10) Dravyaguna (Dravya-guna):
Dravyaguna is an Ayurvedic term referring to the study of the properties and effects of medicinal plants. It highlights the traditional scientific discipline that underpins the research in this article, reinforcing the intersection between ancient wisdom and modern scientific inquiry into natural health products and remedies.

11) Discussion:
Discussion encompasses the section in the study where the authors interpret their findings and compare them to existing literature. This part is essential for analyzing the significance of results, establishing context for the antifungal capabilities of Argemone mexicana, and discussing implications for future research and therapeutic applications.

12) Container:
Container signifies the sealed environment used to store methanolic extracts during the antifungal activity analysis. Proper containment is vital in experimental research to ensure sample integrity and prevent contamination, highlighting the importance of careful methodology in scientific experiments involving natural compounds.

13) Ayurveda (Ayus-veda):
Ayurveda is a traditional Indian system of medicine grounded in holistic health practices. Its historical emphasis on medicinal plants positions the study of Argemone mexicana within a broader context of natural healing methods, showcasing the resurgence of interest in alternative medicine in response to modern health challenges.

14) Species:
Species refers to the specific types of fungi studied, such as Trichophyton rubrum, Epidermophyton floccosum, and Microsporum canis. Understanding these species is crucial for assessing the antifungal efficacy of extracts from plants like Argemone mexicana, and it helps determine the specificity and breadth of their therapeutic potential.

15) Science (Scientific):
Sciences refer to the broader fields encompassing biology, chemistry, and medicine. The interdisciplinary nature of this research draws from various scientific domains to understand the antifungal potential of extracts derived from Argemone mexicana, underlining the collaborative efforts needed for comprehensive studies.

16) Muslin:
Muslin is a type of fabric used in the filtration process during the extraction of antifungal compounds. Using muslin cloth ensures that the extracts obtained are free from solid plant material, allowing for concentration on the liquid extract. Its application highlights a practical aspect of the extraction methodology.

17) Filling (Filled):
Filled indicates the process of adding measured extracts into wells during the antifungal activity testing. This step is crucial in the agar well diffusion method, as it directly affects the assessment of antifungal efficacy and the interpretation of results regarding the growth inhibition of tested fungal strains.

18) Table:
Table refers to the organized presentation of results that summarizes the zones of inhibition observed from the antifungal testing. Such tabulated data facilitates easy comparison and analysis of the efficacy of various extracts and drugs, making it a vital element in scientific reporting.

19) Ravi (Ravin):
Ravi is likely one of the authors of the study, indicating personal contribution to the research. Authors play a crucial role in advancing scientific knowledge, and recognition of individual contributors underscores the collaborative efforts involved in conducting and publishing scientific research.

20) Worm:
Worms represent another group of pathogens that Argemone mexicana may have potential against. The recognition of different pathogens underlines the broader applicability of the extracts beyond fungal infections, expanding its significance in treating various parasitic and infectious conditions.

21) Human body:
Human body refers to the target for medicinal applications and is essential in evaluating the therapeutic effects of Argemone mexicana extracts. It's crucial to investigate how the bioactive compounds interact with human physiology to determine their efficacy and safety for treating infections.

22) Svarnakshiri (Svarnaksiri):
Svarnakshiri is a Sanskrit term often associated with Argemone mexicana, showcasing the historical significance of the plant in traditional Indian medicine. Recognizing such terms emphasizes the cultural heritage intertwined with the scientific exploration of this plant's medicinal potential in contemporary research.

23) Observation:
Observation pertains to the act of noting and recording findings during the antifungal efficacy testing. It is critical in scientific methodology as it helps document the results and supports the conclusions drawn regarding the effectiveness of different extracts in inhibiting fungal growth.

24) Satyanasi (Satyanashi):
Satyanasi is another name for Argemone mexicana in India, reflecting its cultural and regional identity. Understanding its local names enriches the contextual framework of the study, illustrating the connections between traditional medicinal knowledge and modern research endeavors aimed at revealing its potential health benefits.

25) Affection:
Affection in this context highlights the uses of Argemone mexicana in treating skin conditions historically, as 'cutaneous affections.' The focus on skin diseases underscores the practical applications of research findings in addressing common health concerns through ethnomedicine and herbal therapies.

26) Medicine:
Medicine denotes the practice of diagnosing, treating, and preventing diseases, with Argemone mexicana being investigated as a natural remedy. The search for effective antifungal agents within herbal medicine illustrates a significant trend toward integrating traditional plant-based treatments into contemporary medical practices.

27) Sanskrit:
Sanskrit is the ancient language of India, where many traditional medicinal texts are written. Its mention reinforces the importance of ancient agricultural practices and medicinal knowledge in shaping modern therapeutic strategies and research methodologies, offering a historical perspective on the use of plants like Argemone mexicana.

28) Village:
Village denotes the rural setting in Rajasthan where the Argemone mexicana leaves were sourced, representing traditional agricultural practices and the integration of local knowledge in utilizing medicinal flora. It emphasizes the community aspect of herbal medicine and the importance of local biodiversity in medicinal research.

29) Jaipur:
Jaipur likely refers to the city in Rajasthan associated with the laboratory where part of the research was conducted. This geographic reference indicates the importance of local institutions in advancing research on traditional plants and supports the regional significance of such academic inquiries.

30) Family:
Family refers to the biological classification of Argemone mexicana within the Papaveraceae family, pointing to its taxonomic relationships with other plants. Understanding its familial connections assists in exploring similar plants which may share medicinal properties, broadening the research scope for potential therapeutic agents.

31) Bitter:
Bitter describes the taste of the yellow juice from Argemone mexicana, relevant for traditional medicinal practices. Taste properties often relate to the pharmacological effects of plants, and understanding these characteristics aids in developing dosage forms and applications in herbal medicine based on historical uses.

32) Sharman (Sarma, Sharma, Sarman):
Sharma could refer to a contributor, either a researcher or technician involved in the study. Acknowledging individual contributions emphasizes collaboration, accountability, and the importance of teamwork in conducting thorough scientific research aimed at unlocking the therapeutic potential of medicinal plants.

33) Field:
Field, in this context, symbolizes the area of research or study dedicated to exploring the antifungal effects of Argemone mexicana. It emphasizes the structured approach to investigating and validating traditional herbal remedies in scientific domains, contributing to knowledge expansion in pharmacology.

34) Ulcer:
Ulcer indicates a type of skin condition historically treated using Argemone mexicana. Highlighting its applicability in treating ulcers extends the relevance of the plant in modern medicinal practices, reinforcing the need for research on its efficacy in addressing various dermatological ailments.

35) Veda:
Vedic signifies the ancient texts and knowledge systems originating from India, which include references to medicinal plants and health practices. This term highlights the historical roots of Ayurveda and supports the significance of integrating ancient wisdom into modern scientific research of herbal medicine.

36) Alvar (Arvar, Alwar):
Alwar is the specific district in Rajasthan where the Argemone mexicana leaves were collected. Mentioning this locality emphasizes the geographical significance and cultural reliance on local plants for medicinal practices, illustrating the holistic ethos underlying traditional medicine and its continued relevance.

37) Pose:
Pose indicates the significant health challenges presented by infectious organisms. The study addresses how fungi and bacteria can pose severe threats to public health, necessitating research on natural compounds like Argemone mexicana to support sustainable health solutions in the face of growing antimicrobial resistance.

38) Road:
Road refers to the natural habitat of Argemone mexicana in the wild. Its growth along roadsides symbolizes the resilience of the plant and represents an opportunity to study and utilize locally available resources for natural medicine, demonstrating the interconnectedness of nature and health.

39) Wall:
Wall signifies the structural cellular components targeted by the antifungal activity of phytochemicals in Argemone mexicana. The concept of targeting microbial cell walls is crucial for developing effective antifungal strategies, emphasizing the need to understand interactions between biological substances for therapeutic design.

40) Viru:
Viru appears to be a misspelling in the context; however, it may refer to 'virus' or other infectious agents. Clarifying such terms enhances the study's focus on various pathogens and the need to research natural remedies' efficacy against a spectrum of infectious agents.

Other Science Concepts:

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Discover the significance of concepts within the article: ‘Antifungal potential of argemone mexicana l’. Further sources in the context of Science might help you critically compare this page with similair documents:

Medicinal plant, Infectious disease, Ringworm, Ayurvedic literature, Zone of inhibition, Dermatophytes, Phytochemical compound, Aqueous and methanolic extract.

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