Antispasmodic activity of musa paradisiaca peel aqueous extract

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Journal name: World Journal of Pharmaceutical Research
Original article title: Antispasmodic activity of musa paradisiaca peel aqueous extract
The WJPR includes peer-reviewed publications such as scientific research papers, reports, review articles, company news, thesis reports and case studies in areas of Biology, Pharmaceutical industries and Chemical technology while incorporating ancient fields of knowledge such combining Ayurveda with scientific data.
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Original source:

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Author:

Moumita Tambuli, Nayanika Dey, Namrata Thakur, Nabaneeta Ghosh, Hasnat Jahan Ali, Niharika Gupta and Ananya Bhattacharjee


World Journal of Pharmaceutical Research:

(An ISO 9001:2015 Certified International Journal)

Full text available for: Antispasmodic activity of musa paradisiaca peel aqueous extract

Source type: An International Peer Reviewed Journal for Pharmaceutical and Medical and Scientific Research

Doi: 10.20959/wjpr202212-25269


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Summary of article contents:

Introduction

The research conducted by Bhattacharjee et al. examines the antispasmodic activity of the aqueous extract derived from the peels of Musa paradisiaca, commonly known as banana. Traditionally, various parts of the banana plant, including leaves, roots, and seeds, have been utilized for their medicinal properties. The study focuses on understanding the pharmacological effects of banana peels, particularly their ability to influence gastrointestinal motility, which could have implications for treating various gastrointestinal disorders.

Antispasmodic Effect of Musa paradisiaca

The primary objective of the study was to evaluate the inhibitory effects of Musa paradisiaca peel extract on acetylcholine (ACh)-induced contractions in the chicken ileum. The researchers performed phytochemical screening, which revealed a significant presence of flavonoids and tannins. Both high (4 mg/mL) and low (2 mg/mL) doses of the extract were administered in the presence of ACh, resulting in a marked decrease in contractile responses. The extract's activity was comparable to that of the standard antispasmodic drug, atropine, reflecting its potential use as an antidiarrheal agent.

Mechanisms Behind Antispasmodic Activity

The findings suggest that the antispasmodic effects of Musa paradisiaca are likely mediated through the antagonism of muscarinic receptors (M2 and M3) that play crucial roles in gastrointestinal motility. The research indicates that ACh binds to these receptors to stimulate intestinal contractions. The introduction of the aqueous extract led to an increased EC50 for ACh, indicating that a higher concentration of ACh was necessary to produce a 50% response, thus demonstrating the extract's ability to inhibit these contractions.

Role of Phytochemicals

The phytochemical constituents responsible for the observed antispasmodic effects lie predominantly within the flavonoid and tannin compounds present in the banana peel. These compounds are known for their therapeutic properties, including the reduction of intestinal motility. Previous studies have established a correlation between the high content of these phytochemicals and their effectiveness in treating conditions characterized by increased motility, such as diarrhea and irritable bowel syndrome (IBS).

Conclusion

The study concludes that the aqueous extract of Musa paradisiaca peel possesses significant antispasmodic properties and may offer a natural therapeutic option for managing gastrointestinal disorders. The reduction in intestinal contractions induced by ACh suggests potential clinical applications in treating conditions such as diarrhea and IBS. Future research is warranted to further establish these findings and explore the clinical efficacy of banana peel extracts in gastrointestinal health.

FAQ section (important questions/answers):

What was the aim of the study on Musa paradisiaca peel?

The study aimed to evaluate the antispasmodic activity of aqueous extract from the peels of Musa paradisiaca, traditionally used for various medicinal purposes, particularly in gastrointestinal disorders.

Which part of Musa paradisiaca was studied for antispasmodic effects?

The study specifically focused on the peels of Musa paradisiaca, which are used in traditional medicine for their health benefits, including anti-diarrheal properties.

How was the extract of Musa paradisiaca prepared for the study?

The active compounds were extracted using a cold maceration method involving boiling the disinfected peels in distilled water, followed by filtration and concentration.

What was the method used to assess the antispasmodic activity?

The contractile response of acetylcholine on chicken ileum was assessed, comparing the effects of the aqueous extract with a standard antagonist, atropine.

What significant results were found in the study?

The study found that the aqueous extract of Musa paradisiaca significantly reduced the contraction induced by acetylcholine, indicating its potential antispasmodic properties.

What are the implications of the study for gastrointestinal disorders?

The findings suggest that Musa paradisiaca peel extract may serve as a potential treatment for gastrointestinal disorders like diarrhea and irritable bowel syndrome (IBS).

Glossary definitions and references:

Scientific and Ayurvedic Glossary list for “Antispasmodic activity of musa paradisiaca peel aqueous extract”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.

1) Musha (Musa, Musá):
The genus 'Musa' refers to the group of flowering plants that includes bananas and plantains. Members of this genus are known for their large leaves and significant edible fruit. Musa species, particularly Musa paradisiaca, are studied for their nutritional and potential therapeutic benefits, making them relevant in both agriculture and medicine.

2) Musa paradisiaca:
Musa paradisiaca, commonly known as the banana plant, is a species renowned for its nutritional value and medicinal properties. Traditionally, various parts of the plant, especially the peel, have been used in folk medicine. Research into its antispasmodic activity demonstrates its potential role in treating gastrointestinal disorders.

3) Flavonoid:
Flavonoid refers to any individual compound within the broader flavonoid category. These compounds are recognized for their diverse biological activity, including anti-inflammatory and antispasmodic effects. Understanding specific flavonoids in Musa paradisiaca can shed light on mechanisms of action relevant to gastrointestinal health.

4) Activity:
Activity in this context describes the physiological effects of substances, such as the antispasmodic effect observed with Musa paradisiaca. The study of biological activity helps in determining the potential of natural compounds as therapeutic agents and guides their application in medicine.

5) Study (Studying):
Study refers to the systematic investigation into the properties and effects of substances. The study of Musa paradisiaca's antispasmodic activity provides evidence on its medicinal benefits, thereby contributing to knowledge in pharmacology and informing potential applications in treating gastrointestinal disorders.

6) Phytochemical:
Phytochemicals are bioactive compounds found in plants that may confer health benefits. The study of phytochemicals in Musa paradisiaca is essential for identifying their roles in traditional medicine applications, particularly regarding their antispasmodic and antioxidant properties.

7) Disease:
Diseases are disorders characterized by specific symptoms or structural alterations. Understanding how plant-based treatments can modulate symptoms of diseases, particularly gastrointestinal ones, is critical in expanding treatment options and improving health outcomes through natural remedies.

8) Water:
Water is a vital solvent for extracting plant compounds during the preparation of extracts, such as the aqueous extract used in studying Musa paradisiaca. Water plays an essential role in the solubility and bioavailability of phytochemicals, influencing their efficacy in therapeutic applications.

9) Table:
Table refers to a systematic arrangement of data, often seen in research articles. In this study, tables present quantitative results, such as contractile responses in experiments, which aid in visualizing data and understanding the effect of treatments, reinforcing findings through empirical evidence.

10) Drug:
Drugs are chemical substances that alter physiological functions. The exploration of Musa paradisiaca's properties reveals its potential as a source of natural drugs, combining traditional knowledge with scientific validation to develop effective treatments for various disorders.

11) Medicine:
Medicines refer to substances used for treatment of diseases, including both synthetic and natural products. The study of traditional medicines derived from plants like Musa paradisiaca highlights the significance of natural products in pharmacology and their potential effectiveness in clinical applications.

12) India:
India has a rich heritage of traditional medicine, including Ayurvedic practices that utilize various medicinal plants like Musa paradisiaca. The cultural significance and historical use of such plants in Indian medicine underline the ongoing relevance of indigenous knowledge in contemporary scientific research.

13) Indian:
Indians, representing people of India, have a rich tradition of using natural remedies. The historical context of Indian medicine emphasizes the cultural importance of plants like Musa paradisiaca, which have been utilized for centuries in treatment and wellness.

14) Blood:
Blood is essential for transporting nutrients and oxygen throughout the body. Research into how phytochemicals in plants like Musa paradisiaca can affect blood flow or composition can lead to insights in treating disorders related to circulation and gastrointestinal health.

15) Food:
Food provides the necessary nutrients for sustaining life and health. The banana, as a food source from the Musa genus, not only offers nutritional benefits but also has medicinal properties, thus bridging the gap between diet and health.

16) Human body:
The human body is a complex system that can benefit from natural compounds such as those derived from Musa paradisiaca. Understanding how these compounds interact within the body provides insights into their potential therapeutic roles in maintaining health and treating diseases.

17) Pharmacological:
Pharmacological relates to the study of the interactions between drugs and the body. Investigating the pharmacological effects of Musa paradisiaca contributes to understanding its mechanisms as a therapeutic agent, particularly in regulating gastrointestinal motility.

18) Discussion:
Discussion refers to the analysis and interpretation of research results. In the context of Musa paradisiaca, the discussion section emphasizes the implications of findings, suggesting how its antispasmodic properties may inform future therapeutic approaches in gastrointestinal health.

19) Knowledge:
Knowledge refers to the information and understanding gained through study. Expanding knowledge about the medicinal properties of plants like Musa paradisiaca is vital for integrating traditional practices into modern scientific frameworks and enhancing healthcare approaches.

20) Ayurveda (Ayus-veda):
Ayurveda is an ancient Indian system of medicine emphasizing holistic healing using natural substances. The relevance of Musa paradisiaca in Ayurveda underlines the significance of traditional practices in discovering new medicinal uses and validating historical understandings through scientific research.

21) Sanskrit:
Sanskrit is an ancient language of India, in which many traditional texts on medicine and herbalism are written. The use of the term 'Kadali' for Musa paradisiaca in Sanskrit reflects the historical significance of this plant within Indian culture and medicine.

22) Heating:
Heating refers to the process used to extract compounds from plant materials, such as boiling banana peels for the study. The method of extraction can influence the yield and composition of phytochemicals, impacting their efficacy and potential medicinal properties.

23) Species:
Species denotes a specific group of organisms capable of interbreeding. Understanding the species Musa paradisiaca helps researchers identify its unique properties and advantages as a medicinal plant, contributing to biodiversity in both agriculture and pharmacology.

24) Science (Scientific):
Science is the systematic study of the natural world. The application of scientific methods to study Musa paradisiaca's properties exemplifies the integration of traditional knowledge with modern research methodologies, advancing our understanding of plant-based medicine.

25) Kadali:
Kadali is the Sanskrit name for Musa paradisiaca, reflecting the plant's significance in traditional Indian medicine. The use of local nomenclature highlights the plant's cultural relevance and its longstanding role in Ayurvedic practices.

26) Reason:
Reason refers to the justification or cause behind an occurrence. In the study of Musa paradisiaca, understanding the reason behind observed physiological effects can guide future research and applications towards effective treatments for gastrointestinal disorders.

27) Gupta:
Gupta is a common surname in India, often associated with individuals in various fields, including research. In academic contexts, the name might represent contributors to studies exploring the properties of Musa paradisiaca, showcasing collaborative efforts in scientific inquiry.

28) Rich (Rch):
Rich denotes abundance or substantial availability. Describing Indian traditional medicine as rich suggests a wealth of knowledge and variety in natural remedies, highlighting the cultural treasure trove of practices that include studies on plants like Musa paradisiaca for their medicinal benefits.

Other Science Concepts:

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Discover the significance of concepts within the article: ‘Antispasmodic activity of musa paradisiaca peel aqueous extract’. Further sources in the context of Science might help you critically compare this page with similair documents:

Gastrointestinal Tract, Phytochemical screening, Home remedy, Flavonoids and tannins, Acetylcholine, Traditional medicinal system, Antispasmodic activity, Gastrointestinal disorder, Muscarinic receptor, Concentration-response curve.

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