"Managing EoE with IgE antibodies: A single-blind placebo trial"
Journal name: World Journal of Pharmaceutical Research
Original article title: Role of maintaining cause as ige mediated antibodies in the management of eosinophilic esophagitis presenting gerd - a single blind randomized placebo control trial
The WJPR includes peer-reviewed publications such as scientific research papers, reports, review articles, company news, thesis reports and case studies in areas of Biology, Pharmaceutical industries and Chemical technology while incorporating ancient fields of knowledge such combining Ayurveda with scientific data.
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Khatri P., Mathur G., Kansal S. and Mehrotra S.
World Journal of Pharmaceutical Research:
(An ISO 9001:2015 Certified International Journal)
Full text available for: Role of maintaining cause as ige mediated antibodies in the management of eosinophilic esophagitis presenting gerd - a single blind randomized placebo control trial
Source type: An International Peer Reviewed Journal for Pharmaceutical and Medical and Scientific Research
Doi: 10.20959/wjpr202213-25640
Copyright (license): WJPR: All rights reserved
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Summary of article contents:
Introduction
Eosinophilic esophagitis (EoE) is a chronic, immune-mediated inflammation of the esophagus characterized by symptoms such as dysphagia and gastroesophageal reflux disease (GERD). This condition involves the infiltration of eosinophils in the esophageal tissue and is often resistant to conventional GERD treatments. The prevalence of EoE is notably higher in young males, with recent studies indicating a significant occurrence in populations presenting with GERD symptoms. This study aimed to evaluate the effectiveness of individualized homeopathic treatment in managing eosinophilic esophagitis alongside the removal of maintaining causes.
Importance of Removing the Maintaining Cause
The concept of "removing the maintaining cause" is crucial in achieving cure in chronic diseases such as EoE. Maintaining causes refer to avoidable factors that contribute to the persistence of the disease. This study highlights that only addressing these maintaining causes—such as dietary allergies or irritants—can lead to symptom management but is insufficient for a complete resolution. The research found that in conjunction with individualized homeopathic medicines, the removal of these maintaining causes significantly improved GERD symptoms in patients. This dual approach yielded better scores on the GERD-Q questionnaire, indicating enhanced quality of life for those treated.
Outcomes of Individualized Homeopathic Medicine
In this randomized, placebo-controlled trial involving 100 participants, the group receiving individualized homeopathic medications demonstrated superior outcomes compared to the placebo group. Notably, patients in the homeopathic group showed marked improvements in EoE symptoms such as heartburn, regurgitation, and nausea. The most frequently prescribed remedies included China, Arsenic, Nux Vomica, and Lycopodium, which correlated with substantial reductions in GERD-Q scores. The study also recorded an impressive 44% of patients in the treatment group showing significant improvement within three months, emphasizing the potential of individualized homeopathy in managing EoE.
Predominant Miasm in Eosinophilic Esophagitis
The study also explored the relationship between miasms—underlying diseases or conditions that influence susceptibility to illnesses—and eosinophilic esophagitis. The predominant miasm identified in the study was psora, found in 64% of participants. This insight underlines the value of homeopathic philosophy, which emphasizes the need to tailor treatment not only to current symptoms but also to the underlying predisposition that may aggravate or sustain chronic conditions. Understanding the miasmic background allows practitioners to customize treatment plans effectively, potentially leading to better health outcomes.
Conclusion
From the findings of this study, it is clear that a combination of removing the maintaining cause and implementing individualized homeopathic treatments can lead to more effective management of eosinophilic esophagitis presenting with GERD symptoms. The significant improvements in patient outcomes underscore the need for a holistic approach in treatment, considering both symptom management and underlying factors such as miasms. However, the study acknowledges limitations due to the small sample size and the absence of a specifically tailored assessment scale for EoE. Future research with a larger population and rigorous methodological frameworks is essential to validate these findings and broaden their applicability in clinical practice.
FAQ section (important questions/answers):
What is the primary aim of the study on Eosinophilic Esophagitis?
The study aims to compare treatment outcomes of individualized homeopathic medicine versus placebo in patients with Eosinophilic Esophagitis presenting GERD, as measured by the GERD-Q questionnaire.
How many patients were involved in the Eosinophilic Esophagitis study?
A total of 100 patients with Eosinophilic Esophagitis were randomly allocated into two groups: 50 received personalized homeopathic treatment and 50 received a placebo.
What key symptoms are associated with Eosinophilic Esophagitis?
Key symptoms include heartburn, regurgitation, nausea, vomiting, and sleep disturbances, which were assessed using the GERD-Q questionnaire before and after treatment.
What conclusions were drawn about homeopathic treatment effectiveness?
The study concluded that individualized homeopathic treatment, combined with the removal of the maintaining cause, significantly improved symptom relief compared to placebo treatment.
What was the predominant miasm found in the study's patients?
The predominant miasm identified among the patients suffering from Eosinophilic Esophagitis was Psora, with 64% of enrolled cases reflecting this condition.
What limitations were noted regarding the study's findings?
Limitations include a small sample size and lack of a specific scale for treatment outcome assessment, necessitating further research with enhanced methodological rigor to confirm results.
Glossary definitions and references:
Scientific and Ayurvedic Glossary list for “"Managing EoE with IgE antibodies: A single-blind placebo trial"”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.
1) Study (Studying):
The 'Study' refers to a systematic investigation designed to assess the role of individualized homeopathic medicine in managing eosinophilic esophagitis (EoE) presenting with gastroesophageal reflux disease (GERD). This study aimed to evaluate the effectiveness of treatment by measuring changes in symptoms and associated miasmic predispositions, contributing to medical understanding.
2) Medicine:
'Medicines' denotes the various homeopathic remedies utilized in the treatment of patients within the study. The mention of specific medications like China and Nux Vomica reflects the focus on individualized treatment approaches, emphasizing the significance of tailored therapy in managing conditions like eosinophilic esophagitis.
3) Khatri:
'Khatri' is one of the authors of the study, indicating a person significantly involved in researching and documenting findings related to eosinophilic esophagitis and its treatment. Their name represents the contribution of a researcher within the broader academic dialogue on homeopathy, gastrointestinal diseases, and patient care methodologies.
4) Disease:
'Diseases' encompasses various disorders related to eosinophilic esophagitis and potentially concurrent conditions affecting patients. This broader perspective emphasizes the multi-faceted nature of patient health, providing a comprehensive approach while assessing the implications of treatment effectiveness in chronic conditions.
5) Table:
'Table' indicates a structured presentation of data within the study, presenting important statistical findings and patient characteristics. Tables organize complex information clearly, facilitating analysis and comparison of results across different treatment groups, thus providing a visual aid for understanding the outcomes of the study.
6) Nausea:
'Nausea' is a common symptom experienced by patients with eosinophilic esophagitis, highlighted in the study. It emphasizes the need for effective treatment strategies to alleviate this symptom, as it impacts patients' daily lives and overall well-being, thus informing the study’s focus on symptom resolution.
7) Food:
'Food' is relevant as it may trigger eosinophilic esophagitis symptoms in patients. The study investigates the role of food allergens and dietary changes in disease management, emphasizing the need for identifying and removing maintaining causes, thus linking nutrition to the pathophysiology and management of eosinophilic esophagitis.
8) Cina:
'China' refers to one of the homeopathic medicines frequently prescribed in the study. Mentioning specific medicines highlights the individualized treatment model used and reflects the significance of understanding patient-specific needs and responses to therapy in achieving optimal health outcomes for eosinophilic esophagitis.
9) Observation:
'Observation' refers to the act of monitoring participant health changes during the study. It encompasses the systematic assessment of patient symptoms and conditions, aiding researchers in identifying trends, analyzing effects, and determining the overall efficacy of individualized homeopathic treatments for the enrolled patients.
10) Male:
'Male' indicates the demographic distribution of study participants, with a noted predominance among men in cases of eosinophilic esophagitis. This aspect reveals gender-related epidemiological trends and highlights the necessity for further research on the specific needs and treatment responses of diverse populations.
11) Discussion:
'Discussion' encompasses the analytical dialogue about the study's findings in relation to existing literature. It highlights interpretations of data, contextualizes results, connects findings to broader medical understandings, and suggests implications for future research and clinical practices regarding eosinophilic esophagitis management.
12) Rajasthan:
'Rajasthan' is the location of the study, indicating the geographic and cultural context in which the research was conducted. Recognizing regional specifics is vital as it may influence patient demographics, prevalence of eosinophilic esophagitis, and access to treatment modalities available to patients in that area.
13) Suffering:
'Suffering' pertains to the experiences of individuals with eosinophilic esophagitis as they endure symptoms like heartburn, nausea, and vomiting. This language underscores the condition's impact on patients' quality of life and emphasizes the importance of effective treatment strategies that alleviate these distressing symptoms.
14) Vomiting:
'Vomiting' is one of the significant symptoms related to eosinophilic esophagitis and presents challenges in daily functioning for affected individuals. The study's focus on alleviating such symptoms reflects the aim to enhance patient quality of life and highlights the need for effective management strategies.
15) Allergy:
'Allergy' refers to potential food allergies that contribute to the pathogenesis of eosinophilic esophagitis. The study recognizes the interplay between immunological responses and diet, emphasizing the need to identify allergens and adjust treatment strategies accordingly to mitigate symptoms and enhance patient health.
16) Company:
'Company' refers to the pharmaceutical entity responsible for producing the homeopathic remedies used in the study. The mention of a certified company addresses the importance of sourcing medicines from reliable manufacturers to ensure quality and consistency in treatment interventions within clinical research.
17) Diet:
'Diet' is crucial in discussing the management of eosinophilic esophagitis, as dietary factors can exacerbate symptoms. Understanding the role of various foods in the patients' treatment outcomes emphasizes the need for careful dietary management and the importance of removing allergens in symptom resolution.
18) Young men (Young man):
'Young men' highlights a demographic trend seen in eosinophilic esophagitis patients, emphasizing that this condition often affects younger males significantly. Such demographics are essential for understanding prevalence and tailoring treatment approaches to meet the specific needs of this population.
19) Inflammation:
'Inflammation' characterizes the pathological changes in eosinophilic esophagitis, representing the immune response leading to symptomatology. Aiming to resolve this inflammation through individualized treatment reflects the study's goal of addressing underlying mechanisms and improving patient health outcomes.
20) Resolving:
'Resolving' describes the process of alleviating or eliminating symptoms associated with eosinophilic esophagitis through treatment. The emphasis on resolving conditions like heartburn and nausea highlights the study's commitment to reducing the burden of disease and significantly improving patients' quality of life.
21) Pregnant:
'Pregnant' refers to a specific exclusion criterion within the study, as this demographic carries unique health considerations. Recognizing this group’s exclusion ensures researchers focus on populations where the effects of treatment can be assessed without confounding factors related to pregnancy.
22) Habitat:
'Habitat' refers to the living environment of study participants, emphasizing the demographic aspect of the research. The study recognizes that urban or rural living conditions may influence the prevalence, incidence, and experience of eosinophilic esophagitis, informing considerations for comprehensive healthcare delivery.
23) Potter:
'Potter' refers to a researcher whose studies align with findings in this research, lending credence to the observed demographic trends in eosinophilic esophagitis. Acknowledging external research helps in contextualizing results and cross-referencing findings within the scientific community and literature.
24) Mathura (Mathur):
'Mathur' is another author involved in this study, contributing to the research's intellectual and methodological framework. This designation highlights the collaborative nature of scientific exploration and the contributions of multiple experts toward advancing understanding of eosinophilic esophagitis treatments.
25) India:
'India' signifies the geographic context of the study, reflecting a diverse patient population within which eosinophilic esophagitis is being explored. This regional perspective is critical for understanding the local prevalence, healthcare systems, available treatments, and the socio-economic factors affecting patients.
26) Egypt:
'Egypt' is cited to provide comparative data regarding the prevalence of eosinophilic esophagitis in different geographic locales. Including such demographic details enriches the study’s context and allows for a broader understanding of the global landscape of eosinophilic esophagitis research.
27) Fish:
'Fish' is listed among potential food allergens implicated in eosinophilic esophagitis symptoms. Understanding dietary sensitivities plays a significant role in managing the condition, indicating the necessity for allergen identification and dietary adjustments as part of comprehensive treatment strategies.
28) Milk:
'Milk' is another common food allergen associated with eosinophilic esophagitis. Highlighting this specific food emphasizes the dietary restrictions that may be necessary for patient management, reinforcing the association between food intake and symptom exacerbation and the importance of individualized dietary planning.
29) Post:
'Post' refers to assessments made after treatment in the study. Analyzing post-treatment data allows researchers to determine the effectiveness of interventions, providing insights into the health status of patients with eosinophilic esophagitis and yielding crucial information for future therapeutic approaches.
30) Drug:
'Drug' pertains to any therapeutic agent, including the homeopathic remedies discussed in the study. The distinction between conventional drugs and homeopathic treatments emphasizes the diverse approaches available for managing eosinophilic esophagitis and the need for exploring alternative treatment modalities within clinical practice.
31) Life:
'Life' underscores the overall impact of eosinophilic esophagitis on daily living for patients. Understanding how chronic symptoms affect a patient’s lifestyle emphasizes the importance of effective management strategies aimed at alleviating symptoms and improving the quality of life for affected individuals.
Other Science Concepts:
Discover the significance of concepts within the article: ‘"Managing EoE with IgE antibodies: A single-blind placebo trial"’. Further sources in the context of Science might help you critically compare this page with similair documents:
Nausea and vomiting, Sleep disturbance, Sample size, Placebo group, Improvement criteria, Gastroesophageal reflux disease (GERD), Statistical software, Intention to treat analysis, Individualized Homoeopathic Medicine.