A clinical study on effect of harithaladi lepa in dadru kusta

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Journal name: World Journal of Pharmaceutical Research
Original article title: A clinical study on effect of harithaladi lepa in dadru kusta
The WJPR includes peer-reviewed publications such as scientific research papers, reports, review articles, company news, thesis reports and case studies in areas of Biology, Pharmaceutical industries and Chemical technology while incorporating ancient fields of knowledge such combining Ayurveda with scientific data.
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Author:

Dr. Jeevan S. and Dr. Krishna Prakash M. K.


World Journal of Pharmaceutical Research:

(An ISO 9001:2015 Certified International Journal)

Full text available for: A clinical study on effect of harithaladi lepa in dadru kusta

Source type: An International Peer Reviewed Journal for Pharmaceutical and Medical and Scientific Research

Doi: 10.20959/wjpr202213-25574


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Summary of article contents:

1. Introduction

Skin disorders have significant impacts on the quality of life and aesthetics of individuals, particularly in tropical and developing countries like India. The prevalence of such diseases often stems from poor hygiene, inadequate skincare, and dietary habits. In Ayurveda, skin diseases are categorized under "Kushta," with "Dadru Kushta" being a prevalent condition akin to Tinea corporis in modern medical terms. The present study focuses on evaluating the efficacy of Haritaladi Lepa, an Ayurvedic formulation, in treating Dadru Kushta, utilizing a clinical approach with a sample size of 30 diagnosed patients and measuring outcomes over a 21-day period.

2. Efficacy of Haritaladi Lepa

The study demonstrated that Haritaladi Lepa resulted in a significant overall improvement of 54.55% in the symptoms of Dadru Kushta. Treatment included daily applications of the lepa over a span of 14 days, followed by a follow-up to assess efficacy. Notable improvements were observed in various symptoms, including pruritus (Kandu), burning sensation (Daha), and the number and size of lesions (Mandala). Statistically significant results were recorded, indicating that Haritaladi Lepa is an effective intervention for mitigating the manifestations of this skin disorder.

3. Assessment of Symptoms

Assessment criteria for evaluating the impact of Haritaladi Lepa revolved around both subjective and objective parameters derived from Ayurvedic classical texts. Improvements were quantified using established grading systems for symptoms such as Kandu, Daha, Raga (redness), Pidaka (lesions), and Rookshata (dryness). Over the course of the treatment, patients exhibited substantial reductions in these symptoms, with Kandu and Daha showing significant improvement within just three days of treatment. This highlights not only the effectiveness of the formulation but also its relatively rapid action in alleviating distressing symptoms.

4. Demographic Insights & Treatment Characteristics

The analysis of patient demographics revealed that the most affected age group for Dadru Kushta was between 16-25 years. The study found that Haritaladi Lepa yielded better results in patients suffering from moderate to mild severity of the condition. Patients with chronic symptoms (lasting beyond six months) experienced less significant relief compared to those with recent-onset symptoms. Consequently, it was found that the timing of treatment initiation relative to the onset of symptoms plays a crucial role in the overall effectiveness of Haritaladi Lepa.

5. Conclusion

The findings from this clinical study indicate that Haritaladi Lepa is a safe and effective treatment option for Dadru Kushta, with an improvement rate of 54.55% across various symptoms. The absence of complications or side effects during the study further supports the therapeutic value of this Ayurvedic formulation. It can be concluded that Haritaladi Lepa is particularly beneficial in recent cases of Dadru Kushta, underscoring the importance of timely intervention in skin disorders. Moreover, these results contribute to the understanding of Ayurvedic treatments in managing skin conditions comparable to Tinea corporis in contemporary medicine.

FAQ section (important questions/answers):

What is the main focus of the study conducted on Haritaladi Lepa?

The study focuses on the efficacy of Haritaladi Lepa in treating Dadru Kushta, a skin disorder resembling Tinea corporis, and evaluates its effectiveness over a 14-day application period.

How many patients were involved in the clinical study?

A total of 30 patients diagnosed with Dadru Kushta participated in the clinical study conducted at K.V.G Ayurveda Medical College and Hospital.

What were the key findings regarding the improvement in symptoms?

The study reported significant improvement across various symptoms, including Kandu, Daha, and Pidaka, with overall treatment effectiveness measured at 54.55%. Statistically significant results were observed for all assessment parameters.

How is Dadru Kushta related to modern medical conditions?

Dadru Kushta is correlated with Tinea corporis in modern medicine, as it presents similar symptoms and is characterized by fungal infection, indicating its relevance in contemporary dermatological discussions.

What was the duration of treatment with Haritaladi Lepa?

Patients received Haritaladi Lepa for a total of 14 days, with follow-ups to assess ongoing effects after treatment completion, making the overall study duration 21 days.

Were there any side effects observed during the study?

No complications or side effects were reported during or after the treatment with Haritaladi Lepa, indicating its safety and therapeutic value in managing Dadru Kushta.

Glossary definitions and references:

Scientific and Ayurvedic Glossary list for “A clinical study on effect of harithaladi lepa in dadru kusta”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.

1) Dadru:
In Ayurvedic medicine, Dadru refers to a skin condition characterized by the presence of circular lesions similar to Tinea corporis. It is a type of Kushta (skin disease) that results from an imbalance of Doshas, particularly Kapha and Pitta, and is commonly associated with poor hygiene and lifestyle factors.

2) Mandala (Mamdala):
Mandalas refer to the circular lesions characteristic of conditions such as Dadru. Observing the presence and distribution of Mandalas aids in diagnosing severity and guiding treatment options, demonstrating the visual signs of Dosha imbalances in Ayurvedic practice.

3) Study (Studying):
The study in this context refers to a clinical investigation assessing the efficacy of Haritaladi Lepa on patients suffering from Dadru Kushta. It involves systematic observation and recording of symptoms based on Ayurvedic principles, aiming to provide evidence for the treatment's effectiveness and potential benefits.

4) Kandu (Kamdu):
Kandu signifies itching, a primary symptom in many skin diseases, including Dadru. Itching is closely linked to the aggravation of the Kapha Dosha and is a significant factor in determining the severity of skin conditions. The reduction in Kandu is often used as a measure of treatment success.

5) Lepa:
Lepa refers to a medicinal paste applied topically in Ayurveda. Haritaladi Lepa, used in this study, contains herbal ingredients known for their skin-rejuvenating properties. Topical applications like Lepa are key therapeutic modalities in managing skin diseases, directly addressing local symptoms and promoting healing.

6) Table:
In research, Tables are used to organize data systematically for better understanding and clarity. In this study, tables summarize the findings on various symptoms and their gradations, helping visualize the statistical analysis of treatment effects over time, aiding in comparison and interpretation of results.

7) Daha:
Daha indicates a burning sensation, often associated with skin conditions like Dadru Kushta. It reflects the Pitta Dosha's increase and can signal underlying inflammation or irritation. Treatment efficacy is measured by the improvement in this symptom, as a reduction indicates better management of the condition.

8) Guna:
Guna represents the inherent qualities or properties of substances in Ayurveda, which influence their effects on the body. The Snigdha (unctuous) and Rooksha (dry) qualities of herbs determine their therapeutic applications and suitability for balancing the Doshas involved in skin diseases like Dadru.

9) Pidaka:
Pidaka refers to the presence of pustules or lesions associated with skin disorders, particularly in the context of Dadru Kushta. The assessment of Pidaka's severity helps determine the nature and stage of the condition, offering insights into the patient's health and guiding treatment decisions.

10) Kapha:
Kapha is one of the three Doshas in Ayurveda, characterized by qualities of heaviness, moisture, and stability. Its imbalance is implicated in skin conditions like Dadru, leading to symptoms such as itching and lesions. Understanding Kapha’s role helps in crafting appropriate therapeutic strategies.

11) Rasa (Rasha):
Rasa denotes the taste or essence of a substance in Ayurveda, which influences its therapeutic effects. Different Rasa types (like Katu or Madhura) have specific implications for balancing the Doshas and are selected based on their suitability for treating conditions like Dadru Kushta.

12) Pitta:
Pitta is another of the three Doshas, associated with heat, metabolism, and transformation processes. Its imbalance is central to many inflammatory skin conditions in Ayurveda, including Dadru. Managing Pitta through dietary and lifestyle adjustments is crucial for effective treatment.

13) Raga:
Raga refers to the redness observed in skin lesions or conditions. In the context of Dadru Kushta, the grading of Raga's severity aids in determining the extent of inflammation and effectiveness of treatment interventions, directly correlating with Pitta aggravation.

14) Haratala:
Haratala is an important mineral ingredient used in Ayurvedic formulations, particularly in treating skin conditions. It possesses unique properties such as Katu Rasa and Ushna Veerya, which contribute to its effectiveness in managing Dadru Kushta by alleviating symptoms and promoting healing.

15) Disease:
Diseases in this context cover a wide range of health conditions classified in Ayurveda, especially degenerative or imbalanced states caused by Dosha derangements. The principles of treatment and understanding the specific diseases (like Dadru) are crucial for effective healthcare practices.

16) Dosha (Dosa):
Dosa signifies imbalance in Ayurveda, central to the theory of health and disease. Identifying excess Dosa conditions, particularly with Kapha and Pitta in Dadru, directs treatment strategies to rebalance the body and restore skin health.

17) Durva:
Durva is a type of grass used in Ayurvedic formulations, particularly for its medicinal properties. It contributes to the formulation of Haritaladi Lepa, aiding in the treatment of skin disorders by balancing the Doshas, especially Kapha and Pitta, benefiting conditions like Dadru.

18) Saindhava (Saimdhava):
Saindhava, or rock salt, is utilized in Ayurvedic treatments for its therapeutic benefits. In Haritaladi Lepa, it helps to balance the Rasa and Guna of the formulation, providing essential minerals that support skin health while addressing symptoms of conditions like Dadru Kushta.

19) Ayurveda (Ayus-veda):
Ayurveda is an ancient system of medicine from India, emphasizing a holistic approach to health based on balancing the body’s Doshas and maintaining harmony with nature. It provides the theoretical basis for understanding and treating conditions like Dadru Kushta through natural remedies and lifestyle changes.

20) Gomutra (Go-mutra):
Gomutra refers to cow urine, which holds a significant place in Ayurvedic medicine due to its purifying and therapeutic properties. It is used in formulations like Haritaladi Lepa to enhance its efficacy in treating skin conditions by addressing imbalances in the Doshas.

21) Nidana:
Nidana addresses the causative factors contributing to diseases in Ayurveda. In the context of Dadru, identifying Nidana helps in understanding the underlying imbalances that lead to the disease, which is crucial for developing effective treatment approaches tailored to individual patients.

22) Snigdha:
Snigdha signifies the quality of being oily or unctuous. In Ayurveda, substances with Snigdha quality are often used to counterbalance dryness and irritation associated with skin conditions. The use of Snigdha-based preparations in treating Dadru Kushta aids in restoring skin health.

23) Lavana:
Lavana refers to salt in Ayurveda, noted for its properties of enhancing flavors and medicinal benefits. It's commonly used to balance Pitta and Kapha, essential in formulations targeting skin conditions to alleviate symptoms like itching and inflammation inherent in Dadru Kushta.

24) Katu:
Katu describes a pungent taste in Ayurveda, known for its warming qualities. It is used in treatments to stimulate digestion and metabolism while addressing Kapha imbalances. In skin disorders like Dadru, Katu substances help alleviate symptoms such as itching and inflammation.

25) Gandaka (Gamdaka):
Gandaka, or zinc sulfide, is a mineral often included in Ayurvedic treatments for its Kushtahara properties, making it effective against skin diseases. Its inclusion in formulations like Haritaladi Lepa is essential in treating conditions such as Dadru due to its therapeutic actions.

26) Kashaya (Kasaya):
Kashaya denotes an astringent taste known for its drying characteristics. In Ayurvedic medicine, Kashaya is valuable in managing excess moisture and balancing Kapha. Its presence in formulations for conditions like Dadru Kushta aids in reducing symptoms and promoting skin health.

27) Food:
In the context of health, especially Ayurveda, food refers to dietary habits that impact the balance of Doshas. Poor dietary choices can aggravate conditions like Dadru, hence understanding and modifying one's food intake is essential for prevention and treatment.

28) Dakshina Kannada:
Dakshina Kannada is a region in India known for its rich cultural heritage and traditional Ayurvedic practices. The study conducted here reflects local agricultural practices, diet, and environmental factors that contribute to skin conditions, relevant for understanding diseases like Dadru Kushta.

29) Snigdhata:
Snigdhata signifies the quality of being moist or oily. In Ayurveda, mitigating excessive Snigdhata is crucial in managing Kapha-linked conditions. Understanding Snigdhata's role is vital in cases of skin diseases like Dadru, where its imbalance can worsen symptoms.

30) Dakshina (Daksina):
Dakshina translates to 'south' in the local context, often referring to the southern regions of India, including Dakshina Kannada. The geographic and climatic influences in these areas can play a role in skin health and the prevalence of conditions like Dadru Kushta.

31) Kannada:
Kannada is a Dravidian language spoken predominantly in the state of Karnataka, India. The cultural and linguistic context surrounding Ayurveda practices, including medicinal preparations and local dietary influences, can significantly affect the understanding and treatment of diseases like Dadru.

32) Samana (Shamana):
Shamana refers to palliative treatments in Ayurveda aimed at alleviating symptoms without necessarily curing the disease. In the context of Dadru, Shamana therapies provide symptomatic relief, addressing discomfort while working towards rebalancing the involved Doshas through interventions like Haritaladi Lepa.

33) Caraka:
Caraka is a foundational text in Ayurveda that outlines principles of medicine and treatment methods. Its teachings guide practitioners in diagnosing and treating disorders like Dadru Kushta, emphasizing the need to understand the underlying Dosha imbalances for effective treatment.

34) Vyadhin (Vyadhi):
Vyadhi translates to 'disease' in Ayurveda encompassing various conditions caused by imbalances in the Doshas. Understanding Vyadhi helps practitioners identify treatment patterns and create personalized plans that address the specific needs of patients suffering from conditions like Dadru.

35) Guru:
Guru refers to the quality of heaviness or density in Ayurveda. In the context of dietary substances and treatments, foods or medicines characterized by Guru Guna can impact the balance of Kapha, Pitta, and Vata, hence are considered in treatment strategies for conditions like Dadru.

36) Yoga:
In Ayurveda, Yoga refers to therapeutic formulations and practices designed to restore balance to the body. It encompasses the combination of various herbs, minerals, and techniques tailored to address specific symptoms or imbalances in practitioners, crucial for conditions like Dadru Kushta.

37) Post:
In the context of research and documentation, 'Post' typically refers to the content published following the completion of studies. The post provides analysis and findings regarding the efficacy of treatment methods, enhancing the body of knowledge concerning proven Ayurvedic practices.

38) Drug:
Drugs encompass herbal and mineral-based substances used for healing in Ayurveda. They are foundational in the treatment of conditions such as Dadru Kushta, emphasizing the need for appropriate formulations that leverage the properties of Dravyas to restore health.

39) Saindhavalavana (Saimdhavalavana, Saindhava-lavana):
Saindhava-lavana denotes rock salt, often highlighted in Ayurvedic formulations for its balancing properties. Its inclusion in treatments affects taste (Rasa) and helps modulate the Doshas, making it significant in topical preparations aimed at conditions like Dadru Kushta for effective symptom management.

40) Measurement:
Individual Measurement pertains to the evaluation of specific parameters utilized in the study for clinical assessment. These include subjective symptoms like itching (Kandu) and objective signs, providing a comprehensive understanding of treatment benefits and guiding clinical practices.

41) Lakshana (Laksana):
Laksana translates to signs or symptoms, integral to diagnosing diseases in Ayurveda. The Laksanas of Dadru provide a framework for understanding the condition's nature and guiding the formulation of specific interventions to promote healing.

42) Sweating (Sweat):
Sweating is a physiological response that can exacerbate skin conditions, including Dadru Kushta. In Ayurveda, understanding the impact of environmental factors like heat and sweating on Dosha balance is critical for advising patients on prevention and management strategies.

43) Madhura:
Madhura refers to the sweet taste prevalent in various foods and medicines. In Ayurvedic treatments, Madhura Rasa possesses qualities that can help balance Pitta and Kapha, making it relevant in dietary choices and formulations aimed at addressing conditions like Dadru Kushta.

44) Vyayama:
Vyayama means physical exercise and plays a significant role in Ayurveda for maintaining health. It affects the balance of Doshas and can either benefit or aggravate conditions like Dadru, depending on intensity and individual constitution.

45) Ushnata (Usnata):
Ushnata represents heat, a critical concept in Ayurveda impacting health. Elevated Ushnata levels contribute to Pitta aggravation, which can worsen skin diseases like Dadru. Understanding and managing Ushnata through lifestyle modifications and treatments is vital in restoring skin health.

46) Pravara:
Pravara indicates superior strength or robustness in Ayurvedic assessment of patient health. Understanding Pravara helps practitioners tailor treatments towards those with strong constitutions, addressing their unique health needs and potential resiliency against certain skin conditions like Dadru Kushta.

47) Dravya:
In Ayurvedic terminology, Dravya refers to material substances utilized for healing. Ensuring the correct properties and functions of Dravya in formulations like Haritaladi Lepa is essential for effective management of conditions such as Dadru Kushta by addressing symptomatic manifestations.

48) Matsya:
Matsya refers to fish, which is a common dietary constituent. In the study's context, Matsya can exacerbate skin conditions like Dadru when consumed excessively, due to its qualities that may amplify Kapha and Pitta imbalances, warranting a balanced diet for health.

49) Rakta:
Raktha signifies blood and plays an important role in Ayurvedic medicine as part of the Saptadhatu (seven bodily tissues). The role of Raktha in skin conditions highlights its importance in assessing treatment progress for diseases like Dadru Kushta, linking it to Dosha balance.

50) Mamsa (Mamsha):
Mamsa means muscle or flesh, referring to animal protein sources. In dietary considerations for skin health, excessive Mamsa consumption may contribute to Kapha aggravation, underlining the need for a balanced diet in managing conditions like Dadru Kushta effectively.

51) Patra:
Patra signifies a vessel or container used in Ayurvedic preparations. The choice of Patra used in making Haritaladi Lepa impacts its quality and efficacy, ensuring that the active therapeutic properties are preserved and effectively delivered to the skin.

52) Masha (Masa, Ma-sha):
Masha refers to black gram and is included in Ayurvedic diets. Its consumption can have escalating effects on Kapha, making it relevant in the context of dietary modifications needed to manage conditions like Dadru Kushta effectively.

53) Field:
Fields signify agricultural areas where exposure to elements and allergens may increase health risks. In studying conditions like Dadru Kushta, assessing fieldwork conditions becomes important in preventing and mitigating skin disorders driven by environmental factors.

54) Bala:
Bala refers to strength or health, particularly in assessing a patient's overall state. Understanding a patient's Bala helps in formulating suitable treatments that align with their capability to endure and recover from conditions like Dadru Kushta.

55) Amla:
Amla translates to sour or acidic properties in Ayurveda, often affecting Pitta. Foods or substances with Amla Rasa can aggravate conditions like Dadru by increasing heat levels, making awareness of their consumption crucial for treatment strategies.

56) Vata:
Vata is one of the primary Doshas characterized by qualities like dryness and movement. In the context of skin health, Vata imbalances can lead to conditions like dryness and irritation, making its regulation essential in the management of skin diseases.

57) Burning sensation:
The burning sensation is an uncomfortable symptom often associated with skin disorders, indicating inflammation and irritation within. It is critical to assess and manage the burning sensation in conditions like Dadru, highlighting the need for effective treatments to enhance patient comfort.

58) Rogalakshana (Roga-lakshana, Rogalaksana):
Roga-lakshana encompasses the symptoms and signs of ailments in Ayurveda. Recognizing Roga-lakshana is paramount for accurate diagnosis and treatment of conditions like Dadru Kushta, ensuring focused therapeutic interventions that align with observed patient manifestations.

59) Tridoshahara (Tridosahara, Tridosha-hara):
Tridoshahara refers to substances or treatments that pacify all three Doshas—Vata, Pitta, and Kapha. Such formulations are essential in managing conditions like Dadru Kushta, as they address multiple imbalances, promoting overall health and well-being.

60) Madhurarasa (Madhura-rasa):
Madhura-rasa indicates the sweet taste in Ayurvedic foods and medicines. Incorporating Madhura shapes dietary guidelines that balance Kapha and Pitta, which is crucial for maintaining skin health and preventing exacerbation of conditions like Dadru.

61) Observation:
Observation entails systematically noting patient responses during treatment. Accurate observations are key to understanding the impact of therapies like Haritaladi Lepa, essential for evaluating treatment success in skin conditions such as Dadru Kushta.

62) Lavanarasa (Lavana-rasa):
Lavana-rasa refers to the salty taste with various medicinal properties. It influences digestion and can moderate Dosha balance, making it significant in dietary considerations in treating skin ailments like Dadru, promoting effective management strategies.

63) Kaphapitta (Kapha-pitta):
Kapha-pitta denotes the combination of the Kapha and Pitta Doshas, emphasizing the need for understanding how their interplay affects health. In conditions like Dadru, balancing Kapha and Pitta is essential for effective treatment outcomes and skin health restoration.

64) Discussion:
Discussion refers to the analysis and interpretation of study findings regarding Haritaladi Lepa's efficacy in treating skin conditions. Engaging in discussion provides context and understanding of results, enhancing the body of Ayurvedic knowledge and guiding future research.

65) Developing:
Developing in this context refers to forming or evolving treatment methodologies in Ayurveda, emphasizing the continuous improvement of techniques and herbal formulations to effectively address skin conditions like Dadru, ensuring relevance and efficacy in modern practice.

66) Kamadhenu (Kama-dhenu):
Kamadhenu is a mythical cow in Ayurveda believed to fulfill desires. Symbolically, it represents holistic nourishment and health, which parallels the goals in treating conditions like Dadru Kushta, emphasizing balance, harmony, and the nurturing aspect of Ayurvedic practice.

67) Pittahara (Pitta-hara):
Pittahara refers to substances or treatments that pacify Pitta Dosha. Such properties are essential in formulations targeting conditions exacerbated by heat and inflammation, making Pittahara ingredients vital for effectively managing diseases like Dadru Kushta.

68) Container:
In herbal preparations, a container is essential for storing medicinal compounds. Proper containers ensure herbs used in treatments like Haritaladi Lepa maintain their potency and stability, which is crucial for delivering effective therapies for skin conditions.

69) Suffering:
Suffering indicates the physical and emotional distress experienced by patients dealing with health issues. Recognizing suffering in conditions like Dadru Kushta underscores the importance of addressing both symptoms and quality of life through effective Ayurvedic treatments.

70) Medicine:
Medicine encompasses both pharmaceutical and holistic practices aimed at promoting health and treating diseases. In Ayurveda, the combination of herbal remedies and therapies forms a foundational approach to treating conditions like Dadru, illustrating the integration of science and tradition.

71) Vaivarnya:
Vaivarnya signifies a change in skin color, often indicating an underlying imbalance or pathology. Monitoring Vaivarnya is significant in assessing the progress of treatments for skin diseases like Dadru Kushta and aids in understanding the condition's severity.

72) Vagbhata:
Vagbhata is an ancient Ayurvedic scholar whose works contribute to the foundation of Ayurvedic healing. His teachings guide practitioners in diagnosing and treating ailments like Dadru, emphasizing holistic approaches to managing skin diseases within traditional frameworks.

73) Tridosha (Tridosa, Tri-dosha):
Tridosha signifies the three fundamental life energies in Ayurveda—Vata, Pitta, and Kapha. Understanding Tridosha is essential in diagnosing and treating conditions like Dadru Kushta, as imbalances among these energies are critical for assessing health and determining suitable treatments.

74) Madhyama:
Madhyama denotes a moderate or average state of health, particularly in assessing patient strength or Bala. Patients categorized under Madhyama Vyadhibala may respond more favorably to treatments for conditions like Dadru, making health assessment crucial for effective management.

75) Upasarga:
Upasarga refers to external influences or factors contributing to disease, such as contagion or contact with infected individuals. Identifying Upasarga helps practitioners understand disease propagation and emphasizes prevention strategies for conditions like Dadru Kushta.

[Note: The above list is limited to 75. Total glossary definitions available: 109]

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Nidana, Rasadravya, Skin disease, Treatment modalities, Dosha imbalance, Inclusion criteria, Exclusion criteria, Clinical study, Sample size, Diagnostic criteria, Statistically Significant, Treatment duration, Follow Up Period, Overall effect, Symptomatology, Skin disorder, Tinea corporis, Ayurvedic classic, Dadru Kushta, Poor sanitation.

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