Review on pharmacological properties of Vishnukranthi Kudineer for pediatric fever management.

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Journal name: World Journal of Pharmaceutical Research
Original article title: A review on pharmacological properties of siddha formulation vishnukranthi kudineer for the management of fever in pediatrics
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Author:

S. Chitra, A. Silambarasan and S. Mahalakshmi


World Journal of Pharmaceutical Research:

(An ISO 9001:2015 Certified International Journal)

Full text available for: A review on pharmacological properties of siddha formulation vishnukranthi kudineer for the management of fever in pediatrics

Source type: An International Peer Reviewed Journal for Pharmaceutical and Medical and Scientific Research

Doi: 10.20959/wjpr202215-26092

Copyright (license): WJPR: All rights reserved


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Summary of article contents:

Introduction

Fever is a common issue faced in pediatric care, characterized by an abnormal increase in body temperature, typically defined as a rise above 37.5 °C. While fever serves as a physiological mechanism facilitating recovery, it can also lead to discomfort and complications, particularly in children. Traditional medicinal systems, such as Siddha, have formulated herbal remedies to address these health concerns. One such preparation is Vishnukranthi kudineer, which is specifically indicated for managing 64 types of fever in children according to Siddha pediatric texts.

The Siddha Humoural Concept of Fever

In the Siddha system of medicine, fever is classified under the term "Suram," which is linked to an imbalance in the body's functional units: Vatha, Pitha, and Kapha. This imbalance is often attributed to dietary habits and environmental factors. The concept suggests that disturbances, particularly an increase in Kapha, lead to the formation of "Ama," or undigested materials, resulting in fever. The formulation of Vishnukranthi kudineer is believed to help rectify these imbalances by combining specific ingredients with properties designed to pacify the Kapha dosha, thus addressing the root cause of fever.

Ingredients and Their Pharmacological Properties

The key constituents of Vishnukranthi kudineer include Evolvulus alsinoides (Vishnukranthi), Zingiber officinale (Ginger), Terminalia chebula (Kadukkai Thol), Acacia caesia (Indu), and Celastrus paniculatus (Vaaluzhuvai). Each ingredient possesses unique pharmacological actions, such as anti-inflammatory, antimicrobial, and antioxidant properties. For instance, studies highlight that ginger can inhibit pro-inflammatory cytokines and has demonstrated potent antimicrobial activity against various pathogens. In addition, Evolvulus alsinoides has shown effectiveness in reducing fever comparable to standard antipyretic medications like paracetamol.

Antipyretic, Anti-inflammatory, and Antimicrobial Actions

Scientific evaluation of the components in Vishnukranthi kudineer reveals significant antipyretic and anti-inflammatory activities. The formulation functions not only as a fever reducer but also as an agent to mitigate inflammation and combat microbial infections. Research indicates that the extracts from these ingredients can reduce hyperthermia and possess properties that work against such bacterial threats as Escherichia coli and Staphylococcus aureus. This dual action helps address both the symptoms and the underlying causes of fever in children effectively.

Conclusion

The comprehensive review of Vishnukranthi kudineer emphasizes the need for integrating traditional herbal medicine with modern scientific research to validate its efficacy in treating fever in pediatric patients. The Siddha system provides valuable insights into the management of fever through a holistic approach that involves understanding the balance of bodily humors. Continued exploration and clinical studies are necessary to further substantiate the claims surrounding this formulation, paving the way for its potential incorporation into conventional pediatric treatment protocols.

FAQ section (important questions/answers):

What is Vishnukranthi Kudineer and its purpose?

Vishnukranthi Kudineer is a polyherbal Siddha formulation used for managing 64 types of fevers in children, enhancing immune function while alleviating symptoms like fatigue and myalgia.

What are the main ingredients in Vishnukranthi Kudineer?

The key ingredients include Evolvulus alsinoides, Zingiber officinale, Terminalia chebula, Acacia caesia, and Celastrus paniculatus, each contributing to the formulation's medicinal properties.

How does Vishnukranthi Kudineer work on fever?

It provides antipyretic, anti-inflammatory, antimicrobial, and antioxidant effects, balancing bodily humors and addressing the root causes of fever, particularly Ama and Kapha dosha.

What are the benefits of using traditional herbal medicines?

Traditional herbal medicines like Vishnukranthi Kudineer offer a source of therapeutic compounds, often with fewer side effects, and promote natural healing through multi-faceted approaches.

What pharmacological properties have been studied in Vishnukranthi Kudineer?

Studies have explored its antipyretic, anti-inflammatory, antimicrobial, and antioxidant properties, demonstrating its effectiveness in managing fever and related conditions in children.

What is the need for further research on Vishnukranthi Kudineer?

Further preclinical and clinical studies are essential to substantiate its traditional uses and assure safety and efficacy in contemporary medical practice.

Glossary definitions and references:

Scientific and Ayurvedic Glossary list for “Review on pharmacological properties of Vishnukranthi Kudineer for pediatric fever management.”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.

1) Fever:
Fever is a physiological response characterized by an increase in body temperature, usually above 37.5°C. It indicates an underlying health issue, often related to infections or inflammation. In pediatric medicine, managing fever is critical for alleviating discomfort and preventing complications, making it a focal point in various therapeutic approaches, including traditional medicine like Siddha.

2) Siddha:
Siddha is an ancient system of traditional medicine originating from Tamil Nadu, India. It encompasses holistic practices that involve herbal remedies, diet, and lifestyle adjustments. The Siddha system prioritizes balance among bodily elements (doshas) and emphasizes treating root causes of diseases, with a significant focus on fever management for pediatric patients.

3) Activity:
Activity refers to the biological effects or actions that substances can exert, particularly in pharmacological contexts. In this review, the activity of the Siddha formulation Vishnukranthi Kudineer is evaluated for its medicinal properties against fever. Assessing these activities helps in understanding their therapeutic potential and supporting their use scientifically.

4) Study (Studying):
Study refers to scientific investigations aimed at gaining deeper insights into medical treatments and their effectiveness. In the context of Siddha formulations like Vishnukranthi Kudineer, these studies evaluate the pharmacological properties and therapeutic efficacy, providing evidence-based support for traditional practices and informing future clinical applications.

5) Pharmacological:
Pharmacological pertains to the branch of pharmacology that focuses on the effects of drugs and their mechanisms of action in living organisms. This term is crucial in evaluating the medicinal properties of ingredients within Siddha formulations, specifically their antipyretic, anti-inflammatory, and antimicrobial actions relevant for managing fever in children.

6) Terminalia chebula:
Terminalia chebula, commonly known as Belleric Myrobalan, is a key herb in traditional medicine with various therapeutic uses, including as a laxative and anti-inflammatory agent. It plays a significant role in Siddha formulations, contributing to the management of fever and supporting health through its rich phytochemical content and medicinal properties.

7) Pungent:
Pungent is one of the fundamental tastes in Ayurveda and Siddha medicine, associated with certain herbs used in treatments. Ingredients that are pungent are believed to stimulate digestive fire and enhance metabolic processes, making them essential in formulating remedies aimed at addressing fevers and balancing doshas.

8) Kapha:
Kapha is one of the three doshas in the Siddha and Ayurveda systems, representing stability and moisture in the body. Imbalance in Kapha can contribute to various health issues, including fever. Understanding Kapha helps practitioners develop treatments that restore balance and alleviate symptoms associated with increased body temperature and respiratory conditions.

9) Zingiber officinale:
Zingiber officinale, or ginger, is a well-known medicinal plant celebrated for its anti-inflammatory and antimicrobial properties. It is often incorporated into Siddha formulations like Vishnukranthi Kudineer for managing fever due to its effectiveness in reducing symptoms and enhancing overall health, thereby playing a critical role in traditional therapeutic practices.

10) Family:
Family refers to the biological classification of plants or herbs in the study of pharmacology and herbal medicine. Understanding the family of a particular herb, such as Zingiberaceae for ginger, aids researchers and practitioners in predicting the plant's potential uses, pharmacological actions, and interactions based on related species.

11) Drug:
Drugs refer to the bioactive compounds derived from plant and animal sources utilized in medicine. In the context of Siddha and other traditional systems, the focus is on natural compounds that exhibit therapeutic effects in treating conditions like fever, ensuring a holistic approach to health.

12) Science (Scientific):
Scientific relates to the systematic and evidence-based approach of investigating phenomena. In assessing the Siddha formulation of Vishnukranthi Kudineer, scientific evaluation of its pharmacological properties is essential for validating traditional knowledge and integrating these practices into modern healthcare settings for safe and effective treatments.

13) Disease:
Diseases are conditions that disrupt normal bodily functions and can range from infections to chronic illnesses. Understanding the link between fever and various diseases in pediatric patients is essential for effective diagnosis and treatment, particularly in using traditional formulations that address multiple facets of health.

14) Bitter:
Bitter is another essential taste in herbal medicine, considered beneficial as it stimulates digestive processes and exerts detoxifying effects. Many ingredients in Siddha formulations, including those used in Vishnukranthi Kudineer, have bitter properties that help address the root causes of fever by balancing bodily doshas and enhancing digestion.

15) Pittam (Pittham):
Pitham refers to one of the three doshas in the traditional systems of medicine, influencing bodily heat and metabolic processes. Proper management of Pitham is vital in conditions like fever, as imbalance can lead to excessive heat and related symptoms. Understanding Pitham aids practitioners in tailoring treatments to restore health.

16) Inflammation:
Inflammation is the body's response to injury or infection, often resulting in fever as a secondary symptom. The management of inflammation through herbal remedies, such as those in Siddha formulations, is crucial to alleviate pain and discomfort associated with fever, contributing to the overall healing process.

17) Medicine:
Medicine encompasses practices and substances used to treat or prevent illness. The study of both modern pharmaceuticals and traditional systems like Siddha broadens the scope of therapeutic possibilities, particularly in managing complex symptoms like fever in children, through safe and effective herbal formulations.

18) Kledaka:
Kledaka is a subtype of Kapha dosha in Ayurvedic and Siddha medicine associated with moisture and lubrication, impacting digestion and bodily functions. An imbalance can lead to conditions such as fever. Recognizing Kledaka's role helps in creating remedies that restore harmony and facilitate healing.

19) Aureus:
Aureus refers to Staphylococcus aureus, a bacterium known for causing various infections, including those that may induce fever. Understanding the antimicrobial properties of herbs like those used in Vishnukranthi Kudineer is vital for effective treatment options in pediatric medicine, especially against resistant infections.

20) Indian:
Indian refers to the cultural and geographical context of traditional practices, including Siddha medicine. Rooted in the rich biodiversity and history of the Indian subcontinent, remedies utilized in Siddha emphasize natural healing and holistic approaches, particularly in managing conditions prevalent in the region, such as fever.

21) Cukku:
Sukku, or dry ginger (Zingiber officinale), is commonly used in Ayurvedic and Siddha formulations for its anti-inflammatory and digestive properties. It forms a vital part of treatments aimed at alleviating fever and related discomforts in children, showcasing the therapeutic value of traditional herbs.

22) Tol (Tôl):
Thol refers to Terminalia chebula, known for its medicinal properties in traditional practices. Its inclusion in formulations like Vishnukranthi Kudineer emphasizes its role in detoxification, promoting digestion, and managing fever, showcasing the importance of synergistic effects among various herbal ingredients.

23) Phytochemical:
Phytochemical refers to the bioactive compounds found in plants that are responsible for their therapeutic effects. Analyzing the phytochemicals present in Siddha formulations is critical for understanding their pharmacological properties and validating traditional uses in managing conditions like fever, as seen with Vishnukranthi Kudineer.

24) Kancipura (Kancipuram, Kanchipuram, Kamcipura, Kanci-pura, Kamci-pura):
Kanchipuram is a historical city in Tamil Nadu, India, known for its rich heritage and traditional healing practices, including Siddha medicine. The regional focus on herbal remedies underscores the cultural significance of local flora in treating conditions like fever, reflecting the integration of community knowledge into therapeutic practices.

25) Tamilnadu (Tamil-nadu):
Tamilnadu is a state in southern India known for its rich traditions in medicine, particularly Siddha. This cultural backdrop informs the practice and understanding of herbal medicine, demonstrating how regional knowledge can enhance the management of health issues, including pediatric fever treatment.

26) Species:
Species refers to distinct biological classifications of organisms. In traditional medicine, understanding the specific species used in formulations is crucial for predicting therapeutic efficacy. The variety of plant species utilized in Siddha formulations exemplifies biodiversity's importance in enhancing healthcare solutions for diseases prevalent in Tamil Nadu.

27) Vattam:
Vatham is another dosha in the Ayurvedic and Siddha systems representing mobility and bodily movement. Misbalance in Vatham can lead to various health issues, including fever. Recognizing its importance allows practitioners to design effective treatments focusing on restoring balance and promoting overall health.

28) Indu (Imdu):
Indu refers to Acacia caesia, a significant herb in traditional medicine known for its various health benefits. Its role in Siddha formulations is to enhance digestion and exhibit antimicrobial properties, aiding in fever management and showcasing the value of integrating diverse plants in therapeutic practices.

29) Hair:
Hairs may denote physical characteristics of plants or animals relevant in herbal medicine contexts. In the study of herbal remedies, understanding such characteristics contributes to identifying the plant species used in treatments, which can enhance the efficacy of remedies applied to manage conditions like fever.

30) Pain:
Pain is an uncomfortable sensation indicating potential health issues. In pediatric medicine, managing pain associated with fever is crucial for patient comfort. This emphasis underlines the importance of herbal remedies that address both fever and associated discomfort, as exemplified by Siddha formulations.

31) Human body:
Human body refers to the complex biological system in which health and diseases manifest. Understanding the interactions between various systems in the human body is vital for effective treatment design. Siddha medicine focuses on holistic approaches to remedy imbalances that can lead to conditions like fever.

32) Shri-lanka (Srilanka, Sri-lanka, Shrilanka):
Sri Lanka, like Tamil Nadu, has deep-rooted traditions in herbal medicine. Studying regional practices enhances the understanding of phytochemical diversity and their therapeutic applications, which can enrich Siddha formulations and contribute to more effective treatments for diseases prevalent in both regions, including fever.

33) Kledakakapha (Kledaka-kapha):
Kledaka-kapha refers to a specific type of Kapha dosha that governs moisture and digestive lubrication. An imbalance can lead to health issues, including increased body temperature. Understanding this concept is vital for creating effective treatments in Siddha aimed at restoring equilibrium and alleviating fever.

34) Kaphadosha (Kaphadosa, Kapha-dosha):
Kapha-dosha is one of the three fundamental doshas in Siddha and Ayurveda, representing stability and earthiness. Imbalance in Kapha-dosha can lead to various health issues, including fever. Recognizing its role is essential for designing effective therapies that restore balance and promote health.

35) Malkangani:
Malkangani refers to Celastrus paniculatus, a climbing plant known for its diverse therapeutic applications, including neurological benefits. In Siddha formulations, Malkangani contributes to overall health, including managing symptoms associated with fever. Its usage exemplifies the integration of multiple herbs into a comprehensive treatment approach.

36) Irritation:
Irritation refers to a body’s response to inflammation or infection, often presenting alongside symptoms like fever. In traditional medicine, managing irritation is crucial for alleviating discomforts associated with fever, highlighting the need for formulated herbal treatments that address these accompanying symptoms effectively.

37) Antibiotic (Antibacterial):
Antibiotic refers to substances that inhibit the growth of bacteria. In the context of fever treatment, identifying effective natural antibiotics within herbal remedies is vital, especially in pediatrics. Siddha medicine often incorporates such herbs to bolster the body's defenses against infections that may cause fevers.

38) Substance:
Substance refers to individual chemical compounds found in medicinal plants. Identifying active substances in Siddha formulations is essential for establishing their pharmacological benefits, particularly in treating fever and associated health conditions in children, thus bridging traditional knowledge and modern scientific validation.

39) Flavonoid:
Flavonoid represents a class of plant secondary metabolites known for their antioxidant and anti-inflammatory properties. Many herbs used in Siddha formulations contain flavonoids that contribute to their therapeutic effects, including managing fever. These compounds highlight the significance of phytochemical diversity in traditional medicine.

40) Triphala (Tri-phala):
Triphala, a traditional herbal preparation, consists of three fruits that offer various health benefits, including digestive health and detoxification. Its synergy in treating numerous conditions underscores the importance of combining multiple herbs in Siddha formulations, thereby enhancing effectiveness against symptoms like fever.

41) Vitiation (Vitiated):
Vitiated refers to a state of imbalance or disruption in the body's doshas, which can lead to health issues like fever. In Siddha medicine, addressing vitiation is essential for restoring health, emphasizing the need to identify root causes and implement holistic treatments.

42) Leprosy:
Leprosy refers to a chronic infectious disease caused by Mycobacterium leprae, known for causing skin lesions and nerve damage. In Siddha and other traditional medical systems, managing leprosy involves holistic treatments that may include herbal remedies aimed at alleviating symptoms and promoting overall well-being in patients.

43) Arjuna:
Arjuna, referring to Terminalia arjuna, is a medicinal tree used in Ayurvedic and Siddha practices, primarily for its cardiovascular benefits. Its incorporation into formulations highlights the importance of balancing various health aspects in traditional medicine while addressing specific conditions like fever.

44) Nature:
Nature encompasses the biological and ecological resources utilized in traditional medicine. The reliance on natural materials for herbal remedies is essential in systems like Siddha, where the therapeutic properties of plants are harnessed to manage health conditions such as fever effectively.

45) Reason:
Reason signifies the rationale or underlying causes for health conditions. In the context of fever management, identifying the reasons behind symptoms, such as infections or metabolic imbalances, is crucial for selecting the appropriate treatment strategies in both modern and traditional medical practices.

46) Powder:
Powder refers to the ground form of herbal ingredients utilized in Siddha medicine for improved bioavailability and efficacy. The preparation of herbal powders is crucial in traditional practices, allowing easy incorporation into formulations that address health issues such as fever in pediatric care.

47) Dosha (Dosa):
Dosha refers to the three essential energies in Ayurvedic and Siddha medicine—Vatha, Pitha, and Kapha—that govern physiological functioning. Understanding doshas is important for diagnosing health imbalances and tailoring treatment approaches, especially when addressing complex conditions like fever in children.

48) Lanka (Lamka, Lànkà):
Lanka, often referenced in the context of Sri Lanka, highlights the geographic and cultural connections in traditional medicinal practices. Understanding local flora and its medicinal properties enriches the knowledge base for developing effective herbal treatments in both Sri Lankan and Indian traditional systems.

49) Pitha:
Pitha refers to one of the three doshas responsible for metabolic and digestive heat in the body. Maintaining balance in Pitha is essential for health, particularly in managing fever and related symptoms, making it a crucial concept in Siddha and Ayurvedic practices.

50) India:
India, with its rich biodiversity and ancient traditions, serves as the birthplace of numerous traditional healing systems, including Siddha. The diverse flora of India plays a significant role in developing herbal remedies, providing a foundation for effective treatments for conditions like fever.

51) Water:
Water is a critical component in herbal preparations, often utilized for decocting herbs in Siddha formulations. The method of using water in preparing medicines emphasizes the importance of extraction in ensuring the bioavailability of active ingredients, essential for managing health conditions like fever.

52) Tulsi:
Tulsi, or holy basil, is a revered herb in traditional Indian medicine, known for its numerous health benefits including anti-inflammatory and antimicrobial properties. Its role in Siddha formulations underscores its significance in managing fever and promoting overall wellness, illustrating the importance of utilizing holistic approaches.

53) Sugar:
Sugar in herbal medicine often refers to natural sweeteners used in formulations to improve palatability. While managing fever, the balance of taste and therapeutic properties is key in children's treatments, showcasing how traditional remedies can incorporate various sensory elements for effectiveness.

54) Edema (Oedema):
Edema refers to swelling caused by fluid retention, often seen in inflammatory responses. Addressing edema in the context of fever management is essential, as the condition can exacerbate discomfort. Understanding the underlying causes and utilizing effective remedies in Siddha can aid in reducing inflammation and associated symptoms.

55) Table:
Table refers to the organized presentation of data or information, often used in studies to summarize ingredients or findings. In the context of Siddha medicine, tables may depict the components of formulations and their respective properties, facilitating better understanding and evaluation of herbal treatments for fever.

56) Sweating (Sweat):
Sweat is the body's natural cooling mechanism and can be influenced by fever. Managing fever effectively in traditional medicine often involves promoting sweating to facilitate heat dissipation, illustrating the interplay between bodily functions and treatment practices in managing health conditions like fever.

57) Beta:
Beta often refers to a class of compounds or configurations within pharmacological studies. In the context of herbal medicine, various beta-forms of compounds may exhibit specific therapeutic effects, thus broadening the scope of research focused on enhancing treatment modalities for diseases like fever.

58) Neem:
Neem is a versatile medicinal plant renowned for its antibacterial, antiviral, and anti-inflammatory properties. Its use in herbal formulations highlights the importance of traditional knowledge in treating fevers and associated infections, showcasing the efficacy of natural remedies in pediatric care.

59) Food:
Food refers to the substances we consume for nourishment. Traditional medicine, including Siddha, underscores the importance of dietary habits in health management, particularly in preventing issues like fever through balanced nutrition and herbal supplementation, emphasizing holistic approaches to wellness.

60) Tree:
Tree denotes the larger plants from which various medicinal parts can be harvested for use in herbal medicine. Many trees are integral to traditional formulations, contributing essential active compounds that help manage health conditions such as fever, reflecting the significance of biodiversity.

61) Sign:
Sign refers to observable symptoms that indicate underlying health conditions. In managing fever, recognizing the signs allows healthcare practitioners to tailor treatment strategies effectively, whether through traditional remedies or modern approaches, ensuring comprehensive care for patients, particularly children.

62) Rich (Rch):
Rich describes the abundance of bioactive compounds found within certain plants used in Siddha formulations. A rich profile of phytochemicals enhances the therapeutic effectiveness of remedies, ensuring their potency in treating conditions like fever, and emphasizes the role of biodiversity in medicinal practices.

63) Post:
Post often refers to the timeframe following a particular event, such as the resolution of fever. Understanding post-fever conditions is essential for comprehensive patient care, as practitioners can tailor follow-up treatments to promote healing and prevent recurrence of both fever and its underlying causes.

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Terminalia chebula, Zingiber officinale, Celastrus paniculatus, Evolvulus alsinoides, Clinical studies, Anti-inflammatory properties, Antimicrobial properties, Pediatrics.

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