Validation of Naaga Sangu Parpam via FTIR, ICP-OES, and TGA.
Journal name: World Journal of Pharmaceutical Research
Original article title: Scientific validation of naaga sangu parpam through ftir, icp-oes and tga analysis
The WJPR includes peer-reviewed publications such as scientific research papers, reports, review articles, company news, thesis reports and case studies in areas of Biology, Pharmaceutical industries and Chemical technology while incorporating ancient fields of knowledge such combining Ayurveda with scientific data.
This page presents a generated summary with additional references; See source (below) for actual content.
Original source:
This page is merely a summary which is automatically generated hence you should visit the source to read the original article which includes the author, publication date, notes and references.
Kingsley J., Murugavel R., Anbarasan B., Arunkumar G. and Sivakkumar S.
World Journal of Pharmaceutical Research:
(An ISO 9001:2015 Certified International Journal)
Full text available for: Scientific validation of naaga sangu parpam through ftir, icp-oes and tga analysis
Source type: An International Peer Reviewed Journal for Pharmaceutical and Medical and Scientific Research
Doi: 10.20959/wjpr20211-16060
Copyright (license): WJPR: All rights reserved
Download the PDF file of the original publication
Summary of article contents:
Introduction
The Siddha system of medicine, a unique traditional medicinal practice, has long utilized plants and metals for therapeutic purposes. The study presented focuses on the scientific validation of Naaga Sangu Parpam, a herbo-metallic preparation. Through advanced analytical techniques such as Fourier Transform Infrared Spectroscopy (FTIR), Inductively Coupled Plasma Optical Emission Spectrometry (ICP-OES), and Thermogravimetric Analysis (TGA), the researchers aim to standardize this traditional formulation and confirm its medicinal properties. The study demonstrates the relevance of integrating traditional knowledge with modern scientific validation methods to ensure safe and effective use of herbal medicines.
FTIR Analysis of Naaga Sangu Parpam
FTIR analysis is a crucial aspect of this study, as it identifies various functional groups within Naaga Sangu Parpam. The spectra recorded significant peaks associated with different functional groups, including amines, acids, alkanes, alcohols, and alkyl halides. The presence of these organic functional groups indicates that the formulation may possess various medicinal properties, supporting its application in Siddha medicine. The detailed vibrational modes at specific wave numbers highlight the composite nature of the formulation, showcasing the potential for further therapeutic exploration.
ICP-OES Analysis Results
The ICP-OES analysis assesses the elemental composition of Naaga Sangu Parpam and confirms the presence of several vital elements, such as Calcium, Iron, Potassium, and Zinc, which contribute to its therapeutic value. Importantly, the study reveals that heavy metals like Arsenic, Mercury, Lead, and Cadmium were found to be below detectable limits, indicating the safety of the formulation concerning toxic heavy metal contamination. This validation not only strengthens the credibility of the Siddha medicine but also encourages confidence in its use among practitioners and patients.
Thermogravimetric Analysis Findings
Thermogravimetric Analysis (TGA) was conducted to evaluate the stability and decomposition characteristics of Naaga Sangu Parpam. The results indicated that the formulation remains stable at temperatures ranging from 50 °C to 460 °C. The decomposition point was noted to occur beyond 460 °C, with a substantial amount of residual matter (88.73%) remaining post-analysis. These findings illustrate that Naaga Sangu Parpam can withstand a variety of thermal conditions, thereby affirming its stability and longevity as a medicinal formulation.
Conclusion
In summary, the study successfully employs modern analytical techniques to validate the traditional Siddha preparation, Naaga Sangu Parpam. The integrated approach of FTIR, ICP-OES, and TGA not only confirms the medicinal properties and safety of the formulation but also establishes the importance of scientific validation in traditional medicine. By bridging the gap between ancient practices and contemporary standards, this research underscores the significance of rigorous scientific inquiry in enhancing the efficacy and reliability of herbal treatments.
FAQ section (important questions/answers):
What is the purpose of studying Naaga Sangu Parpam?
The study aims to standardize Naaga Sangu Parpam, a Siddha herbo-metallic preparation, using modern techniques like FTIR, ICP-OES, and TGA analysis to validate its scientific basis.
What methods were used to analyze Naaga Sangu Parpam?
The analysis was conducted using Fourier Transform Infrared Spectroscopy (FTIR), Inductively Coupled Plasma Optical Emission Spectrometry (ICP-OES), and Thermogravimetric Analysis (TGA) to assess its composition and stability.
What functional groups are present in Naaga Sangu Parpam?
FTIR analysis revealed the presence of amines, acids, alkanes, alcohols, alkenes, and alkyl halides, indicating its complex organic composition.
What elements were found in Naaga Sangu Parpam?
Elements like Calcium, Iron, Sodium, Potassium, Magnesium, Sulphur, Phosphorus, and Zinc were present, while heavy metals like Arsenic, Mercury, Lead, and Cadmium were below detectable levels.
What did TGA reveal about Naaga Sangu Parpam's stability?
Thermogravimetric Analysis showed that Naaga Sangu Parpam is stable between temperatures of 50°C and 460°C, beginning to decompose above that range.
Which institutions contributed to the research on Naaga Sangu Parpam?
The research was conducted by faculty and scholars from the National Institute of Siddha, along with contributions from various authenticated departments concerning the raw materials used.
Glossary definitions and references:
Scientific and Ayurvedic Glossary list for “Validation of Naaga Sangu Parpam via FTIR, ICP-OES, and TGA.”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.
1) Siddha:
Siddha is a traditional system of medicine originating from South India, characterized by its unique blend of herbal and mineral-based remedies. It emphasizes holistic treatment, addressing both physical and spiritual health, and uses specific formulations and therapeutic practices that have been passed down through generations.
2) Chennai:
Chennai, the capital city of Tamil Nadu, India, serves as a significant hub for traditional medicine practices, including Siddha. It houses numerous institutions, like the National Institute of Siddha, which play a vital role in research, education, and promotion of Siddha medicine and herbal pharmacology.
3) Drug:
Drugs are substances used to diagnose, treat, or prevent illnesses. In Siddha, drugs can be classified into various categories based on their origin, including herbo-mineral preparations. The study specifically analyzes 'Naaga Sangu Parpam', illustrating the application of these traditional remedies in modern contexts.
4) Medicine:
Medicines refer to various therapeutic substances used in the treatment of diseases. In Siddha, the term indicates a wide range of remedies that include both herbal preparations and herbo-mineral formulations, each designed to serve specific therapeutic purposes and improve health outcomes.
5) Study (Studying):
The study reviewed in the document focuses on the scientific validation of 'Naaga Sangu Parpam'. It employs modern analytical techniques such as FTIR, ICP-OES, and TGA to authenticate and evaluate the properties, composition, and therapeutic efficacy of the traditional Siddha preparation.
6) Transformation (Transform, Transforming):
Transform refers to the process of changing something into a different form. In the context of Siddha medicine, transformation could signify the conversion of raw plant or mineral materials into therapeutic drugs through specific preparation and processing techniques essential for enhancing medicinal properties.
7) Science (Scientific):
Scientific denotes a systematic and methodological approach to understanding phenomena, supported by empirical evidence. In the context of validating Siddha preparations, it emphasizes the importance of research to authenticate traditional practices and validate their efficacy through modern scientific methods and analysis.
8) Table:
In academic and research settings, a table is used to present data systematically for easy comparison and analysis. The document includes tables summarizing the results of FTIR and ICP-OES analyses, facilitating the understanding of the functional groups and elemental composition of 'Naaga Sangu Parpam'.
9) Rich (Rch):
Rich describes a high abundance or presence of certain elements or compounds. In the study, it refers to India's extensive biodiversity and variety of medicinal plants, suggesting a valuable resource for developing potent herbal medicines, as well as the rich composition of therapeutic components in Siddha formulations.
10) Mineral:
Minerals are essential inorganic elements contributing to physiological functions and health. In the context of Siddha medicine, various minerals form critical components in herbo-mineral formulations, providing therapeutic benefits and enhancing the overall potency of traditional medications used in treating various health conditions.
11) India:
India is the country of origin for the Siddha system of medicine. It has a rich heritage of traditional health practices and a diverse flora, providing the basis for many herbal and mineral medicines. India serves as a significant center for research and education in alternative medicine.
12) Line:
In scientific research, 'line' can refer to a boundary or distinction within a spectrum or dataset. In the context of the study, it may also refer to the emission lines observed during ICP-OES analysis, which represent distinct wavelengths corresponding to specific elemental concentrations in the drug formulation.
13) Hand:
Hand may refer to the manual process involved in preparing herbal formulations or performing traditional healing practices. In Siddha medicine, techniques often rely on skilled practitioners who traditionally create potent medicines, ensuring quality and adherence to ancient methods passed on through generations.
14) Phytochemical:
Phytochemicals are naturally occurring compounds found in plants that have beneficial health effects. In Siddha medicine, the presence of phytochemicals in herbal medicines contributes to their therapeutic properties, forming an integral part of evaluating the efficacy of remedies like 'Naaga Sangu Parpam'.
15) Discussion:
Discussion in the context of a research paper refers to the section where results are interpreted and implications are elaborated. It provides insights on how findings from the study on 'Naaga Sangu Parpam' contribute to understanding the medicine's efficacy and potential applications in therapeutic practices.
16) Developing:
Developing relates to countries or regions that are in the process of industrial growth and modernization. The text highlights the importance of integrating traditional knowledge with scientific validation in developing nations, emphasizing the need for a cohesive approach to healthcare that respects and incorporates traditional medicine.
17) Knowledge:
Knowledge pertains to the understanding and information acquired through experience or education. In this context, it emphasizes the rich heritage of Siddha medicine, the importance of preserving traditional knowledge, and the necessity for scientific investigation to validate these practices in modern healthcare settings.
18) Container:
Container usually refers to any receptacle used to hold or store substances. In the context of the study, it may signify the plastic containers used for sample preparation in ICP-OES analysis, which ensure that the samples maintain their integrity and are properly handled for accurate measurement.
19) Murukavel:
Murugavel refers to one of the authors involved in the research study. Individuals like Murugavel contribute to the scientific validation and standardization of traditional medicines, enhancing the credibility and understanding of Siddha practices within the scientific community and promoting their relevance in modern healthcare.
20) Disease:
Disease signifies a state of health characterized by specific symptoms or dysfunctions. Siddha medicine aims to treat diseases through holistic approaches that involve natural remedies, incorporating both herbal ingredients and minerals, reflecting the system’s comprehensive understanding of health and well-being.
21) Filling (Filled):
Filling denotes the process of adding material into a container or space. In laboratory processes, it can refer to filling crucibles with samples during thermal or analytical testing, ensuring that the necessary conditions for accurate analysis, such as that of 'Naaga Sangu Parpam', are achieved.
22) Surface:
Surface refers to the outermost layer of an object or material. In the context of laboratory analysis, surface characteristics can influence reactions or measurements, such as in thermogravimetric analysis, where the surface condition of a sample can affect heat transfer and resulting data observed during experiments.
23) Medium:
Medium in the context of analytical chemistry often refers to a substance through which samples are prepared or analyzed, like the aqueous solutions in ICP-OES. It denotes the environment used to facilitate reactions or deliver substances during testing procedures of herbal formulations.
24) Powder:
Powder refers to a finely ground solid substance. In the preparation of Siddha medicines, herbs or minerals are often ground into powder to facilitate mixing, extraction, or further processing, as seen in the preparation of samples for FTIR analysis in validating the properties of 'Naaga Sangu Parpam'.
25) Madra:
Madra serves as an alternative historically used term for Madras. It underscores the city's rich cultural background and its association with traditional sciences, including Siddha medicine, emphasizing the importance of place in the heritage and practice of ancient medicinal systems within contemporary contexts.
26) Water:
Water is vital for all forms of life and is often an essential medium in scientific procedures. In the study, the term likely refers to the usage in creating solutions for sample preparation in analytical techniques, including dilution steps necessary for accurate elemental analysis in ICP-OES.
27) Field:
Field often denotes an area of study or specialized practice. In the context of the research, it represents the field of pharmaceutical research, particularly the integration of traditional medical practices with modern scientific methods to validate and understand the efficacy of Siddha remedies.
Other Science Concepts:
Discover the significance of concepts within the article: ‘Validation of Naaga Sangu Parpam via FTIR, ICP-OES, and TGA.’. Further sources in the context of Science might help you critically compare this page with similair documents:
Active principle, Herbo-mineral formulation, Fourier transform infrared spectroscopy, Inductively coupled plasma optical emission spectrometry, Siddha system of medicine, Traditional medicinal system, Thermogravimetric analysis, Functional group, Residual Volume, Organic functional groups, Phytochemicals and minerals.