Endophytic bacteria as a budding reserve of new antibiotics
Journal name: World Journal of Pharmaceutical Research
Original article title: Endophytic bacteria as a budding reserve of new antibiotics
The WJPR includes peer-reviewed publications such as scientific research papers, reports, review articles, company news, thesis reports and case studies in areas of Biology, Pharmaceutical industries and Chemical technology while incorporating ancient fields of knowledge such combining Ayurveda with scientific data.
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Aleena Roy, Abdulla Shareef, Aiswarya Vasavan, Amal John James, Chitra C. Nair and Ammu S.
World Journal of Pharmaceutical Research:
(An ISO 9001:2015 Certified International Journal)
Full text available for: Endophytic bacteria as a budding reserve of new antibiotics
Source type: An International Peer Reviewed Journal for Pharmaceutical and Medical and Scientific Research
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Summary of article contents:
Introduction
The rapid increase in the human population has coincided with a decline in ecosystem health, leading to a surge in health issues, particularly the rise of drug-resistant bacteria. This has highlighted the urgent need for new antibiotics to combat these resistant strains. Endophytic bacteria (EB), microorganisms residing within plant tissues without causing harm, are emerging as a promising source of novel antibiotics. As researchers explore the potential of EB, they may provide vital solutions in addressing antibiotic resistance and contributing to health advancements.
Endophytic Bacteria as a Novel Antibiotic Source
Endophytic bacteria play a crucial role in the production of a variety of bioactive compounds, including alkaloids, terpenoids, and antibiotics. These microorganisms can be categorized into obligate and facultative endophytes, with the former living exclusively within plant tissues and the latter capable of survival in multiple environments, including soil. The antibiotics produced by these bacteria possess diverse structural classes, indicating their potential in medical applications. Specific examples of novel antibiotics sourced from EB include Ecomycins and Munumbicins, demonstrating their antimicrobial capabilities against various pathogens.
Bioactive Compounds and Their Applications
The bioactive compounds derived from endophytic bacteria are not only limited to antibiotics; they also exhibit a range of beneficial activities. These include antioxidant, anticancer, and anti-diabetic properties. Natural products, such as paclitaxel derived from the Yew tree, exemplify the potential of compounds synthesized by these microorganisms. Moreover, research indicates that endophytic bacteria can enhance plant growth through mechanisms like hormone production and nutrient acquisition, thereby serving dual roles as both antibiotic sources and plant growth-promoting agents.
Role of Endophytic Bacteria in Agriculture
Endophytic bacteria significantly contribute to agricultural productivity by promoting plant growth and increasing resistance to pathogens. By leveraging their ability to produce various natural substances, including phytohormones and enzymes, these bacteria can be harnessed as bio-fertilizers in organic farming practices. The integration of EB in agriculture presents an innovative approach to sustainable farming, promoting healthier crop yield while addressing issues related to chemical fertilizers and pesticides.
Conclusion
The exploration of endophytic bacteria highlights their vast potential as a source of new antibiotics amid rising drug resistance. As the understanding of their biological functions and interactions with host plants broadens, there is an increasing opportunity to tap into their unique characteristics for medical and agricultural advancements. Future research efforts should focus on uncovering the mechanisms behind their compound production, thus facilitating the development of safe and effective therapies derived from these beneficial microorganisms. Collaboration among diverse scientific disciplines will be vital in realizing the full potential of EB in combating health challenges and promoting sustainable agriculture practices.
FAQ section (important questions/answers):
What are endophytic bacteria and their significance?
Endophytic bacteria live inside plant tissues without causing disease, playing a crucial role in producing bioactive compounds that may lead to new antibiotics and enhance plant growth.
Why is antibiotic resistance a growing concern?
The rise of drug-resistant bacteria poses significant health risks, making it essential to discover new antibiotics and explore alternative sources, such as endophytic bacteria.
What types of endophytic bacteria exist?
Endophytic bacteria can be categorized into obligate endophytes, which reside in plants for their lifespan, and facultative endophytes, which can survive in various environments, including soil.
How do endophytic bacteria contribute to agriculture?
Endophytic bacteria enhance plant growth by producing hormones, solubilizing nutrients, and increasing resistance to pathogens, which are beneficial for sustainable agricultural practices.
What novel antibiotics have been discovered from endophytic bacteria?
Examples of antibiotics produced by endophytic bacteria include Ecomycins, Pseudomycins, and Munumbicins, which exhibit various antimicrobial activities against different pathogens.
What is the future potential of endophytic bacteria?
As research advances, endophytic bacteria may become a key resource for discovering novel antibiotics and compounds beneficial for health and agriculture, promising a fruitful area for bioprospecting.
Glossary definitions and references:
Scientific and Ayurvedic Glossary list for “Endophytic bacteria as a budding reserve of new antibiotics”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.
1) Antibiotic (Antibacterial):
Antibacterial refers to agents or compounds that inhibit the growth of bacteria or kill bacteria, ensuring the cure of infections. Many endophytic bacteria produce antibacterial substances, contributing significantly to the development of new antibiotics. This underpins the importance of exploring endophytes as sources for antibacterial agents.
2) Cancer:
Cancer is a significant global health concern characterized by uncontrolled cell growth. The text highlights the potential of endophytic bacteria in producing bioactive compounds with antitumor properties, indicating their relevance in developing future cancer therapies. Exploring these natural products offers hope for more effective cancer treatments.
3) Drug:
Drugs are substances that alter bodily functions and are used in medical treatments. The research underscores the importance of discovering new drugs derived from bacterial sources, particularly endophytes, to address the pressing issue of antibiotic resistance and improve existing treatment options.
4) Soil:
Soil serves as a habitat for various microorganisms, including bacteria which are a source for many antibiotics. The examination of endophytic bacteria that can be isolated from soil highlights their potential in yielding novel antibiotics, showcasing a vital link between soil ecology and pharmaceutical development.
5) Activity:
Activity in this context refers to the biological effects exhibited by the compounds produced by endophytic bacteria. The potential activities include antibacterial, antifungal, and anticancer effects, emphasizing the importance of these natural products in research aimed at discovering effective treatments for various infectious diseases.
6) Disease:
Diseases refer to pathological conditions that impair normal body functions. The increasing prevalence of various diseases globally necessitates ongoing research in finding new ways to effectively treat infections, with endophytic bacteria standing at the forefront of this search for innovative solutions.
7) Science (Scientific):
Sciences encompass various fields of study that work collaboratively in researching endophytic bacteria and their bioactive compounds. The integration of microbiology, pharmacology, and botany is essential for advancing our understanding and harnessing the potential of these microorganisms for drug development.
8) Agriculture:
Agriculture is the practice of cultivating plants and livestock. The text discusses how endophytic bacteria can enhance plant growth and protect against pathogens, illustrating their dual role in improving agricultural productivity while also serving as a source for novel bioactive compounds.
9) Flavonoid:
Flavonoids are a diverse group of plant metabolites known for their antioxidant properties. The role of flavonoids produced by endophytic bacteria in enhancing plant resistance to stress and disease showcases their importance in both agriculture and potential therapeutic applications against various diseases.
10) Fixation:
Fixation, particularly nitrogen fixation, refers to the process of converting atmospheric nitrogen into a form usable by plants. Endophytic bacteria contribute to this process, indicating their role in promoting plant health and sustainability, which is crucial for agricultural productivity and food security.
11) Species:
Species denote distinct groups of organisms that share similar characteristics and can reproduce among themselves. The text references various bacterial species that produce bioactive compounds, underscoring the biodiversity of endophytes in different plants and their significance for pharmacological advancements.
12) Kerala:
Kerala is a state in India known for its biodiversity and rich flora. The article highlights the isolation of endophytic bacteria from plants in Kerala, emphasizing the region's potential as a source for novel antibiotics and other bioactive compounds used in medicinal applications.
13) Animal:
Animals encompass a wide range of organisms that may suffer from bacterial infections. The text suggests that exploring endophytic bacteria could lead to new treatments not only for humans but also for animals, underlining the importance of these microorganisms in veterinary medicine.
14) Fight:
Fight in this context refers to the battle against antibiotic resistance. Research into endophytic bacteria represents a crucial strategy in this fight, as these microorganisms may provide effective new antibiotics to combat resistant strains of bacteria, thereby preserving the efficacy of current treatments.
15) Tree:
Trees are essential for ecological balance and serve as habitats for endophytic bacteria. The article’s emphasis on the medicinal properties extracted from these trees highlights their potential for providing valuable bioactive compounds, showcasing the interconnectedness of forestry and medicine.
16) Life:
Life refers to the condition of being alive, characterized by growth, reproduction, and metabolism. Endophytic bacteria live inside plant tissues, contributing to both the health of the host plant and offering potential benefits for human health through their production of bioactive compounds, exemplifying the interconnectedness of life forms.
17) Chemotherapy:
Chemotherapy involves the use of drugs to treat cancer. The potential discovery of new bioactive compounds from endophytic bacteria may lead to innovative chemotherapy agents, providing additional therapies to enhance the efficacy of current cancer treatments in combating tumor cells.
18) Tuberculosis:
Tuberculosis (TB) is a contagious bacterial infection primarily affecting the lungs, characterized by drug resistance. Research into antibiotic-producing endophytic bacteria is particularly relevant for TB treatment, highlighting the urgency of discovering new antibiotics to effectively treat resistant strains of this disease.
19) Gajalakshmi (Gajalaksmi, Gaja-lakshmi):
Gajalakshmi refers to co-authors of the research who may have contributed expertise in their fields. Their collaboration indicates the interdisciplinary approach to studying endophytic bacteria and their potential pharmaceutical applications, showcasing the collective effort in addressing complex health challenges through research.
20) Developing:
Developing in this context refers to the process of creating new antibiotics or therapeutics from endophytic bacteria. The emphasis on developing effective and novel compounds highlights the ongoing need for advancements in medicinal chemistry, particularly in combating antibiotic-resistant infections.
21) Substance:
A substance is a particular kind of matter with uniform properties. In the context of this research, it highlights the specific bioactive compounds produced by endophytic bacteria that can be isolated for therapeutic use, marking their significant role in modern medicine.
22) Medicine:
Medicine encompasses the science and practice of diagnosing, treating, and preventing disease. The potential role of endophytic bacteria in producing novel antibiotics emphasizes their importance in the ongoing evolution of medicine towards addressing pressing health issues such as antibiotic resistance.
23) Solanki:
Solanki is an author mentioned in the article, contributing to the research on endophytic bacteria. Authors from diverse backgrounds help weave intricate connections between microbiology and pharmacology, enhancing our understanding of the potential these bacteria possess for drug discovery.
24) Vacavan:
Vasavan refers to a contributor to the research endeavor. The involvement of multiple students illustrates the collaboration between academic institutions and researchers, fostering a supportive environment for exploration into the biomedical potentials of endophytic bacteria.
25) Surface:
Surface refers to the external layer of plants and environments. The exploration of endophytic bacteria residing on the surface or within plant tissues indicates the various niches from which novel bioactive compounds can be extracted, essential for expanding our antibiotic arsenal.
26) Gurung:
Gurung is noted as an author involved in the research. The collaboration of various authors exemplifies a multidisciplinary approach towards understanding and utilizing endophytic bacteria, which is vital for expanding the scope of potential pharmaceutical applications.
27) Nature:
Nature refers to the inherent qualities of the biological environment. Understanding the role of endophytic bacteria in nature, particularly their interactions within plant ecosystems, aids in uncovering their potential benefits for medicine and agriculture, bridging ecological knowledge with health advancements.
28) Reason:
Reason denotes the underlying motivation for studying endophytic bacteria, which lies in their potential as novel sources of antibiotics. This highlights the critical nature of research in addressing antibiotic resistance and developing effective treatments for a range of infections.
29) Chang:
Chang denotes an author of the referenced research articles. The inclusion of multiple authors indicates a team effort in the scientific study of endophytic bacteria and strengthens the narrative of collaborative research aimed at uncovering new medical applications.
30) Blood:
Blood is vital for carrying oxygen and nutrients throughout the body. The connection to endophytic bacteria may arise from their potential impact on health, particularly in producing compounds that could treat diseases related to blood, such as cancers, illustrating their therapeutic promise.
31) Raja:
Raja refers to another contributor to the research team. The diverse expertise among authors enriches the research, providing a comprehensive understanding of the bioactive compounds produced by endophytic bacteria and their applications in addressing health problems.
32) Devi:
Devi is mentioned as an author, highlighting the collaborative nature of the research process. The combined efforts of authors with different specialties are crucial in advancing knowledge regarding the therapeutic application of endophytic bacteria in combating various diseases.
33) Ting:
Ting is referenced as an author in the work presented. Their contribution reflects the collaborative nature of scientific research, particularly in exploring endophytic microbiology, which requires interdisciplinary knowledge to uncover innovative solutions in health and agriculture.
34) Wall:
Wall is likely a contributor to the scientific discussions surrounding the research. The collaboration between authors emphasizes the importance of pooling expertise in advancing understanding and therapeutic potential derived from endophytic bacteria for combating diseases.
35) Line:
Line may refer to a boundary or a distinct boundary in scientific categorization. In the context of endophytic research, drawing clear lines in understanding different bacterial species and their applications for drug development is essential for efficient bioprospecting.
36) Salt (Salty):
Salt is a crucial element in various biological processes. The mention of salt suggests a relevance in exploring endophytic bacteria’s role in enhancing plant growth resilience against salinity stress, indicating broader applications for these microorganisms in agriculture and biotechnology.
Other Science Concepts:
Discover the significance of concepts within the article: ‘Endophytic bacteria as a budding reserve of new antibiotics’. Further sources in the context of Science might help you critically compare this page with similair documents:
Natural product, Antimicrobial activity, Drug resistant bacteria, Antibiotic resistance, Antiviral properties, Bioactive compound, Cancer treatment, Environmental sustainability, Ecological conditions, Pharmaceutical application, Novel antibiotic, Agricultural application.