Study of Trishna Nigrahana Mahakashaya for managing Type 2 Diabetes

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Journal name: World Journal of Pharmaceutical Research
Original article title: A pharmaceutical and pharmacognostical study of trishna nigrahana mahakashaya ghanavati in the management of kleda w.s.r. to madhumeha (type 2 diabetes)
The WJPR includes peer-reviewed publications such as scientific research papers, reports, review articles, company news, thesis reports and case studies in areas of Biology, Pharmaceutical industries and Chemical technology while incorporating ancient fields of knowledge such combining Ayurveda with scientific data.
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Author:

Priya Gupta, A. S. Baghel and Harisha C. R.


World Journal of Pharmaceutical Research:

(An ISO 9001:2015 Certified International Journal)

Full text available for: A pharmaceutical and pharmacognostical study of trishna nigrahana mahakashaya ghanavati in the management of kleda w.s.r. to madhumeha (type 2 diabetes)

Source type: An International Peer Reviewed Journal for Pharmaceutical and Medical and Scientific Research

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Summary of article contents:

Introduction

The study conducted by Priya Gupta et al. focuses on the Ayurvedic formulation known as Trishna Nigrahana Mahakashaya Ghanavati, which aims to manage Kleda, or body moisture, particularly in the context of Type 2 Diabetes (Madhumeha). The research emphasizes the importance of water in Ayurveda, not just as a crucial element of the body but also as a therapeutic component. In Ayurvedic tradition, thirst is recognized as a natural urge and can be treated through specific herbal formulations. This study provides pharmacognostical and physicochemical evaluations of the Ghanavati form, thereby validating its potential role in treatment.

Importance of Trishna Nigrahana Mahakashaya

Trishna Nigrahana Mahakashaya consists of several herbs including Zingiber officinale (Nagar), Fagonia cretica (Dhanvayasa), and Cyperus rotundus (Musta), among others. These ingredients are traditionally considered beneficial for controlling excessive thirst and managing moisture in the body. The formulation aims to suppress the urge to drink unnecessarily, which is particularly beneficial for diabetic patients who often experience increased thirst due to frequent urination. The study underscores the Ayurvedic perspective that acknowledges Pipasa (the urge to drink) as a potential exacerbating factor in lifestyle disorders.

Pharmacognostical Evaluation

Pharmacognostical analysis confirms the authenticity of the constituents used in the formulation. The study meticulously details the organoleptic characteristics such as texture, color, and odor, and employs microscopic techniques to identify specific features of the ingredient herbs. Each herb's morphological traits were documented, providing a comprehensive account of the formulation's authenticity. Key findings include the identification of starch grains, fibers, and various cellular structures, illustrating the diverse botanical composition of the Ghanavati.

Physicochemical Parameters

The physicochemical evaluation of Trishna Nigrahana Mahakashaya Ghanavati revealed critical attributes about its quality and efficacy. The parameters assessed include tablet hardness, disintegration time, loss on drying, and extractive values. The tablet exhibited favorable characteristics, confirming its consistency and stability. With significant values for both water-soluble (31.12% w/w) and methanol-soluble extracts (21.36% w/w), the formulation is likely to provide therapeutic efficiency that aligns with Ayurvedic principles regarding dosage and efficacy.

Conclusion

The transition from a decoction form (Kwatha) to a tablet form (Ghanavati) addresses the practical challenges of preparation and adherence often faced by patients. The Ghanavati formulation is viewed as user-friendly, convenient for consumption, and potentially more attractive due to its improved shelf life and portability. This study not only confirms the pharmacognostical and physicochemical profiles of the Trishna Nigrahana Mahakashaya Ghanavati but also highlights its relevance in managing Kleda in Type 2 Diabetes. Future research should focus on clinical evaluations to further establish the formulation's effectiveness and integration into contemporary treatment protocols for lifestyle diseases.

FAQ section (important questions/answers):

What is the focus of the study on Trishna Nigrahana Mahakashaya Ghanavati?

The study evaluates the role of Trishna Nigrahana Mahakashaya Ghanavati in managing Kleda, or body moisture, particularly related to Madhumeha (Type 2 Diabetes).

What principles does Ayurveda emphasize regarding water and thirst management?

Ayurveda considers water a vital element and uses thirst control as a treatment modality, integrating it into a comprehensive approach towards health and disease management.

How was the Trishna Nigrahana Mahakashaya Ghanavati prepared?

The formulation was prepared by mixing authenticated herbal drugs, boiling the mixture with water, and then forming tablets from the concentrated extract, known as Ghana.

What were the significant findings from the pharmacognostical evaluation?

The evaluation revealed characteristic structures like collenchyma cells of Guduchi and starch grains of Shunti, confirming the authenticity of the ingredients used in the formulation.

What were the physicochemical parameters assessed for the formulation?

Parameters included average tablet weight, hardness, disintegration time, loss on drying, and extractive values, which helped ensure quality and efficacy.

What is the expected outcome of this Ayurvedic formulation?

The formulation is designed to manage body moisture levels and control thirst in diabetic patients, aiming to break the cycle of excessive water intake associated with Diabetes.

Glossary definitions and references:

Scientific and Ayurvedic Glossary list for “Study of Trishna Nigrahana Mahakashaya for managing Type 2 Diabetes”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.

1) Mahakashaya (Mahakasaya, Maha-kashaya):
Mahakashaya refers to a specific group of Ayurvedic formulations, primarily used for treating various ailments. These therapeutic mixtures facilitate balance within the body and often emphasize the benefits of herbal ingredients to manage particular health issues, such as thirst and liquid consumption moderation, making them essential elements in Ayurvedic practice.

2) Trishna (Trsna):
Trishna translates to 'thirst' in Sanskrit and represents not only the physical sensation of needing water but also a profound concept in Ayurveda. It signifies the body's signals and encourages practitioners to understand the underlying imbalances that cause this urge, and thus helps in the treatment of various conditions including diabetes.

3) Trishnanigrahana (Trsnanigrahana, Trishna-nigrahana):
Trishna-nigrahana means the restraining or controlling of thirst. It embodies Ayurvedic practices that help mitigate excessive thirst, which is often linked to conditions like diabetes. This concept emphasizes balancing bodily fluids and can be applied in therapeutic contexts for enhancing patient care and overall health.

4) Vati:
Vati is a term that denotes a tablet or pill in Ayurvedic medicine. It refers to herbal formulations compressed into a solid dosage, facilitating easier administration, consistent dosing, and improved stability compared to decoctions. This form greatly enhances patient compliance and is particularly relevant in managing chronic conditions.

5) Water:
Water, known as 'Jala' in Ayurveda, is viewed as a foundational element of life and an essential part of human health. Its role encompasses hydrating the body and aiding in treatment regimes for various diseases, emphasizing moderation in consumption—a critical aspect for conditions like diabetes.

6) Patola:
Patola, or Trichosanthes dioica, is a medicinal plant in Ayurveda known for its therapeutic properties. It's included in formulations aimed at managing various ailments, including diabetes. Patola contributes to balancing bodily moisture and plays a significant role in enhancing the effectiveness of holistic treatments.

7) Musta (Mushta):
Musta, or Cyperus rotundus, is a vital herb in Ayurvedic medicine known for its cooling properties and effectiveness in managing gastrointestinal and metabolic disorders. Its inclusion in formulations like Trishna Nigrahana Mahakashaya Ghanavati aids in managing thirst and helps improve overall health.

8) Gupta:
Gupta is the surname of researchers mentioned in the study, likely a principal investigator or author. Their contributions are crucial for advancing knowledge in the field of Ayurvedic pharmacology and pharmacognosy, reflecting the collaborative efforts in researching and validating traditional practices in modern contexts.

9) Thirst:
Thirst is a natural physiological response that signals the need for hydration. In Ayurvedic terms, it is associated with imbalances that need to be addressed through dietary modifications and herbal therapies, particularly for managing conditions such as diabetes, where controlling water intake is pivotal.

10) Drug:
Drugs in the Ayurvedic context refer to medicinal compounds, typically derived from plants. They play a vital role in treatment strategies for various diseases, signifying the importance of traditional herbal medicine in providing therapeutic solutions within comprehensive healthcare frameworks.

11) Pharmacognostical:
Pharmacognostical relates to the study of medicinal drugs derived from plants and other natural sources. This aspect is critical in Ayurveda for authenticating herbal ingredients and assessing their medicinal properties, which is essential for ensuring quality control and efficacy in therapeutic applications.

12) Table:
In this document, 'table' refers to organized data presentations that summarize ingredients, observations, and results regarding Ayurvedic formulation research. Such tables facilitate clarity and comparison, allowing researchers and practitioners to synthesize information and understand the relevance of various components in treatments.

13) Dhanyaka:
Dhanyaka, or Coriandrum sativum, is often utilized in Ayurvedic medicine for its carminative and digestive properties. It aids in enhancing the efficacy of treatments by promoting overall health and stability in bodily functions, making it a significant ingredient in herbal formulations.

14) Gujarat:
Gujarat is a state in India where the research was conducted. It is home to Gujarat Ayurved University, an institution dedicated to Ayurvedic education and research, thereby forming a vital backdrop for the studies on herbal formulations and traditional healthcare practices.

15) Study (Studying):
The term 'study' in this context refers to structured research on the pharmacological and pharmacognostical evaluation of Ayurvedic remedies. Such studies are essential for validating traditional practices, enhancing the precision of treatments, and bridging the gap between ancient methodologies and modern scientific inquiry.

16) Ayurveda (Ayus-veda):
Ayurveda is a traditional Indian system of medicine focusing on holistic health through balance and harmony in body, mind, and spirit. It employs natural remedies, dietary practices, and lifestyle modifications, rendering it significant in managing chronic conditions such as diabetes through herbal formulations.

17) Disease:
Diseases denote various health conditions affecting individuals. In Ayurveda, a deep understanding of disease progression leads to tailored treatments using natural remedies, emphasizing the importance of individualized therapeutic approaches for promoting health and preventing chronic conditions.

18) Kleda:
Kleda signifies moisture in the body according to Ayurvedic concepts. It is related to various conditions, particularly in diabetes, where managing body moisture levels is crucial. Herbal formulations such as Trishna Nigrahana Mahakashaya Ghanavati help control Kleda, aiding in overall disease management.

19) Bitter:
Bitter is one of the tastes described in Ayurveda, playing a critical role in digestion and detoxification. Herbs with bitter properties are often used in formulations to stimulate digestive enzymes and enhance metabolic processes, making them valuable in managing excess moisture and related conditions.

20) Powder:
Powder refers to the form in which many herbs and ingredients are processed in Ayurveda. This state allows for easy incorporation into formulations and aids in the extraction of essential compounds, enhancing the effectiveness of the medicinal properties of the ingredients used.

21) India:
India, the birthplace of Ayurveda, houses a rich tradition of medicinal practices and holistic health approaches. Its diverse flora has been extensively utilized for centuries in the formulation of herbal medicines, significantly contributing to the global understanding of natural therapies and drug discovery.

22) Medicine:
Medicine here refers to the practice and application of health care, particularly in the context of Ayurveda. It encompasses a comprehensive system of healing, focusing on preventive measures, holistic well-being, and the use of natural substances for curing ailments.

23) Performance:
Performance refers to the effectiveness and quality of Ayurvedic formulations in achieving desired health outcomes. Rigorous evaluations ensure that herbal medicines work effectively within specific therapeutic contexts, helping practitioners recommend reliable treatment strategies to their patients.

24) Pipasa:
Pipasa is the Sanskrit word for 'thirst' and represents the physiological desire for water. It is relevant in Ayurvedic treatments, especially in understanding the conditions that lead to excess thirst, and the necessary interventions to manage such symptoms wisely.

25) Tinospora cordifolia:
Tinospora cordifolia, or Guduchi, is a crucial herb in Ayurveda recognized for its medicinal properties. It is touted for immunomodulatory effects and is included in various formulations targeted towards regulating body moisture and managing diseases like diabetes.

26) Zingiber officinale:
Zingiber officinale, commonly known as ginger, is a widely used herb in Ayurveda. Its warming properties aid digestion and circulation, making it a valuable ingredient in treatments aimed at managing conditions stemming from an imbalance of bodily fluids, particularly gastrointestinal issues.

27) Cyperus rotundus:
Cyperus rotundus, known as Musta, is an important herb in Ayurvedic medicine with applications in digestive health and metabolic regulation. It is included in formulations aimed at managing moisture levels in the body and improving overall health through balancing properties.

28) Santalum album:
Santalum album refers to sandalwood, a precious herb with a long history in Ayurvedic practices. Its aroma and properties are believed to provide calming effects, making it integral in managing conditions related to excess Kleda and promoting emotional and physical well-being.

29) Kiratatikta (Kirata-tikta):
Kiratatikta, or Swertia chirata, is an Ayurvedic herb known for its bitter taste and detoxifying effects. It is especially useful in balancing bodily fluids and used in formulations aimed at managing excess moisture and overall metabolic balance.

30) Observation:
Observation refers to the systematic examination of results from clinical and pharmacological experiments. This aspect is essential in Ayurvedic research to validate the efficacy of herbal formulations, facilitating scientific insights into traditional practices.

31) Apatarpana:
Apatarpana signifies a therapeutic approach in Ayurveda that focuses on reducing excess within the body. It is a crucial concept for managing conditions that lead to imbalance, particularly in obesity and metabolic disorders like diabetes, advocating for interventions that restore balance.

32) Parpataka:
Parpataka, or Fumaria parviflora, is a medicinal plant used in Ayurveda for its beneficial properties related to stimulate digestion and detoxification. Its incorporation in herbal formulas aids in managing Kleda and other lifecycle imbalances in patients.

33) Tikta:
Tikta is the Sanskrit word for 'bitter' and is one of the six tastes recognized in Ayurveda. Bitter herbs are often used to aid digestion, detoxify, and promote metabolic balance, playing an essential role in managing diseases like diabetes.

34) Priya:
Priya likely refers to the lead author or primary researcher of the study. Their efforts reflect the significance of scientific inquiry in Ayurveda, promoting rigorous methodologies and validation of traditional healing practices within modern medical frameworks.

35) Ghana:
Ghana refers to a concentrated herbal extract in Ayurvedic medicine. This form is crucial for creating potent preparations that enhance the bioavailability of active ingredients, thereby improving the therapeutic efficacy of formulations used in patient care.

36) Rules:
Rules in Ayurveda encompass the guidelines and principles governing the practice of medicine. These dictate dietary habits, herbal usage, and lifestyle choices essential for maintaining health and preventing diseases, thereby establishing a holistic approach to wellness.

37) Nakar:
Nagar refers to Zingiber officinale, an important herb recognized for its health benefits in Ayurveda. Its incorporation in various formulations enhances digestive health and plays a role in regulating bodily moisture, making it valuable in the context of diabetes treatment.

38) Rasa (Rasha):
Rasa translates to 'taste' in Sanskrit and is a cornerstone concept in Ayurveda, classifying foods and herbs based on their flavor profiles. Understanding Rasa is key for determining how various substances influence bodily balance and health.

39) Trichosanthes dioica:
Trichosanthes dioica, known as Patola, is an important herb in Ayurveda recognized for its health benefits, particularly in managing metabolic disorders. It plays a pivotal role in formulations aimed at regulating bodily moisture and treating thirst-related issues.

40) Sutrasthana (Sutra-sthana):
Sutra-sthana refers to a section in ancient Ayurvedic texts, often discussing foundational principles of treatment and health management. Knowledge from this classical literature underpins modern Ayurvedic practices and contributes to the understanding of balancing bodily functions.

41) Dhanvayasa:
Dhanvayasa, or Fagonia cretica, is a plant used in Ayurvedic formulations due to its health-promoting properties. Its role in managing symptoms related to diabetes and Kleda emphasizes the significance of incorporating various herbs in holistic treatments.

42) Discussion:
Discussion in research encompasses the interpretation of findings, relating them to existing knowledge and clinical implications. This section is crucial for advancing understanding in Ayurvedic research, fostering a dialogue on the effectiveness of traditional practices in the modern healthcare landscape.

43) Mahabhuta (Maha-bhuta):
Mahabhuta refers to the five great elements in Ayurveda—earth, water, fire, air, and ether—which constitute all matter. Understanding these elements is fundamental to Ayurvedic philosophy and practice, thereby influencing the basis of disease, treatment, and overall health.

44) Ghanavati:
Ghanavati denotes the solid extract or tablet form of Ayurvedic formulations. This format enhances convenience and stability of herbal medications, making it easier to administer and consume compared to traditional liquid decoctions, addressing practical challenges in patient treatment regimens.

45) Container:
Container signifies the vessel used for preparing or storing herbal formulations in Ayurveda. Proper containment is essential for preserving the integrity and potency of medicinal preparations, highlighting the relevance of materials used in the preparation processes.

46) Langhana (Lamghana):
Langhana refers to a therapeutic approach in Ayurveda aimed at reducing excess body mass or fluids. This principle is particularly beneficial in managing obesity and diseases associated with excess moisture, emphasizing the necessity of balanced bodily substances.

47) Harisha (Harisa):
Harisha likely refers to one of the co-authors in the study, contributing to the research on Ayurvedic formulations. The collaborative efforts exemplify the importance of teamwork and diverse skill sets in advancing Ayurvedic medicinal practices.

48) Kashaya (Kasaya):
Kashaya means 'astringent' in Ayurveda and is one of the six tastes recognized in the system. Astringent herbs are particularly effective in managing imbalances related to moisture, which can be crucial for treating conditions like diabetes and excess Kleda.

49) Pungent:
Pungent represents one of the six tastes in Ayurveda, associated with stimulating digestion and circulation. Herbs with pungent characteristics are vital in formulations targeting metabolic disorders, helping to balance bodily fluids and encourage detoxification.

50) Channel:
Channel refers to pathways or systems in the body through which substances and energies flow. In Ayurveda, understanding these channels is essential for diagnosing and treating diseases effectively, highlighting the interconnectedness of bodily functions.

51) Heating:
Heating in the context of Ayurvedic preparations refers to the process of cooking or processing herbs to extract beneficial compounds. This technique is crucial for enhancing the potency of medicinal formulations, thereby affecting therapeutic outcomes.

52) Burning (Burn, Burned, Burnt):
Burning represents a method used in certain Ayurvedic preparations to alter the properties of herbs. This practice is often aimed at enhancing the effectiveness of the active components, although it requires care to avoid harmful degradation of the medicinal properties.

53) Science (Scientific):
Science in this context refers to the systematic study and validation of Ayurveda using empirical research methods. Integrating scientific approaches helps bridge traditional knowledge and modern medicine, enhancing understanding and acceptance of Ayurvedic practices in contemporary healthcare.

54) Vikara:
Vikara relates to diseases or disorders in Ayurvedic terminology. Understanding Vikara is essential for identifying imbalances and developing targeted treatment strategies aimed at restoring harmony within the body, thereby addressing health concerns effectively.

55) Ruksha (Ruksa):
Ruksha signifies 'dryness' in Ayurveda and is associated with specific therapeutic properties. It describes certain herbs that can help reduce moisture and excessive bodily fluids, making them valuable in the management of diseases like diabetes associated with Kleda.

56) Sthana:
Sthana means 'location' or 'place' in Sanskrit and refers to the positioning of various bodily elements and functions in Ayurvedic philosophy. Understanding Sthana is vital for diagnosing diseases and formulating appropriate treatments within the holistic framework of Ayurveda.

57) Cotton:
Cotton typically refers to the material used for filtering herbal preparations in Ayurveda. Its inclusion in the preparation process helps in obtaining clear extracts, ensuring that the medicinal properties of the ingredients are preserved effectively.

58) Sutra:
Sutra refers to aphorisms or concise statements that encapsulate Ayurvedic principles and practices. They serve as foundational guidelines for understanding and practicing Ayurveda, facilitating the transmission of knowledge across generations.

59) Ushna (Usna):
Ushna translates to 'hot' in Ayurveda, describing the properties of certain herbal substances. This classification is important for treatments targeting cold conditions or excess moisture, as Ushna herbs can provide balancing effects within the body.

60) Virya:
Virya refers to the inherent potency or strength of a substance in Ayurveda. It determines the therapeutic action of herbs, influencing their medicinal properties, and is a crucial concept in the formulation of effective treatments.

61) Agni:
Agni signifies 'digestive fire' in Ayurveda, representing the body's capacity to digest food and process nutrients. Maintaining balanced Agni is foundational for overall health, influencing everything from metabolism to disease management.

62) Katu:
Katu refers to the 'pungent' taste in Ayurveda, associated with stimulating digestion and promoting circulation. This taste plays a significant role in herbal formulations, particularly those intended for metabolic health and maintaining fluid balance.

63) Guna:
Guna denotes the inherent qualities or attributes of substances in Ayurveda. Each Guna has implications for its therapeutic effects, guiding practitioners in selecting the appropriate herbs and treatments for individual patient needs.

64) Jala:
Jala translates to 'water' in Sanskrit, underscoring its fundamental importance in Ayurvedic practices. Water is regarded as essential for life, influencing the various bodily processes and representing a central focus in treatments addressing hydration and moisture management.

65) Fire:
Fire in Ayurveda is represented by Agni or digestive heat, central to metabolic processes. Understanding the functional role of fire is crucial in treatment strategies, impacting digestion, absorption, and overall health maintenance.

66) Hand:
Hand signifies the tangible application of Ayurvedic principles in preparing herbal medications. It reflects the artisanal aspect of this ancient practice, emphasizing the integration of knowledge and skill in formulating effective remedies.

67) Life:
Life represents the holistic understanding of health in Ayurveda, emphasizing the integral connection between physical, mental, and spiritual well-being. Managing health through Ayurvedic practices fosters a balanced lifestyle, promoting vitality and longevity.

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Pipasa, Madhumeha, Ayurvedic system of medicine, Kwatha, High performance thin layer chromatography, Research article, Pharmaceutical evaluation, Pharmacognostical study, Physicochemical evaluation, Organoleptic features.

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