Recent Advances in Emulgels for Enhanced Topical Drug Delivery
recent developments
Journal name: World Journal of Pharmaceutical Research
Original article title: Emulgels
The WJPR includes peer-reviewed publications such as scientific research papers, reports, review articles, company news, thesis reports and case studies in areas of Biology, Pharmaceutical industries and Chemical technology while incorporating ancient fields of knowledge such combining Ayurveda with scientific data.
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Subtitle: recent developments
Original source:
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Chandel Mehak and Sharma Chandan
World Journal of Pharmaceutical Research:
(An ISO 9001:2015 Certified International Journal)
Full text available for: Emulgels
Source type: An International Peer Reviewed Journal for Pharmaceutical and Medical and Scientific Research
Doi: 10.20959/wjpr20215-20414
Copyright (license): WJPR: All rights reserved
Download the PDF file of the original publication
Summary of article contents:
Introduction
The article discusses the development and advantages of emulgels as a modern form of topical drug delivery, particularly in comparison to traditional creams and gels. Emulgels combine the properties of emulsions and gels, making them effective carriers for both hydrophobic and hydrophilic drugs. This review highlights the rationale for using emulgels, various formulations, and their beneficial characteristics, along with a survey of recent research advancements in this field.
Unique Advantages of Emulgels
One of the prominent advantages of emulgels is their ability to effectively deliver hydrophobic drugs, which is a limitation faced by conventional topical formulations like creams and gels. Emulgels facilitate the incorporation of lipophilic drugs within an oil-based aqueous phase, enhancing their absorption through the skin. This dual mechanism not only improves the bioavailability of these drugs but also allows for better patient compliance by providing a greaseless and easily spreadable formulation. The review further enumerates advantages such as superior loading capacity, controlled drug release, and avoidance of gastrointestinal incompatibility.
Formulation Components
The preparation of emulgels involves several critical components that contribute to their effectiveness. Key ingredients include various vehicles (water, alcohol), oils for emulsion formulation, emulsifying agents to stabilize the mixture, gelling agents for textural properties, and penetration enhancers that increase drug permeation through the skin. The choice of these constituents is crucial, as they must be biologically safe, non-irritating, and compatible with the drug being delivered. A detailed list of potential ingredients is provided, showcasing the flexibility and adaptability in formulating emulgels for various applications.
Evaluation Techniques
The review outlines essential evaluation techniques for assessing emulgel formulations. These include testing parameters for physical properties such as color, homogeneity, and consistency, as well as advanced evaluations like in vitro drug release studies using Franz diffusion cells. Additionally, stability studies and skin irritation tests are conducted to ensure product safety and efficacy before clinical applications. These evaluation techniques are vital to confirm the commercial viability of emulgel products and ensure they meet quality standards.
Conclusion
In conclusion, emulgels represent a significant advancement in the topical drug delivery system, addressing many challenges associated with hydrophobic drug formulation. With increased stability, patient compliance, and the ability to deliver a wide range of drug molecules, emulgels are positioned as an innovative solution in the pharmaceutical landscape. The review emphasizes that the ongoing research and development in this area will likely expand the application of emulgels, making them an important part of the future of topical drug delivery.
FAQ section (important questions/answers):
What are emulgels and their primary use?
Emulgels are a combination of emulsions and gels, providing a dual release for topical drug delivery, especially effective for delivering both hydrophobic and hydrophilic drugs to treat dermatological conditions.
What are the advantages of using emulgels?
Emulgels offer several advantages like superior drug loading capacity, controlled release, improved stability, and they bypass first-pass metabolism, making them suitable for self-medication and enhancing patient compliance.
What are common ingredients in emulgel formulations?
Emulgels typically contain a drug, emulsifying agents, gelling agents, penetration enhancers, and aqueous or oil phases. Examples include Carbopol for gelling and propylene glycol as a penetration enhancer.
What challenges do formulations of emulgels face?
Challenges include ensuring non-toxicity, non-irritation, formulating physically stable emulgels, and determining appropriate permeability features for various dermal applications.
How are emulgels prepared for topical use?
Emulgels are prepared by forming an emulsion, creating a gel base, and mixing the two. This process often involves heating the oil and water phases followed by rapid stirring.
What is the significance of gelling agents in emulgels?
Gelling agents, such as Carbopol or HPMC, are crucial in forming stable structures in emulgels, enhancing viscosity and providing the desired consistency for effective topical application.
Glossary definitions and references:
Scientific and Ayurvedic Glossary list for “Recent Advances in Emulgels for Enhanced Topical Drug Delivery”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.
1) Drug:
Drugs are compounds that can have therapeutic effects when introduced into the body. In emulgel formulations, various types of drugs are explored for their ability to be successfully delivered through the skin, particularly hydrophobic drugs that face challenges in solubility and bioavailability.
2) Water:
Water serves as a crucial component in emulgel formulations, functioning as the aqueous phase that helps dissolve hydrophilic drugs. Its role is vital in creating stable mixtures in emulgels, allowing for effective drug delivery through the skin and enhancing the solubility of various therapeutic agents.
3) Study (Studying):
Study refers to research activities performed to comprehend the characteristics, formulation, and effectiveness of emulgels in drug delivery. It involves rigorous evaluations, experiments, and analyses that lead to knowledge about how emulgels work, their stability, and their potential in treating skin-related ailments.
4) Medium:
Medium, in the context of emulgel preparation, refers to the phase in which the active pharmaceutical ingredient (drug) is dispersed. This includes aqueous materials and oils, which together form the emulsion base necessary for combining and stabilizing the emulgel formulation effectively.
5) Animal:
Animals are often utilized in preclinical studies to assess the safety and effectiveness of emugel formulations. Testing emulgels on animal skin ensures that the formulations do not cause irritation and can be safely applied to human skin for therapeutic use.
6) Kumar:
Kumar is a reference likely to the researcher D. Kumar, who contributed to the understanding of emulgel formulations. His work has been cited to emphasize the formulation techniques and benefits of emulgels, showcasing ongoing research in the domain of pharmaceutical sciences and drug delivery.
7) Irritation:
Irritation refers to the potential adverse effects observed when a substance comes into contact with the skin. In emulgel formulations, irritation tests are critical to ensure that the product does not cause adverse reactions upon application, thus ensuring patient safety and comfort during use.
8) Activity:
Activity in the context of emulgels can relate to how these formulations exhibit therapeutic effects, such as antimicrobial or anti-inflammatory properties. The evaluation of biological activity is essential to validate the effectiveness of the drug encapsulated within the emulgel formulation.
9) Science (Scientific):
Science generally refers to the systematic study of the structure and behavior of the physical and natural world. In emulgel research, scientific principles guide the formulation processes, evaluations, and interpretations of results, validating the effectiveness and safety of drug delivery systems.
10) Sharman (Sarma, Sharma, Sarman):
Sharma refers to a researcher, likely Sharma Chandan, who is involved in the investigation of emulgels. His contributions encompass various aspects of emulgel formulation, highlighting the importance of specific gelling agents and their roles in delivering hydrophobic drugs effectively.
11) Field:
Field pertains to the area of study related to pharmaceutical formulations, specifically focusing on topical drug delivery systems like emulgels. This field encompasses ongoing research and advancements aimed at improving drug absorption and effectiveness through novel delivery methods.
12) Life:
Life may refer to the biological systems being targeted by emulgel formulations. The purpose of these formulations is to enhance the quality of life by providing effective treatments for dermal conditions, thereby improving patient health and well-being through optimized drug delivery mechanisms.
13) Oil:
Oils are a critical component in emulgel formulations, serving as the hydrophobic phase necessary for incorporating lipophilic drugs. The choice of specific oils can influence the stability, texture, and delivery characteristics of the emulgel, thereby impacting its overall effectiveness in topical applications.
14) Rheumatoid arthritis:
Rheumatoid arthritis is an inflammatory disorder affecting joints, which may be treated with analgesic and anti-inflammatory medications delivered via emulgels. The formulation of emulgels for such conditions aims to enhance local drug delivery and reduce systemic side effects often associated with traditional therapies.
15) Shailendra (Sailendra, Shaila-indra, Shailemdra):
Shailendra refers to Shailendra Panwar, who contributed to the understanding of skin structure and related dermatological applications. His work supports the scientific framework for incorporating topical delivery systems, including emulgels, in the treatment of skin-related ailments.
16) Punjab:
Punjab may refer to the region in India where significant research institutions such as the University Institute of Pharma Sciences are located. This geographic context contributes to the development and study of pharmaceutical innovations like emulgel formulations in that area.
17) Priya:
Priya likely refers to a researcher who has focused on the evaluation of emulgel formulations. Her contributions help to validate the pharmacological efficacy and stability of topical drug delivery systems, enriching the collective knowledge within the realm of pharmaceutical sciences.
18) Joshi (Josi):
Joshi refers to another researcher involved in studies concerning emulgel formulations. His work emphasizes comparative evaluations of emulgels, exploring their efficiency against traditional formulations, thus enhancing the understanding of emulgel benefits in drug delivery.
19) Pur:
Poor refers to the challenges that hydrophobic drugs face in terms of solubility and bioavailability. Emulgels serve as an innovative solution to overcome these barriers, effectively aiding the delivery of poorly soluble drugs through the skin and improving overall therapeutic outcomes.
20) Antibiotic (Antibacterial):
Antibiotic relates to the pharmacological agents that fight bacterial infections, which can be delivered effectively using emulgel formulations. The use of emulgels for antibiotic delivery aims to provide localized treatment while minimizing systemic exposure, thus enhancing therapeutic effectiveness.
21) Substance:
Substance is a term referring to any chemical compound that can be incorporated into emulgel formulations. The choice of substances, including active ingredients and excipients, directly influences the stability, safety, and effectiveness of the final product for topical application.
22) Ramaswamy (Ramaswami):
Ramaswamy likely refers to a researcher contributing to the field of pharmaceutical sciences, particularly in relation to emulgel formulations. His efforts may focus on exploring innovative solutions for improving drug delivery and efficacy in topical treatments.
23) Swelling:
Swelling refers to the increase in volume of the emulgel when it interacts with moisture or skin. This property is significant in emulgel applications as it may affect drug release rates and absorption when applied to the skin, influencing therapeutic outcomes.
24) Disease:
Disease generally refers to any condition that impairs bodily functions or health, potentially treated by topical emulgels. Emulgels provide a novel route for delivering active pharmaceutical ingredients directly to the site of disease on the skin, enhancing therapeutic efficacy.
25) Pranali:
Pranali is likely a researcher who conducted studies on emulgel formulations. Her work contributes to the understanding of how different formulation components affect drug release, stability, and efficacy when applied in topical treatments.
26) Mineral:
Mineral generally refers to naturally occurring substances, such as mineral oils, which are utilized in emulgel formulations. These oils provide essential properties for stabilizing the emulsion and ensuring the effective delivery of lipophilic drugs through the skin.
27) Castor:
Castor oil is a specific type of oil derived from castor beans, often used in emulgel formulations. Its unique properties can enhance the solubility of hydrophobic drugs while supporting the stability and consistency of the emulgel for effective topical applications.
28) Asara (Ashara):
Ashara may refer to a researcher exploring emulgel formulations, contributing to the body of knowledge regarding the preparation, characterization, and efficacy of these innovative drug delivery systems in the context of topical therapeutics.
29) Ranga (Ramga):
Ranga refers to a researcher who has likely investigated the formulation aspects and pharmacodynamics of emulgels. Their contributions may enhance the understanding of how different agents influence the performance of emulgel systems for topical delivery.
30) Table:
Table refers to information summarized in a structured format, such as the tables found in reviews outlining constituents, properties, and characteristics of various emulgel formulations. Tables aid in organizing knowledge for easier comprehension and comparison of data.
31) Blood:
Blood may relate contextually to the systemic effects of drug delivery via emulgels. The intention of topical formulations is often to minimize systemic circulation and deliver medications effectively at the site of application, reducing the chance of systemic side effects.
32) Cage:
Cage relates to the controlled testing environment for animals during emulgel evaluation studies. Ensuring proper care and environment for test subjects is essential for ethical considerations and the reliability of study results regarding formulation safety and efficacy.
33) Vani:
Vani is potentially a researcher focused on formulating emulgels and evaluating their effectiveness in delivering hydrophobic drugs. Her contributions enhance the understanding of formulation strategies and therapeutic outcomes in the development of topical drug delivery systems.
34) Arti:
Arti may refer to a researcher involved in the study and formulation of emulgels. The research conducted by Arti contributes to the knowledge regarding the preparation and efficacy of hydrophobic drug delivery through novel emulgel systems.
35) Sabu:
Sabu refers to a researcher whose work likely investigates the pharmacological applications of emulgels, contributing to the development of formulations aimed at treating various infections and conditions using topical delivery mechanisms.
36) Fish:
Fish may symbolize aquatic sources for obtaining oils, such as fish liver oil, used in emulgel formulations. These oils can provide distinct properties that enhance the stability and delivery of hydrophobic drugs through topical applications.
Other Science Concepts:
Discover the significance of concepts within the article: ‘Recent Advances in Emulgels for Enhanced Topical Drug Delivery’. Further sources in the context of Science might help you critically compare this page with similair documents:
Bioavailability, Controlled release, First Pass Metabolism, Patient compliance, Stability Studies, Skin irritation, Spreadability, Marketed formulation, Drug content, Penetration enhancer, Gelling agent, Topical drug delivery, Hydrophobic drug, Lipophilic drug, Drug candidate, Evaluation technique.