Herbal liposomes with effectiveness against diabetes

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Journal name: World Journal of Pharmaceutical Research
Original article title: Herbal liposomes with effectiveness against diabetes
The WJPR includes peer-reviewed publications such as scientific research papers, reports, review articles, company news, thesis reports and case studies in areas of Biology, Pharmaceutical industries and Chemical technology while incorporating ancient fields of knowledge such combining Ayurveda with scientific data.
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Original source:

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Author:

Rajat Singh, Shivam, Avadh Biharee, Deepak Tomar, Pankaj Kumar, Dheeraj Dubey


World Journal of Pharmaceutical Research:

(An ISO 9001:2015 Certified International Journal)

Full text available for: Herbal liposomes with effectiveness against diabetes

Source type: An International Peer Reviewed Journal for Pharmaceutical and Medical and Scientific Research

Copyright (license): WJPR: All rights reserved


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Summary of article contents:

1) Introduction

Diabetes has become an alarming health crisis, particularly in India, where over 62 million people are diagnosed with this chronic disorder affecting carbohydrate, fat, and protein metabolism. This condition can lead to severely elevated blood sugar levels and a range of complications, such as cardiovascular disease and chronic kidney failure. The research conducted by Dubey et al. focuses on developing herbal liposomal formulations utilizing the plant Pterocarpus marsupium (Vijaysar), known for its anti-diabetic properties. The purpose of this study is to enhance the drug delivery of hydrophilic herbal medications and to create an economical solution for consumers facing diabetes.

2) Liposome Formulation and Benefits

The primary objective of the study was to formulate liposomes that encapsulate Pterocarpus marsupium, effectively enhancing the permeability of its active compounds through biological membranes. Liposomes are nanosized carriers that can significantly increase the bioavailability of hydrophilic drugs. The study compared the inhibitory effects on alpha-amylase between liposome-loaded Pterocarpus marsupium and the synthetic drug acarbose. Results showed that the herb-loaded liposomes exhibited comparable efficacy to acarbose, making it a promising alternative for diabetic treatment. Additionally, the study aimed to provide a cost-effective formulation accessible to consumers.

3) Phytochemical Analysis of Pterocarpus marsupium

Pterocarpus marsupium is characterized by rich phytochemical constituents that contribute to its therapeutic effects. The plant is abundant in polyphenolic compounds, tannins, and other active components such as pterostilbene, alkaloids, and flavonoids. The study's crude extract was prepared using hydro-ethanol, which concentrated these beneficial compounds. Further analysis confirmed that the encapsulation of these compounds in liposomes not only maintained their properties but also enhanced their therapeutic effectiveness against diabetes compared to conventional forms of the herb.

4) In Vivo and In Vitro Assessment of Efficacy

The study included both in vitro and in vivo assessments to evaluate the effectiveness of the liposome formulation. In vitro tests demonstrated that the encapsulated herbal extract had a significant inhibitory effect on alpha-amylase, a key enzyme involved in carbohydrate digestion, thus potentially reducing postprandial blood sugar levels. The in vivo trials involved administering the liposomal formulation to Alloxan-induced diabetic rats. Results indicated a marked decrease in blood glucose levels, significantly lower than the levels observed with the unencapsulated extract. This enhanced efficacy highlights the potential of liposomal formulation to serve as an effective therapeutic strategy in diabetes management.

5) Conclusion

The research presented by Dubey et al. offers compelling evidence that herbal liposomes of Pterocarpus marsupium present a viable and effective alternative to traditional synthetic anti-diabetic medications. The formulation not only improved drug delivery and bioavailability but also demonstrated substantial hypoglycemic effects in diabetic rats, potentially leading to better health outcomes. The study emphasizes the importance of exploring herbal alternatives in modern medicine, particularly in addressing the growing global diabetes epidemic, while also hinting at the need for further research into optimizing these formulations for human applications.

FAQ section (important questions/answers):

What is the primary aim of the study on herbal liposomes?

The study aimed to formulate an herbal drug-loaded nanosized carrier to enhance the permeability of hydrophilic herbal drugs and increase their concentration in systemic circulation as an effective and affordable diabetes treatment.

Which herbal plant was used in the liposome formulation?

The study utilized *Pterocarpus marsupium*, commonly known as Vijayasar, as the herbal plant in liposome formulation, known for its effectiveness in treating diabetes.

What method was used to prepare the liposomes?

The preparation of the liposomes involved the bath sonication method, using cholesterol, phospholipids, and phosphate buffer saline to create both blank and drug-loaded liposomes.

How was the effectiveness of the liposomal formulation evaluated?

Effectiveness was evaluated through in vitro inhibition of alpha-amylase compared to acarbose and by in vivo studies assessing the impact on blood glucose levels in diabetic rats.

What were the key findings regarding blood glucose levels?

The experimental liposome formulation significantly reduced blood glucose levels in diabetic rats, showing lower levels compared to the normal extract of *Pterocarpus marsupium*.

What advantages do liposomes provide for drug delivery?

Liposomes enhance drug absorption through membranes, improve pharmacokinetics, and prolong the drug's action, resulting in effective delivery of hydrophilic herbal drugs.

Glossary definitions and references:

Scientific and Ayurvedic Glossary list for “Herbal liposomes with effectiveness against diabetes”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.

1) Drug:
Drugs are substances used for treatment, prevention, or diagnosis of diseases. The research compares the effectiveness of the herbal liposomes derived from 'Pterocarpus marsupium' against synthetic drugs, emphasizing the exploration of natural alternatives in therapeutic regimens.

2) Study (Studying):
A study is a systematic investigation to establish facts, principles, or generalizable knowledge. The research in question aimed to explore the potential of herbal liposomes derived from 'Pterocarpus marsupium' for managing diabetes, thereby contributing to the fields of medicinal chemistry and pharmacology.

3) Table:
A table organizes data systematically in rows and columns for easier comprehension. In this document, various tables present results from experiments, showcasing measurements such as drug concentration and effects on blood sugar levels in different experimental setups with clear numerical data for analysis.

4) Blood:
Blood is a vital fluid that circulates throughout the body, delivering oxygen and nutrients while removing waste. The study measures blood glucose levels in rats to assess the efficacy of the 'Pterocarpus marsupium' treatment, which aims to lower excessive blood sugar related to diabetes.

5) Animal:
Animals are multicellular organisms that can be used in research. In this study, healthy rats were utilized to assess the safety and efficacy of the formulated liposomes from 'Pterocarpus marsupium' in controlling blood sugar levels, reflecting broader implications in pharmacological research.

6) Inference:
Inference involves drawing conclusions based on evidence and reasoning. The study's inferences highlight the effectiveness of the herbal liposome formulations compared to conventional diabetic treatments, demonstrating significant blood sugar reduction which suggests potential for future therapeutic applications.

7) Sugar:
Sugar refers to simple carbohydrates, commonly glucose, that serve as an energy source. The research targets blood sugar levels in diabetic rats to evaluate the impact of the herbal medication, aiming to achieve a significant reduction in blood glucose concentrations through the tested formulations.

8) Water:
Water is an essential solvent and medium for biological reactions. In the experiments, various aqueous solutions, including those used for extracting and administering the herbal liposomal formulations, are critical for effectively delivering the active compounds and supporting physiological processes in test subjects.

9) Tree:
A tree is a perennial plant with an elongated stem, or trunk. 'Pterocarpus marsupium,' also known as Vijayasar, is a medicinal tree studied for its therapeutic properties in diabetes management, emphasizing the importance of botanical sources in developing natural treatment alternatives.

10) Disease:
Diseases signify pathological conditions affecting bodily systems. The focus on diabetes and related diseases underscores the necessity of developing effective treatment strategies, leveraging herbal sources such as 'Pterocarpus marsupium' as potential therapeutic avenues to explore.

11) India:
India is a diverse country with a significant population suffering from diabetes. This study addresses the increasing diabetes epidemic in India by exploring herbal medicines for treating diabetes, thus focusing on traditional practices as viable solutions for modern healthcare challenges.

12) Calculation:
Calculation refers to the process of determining numerical values through arithmetic operations. In this document, calculations are performed to understand drug entrapment efficiency, dosages in animal studies, and statistical analysis of results, guiding the interpretation of the study's findings.

13) Activity:
Activity in this context refers to the biological effects produced by the tested formulations. The study evaluates the anti-diabetic activity of 'Pterocarpus marsupium' through various in vitro and in vivo experiments, measuring its impact on blood glucose levels.

14) Heating:
Heating refers to the application of warmth, often necessary for chemical processes. In the extraction and liposome preparation methods, controlled heating is utilized to facilitate the dissolution of substances, confirming the processes of drug formulation and product stabilization.

15) Species:
A species is a group of living organisms capable of interbreeding. 'Pterocarpus marsupium' is a specific plant species under investigation for its potential therapeutic properties in diabetes management, illustrating the significance of species-specific studies in herbal medicine.

16) Family:
Family in biological taxonomy refers to a rank in the hierarchy that groups related plants. 'Pterocarpus marsupium' belongs to the Fabaceae family, indicating common characteristics shared with other plants within this family, important for understanding ecological and pharmacological interactions.

17) Gold (Golden):
Golden often describes color or valuable traits. In this document, the term may refer to the golden-yellow heartwood of 'Pterocarpus marsupium,' which is significant for its aesthetic and medicinal qualities, offering insights into its use as a natural remedy.

18) Gupta:
Gupta is a common surname in India, often associated with researchers or contributors in the scientific fields. In this context, it likely references co-authors in the study, reflecting the collaborative nature of research and integration of expertise in evaluating herbal remedies.

19) Post:
Post typically indicates something following or after an event. In the research, post-treatment evaluations are significant in assessing the long-term effects of the liposomal formulations on blood glucose levels, leading to conclusions about their sustained efficacy for diabetes management.

20) Cinnamomum zeylanicum:
Cinnamomum zeylanicum, known as cinnamon, is a spice with medicinal properties. Its inclusion in the study references other herbal remedies that demonstrate potential benefits in diabetes control, highlighting the trend of using natural substances for health improvements.

21) Tinospora cordifolia:
Tinospora cordifolia is a medicinal herb used in Ayurveda. This mention emphasizes the role of traditional plants in treating ailments like diabetes, mirroring the study's focus on 'Pterocarpus marsupium' as a potential herbal solution.

22) Zingiber officinale:
Zingiber officinale refers to ginger, another plant with recognized health benefits. Including it in the research aligns with exploring diverse herbal remedies as alternatives or supplements to conventional diabetes treatments, branching out into holistic healthcare.

23) Azadirachta indica:
Azadirachta indica, or neem, is known for its medicinal properties, particularly in diabetes management. Its mention reflects the broader context of herbal treatments being explored alongside 'Pterocarpus marsupium,' highlighting an interest in traditional herbal therapies.

24) Ocimum sanctum:
Ocimum sanctum, commonly known as holy basil, is a herb recognized for its health benefits. Mentioning it in this study situates the research within a larger framework of exploring various herbs for therapeutic uses against diabetes.

25) Momordica charantia:
Momordica charantia, or bitter melon, is another traditional remedy noted for its anti-diabetic properties. Including this reference emphasizes the rich tapestry of herbal treatments explored in conjunction with 'Pterocarpus marsupium' for managing blood sugar levels.

26) Aegle marmelos:
Aegle marmelos, also known as bael, is a sacred tree in India with medicinal uses. The inclusion of this plant relates to the study's focus on various herbal sources that could impact diabetes treatment strategies.

27) Science (Scientific):
Scientific refers to systematic study and empirical methods employed to derive knowledge. The research adheres to scientific principles in examining the efficacy of herbal liposomes, ensuring the findings are credible and can contribute meaningfully to medicinal research.

28) Fenugreek:
Fenugreek, a herb known for its culinary and medicinal applications, is acknowledged for potential benefits in blood glucose regulation. Its mention reflects the diversity of plants under investigation alongside 'Pterocarpus marsupium' in the diabetes research landscape.

29) Substance:
A substance is a form of matter with specific properties. In this research, herbal substances derived from 'Pterocarpus marsupium' are the focal point, studied for their ability to influence physiological processes like blood sugar management.

30) Flavonoid:
Flavonoids are plant compounds with known antioxidant properties that may have health benefits. This study may reference flavonoids in 'Pterocarpus marsupium' to underline the active components contributing to its effectiveness in managing diabetes.

31) Medicine:
Medicine encompasses both the science of healing and the substances used to treat disease. The study aims to develop a herbal medicine from 'Pterocarpus marsupium,' exploring its physiological effects and practical applications in managing diabetes.

32) Cinnamon:
Cinnamon is a spice derived from bark with numerous health benefits, especially in controlling blood sugar levels. Its reference serves to contextualize the study within a broader scope of dietary influences and traditional remedies in diabetes treatment.

33) Epidemic:
An epidemic refers to a widespread occurrence of an infectious disease in a population. This study notes diabetes as a growing epidemic in India, showcasing the urgency for effective treatments, such as herbal remedies, to combat this health crisis.

34) Dividing:
Dividing refers to partitioning or separating into parts. In experimental setups, dividing animals into groups is crucial for scientifically assessing control versus treatment effects, ensuring that results are valid and reliable for understanding treatment efficacy.

35) Relative:
Relative commonly denotes a comparison. In the context of this study, relative measures such as body weight or glucose levels are used to gauge the effectiveness of treatments among different animal groups, providing comparative data that informs conclusions.

36) Mustard:
Mustard, particularly the black mustard, is acknowledged for its health benefits, including potential anti-diabetic effects. Its inclusion in this context signals the diverse array of plants considered in research for their therapeutic roles in diabetes management.

37) Maurya:
Maurya is a surname likely associated with one of the researchers in this study. It reflects the collaborative effort in scientific research, lending credibility and authoritative insights into the efficacy assessments of herbal treatments discussed.

38) Garlic:
Garlic is a bulbous plant widely known for its medicinal properties, including benefits for diabetes control. Referencing garlic emphasizes the traditional knowledge surrounding herbal remedies, contextualizing the study within a comprehensive review of potential treatment options.

39) Bitter:
Bitter typically describes flavors associated with certain plant compounds. The term may refer to the bitter taste of some medicinal herbs, including bitter melon, which is recognized for its importance in herbal treatments aimed at managing blood sugar levels.

40) Reason:
Reason denotes a cause or justification. In the context of this study, the reasons for exploring 'Pterocarpus marsupium' as an anti-diabetic agent relate to its historical use in traditional medicine and increasing incidence of diabetes requiring novel treatments.

41) Silver:
Silver may refer to silver nanoparticles, which are noted to have health applications but are costly compared to herbal alternatives. This highlights the drive towards finding economically viable herbal remedies like those derived from 'Pterocarpus marsupium' for treating diabetes.

42) Thirst:
Thirst can signify a symptom of diabetes characterized by excessive drinking due to high blood sugar levels. The study addresses this symptom by evaluating treatments that effectively lower blood glucose levels, targeting overall diabetes management.

43) Indian:
Indian refers to the nationality associated with India. In this study, the emphasis on 'Pterocarpus marsupium' highlights the cultural and geographical significance of indigenous plants in herbal medicine, particularly in addressing local health challenges such as diabetes.

44) Filling (Filled):
Filled often describes being occupied or loaded. This term may refer to the manner in which the drug is incorporated into liposomes, highlighting the formulation science aimed at enhancing drug delivery efficacy through advanced drug delivery systems.

45) Nanda (Namda):
Nanda is likely a surname of one of the study's contributors, indicating collaborative research efforts. Their involvement underscores the academic partnerships essential for validating findings and pushing forward traditional medicine research toward evidence-based applications.

46) Kumar:
Kumar is a common Indian surname, likely belonging to one of the study’s authors. This signals collaborative involvement from multiple researchers, emphasizing teamwork as a fundamental component in conducting comprehensive medical and pharmaceutical studies.

47) Nayak:
Nayak is another surname associated with one of the contributors in the study. Their inclusion showcases the collaborative dynamics essential for advancing research, indicating the interdisciplinary efforts in exploring and validating health interventions.

48) Glass:
Glass often refers to laboratory apparatus used for conducting experiments. In the research, glassware such as beakers and flasks are essential for chemical reactions and measurements, ensuring precision in the studies evaluating herbal formulations.

49) Jamun:
Jamun refers to the fruit of the Syzygium cuminii plant known for its health benefits, including potential anti-diabetic properties. Its mention reflects the broader array of traditional plants considered in creating herbal remedies for managing blood glucose.

50) Ulcer:
An ulcer represents a sore or lesion, often a complication of diabetes. In discussing diabetes treatments, the study indirectly addresses diabetic complications by focusing on the effectiveness of 'Pterocarpus marsupium' in helping manage the core condition to prevent such outcomes.

51) Doubt:
Doubt pertains to uncertainty or lack of confidence regarding a situation. In relation to healthcare, patients may have doubts about treatment efficacy. The exploration of effective herbal treatments like those studied aims to relieve such doubts through proven efficacy.

52) Death:
Death signifies the cessation of vital functions. In the context of diabetes, particularly when unchecked, it highlights the severe consequences of the disease. The study underscores the necessity for effective treatment options to prevent life-threatening complications associated with diabetes.

53) House:
House often denotes a physical structure for human habitation. In this context, the term may signify the animal house or housing conditions for test subjects, ensuring that controlled environments are maintained in the experimental procedures.

54) Worry (Worried, Worrying):
Worry reflects concerns or anxieties, which can impact health. In diabetes management, patients may experience worry related to their condition. The research emphasizes developing reliable treatments to alleviate concerns about blood sugar control and health outcomes.

55) Genu:
Genu typically means knee in a biological context. If mentioned here, it might be referring to botanical structures or configurations that are being examined in the research. This demonstrates the intricate details considered in plant studies for medicinal purposes.

56) Java:
Java may refer to a particular plant species or context related to herbal research. In this setting, Java may connect to a broader discussion around traditional remedies and their applications in managing health conditions like diabetes.

57) Neem:
Neem is a tree known for its numerous health benefits, particularly in traditional medicine and diabetes management. Referencing neem contextualizes the broader framework of herbal treatments studied for their efficacy in controlling blood glucose levels.

58) Food:
Food refers to edible substances consumed for nutrition. The study takes into account dietary impacts on diabetes, emphasizing that treatments like 'Pterocarpus marsupium' can complement dietary management strategies to regulate blood sugar effectively.

59) Diet:
Diet signifies the consumption patterns of food, which can profoundly affect health outcomes in diabetes. The research implies that along with medication, attention to diet is crucial for holistic diabetes management strategies.

60) Rich (Rch):
Rich often describes an abundance of a particular substance. In this study, it may refer to the rich polyphenolic content in 'Pterocarpus marsupium,' which supports its therapeutic potentials, emphasizing the importance of active compounds in herbal formulations.

61) Life:
Life signifies the state of being alive and functioning. The relevance of life in this context connects to the study's ultimate goal—to enhance the quality of life for individuals suffering from diabetes through effective herbal treatments, aiming for better health outcomes.

Other Science Concepts:

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Discover the significance of concepts within the article: ‘Herbal liposomes with effectiveness against diabetes’. Further sources in the context of Science might help you critically compare this page with similair documents:

Pterocarpus marsupium, Diabetes mellitus, In vitro study, Ethanolic extract, Blood sugar level, Phytomedicine, Systemic circulation, Zeta potential, Stability Studies, Animal Study, Formulation Development, Hydro ethanol extract.

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