Surgical vs. Medical Management of Caries Spine: A Comparative Study

comparison of combined surgical and medical management with medical management at bolan medical college, balochistan

| Posted in: Health Sciences Science

Journal name: World Journal of Pharmaceutical Research
Original article title: Caries spine
The WJPR includes peer-reviewed publications such as scientific research papers, reports, review articles, company news, thesis reports and case studies in areas of Biology, Pharmaceutical industries and Chemical technology while incorporating ancient fields of knowledge such combining Ayurveda with scientific data.
This page presents a generated summary with additional references; See source (below) for actual content.
Subtitle: comparison of combined surgical and medical management with medical management at bolan medical college, balochistan

Original source:

This page is merely a summary which is automatically generated hence you should visit the source to read the original article which includes the author, publication date, notes and references.

Author:

Dr. Saleem Khan, Dr. Bezan Baloch, Dr. Rehana Kamal, Dr. Afshan Mushtaq, Dr. Huma Naeem Tareen, Dr. Muhammad Saleem, Dr. Hayat Muhammad Kakar and Mir Zaman Kasi


World Journal of Pharmaceutical Research:

(An ISO 9001:2015 Certified International Journal)

Full text available for: Caries spine

Source type: An International Peer Reviewed Journal for Pharmaceutical and Medical and Scientific Research

Doi: 10.20959/wjpr20218-20037

Copyright (license): WJPR: All rights reserved


Download the PDF file of the original publication


Summary of article contents:

Introduction

Caries spine, primarily caused by tuberculosis (T.B.), is a significant health issue, particularly in developing countries like Pakistan. The condition, characterized by spinal infection, raises a debate about the most effective treatment approach: whether to rely solely on medical therapy or to incorporate surgical intervention alongside antituberculous therapy (ATT). This study compares the short-term outcomes of patients with caries spine managed through either combined surgical and medical management or medical management alone, with a follow-up period of six months.

Surgical vs. Medical Management

The study revealed statistically significant differences in outcomes between the two treatment groups. In the surgical group (Group A), 88.88% of patients experienced improvement in their neurological status compared to 35.29% in the medical management group (Group B). The analysis focused on the Frankel Grade—a scale for assessing neurological function—bladder involvement, and erythrocyte sedimentation rate (ESR) decline, indicating better results for the surgical group. This finding suggests a need to consider surgical options for patients diagnosed with caries spine, especially when neurological impairment is significant.

Importance of Early Intervention

The research emphasized the crucial aspect of timely diagnosis and intervention. Many patients, especially from underprivileged backgrounds, often present the disease in its advanced stages, complicating treatment outcomes. The study highlighted that surgical intervention not only addresses immediate physical challenges but may also prevent long-term disability by reducing the risk of complications like kyphosis. The successful surgical techniques employed in the study included anterior cervical decompression and thoracic thoracotomy for the decompression and stabilization of affected spinal areas.

Efficacy of Antituberculous Therapy

The study also presented data showing the effectiveness of a standardized antituberculous regimen, which included a combination of four drugs: Rifampicin, Isoniazid, Pyrazinamide, and Ethambutol. It reinforced that all patients received ATT, which is essential in managing spinal tuberculosis. However, the researchers noted that the combined approach of surgery and chemotherapy yielded significantly faster reductions in ESR levels, an important marker for inflammation and disease activity, between the two groups.

Conclusion

In conclusion, the study supports the efficacy of combining surgical interventions with medical treatment for patients with caries spine, particularly in enhancing neurological outcomes. As evidenced by the differences in recovery rates and significant improvements in clinical parameters, surgical management, when indicated, can offer patients rapid and effective recovery, justifying its application in appropriately selected cases. The study advocates for further consideration of surgical options in clinical settings to improve outcomes for those suffering from this debilitating condition.

FAQ section (important questions/answers):

What is the main focus of the study on caries spine?

The study compares the short-term outcomes of combined surgical and medical management against medical management alone for patients with caries spine, focusing on a six-month follow-up.

What treatment options are compared in the research?

The research compares two groups: one receiving combined surgical intervention along with antituberculous treatment (ATT), and the second receiving ATT alone.

What is the significance of the study's findings?

The findings indicate that surgical intervention significantly improves neurological outcomes in patients with caries spine compared to medical treatment alone.

How was the data for the study collected?

Data was collected from patients diagnosed with caries spine, through clinical examination, imaging, and follow-ups over six months, focusing on recovery and complications.

What were the main results regarding patient improvement?

At the end of six months, 88.88% of the surgical group improved significantly compared to 35.29% in the medical treatment-only group.

What conclusion does the study reach about caries spine management?

The study concludes that surgical intervention, when combined with chemotherapy, shows better short-term recovery in neurological function for caries spine patients.

Glossary definitions and references:

Scientific and Ayurvedic Glossary list for “Surgical vs. Medical Management of Caries Spine: A Comparative Study”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.

1) Study (Studying):
A study refers to a systematic investigation aimed at understanding or answering a specific research question. In the context of caries spine, this study explored the outcomes of surgical versus medical management in treating spinal tuberculosis. It employs methods such as randomized controlled trials to gather data and draw conclusions regarding treatment effectiveness.

2) Table:
Tables are structured formats used to present data clearly and efficiently. In this article, tables summarize findings related to patient demographics, treatment outcomes, and statistical analyses, making it easier for readers to grasp key results and compare various aspects of the study, such as age distribution or surgical procedures performed.

3) Tuberculosis:
Tuberculosis (TB) is an infectious disease primarily caused by the bacterium Mycobacterium tuberculosis. It significantly contributes to morbidity and mortality worldwide, especially in developing countries. In the study, TB's impact on spinal health, particularly caries spine or spinal tuberculosis, highlights its clinical relevance and underscores the need for effective treatment strategies.

4) Chemotherapy:
Chemotherapy refers to the use of medication to treat diseases, primarily cancer, and infections such as tuberculosis. In the context of this study, antituberculous chemotherapy is critical for managing caries spine, showcasing how a combination of surgical intervention and medication can lead to improved patient outcomes in treating spinal TB.

5) Disease:
Diseases signify pathological conditions that affect the body's normal functioning. This study specifically addresses spinal tuberculosis as a critical health issue. Understanding various diseases, including their manifestations and treatment methodologies, enables healthcare practitioners to devise effective interventions and improve patient care in affected populations.

6) Post:
Post refers to the period after an event or a procedure. In medical research, 'post' typically relates to follow-up evaluations after treatment. In this study, post-treatment outcomes are assessed at six months to determine the effectiveness of different management approaches for caries spine, particularly regarding neurological recovery and symptom relief.

7) Pur:
Poor describes a suboptimal condition or outcome, particularly in medical contexts. In the study, patient outcomes are categorized as good or poor based on Frankel grades, which gauge neurological function post-treatment. Identifying poor outcomes is vital for understanding treatment efficacy and guiding future healthcare decisions for caries spine patients.

8) Male:
Male refers to the gender designation for individuals of the male sex. In the study, gender distribution is analyzed, revealing insights into the demographics of patients with caries spine. Understanding gender-related factors can inform targeted interventions and illuminate potential variations in disease presentation and treatment response.

9) Drug:
A drug is any substance that causes physiological changes in the body. In this study, anti-tubercular drugs are central to treatment regimens, specifically antituberculosis chemotherapy, highlighting the role of pharmacological agents in managing infectious diseases like tuberculosis and improving patient outcomes in caries spine cases.

10) Performance:
Performance refers to the ability to carry out tasks or functions effectively. In medical studies, performance can relate to patient metrics, such as the Frankel grading scale for neurological function. Evaluating performance in the context of caries spine helps assess recovery and the effectiveness of surgical and medical treatments.

11) Developing:
Developing refers to nations or regions with lower income levels and healthcare infrastructure. In the context of this study, it highlights the prevalence and challenges associated with tuberculosis in such countries, stressing the importance of effective treatment solutions for diseases like caries spine and the need for healthcare improvements.

12) Activity:
Activity in a medical context often pertains to the degree of function or physiological engagement within a biological system. In the study, it relates to patients' recovery levels, emphasizing how surgical intervention may promote better activity recovery in neurological functions after the treatment of caries spine.

13) Visit:
Visits indicate the number of times patients consult healthcare services for evaluations or treatments. Consistent follow-up visits are crucial in the study to monitor recovery and treatment response. They provide crucial data for assessing the effectiveness of interventions in managing caries spine and optimizing patient care.

14) Balochistan:
Balochistan is a province in Pakistan where the study was conducted. Its geographical and demographic context helps frame issues like healthcare access, epidemiology of diseases such as caries spine, and the relevance of local healthcare practices and treatment outcomes within this specific regional population.

15) Discussion:
Discussion refers to the interpretative section of a study where findings are analyzed, compared with existing literature, and contextualized within broader medical understandings. In this study, the discussion section elaborates on the implications of results, patient outcomes, and the relevance of surgical versus medical treatment for caries spine.

16) Antibiotic (Antibacterial):
Antibiotics are medications used to treat bacterial infections, playing a significant role in infectious disease management. In caries spine treatment, antibiotics may be utilized alongside anti-tuberculous chemotherapy to address potential co-infections, underscoring the importance of comprehensive medical care in managing complex diseases like tuberculosis.

17) Medicine:
Medicine refers to the science and practice of diagnosing, treating, and preventing illness. The study underscores the role of medicine—specifically antituberculous treatments—in managing caries spine effectively, emphasizing both pharmacological and surgical procedures as essential components in improving patient health outcomes.

18) Account:
Account can also refer to a narrative or report of personal experiences or cases. In medical research, patient accounts can provide valuable qualitative insights into treatment experiences, impacting clinical judgment and guiding future studies, especially in understanding and refining approaches to managing diseases like caries spine.

19) Meeting:
Meeting refers to the gathering or consultation, often for discussion or decision-making. In the healthcare context, meetings among professionals can facilitate reviews of ongoing studies, treatment plans, and patient outcomes. They foster collaboration among healthcare providers to optimize strategies for managing conditions like caries spine.

20) Nature:
Nature can imply the essence or inherent characteristics of a subject. In medical and epidemiological discussions, understanding the nature of diseases, such as their progression and treatment responses, is vital. This knowledge guides effective strategies for managing complex cases like caries spine and informs clinical decision-making.

21) Reason:
Reason pertains to the rationale behind decisions or beliefs. In medical research, reasoning is essential to justify treatment strategies. Analyzing the reasons for choosing surgical intervention versus medical treatment underscores the need for evidence-based practices tailored to improve patient outcomes in conditions like caries spine.

22) India:
India is a neighboring country to Pakistan and a relevant point of comparison in the context of tuberculosis treatment and management. Research findings from India inform interventions in Pakistan, particularly regarding caries spine, as both countries experience similar challenges in addressing the TB burden.

23) Kakar:
Kakar is likely a reference to one of the authors of the study conducted at Bolan Medical College. Author names contribute to establishing credibility and context for research findings, and acknowledging their contributions is essential when discussing study outcomes and insights related to caries spine.

24) Blood:
Blood analysis is essential in diagnosing and managing infections and diseases. In this study, blood tests, including ESR, provide important baseline data to assess patient conditions and treatment responses, exemplifying the role of laboratory evaluations in guiding effective care for patients with caries spine.

25) Kashi (Kasi):
Kasi is another one of the authors mentioned in the study. Authors play a key role in research, contributing expertise and insights that inform study objectives, methodology, and result interpretations. Acknowledging authors fosters trust and accountability in presenting research findings to the broader medical community.

26) Sah:
Shah is likely another author referenced in the study. Each author’s expertise contributes to the credibility of the research. Recognizing the contributions of various authors is vital for understanding the collaborative effort behind the study, which investigates caries spine treatments and their efficacy in improving patient outcomes.

27) Line:
Line can refer to a reasoning thread or a methodology in medical research. In the study, maintaining clear lines of methodological rigor is crucial for protecting against biases and ensuring the reliability of findings related to the treatment of patients with caries spine, influencing clinical practice accordingly.

Other Science Concepts:

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Discover the significance of concepts within the article: ‘Surgical vs. Medical Management of Caries Spine: A Comparative Study’. Further sources in the context of Science might help you critically compare this page with similair documents:

Two groups, Surgical intervention, Complications in surgery, Randomized controlled trial, Statistical Significance, Neurological Deficit, Surgical Procedure, Age distribution, Outcome assessment, Informed written consent, Pott's disease, Medical management, Sex distribution, Post void residual volume, Neurosurgery department, Bolan Medical College, Caries spine, Combined surgical and medical management, Antituberculous chemotherapy, Frankel grade, ESR decline, Dorsal spine, Sphincter control, Mean age at presentation, Residual motor power, WHO report on tuberculosis.

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