Comparison of zoledronate and alendronate gels in periodontitis.
Journal name: World Journal of Pharmaceutical Research
Original article title: Clinical and radiographic comparison of 0.05% zoledronate gel (zometa) ®and 1% alendronate gel (fosamax) ® as a local drug delivery in the treatment of chronic periodontitis- a split mouth study
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Dr. Rameshwari B., Dr. Suchetha Aghanashini, Dr. Sapna Nadiger, Dr. Darshan B. Mundinamane, Dr. Apoorva S. M., Dr. Divya Bhat, Dr. Shwetha Baliga
World Journal of Pharmaceutical Research:
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Full text available for: Clinical and radiographic comparison of 0.05% zoledronate gel (zometa) ®and 1% alendronate gel (fosamax) ® as a local drug delivery in the treatment of chronic periodontitis- a split mouth study
Source type: An International Peer Reviewed Journal for Pharmaceutical and Medical and Scientific Research
Doi: 10.20959/wjpr202111-21438
Copyright (license): WJPR: All rights reserved
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Summary of article contents:
Introduction
Chronic periodontitis is a significant microbial infectious disease resulting in attachment loss, bone loss, and periodontal pocket formation. Traditional periodontal therapy primarily includes mechanical debridement, which may not completely eliminate infections present in inaccessible regions. To enhance the effectiveness of non-surgical therapy, local drug delivery systems have emerged as adjunct treatments, with bisphosphonates, such as Alendronate and Zoledronate, being explored for their therapeutic potential. This study aims to compare the clinical and radiographic efficacy of 0.05% Zoledronate gel and 1% Alendronate gel as local adjuncts to scaling and root planing (SRP) in treating chronic periodontitis.
Efficacy of Local Drug Delivery Systems
Local drug delivery systems, particularly bisphosphonates like Alendronate and Zoledronate, serve as potent inhibitors of bone resorption. Recent studies have indicated their successful use in controlling osteolysis and enhancing periodontal healing. The study documented significant improvements in clinical parameters, including probing pocket depth (PPD) and clinical attachment level (CAL), with both Zoledronate and Alendronate showing better results compared to SRP alone. Noteworthy reductions in plaque index (PI) and gingival index (GI) were also observed, suggesting that local delivery may enhance patients' periodontal health by directly targeting the affected areas.
Comparative Analysis of Alendronate and Zoledronate
The comparative efficacy of Alendronate and Zoledronate was assessed through a split-mouth study involving 15 patients diagnosed with chronic periodontitis. While both drugs demonstrated significant clinical improvements, Zoledronate exhibited superior results in various clinical parameters, including a greater reduction in PPD and improved CAL gain at 6 months compared to Alendronate. This suggests that Zoledronate not only effectively reduces periodontal inflammation but may also facilitate better periodontal regeneration, making it a promising candidate for local drug delivery in chronic periodontitis management.
Statistical Findings
The study employed rigorous statistical analysis to validate the results of both treatment modalities. Significant differences were established between the control and treatment groups at multiple time points, with specific attention to the reduction of key clinical indices. For example, reductions in the gingival index and sulcus bleeding index were markedly significant at both 3 and 6 months post-treatment, reinforcing the effectiveness of Zoledronate and Alendronate in managing periodontal disease. Furthermore, the results indicated the importance of patient compliance, as improved oral hygiene was associated with better outcomes across all groups.
Conclusion
In summary, both 0.05% Zoledronate and 1% Alendronate gels showed significant clinical benefits in treating chronic periodontitis when used alongside scaling and root planing. The study concluded that Zoledronate gel may hold a slight advantage over Alendronate in terms of clinical efficacy and radiographic outcomes. However, further long-term studies and research are necessary to substantiate these findings fully and explore potential histomorphometric benefits of these bisphosphonates in periodontal therapy. This research contributes valuable insights into enhancing periodontal treatment strategies, particularly for cases involving intrabony defects.
FAQ section (important questions/answers):
What was the aim of the study conducted by Rameshwari et al.?
The study aimed to clinically and radiographically compare the efficacy of 0.05% zoledronate gel and 1% alendronate gel for local drug delivery in the treatment of chronic periodontitis.
How many patients participated in the study and what treatments were given?
Fifteen patients were involved in the study, receiving either scaling and root planning alone, scaling and root planning plus 1% alendronate gel, or scaling and root planning plus 0.05% zoledronate gel.
What clinical parameters were assessed during the study?
The study evaluated plaque index, gingival index, sulcus bleeding index, probing pocket depth, clinical attachment level, and depth of defect at baseline, 3 months, and 6 months after treatment.
What were the main findings regarding zoledronate and alendronate gel?
Both gels significantly reduced probing pocket depth and improved clinical attachment levels. Zoledronate showed slightly superior results compared to alendronate in terms of clinical and radiographic parameters.
How were the results evaluated at different time intervals?
Results were analyzed at baseline, 3 months, and 6 months using statistical tests to determine significance in clinical parameters between different treatment groups.
What conclusions were drawn from the study regarding treatment efficacy?
The study concluded that both zoledronate and alendronate gels were more effective than scaling and root planning alone, with zoledronate exhibiting a slight advantage in managing chronic periodontitis.
Glossary definitions and references:
Scientific and Ayurvedic Glossary list for “Comparison of zoledronate and alendronate gels in periodontitis.”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.
1) Study (Studying):
The term 'Study' refers to the systematic investigation conducted to evaluate the efficacy of 0.05% zoledronate and 1% alendronate gels in the treatment of chronic periodontitis. It encompasses various clinical and radiographic parameters assessed over time, providing insights into the effectiveness of local drug delivery systems in periodontal therapy.
2) Bleeding:
In the context of this research, 'Bleeding' refers to the Sulcus Bleeding Index (SBI), a clinical parameter measured to evaluate the health of the periodontal tissues. Assessing bleeding upon probing helps determine inflammation and tissue health, which are crucial in understanding the severity and resolution of periodontal disease.
3) Table:
'Table' refers to the structured data presentations within the study that summarize findings from clinical assessments, such as plaque index, gingival index, and other key metrics at various intervals. Tables enhance readability, allow for easy comparison of results, and aid in visualizing trends over time between treatment groups.
4) Disease:
'Diseases' is a broader term referring to various pathological conditions studied within the field of periodontology. While this study focuses on chronic periodontitis, understanding related diseases provides a comprehensive approach to dental health, emphasizing the significance of effective treatments for various periodontal conditions.
5) Drug:
'Drugs' in this context refers to a class of therapeutic agents, particularly the bisphosphonates (like alendronate and zoledronate) that are investigated for their efficacy in the treatment of periodontal disease. This highlights the pharmacological aspect of the study and its relevance in improving patient care.
6) Post:
'Post' in this text usually refers to the postoperative evaluation of clinical parameters. It indicates the assessments conducted after the treatments have been administered, focusing on measuring changes in the periodontal conditions over specified follow-up periods (3 and 6 months in this study).
7) Measurement:
'Measurements' reiterate the clinical parameters assessed during the study, similar to 'measurement.' The term underscores the meticulous process of evaluating periodontal conditions, equipped with statistical tools for analysis, ensuring that data gathered is reliable and informative for treatment assessments.
8) Gupta:
'Gupta' refers to a contributor or reference to previous studies cited within the research. It underscores the reliance on prior work and its findings to contextualize this study's objectives, design, and anticipated outcomes, demonstrating the continuity and evolution of periodontal research.
9) Male:
'Male' refers to the demographic aspect of the study population, indicating the gender distribution among participants. This term is relevant to discuss any sex-based variations in clinical responses to treatments, which are crucial when analyzing the efficacy and safety profiles of the studied agents.
10) Fixation:
'Fixation' relates to the stabilization of bone structure post-treatment. In the context of the study, it implies how the application of zoledronate and alendronate gels could enhance the anchorage of teeth to alveolar bone and promote beneficial bone remodeling in periodontal defects.
11) Dressing:
'Dressing' refers to the periodontal dressing applied post-treatment to promote healing and protect the treated areas. It aids in maintaining stability of the gel delivered and facilitates recovery, contributing to the overall success of the periodontal therapy conducted in the study.
12) Hygiene (Hygienic):
'Hygiene' pertains to dental hygiene practices recommended to patients during the study. Its significance lies in ensuring effective plaque control and overall mouth cleanliness, which serves as a foundational aspect of periodontal disease management and influences the outcomes of therapeutic interventions.
13) Surface:
'Surface' typically refers to the root surfaces involved in periodontal treatment. The health and condition of these surfaces are crucial as they harbor bacteria and plaque, which interact with the treatments, highlighting the importance of effective cleaning protocols in periodontal therapy.
14) Abhaya:
'Abhaya' refers to a researcher or author whose work may have provided insights or foundational studies relevant to the current research. Citing previous works by Abhaya allows for a basis for comparisons and enhances the credibility of the ongoing investigations.
15) India:
'India' designates the geographical context within which this study was conducted. It highlights the regional population involved and may indicate the relevance of cultural and environmental factors in the prevalence and treatment of chronic periodontitis in the studied demographic.
16) Pharmacological:
'Pharmacological' refers to the properties of the drugs investigated in the study. It underscores the understanding of how these medications operate on a biochemical level, particularly in inhibiting bone resorption and influencing healing processes in periodontal tissues.
17) Inflammation:
'Inflammation' is a critical pathological response in chronic periodontitis. The study measures indications of inflammation, such as bleeding and tissue health, to determine treatment effectiveness. Understanding inflammation is vital, as it drives the disease's progression and influences therapeutic outcomes.
18) Discussion:
'Discussion' refers to the section in research that interprets the results obtained from the study. This segment elaborates on the significance of findings, potential implications in clinical practice, and future areas of investigation, providing a comprehensive understanding of the research outcomes.
19) Antibiotic (Antibacterial):
'Antibiotic' refers to a class of drugs often considered in conjunction with local drug delivery therapies for periodontal disease. While the focus here is on bisphosphonates, understanding antibiotics' role highlights their potential in conjunction with mechanical debridement in treating infections.
20) Toxicity:
'Toxicity' refers to the adverse effects that drugs may present. In this context, it is particularly relevant to bisphosphonates, as the study emphasizes the importance of localized treatment to reduce potential systemic side effects commonly associated with prolonged pharmacological therapies.
21) Language:
'Language' in this instance refers to the manner in which the study's methodology and findings are communicated. Clear and comprehensible language is essential for effectively conveying complex medical information to both professional audiences and patients for better understanding.
22) Pregnant:
'Pregnant' highlights the exclusion criteria within the study, indicating that pregnant women were not involved in the research. This is crucial as hormonal changes during pregnancy can significantly impact periodontal health and the response to treatment.
23) Allergy:
'Allergy' pertains to the specific exclusion criteria where participants with known allergies to the drugs studied were discarded. It reflects the importance of ensuring participant safety and addressing potential adverse reactions, which is essential in clinical trials.
24) Nature:
'Nature' refers to the inherent characteristics of the periodontal condition and treatment methods explored in the study. Understanding the natural progression of diseases and the biological responses to treatment is vital for developing effective therapeutic strategies.
25) Animal:
'Animal' refers to prior studies conducted on animal models that inform the current research on periodontal treatments. Animal studies are often critical for early-stage evaluations of efficacy and safety before human applications, helping guide clinical research design.
26) Divya:
'Divya' is likely another contributor or author associated with the present study. Engaging multiple researchers emphasizes collaboration in scientific investigations and underscores the collective efforts in advancing knowledge in the field of periodontology.
27) Field:
'Field' refers to the domain of dentistry, particularly periodontology, where this study is situated. This term encapsulates the continuous research and clinical advancements aimed at improving patient outcomes in managing periodontal diseases.
28) Sign:
'Sign' refers to clinical indicators observable during the study, such as bleeding or probe depths. Signs are essential for assessing the presence and severity of periodontal disease, thereby informing treatment efficacy and guiding further interventions.
29) Life:
'Life' in this context suggests the overarching goal of the study, which is to enhance the quality of life for patients suffering from chronic periodontitis. Effective treatment strategies are vital for improving overall health and well-being in affected individuals.
Other Science Concepts:
Discover the significance of concepts within the article: ‘Comparison of zoledronate and alendronate gels in periodontitis.’. Further sources in the context of Science might help you critically compare this page with similair documents:
Statistical analysis, Randomized controlled trial, Ethical Clearance, Gingival index, Chronic periodontitis, Sulcus bleeding index, Scaling and root planing, Probing pocket depth, Clinical attachment level, Local Drug Delivery, Clinical parameter, Depth of Defect, Bisphosphonates, Intrabony defect.