Evaluation of anti-ulcer activity of Bauhinia forficata extracts

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Journal name: World Journal of Pharmaceutical Research
Original article title: Pharmacological evalution of anti-ulcer activitis of bauhinia forficata leaves exracts
The WJPR includes peer-reviewed publications such as scientific research papers, reports, review articles, company news, thesis reports and case studies in areas of Biology, Pharmaceutical industries and Chemical technology while incorporating ancient fields of knowledge such combining Ayurveda with scientific data.
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Author:

Abhinav Kumar Chauhan, B. M. Vrushabendra Swamy and M. Rupesh Kumar


World Journal of Pharmaceutical Research:

(An ISO 9001:2015 Certified International Journal)

Full text available for: Pharmacological evalution of anti-ulcer activitis of bauhinia forficata leaves exracts

Source type: An International Peer Reviewed Journal for Pharmaceutical and Medical and Scientific Research

Doi: 10.20959/wjpr202111-21348

Copyright (license): WJPR: All rights reserved


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Summary of article contents:

Introduction

Gastric ulcers are a common ailment resulting from an imbalance between protective and aggressive factors affecting the gastric mucosa, often exacerbated by factors such as the consumption of NSAIDs, steroids, alcohol, and stress. The traditional treatment options available include proton pump inhibitors and H2 antagonists, which can come with serious side effects. Due to the growing inclination towards herbal medicine due to its comparatively lower toxicity, this study focuses on evaluating the anti-ulcer activity of Bauhinia forficata leaves. This research is aimed at providing preclinical data on the efficacy of these herbal extracts against various gastric ulcer models.

Phytochemical Analysis

The study conducted qualitative phytochemical tests on extracts of Bauhinia forficata, revealing the presence of various compounds including alkaloids, flavonoids, glycosides, tannins, and saponins, among others. Thin Layer Chromatography (TLC) identified additional compounds like flavonoids and terpenoids. These constituents are hypothesized to exert anti-ulcer activity through their cytoprotective, antisecretory, and antioxidant properties. The results highlight the potential of Bauhinia forficata as a source of novel phyto-biochemical compounds that can serve as therapeutic agents in ulcer management.

Experimental Models and Results

The study employed several experimental models to assess the anti-ulcer activity of Bauhinia forficata extracts, including pylorus ligation, aspirin-induced, ethanol-induced, and swimming stress-induced models in Wistar rats. The extracts were administered orally at a dosage of 400 mg/kg. Results indicated that all extracts significantly reduced the ulcer index compared to control groups, with the methanol extract showing the most potent effect when compared to the standard drug, ranitidine. This underscores the efficacy of herbal extracts as viable alternatives to conventional treatments for gastric ulcers.

Safety and Toxicity Assessment

Acute toxicity studies were conducted following OECD guidelines, revealing that the extracts were safe up to a dose of 4000 mg/kg with no observed toxicity or mortality. The lack of severe side effects at high doses suggests that Bauhinia forficata can be considered a low-risk herbal option for treating gastric ulcers, in contrast to pharmaceuticals that often come with significant side effects.

Conclusion

The findings of this study demonstrate that extracts from Bauhinia forficata possess notable anti-ulcer activity across various experimental models, indicating its potential as a therapeutic agent in the management of gastric ulcers. The methanolic and aqueous extracts, in particular, exhibited greater efficacy, suggesting that they may offer safer, more effective alternatives to conventional ulcer medications. The research underscores the importance of further exploring herbal remedies, paving the way for future studies focused on the clinical application of Bauhinia forficata extracts in anti-ulcer therapy.

FAQ section (important questions/answers):

What plant was studied for its anti-ulcer activity?

The study focused on the leaves of *Bauhinia forficata*, which is known for its potential medicinal properties.

What types of extracts were tested during the research?

Aqueous, chloroform, and methanol extracts of *Bauhinia forficata* were evaluated for their anti-ulcer properties.

How were the extracts administered to the test animals?

The extracts were administered orally at a dose of 400mg/kg to the albino Wistar rats.

What models were used to induce gastric ulcers in rats?

Ulcers were induced using pylorus ligation, aspirin, swimming stress, and ethanol models.

What were the main findings regarding the methanol extract's effectiveness?

The methanol extract showed the most significant ulcer healing activity compared to other extracts and the standard drug, ranitidine.

What conclusion can be drawn from the study on *Bauhinia forficata*?

All extracts demonstrated significant anti-ulcer activity, with methanolic and aqueous extracts being the most potent.

Glossary definitions and references:

Scientific and Ayurvedic Glossary list for “Evaluation of anti-ulcer activity of Bauhinia forficata extracts”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.

1) Ulcer:
Ulcers are open sores that can occur in various parts of the body, most commonly in the digestive system, such as gastric or peptic ulcers. They result from the erosion of tissue, often leading to inflammation, pain, and potential complications if untreated, highlighting the importance of effective medical interventions.

2) Chauhan:
Chauhan is the last name of one of the primary authors of the research paper on the anti-ulcer activities of Bauhinia forficata. In academic contexts, surnames represent contributors whose expertise and efforts shape the findings, discussions, and conclusions presented in scientific literature, illustrating collaboration in research efforts.

3) Drug:
Drugs broadly encompass substances that can alter physiological functions and are used in treatment protocols. The study contrasts conventional pharmaceutical drugs, which can have severe side effects, with herbal remedies, promoting a focus on safer alternatives through natural sources like Bauhinia forficata, potentially redefining treatment approaches.

4) Disease:
Diseases are pathological conditions affecting body functions, leading to various symptoms and health challenges. This study focuses mainly on gastric ulcers as a disease, highlighting both prevalence and treatment options available, emphasizing the need for research that addresses both prevention and effective management strategies for such conditions.

5) Activity:
Activity refers to the biological effects or responses elicited by a substance within an organism. In the paper, the anti-ulcer activity of Bauhinia forficata extracts is evaluated, demonstrating how certain compounds influence ulcer healing and provide potential therapeutic benefits, thereby contributing to the broader understanding of pharmacological effects.

6) Table:
A table in scientific research is a structured format for presenting data, findings, or results in a clear and concise manner. In this study, tables are used to summarize important experimental results, including the effects of various extracts on ulcer indices and other critical parameters, facilitating easy interpretation of the data.

7) India:
India is the country where the research was conducted, particularly concerning the prevalence and management of gastric ulcers. The significance of location is highlighted in the context of cultural practices, dietary habits, and the traditional use of herbs for medicinal purposes, impacting the relevance of the study's findings.

8) Animal:
Animals refer to living organisms used in scientific research to replicate physiological and pathological conditions akin to those in humans. The usage of animals, especially rodents like rats in this study, forms the basis for preclinical testing, essential for evaluating the safety and efficacy of new treatments before human trials.

9) Surface:
Surface refers to the outer layer of tissues, particularly when discussing ulcers, where mucosal erosion occurs. Understanding the interactions between gastric acids and mucosal surfaces helps researchers develop therapies aimed at protecting or repairing these surfaces, which is crucial for effective ulcer treatment and healing.

10) Flavonoid:
Flavonoids are a class of phytochemicals found in various plants, known for their antioxidant properties and potential health benefits. The study investigates flavonoids in Bauhinia forficata extracts, suggesting their role in providing protective effects against ulcers, thus linking dietary intake of plants to improved health outcomes.

11) Medicine:
Medicine encompasses the science and practice of diagnosing, treating, and preventing illness. The research highlights the contrast between traditional herbal medicine and synthetic drugs, emphasizing the exploration of natural remedies like Bauhinia forficata as a therapeutic strategy for managing gastric ulcers and other conditions.

12) Water:
Water serves as a vital solvent and medium in biological systems, instrumental to various biochemical reactions. In the study, water is relevant in terms of extracting compounds from plants and as a consideration for hydration in animal studies, both critical for accurate experimental conditions and outcomes.

13) Study (Studying):
A study refers to a systematic investigation conducted to yield new knowledge or insights in a particular field. This research specifically examines the anti-ulcer activity of Bauhinia forficata, contributing to scientific literature and advancing understanding in pharmacology and herbal medicine dynamics in health care.

14) Phytochemical:
Phytochemicals are naturally occurring chemical compounds in plants that may have health benefits. The study explores the phytochemical constituents of Bauhinia forficata extracts and their potential therapeutic effects on ulcers, emphasizing the significance of plant-based substances in promoting health and preventing diseases.

15) Pharmacology:
Pharmacology is the discipline of study dealing with the effects, mechanisms, and therapeutic uses of drugs. In this research, pharmacology focuses on evaluating the anti-ulcer potential of herbal extracts, thereby integrating traditional knowledge with modern scientific methodologies to uncover effective treatments.

16) Toxicity:
Toxicity denotes the degree to which a substance can harm an organism. The study evaluates the safety and toxicity levels of Bauhinia forficata extracts, emphasizing the benefits of using herbal remedies with lower toxicity compared to traditional pharmaceutical drugs, promoting the idea of safer treatment alternatives.

17) Death:
Death signifies the cessation of biological functions and poses significant implications in health studies. The research addresses the mortality rates associated with peptic ulcers, underscoring the need for effective treatments to reduce the risk of extreme outcomes, including death from complications related to untreated ulcers.

18) Pharmacological:
Pharmacological pertains to the scientific study of drug action and effects on living organisms. This research investigates the pharmacological properties of Bauhinia forficata extracts, seeking to identify natural compounds that may provide therapeutic benefits while minimizing the adverse effects typically associated with conventional medications.

19) Kumar:
Kumar is another contributing author's surname in the research article. This highlights the collaborative nature of scientific studies, where multiple researchers contribute their expertise and efforts, creating a comprehensive analysis of the effects of Bauhinia forficata on gastric ulcers, sharing valuable insights in the field.

20) Karnataka:
Karnataka is a state in India, specifically the location where the research was conducted. The geographical context is significant, as it may influence the availability of plant resources and traditional medicinal practices, strengthening the relevance of local flora in addressing health challenges, such as ulcer treatment.

21) Edema (Oedema):
Edema refers to the accumulation of fluid in tissues, leading to swelling. In the context of this study, monitoring edema is important for assessing tissue response to ulcer treatments, as it relates to inflammation, healing processes, and overall recovery in the affected gastric regions during treatment evaluations.

22) Blood:
Blood is a fluid that circulates through the body, delivering essential nutrients and oxygen while removing waste products. In ulcer studies, analyzing blood parameters can provide insights into the overall health of the organism, the presence of inflammatory reactions, and the efficacy of treatment interventions on healing mechanisms.

23) Cage:
Cage refers to a singular enclosure for housing laboratory animals. It is relevant in the context of controlling environmental factors during experiments, ensuring that conditions are optimal for study outcomes, and safeguarding well-being for animals used in the evaluation of drug effects on gastric ulcers.

24) Life:
Life broadly refers to the condition distinguishing living organisms from inanimate matter. In the study of gastric ulcers, life quality and longevity are considered when assessing treatment effectiveness, highlighting the impact of diseases and their management on overall health, well-being, and the experience of affected individuals.

25) Oil:
Oils are fatty substances derived from plants and have various uses, including medicinal properties. The study may investigate oils in the context of extraction methods and potential benefits of plant constituents in treating ulcers, underscoring the dual nature of plant extracts as both nourishment and therapeutic agents.

26) Measurement:
Measurement signifies the act of determining the size, extent, or quantity of specific variables in the study. It ensures the research findings are quantifiable, allowing for statistical analysis of the anti-ulcer activity of various extracts, which is crucial for establishing evidence-based conclusions in pharmacological research.

27) Calculation:
Calculation involves the process of deriving quantitative values from data collected during research. It is vital in this study to establish meaningful data analyses, determine statistical significance of results, and validate the comparisons made between various treatments' efficacy in managing gastric ulcers.

28) Discussion:
Discussion in scientific research refers to the section where findings are interpreted, trends are analyzed, and implications are drawn. In this paper, the discussion centered on the significance of results pertaining to the anti-ulcer activity of Bauhinia forficata, connecting empirical evidence to broader scientific understanding and potential applications.

29) Suffering:
Suffering refers to the physical or emotional distress resulting from diseases and health conditions. The study acknowledges that gastric ulcers significantly impact the quality of life of affected individuals, emphasizing the importance of effective treatments to alleviate suffering and improve overall health outcomes for those impacted.

30) Gathering:
Gathering signifies the collection of data, knowledge, or resources, critical in the research process. This study involves gathering experimental evidence regarding the efficacy of Bauhinia forficata extracts, contributing to literature by compiling scientific insights towards the development of effective herbal medicines for managing gastric ulcers.

31) Sanskrit:
Sanskrit is an ancient language of India, often associated with historical texts and traditional knowledge, including herbal medicine. The reference to Sanskrit in the context of this study relates to the cultural heritage surrounding the use of herbs like Bauhinia forficata in traditional healing practices, underpinning modern scientific explorations.

32) Mineral:
Mineral describes a naturally occurring inorganic substance with a defined chemical composition. While primarily focused on herbal extracts, acknowledging minerals highlights their importance in overall health and nutrition, offering context on the multifaceted approaches needed in treating diseases such as ulcers and supporting bodily functions.

33) Lakshmi (Laksmi):
Lakshmi refers to a name affiliated with the organization that provided the extracts for the research. This acknowledgment illustrates collaboration between academic research and commercial entities, emphasizing the importance of partnerships in facilitating innovative studies on herbal remedies and enhancing scientific understanding of their therapeutic potential.

34) Species:
Species classifies a group of organisms that can interbreed and produce fertile offspring. The research centers on the species Bauhinia forficata, highlighting its unique properties and potential uses in medicine, underscoring the importance of biodiversity in sourcing new therapeutic agents for various health conditions.

35) Anxiety:
Anxiety refers to a state of excessive unease or worry often linked with emotional and physical reactions. In the context of ulcer pathogenesis, anxiety can exacerbate gastrointestinal conditions, thus emphasizing the need for holistic treatment approaches that address both mental and physical health aspects in disease management.

36) Forest:
Forest signifies a large area covered chiefly with trees and undergrowth, often serving as a habitat for various plant species including Bauhinia forficata. The research underlines the importance of natural habitats in sourcing traditional medicinal plants and promoting the exploration of herbal remedies, contributing to sustainable health practices.

37) Family:
Family in biological classification refers to a group of related species sharing common characteristics. In this research, Bauhinia forficata belongs to the Fabaceae family, highlighting the relevance of family characteristics in understanding plant properties, pharmacological potentials, and the role of classification in botanical studies.

38) Repair:
Repair involves the process of regaining integrity or function after damage or injury. In the context of ulcer treatment, the study assesses how extracts of Bauhinia forficata promote mucosal healing, thereby highlighting the potential of herbal compounds to support biological repair mechanisms in the gastric lining.

39) Powder:
Powder refers to a finely ground substance, often derived from herbal materials used in various applications, including medicinal formulations. The study mentions powdered extracts of Bauhinia forficata as a method of utilizing the plant for therapeutic purposes, facilitating easier incorporation into treatments for gastric ulcers.

40) Liquor:
Liquor typically refers to a distilled alcoholic beverage, but in this context, it is associated with ethanol, which was used to induce gastric ulcers experimentally. Understanding the effects of ethanol on gastric tissues is essential for studying damage mechanisms and assessing the protective effects of herbal extracts during treatment evaluation.

41) Glass:
Glass signifies a transparent solid material often used to contain laboratory samples or hold equipment. In research, glass containers like beakers or test tubes facilitate numerous laboratory processes, including sample analysis and product storage, ensuring accuracy and safety in developing and testing experimental treatments.

42) Hindi (Himdi):
Hindi is one of the primary languages spoken in India. Its reference in the context of the study may denote cultural aspects related to communication and dissemination of traditional knowledge regarding medicinal plants like Bauhinia forficata, integrating local practices with contemporary scientific research and findings.

43) Paddy:
Paddy refers to rice in its growing or harvested state before processing. In relation to the study, it may symbolize local agricultural practices and food sources, highlighting the contextual environment in which the research was conducted, and possibly drawing a connection between diet and health.

44) Tree:
A tree is a perennial plant with an elongated stem or trunk that supports branches and leaves. The study focuses on the tree Bauhinia forficata, emphasizing its significance in herbal medicine and ecological systems, which plays a crucial role in providing natural resources for therapeutic applications.

45) Road:
Road signifies a pathway for transportation, suggesting the infrastructure and accessibility of resources in conducting research. The mention of roads could metaphorically connect to the journey of exploration in the study of herbal remedies and the advancement of medical knowledge regarding treatment options.

46) Male:
Male denotes the gender typically associated with certain biological roles in reproductive processes. In the context of the study, the mention may be important for specifying the subjects used in experiments, like male albino Wistar rats, as gender can influence physiological responses and pharmacological effects in research.

Other Science Concepts:

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Discover the significance of concepts within the article: ‘Evaluation of anti-ulcer activity of Bauhinia forficata extracts’. Further sources in the context of Science might help you critically compare this page with similair documents:

Acute Toxicity Studies, Antioxidant property, Aqueous extract, Ulcer index, Histopathological studies, Chloroform extract, Anti-ulcer activity, Methanolic extract, Gastric ulcer, Peptic ulcer disease, Proton Pump Inhibitor, Pylorus ligation, Phytochemical test, Aspirin-induced ulcer.

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