Phytochemical, antioxidant, and AChE inhibition of Himalayan berry.
myrica esculenta buch ham ex d. don
Journal name: World Journal of Pharmaceutical Research
Original article title: Phytochemical analysis, antioxidant and acetylcholinesterase inhibition activity of himalayan berry fruit
The WJPR includes peer-reviewed publications such as scientific research papers, reports, review articles, company news, thesis reports and case studies in areas of Biology, Pharmaceutical industries and Chemical technology while incorporating ancient fields of knowledge such combining Ayurveda with scientific data.
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Subtitle: myrica esculenta buch ham ex d. don
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Parul Sood, Hurmat Khan and Richa Shri
World Journal of Pharmaceutical Research:
(An ISO 9001:2015 Certified International Journal)
Full text available for: Phytochemical analysis, antioxidant and acetylcholinesterase inhibition activity of himalayan berry fruit
Source type: An International Peer Reviewed Journal for Pharmaceutical and Medical and Scientific Research
Doi: 10.20959/wjpr202113-21982
Copyright (license): WJPR: All rights reserved
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Summary of article contents:
Introduction
The study conducted by Sood et al. primarily aimed at evaluating the phytochemical constituents, antioxidant properties, and acetylcholinesterase inhibition activity of the Himalayan berry fruit Myrica esculenta. With the rising incidence of Alzheimer’s disease (AD), which is characterized by a cholinergic deficit affecting cognitive functions, the research emphasizes the importance of exploring natural sources for potential therapeutic strategies. This paper highlights the rich antioxidant capacity of the fruit and its role in inhibiting acetylcholinesterase, which could be beneficial for Alzheimer's treatment.
Antioxidant Properties of Myrica esculeuta
Antioxidants are essential in mitigating oxidative stress, a significant contributing factor to neurodegenerative diseases. The study determined antioxidant activity through the DPPH radical scavenging assay, establishing that the methanol extract of M. esculenta exhibited the highest antioxidant capability, with an IC50 value of 100.17 µg/ml. This suggests that the fruit contains potent antioxidant compounds, primarily polyphenols, which may help combat oxidative damage associated with cognitive decline and neurodegeneration.
Acetylcholinesterase Inhibition Activity
The inhibition of acetylcholinesterase (AChE) is crucial for mitigating the cognitive deficits seen in Alzheimer's disease. Sood et al. found that the methanol extract of M. esculenta demonstrated significant AChE inhibition, with an IC50 value of 6.06 mg/ml. This activity is attributed to the fruit’s high concentration of phenolic and flavonoid compounds, which interact with the enzyme to enhance acetylcholine levels in the synaptic cleft, thereby supporting cognitive functions.
Phytochemical Analysis
The study not only assessed AChE inhibition and antioxidant properties but also performed comprehensive phytochemical screening of M. esculenta extracts. Various active compounds, including alkaloids, flavonoids, and phenols, were identified through standard tests. The methanol extract presented the highest phenolic content (27.64 mg GAE/g), reinforcing the connection between phytoconstituent profiles and functional properties, further supporting the potential of these compounds in therapeutic applications against neurodegenerative diseases.
Conclusion
This research presents a pioneering evaluation of the antioxidant and cholinergic inhibitory activities of M. esculenta fruit extracts, associating its health benefits with significant levels of phenolic and flavonoid compounds. The findings suggest that M. esculenta can be a valuable natural source of bioactive compounds for the pharmaceutical industry, particularly in developing treatments for Alzheimer's disease. With promising in vitro results, future studies should focus on in vivo testing to fully understand the efficacy and therapeutic potential of this medicinal fruit.
FAQ section (important questions/answers):
What is the focus of the study on Myrica esculenta fruit?
The study evaluates the antioxidant and acetylcholinesterase inhibition activities of Myrica esculenta extracts, aiming to explore their potential as natural sources for combating Alzheimer's disease.
What are the significant findings regarding Myrica esculenta's extracts?
The methanol extract showed the highest acetylcholinesterase inhibitory activity and total flavonoid content, while the aqueous extract exhibited the strongest antioxidant activity.
How was the phytochemical content of Myrica esculenta assessed?
Phytochemical screening revealed various active compounds including alkaloids, phenolics, and flavonoids across different extracts, using established methodologies for evaluation.
What are acetylcholinesterase inhibitors, and why are they important?
Acetylcholinesterase inhibitors are compounds that inhibit the enzyme responsible for degrading acetylcholine, potentially enhancing cognitive function and aiding treatment for Alzheimer's disease.
What did the study conclude about Myrica esculenta's potential uses?
Myrica esculenta extracts could serve as natural antioxidants and cholinesterase inhibitors, useful in pharmaceutical applications, particularly for Alzheimer's disease management.
What future research is suggested based on this study?
The authors recommend further studies in animal models of Alzheimer's disease to confirm the in vivo effectiveness of Myrica esculenta extracts.
Glossary definitions and references:
Scientific and Ayurvedic Glossary list for “Phytochemical, antioxidant, and AChE inhibition of Himalayan berry.”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.
1) Activity:
Activity refers to the biological functions or effects demonstrated by a substance. In this context, it highlights the extent to which Himalayan berry fruit extracts exhibit antioxidant properties and acetylcholinesterase inhibition, indicating its potential as a therapeutic agent in combating neurodegenerative conditions like Alzheimer's disease.
2) Flavonoid:
Flavonoids are a class of polyphenolic compounds found widely in plants, known for their antioxidant properties. In the study, flavonoids within Myrica esculenta were evaluated for their role in inhibiting acetylcholinesterase, contributing significantly to the fruit's potential health benefits, particularly in neuroprotection.
3) Sood:
Sood is the last name of the corresponding author, Parul Sood, who conducted this research on Myrica esculenta. Including the author's name emphasizes credibility and attribution, allowing readers to identify the researcher behind the findings and relate them to broader academic contributions in the field.
4) Phytochemical:
Phytochemicals are bioactive compounds produced by plants that can have health benefits. The study assesses various phytochemicals, primarily phenolic compounds and flavonoids, present in Myrica esculenta, linking these compounds to antioxidant and acetylcholinesterase inhibition activities, which are essential for developing natural therapeutic agents.
5) Disease:
Diseases refer to abnormal conditions impacting bodily functions. This research focuses on Alzheimer’s disease as a neurological condition where the antioxidant and acetylcholinesterase inhibitory properties of Myrica esculenta could provide preventive or therapeutic benefits, thereby addressing significant public health issues associated with cognitive decline.
6) Table:
Tables are used in academic research to present data clearly and succinctly. In this study, tables summarize the findings related to phytochemical content, antioxidant activity, and acetylcholinesterase inhibition, providing a quick reference to compare results systematically, contributing to clarity and efficiency in data interpretation.
7) Study (Studying):
The study outlines the comprehensive research conducted to evaluate the antioxidant and acetylcholinesterase inhibitory effects of Myrica esculenta fruit extracts. This research adds to existing knowledge, highlighting the fruit's potential health benefits and suggesting directions for future investigation in phytomedicine and neuropharmacology.
8) India:
India is the geographical origin of the Myrica esculenta plant. It emphasizes the plant's cultural and medicinal significance within traditional Indian medicine and underscores the relevance of the study in the local context, aiming to promote indigenous plants for health and well-being.
9) Species:
Species refers to the biological classification of organisms. In the study, Myrica esculenta is highlighted, stressing its unique characteristics and therapeutic potential. Understanding species-specific traits is vital for phytochemical investigations, as different species may exhibit varying biological activities and health benefits.
10) Rich (Rch):
Rich indicates a high concentration of beneficial compounds. In this context, it refers to the fruit of Myrica esculenta being rich in antioxidants and phytochemicals, which are significant for promoting human health and preventing diseases, particularly in enhancing neuroprotective effects against cognitive disorders.
11) Drug:
Drug signifies a substance used for medical treatment. The research explores the potential of Myrica esculenta fruit extracts as natural alternative drugs or supplements to conventional pharmaceutical treatments, particularly targeting Alzheimer's disease, thus reflecting the ongoing search for safer and effective therapeutic options.
12) Pharmacological:
Pharmacological pertains to the branch of medicine concerned with the uses and effects of drugs. This study contributes to pharmacological knowledge by examining the effects of compounds derived from Myrica esculenta fruit, demonstrating their therapeutic potential and informing drug development aimed at treating Alzheimer's disease.
13) Knowledge:
Knowledge encompasses the understanding gained through study and experience. This research expands scientific knowledge regarding the health benefits of Myrica esculenta, particularly its bioactive compounds, and their role in treating Alzheimer’s disease, which can inform future studies and therapeutic approaches in medicinal sciences.
14) Nature:
Nature refers to the physical world and natural phenomena, including plants and their properties. The study emphasizes the importance of natural sources like Myrica esculenta for finding therapeutic agents against diseases, advocating for the preservation and utilization of natural biodiversity in medicine.
15) Powder:
Powder denotes the processed form of plant material. In this study, it relates to the dried and powdered Myrica esculenta fruit used for extraction. The preparation of the powder is crucial for evaluating phytochemical content and ensuring the consistency of results across various assays.
16) Nagin (Nagi):
Nagi is a synonym for Myrica esculenta, indicating the plant's regional vernacular names. Recognizing local names enriches the understanding of Myrica esculenta's cultural significance and aids in its identification, fostering greater appreciation for its role in traditional herbal medicine practices.
17) Transmission:
Transmission refers to the process of communicating or passing something. In this context, it highlights the transmission of neurotransmitters in neurological functions. The study underscores the importance of acetylcholinesterase inhibition in enhancing acetylcholine transmission, essential for cognitive functions affected in Alzheimer’s disease.
18) Accumulation (Accumulating, Accumulate):
Accumulating refers to the gradual gathering of substances or effects. In the study, it pertains to the accumulating evidence of the beneficial effects of antioxidants from Myrica esculenta, suggesting their cumulative influence in mitigating oxidative stress and neurodegeneration, particularly in Alzheimer's disease.
19) Inflammation:
Inflammation is a biological response to harmful stimuli. In the context of neurodegenerative diseases, inflammation can exacerbate cognitive decline. The study considers Myrica esculenta’s potential anti-inflammatory properties, highlighting its dual role in antioxidant and anti-inflammatory activities as significant for managing Alzheimer’s disease.
20) Agriculture:
Agriculture pertains to the practice of cultivating plants for food and other products. The study's focus on collecting Myrica esculenta from agricultural fields emphasizes the importance of sustainable agricultural practices and the role of cultivated natural resources in improving health through medicinal plants.
21) Discussion:
Discussion is a segment in academic papers where results are interpreted and contextualized. In this study, the discussion elaborates on the significance of findings regarding the antioxidant and cholinergic activities of Myrica esculenta, linking them to existing literature and proposing implications for future research.
22) Srivastava (Sri-vastava, Shrivastava, Shri-vastava):
Srivastava refers to the scientist involved in the authentication of Myrica esculenta. Citing experts like Srivastava lends authority to the study, ensuring proper identification of the plant species and reinforcing the credibility of research outputs in natural product studies.
23) Himalaya (Hima-alaya):
Himalaya, often in reference to the singular form of the mountain range, underscores the geographical and ecological importance of this region. The unique Himalayan biodiversity is pivotal in discovering valuable medicinal plants, enhancing the knowledge base for herbal medicine, particularly in the context of Myrica esculenta.
24) Medicine:
Medicine encompasses the science and practice of diagnosing, treating, and preventing diseases. This study highlights the potential of Myrica esculenta fruit extracts in traditional medicine applications, demonstrating its relevance in developing natural medicinal products and enhancing therapeutic practices for cognitive disorders.
25) Learning:
Learning refers to the process of acquiring knowledge and skills. In the context of this research, it signifies the ongoing accumulation of scientific understanding regarding the pharmacological properties of plants like Myrica esculenta, essential for advancing research in the fields of botany and medicine.
26) Science (Scientific):
Science is the pursuit of knowledge through systematic study. This study embodies scientific inquiry into the properties of Myrica esculenta, exploring its potential applications in treating Alzheimer’s disease, exemplifying the role of empirical research in advancing healthcare and therapeutic strategies.
27) Allergy:
Allergy refers to the inappropriate immune response to a substance. While not directly addressed in the study, the broader implications of using natural extracts like Myrica esculenta provide potential benefits in preventing allergic reactions or managing symptoms, highlighting the plant’s versatile pharmacological profile.
28) Gelatin:
Gelatin is a protein derived from collagen, often used as a gelling agent. Although not directly examined in this study, its inclusion in methodologies or assays may be relevant in other pharmacological studies, reflecting the diversity of compounds that can interact within biological contexts.
29) Punjab:
Punjab is a region in India known for its agricultural output. Mentioning Punjab can reflect the localization of Myrica esculenta cultivation and its integration into traditional medicine practices, thereby emphasizing regional knowledge concerning the plant's uses and contributions to health.
30) Family:
Family is a taxonomic rank grouping related species. In the study, Myrica esculenta belongs to the Myricaceae family, highlighting its relationships to other plants within this classification and providing context for understanding its characteristics and potential pharmacological effects.
31) Cancer:
Cancer is a disease characterized by uncontrolled cell growth. While the research focuses on Alzheimer's disease, the potential anticancer properties of antioxidants in Myrica esculenta could warrant additional investigations, portraying the multifunctional aspects of natural plant compounds in disease prevention.
32) Animal:
Animal refers to living organisms from the kingdom Animalia. The study’s implications suggest future research may involve animal models to evaluate the in vivo effects of Myrica esculenta extracts, essential for understanding their therapeutic potential and biological interactions within complex systems.
33) Indian:
Indian denotes the geographical and cultural origin of Myrica esculenta. This connection emphasizes the plant's traditional uses in Indian medicine and its significance in preserving indigenous knowledge and practices related to herbal remedies and natural health products.
34) Ulcer:
Ulcer refers specifically to a sore that results from the disruption of the skin or mucous membrane. The research highlights the historical medicinal use of Myrica esculenta for treating conditions like ulcers, reflecting its relevance in traditional herbal remedies for various ailments.
35) Field:
Field denotes a space or area dedicated to a specific purpose, often seen in agriculture. The mention underscores the importance of studying plants like Myrica esculenta within their natural habitat, emphasizing the plant’s role in traditional practices and ecological interactions.
36) Water:
Water is fundamental for life and a critical solvent in many chemical reactions. In the context of the study, water may relate to the aqueous extract preparation of Myrica esculenta, emphasizing the method's relevance in obtaining and evaluating the phytochemicals present in the fruit.
37) Fever:
Fever is a temporary increase in body temperature, often in response to infection or illness. The study notes Myrica esculenta's use in treating fever, reflecting its traditional medicinal significance and the search for natural compounds with varied therapeutic properties.
38) Blood:
Blood is the fluid that circulates in the body, transporting nutrients and oxygen. While not a primary focus of the study, the potential health properties of Myrica esculenta, including its role in improving overall health, could encompass blood-related benefits, suggesting further research possibilities.
39) Genu:
Genu, often related to biological terminology, refers to a bend or knee in structures. Although not explicitly covered in this study, the term showcases the interconnectedness of biological terminology in the broader context of plant morphology and taxonomy within scientific literature.
40) Shri (Sri, Sr):
Shri is a respectful honorific used in India, often attached to names. Its presence indicates respect towards individuals mentioned, such as Richa Shri in the research. Such acknowledgments reflect cultural norms in academia and promote the importance of collaboration in scholarly work.
41) Food:
Food refers to any substance consumed for nutritional support. The study examines the relevance of Myrica esculenta as a natural source of antioxidants, suggesting potential uses in dietary practices as functional foods to improve health and prevent diseases, particularly neurodegenerative disorders.
42) Diet:
Diet represents the combination of foods and beverages consumed by an individual or group. The inclusion of Myrica esculenta in dietary practices promotes the idea of incorporating natural antioxidants into diets, reinforcing the importance of nutrition in maintaining cognitive health and preventing conditions like Alzheimer's disease.
43) Post:
Post denotes a position after an event or action. In academic papers, it often refers to the points following the main arguments or results, where authors may elaborate on implications, future work, or discussions surrounding their findings. Clarity in this section is vital for readers' comprehension.
Other Science Concepts:
Discover the significance of concepts within the article: ‘Phytochemical, antioxidant, and AChE inhibition of Himalayan berry.’. Further sources in the context of Science might help you critically compare this page with similair documents:
Traditional medicine, Alzheimer's disease, Phytochemical screening, Oxidative stress, Total phenolic content, Antioxidant, In vitro antioxidant activity, Total flavonoid content, Myrica esculenta, Synthetic antioxidant.