Validation of gandhaga sarkkarai via FTIR, ICP-OES, TGA analysis

| Posted in: Health Sciences Science

Journal name: World Journal of Pharmaceutical Research
Original article title: Scientific validation of gandhaga sarkkarai through ftir, icp-oes and tga analysis
The WJPR includes peer-reviewed publications such as scientific research papers, reports, review articles, company news, thesis reports and case studies in areas of Biology, Pharmaceutical industries and Chemical technology while incorporating ancient fields of knowledge such combining Ayurveda with scientific data.
This page presents a generated summary with additional references; See source (below) for actual content.

Original source:

This page is merely a summary which is automatically generated hence you should visit the source to read the original article which includes the author, publication date, notes and references.

Author:

Arunkumar G., Murugavel R., Anbarasan B., Kingsley J. and Visweswaran S.


World Journal of Pharmaceutical Research:

(An ISO 9001:2015 Certified International Journal)

Full text available for: Scientific validation of gandhaga sarkkarai through ftir, icp-oes and tga analysis

Source type: An International Peer Reviewed Journal for Pharmaceutical and Medical and Scientific Research

Doi: 10.20959/wjpr20201-16143

Copyright (license): WJPR: All rights reserved


Download the PDF file of the original publication


Summary of article contents:

Introduction

The Siddha system of medicine has a rich history that incorporates the use of plants and minerals for therapeutic purposes. This study focuses on the standardization of Gandhaga Sarkkarai, a Siddha herbo-mineral preparation, through modern analytical techniques. The research employs Fourier Transform Infrared Spectroscopy (FTIR), Inductively Coupled Plasma Optical Emission Spectrometry (ICP-OES), and Thermogravimetric Analysis (TGA) to scientifically validate the properties of Gandhaga Sarkkarai. The results shed light on its composition, containing various organic functional groups and essential minerals, indicating its potential medicinal value.

FTIR Analysis: Identifying Functional Groups

The FTIR analysis conducted on Gandhaga Sarkkarai revealed the presence of several organic functional groups, including Alcohol, Alkene, Aromatic, Amine, Ether, Ester, and Alkyl halide. Specific peak values associated with these groups were observed, such as 3397 cm⁻¹ for O-H strong (Alcohol) and 1620 cm⁻¹ for C=C variable (Alkene). These findings provide a molecular fingerprint of the substance, confirming the diverse phytochemical composition that may contribute to its therapeutic effects.

ICP-OES Study: Elemental Composition

Inductively Coupled Plasma Optical Emission Spectrometry (ICP-OES) was employed to analyze the mineral content of Gandhaga Sarkkarai. The results indicated that elements such as Calcium, Iron, Sodium, Potassium, Magnesium, Sulphur, Phosphorus, and Zinc were present within therapeutic levels. Notably, toxic heavy metals like Arsenic, Mercury, Lead, and Cadmium were found to be below detectable limits, affirming the safety of the formulation for medicinal use. This mineral composition underlines the potential efficacy of Gandhaga Sarkkarai in various health conditions.

TGA: Stability Assessment

Thermogravimetric Analysis (TGA) of Gandhaga Sarkkarai provided insights into its thermal stability, indicating that the formulation remains stable between temperatures of 50 to 400 ºC. The analysis demonstrated a significant weight loss beyond 400 ºC, marking the decomposition point of the drug. With a residual volume of 68.04% after TGA, these results suggest that Gandhaga Sarkkarai can endure significant thermal stress, which is crucial for its storage and formulation processes.

Conclusion

The scientific validation of Gandhaga Sarkkarai through FTIR, ICP-OES, and TGA demonstrates its compound integrity and safety for use in traditional medicine. The presence of beneficial functional groups and essential minerals, along with a favorable stability profile, highlights the therapeutic potential of this Siddha herbo-mineral preparation. This study reinforces the importance of integrating modern analytical techniques to understand and authenticate traditional medicinal formulations. As interest in herbal medicine continues to grow, findings like these play a vital role in bridging the gap between traditional and modern medical practices.

FAQ section (important questions/answers):

What is the purpose of the study on Gandhaga Sarkkarai?

The study aims to scientifically validate and standardize Gandhaga Sarkkarai, a Siddha herbo-mineral preparation, using modern analytical techniques like FTIR, ICP-OES, and TGA.

What methods were used for the analysis of Gandhaga Sarkkarai?

The analysis included Fourier Transform Infrared Spectroscopy (FTIR), Inductively Coupled Plasma Optical Emission Spectrometry (ICP-OES), and Thermogravimetric Analysis (TGA) to identify the drug's components and stability.

What organic functional groups were identified in Gandhaga Sarkkarai?

FTIR analysis revealed the presence of functional groups such as Alcohol, Alkene, Aromatic, Amine, Ether, Ester, and Alkyl halide in Gandhaga Sarkkarai.

What elements were found in the ICP-OES study of Gandhaga Sarkkarai?

The ICP-OES study identified elements like Calcium, Iron, Sodium, Potassium, Magnesium, Sulphur, Phosphorus, and Zinc, while heavy metals were below detectable limits.

What did the TGA results indicate about Gandhaga Sarkkarai's stability?

The TGA results indicated that Gandhaga Sarkkarai is stable at temperatures ranging from 50 to 400 ºC, with decomposition beginning beyond 400 ºC.

Who conducted the research on Gandhaga Sarkkarai?

The research was conducted by a team of scholars from the National Institute of Siddha, including Arunkumar G. and his colleagues from various departments.

Glossary definitions and references:

Scientific and Ayurvedic Glossary list for “Validation of gandhaga sarkkarai via FTIR, ICP-OES, TGA analysis”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.

1) Siddha:
Siddha refers to a traditional Indian system of medicine, primarily practiced in Tamil Nadu. It integrates herbal and metal-based treatments and emphasizes holistic health through natural sources. The Siddha approach typically involves the usage of potent herbs and minerals to promote wellness and treat various ailments, highlighting the system’s unique herbal knowledge.

2) Drug:
Drugs refer to substances that induce a physiological change in the body, particularly for therapeutic purposes. The study emphasizes the formulation of drugs in the Siddha system, specifically investigatory formulations like 'Gandhaga Sarkkarai,' showcasing traditional wisdom through contemporary research methods that enhance understanding of their medicinal value.

3) Chennai:
Chennai is the capital city of the Indian state of Tamil Nadu, known for its rich cultural tradition, especially in medicine. The study on 'Gandhaga Sarkkarai' took place at the National Institute of Siddha in Chennai, a key institution for research and promotion of Siddha medicine, contributing to the validation of traditional practices.

4) Medicine:
Medicines are various substances or compounds utilized for diagnosis, treatment, prevention, or relief of ailments. In the Siddha system, medicines may be herbal, mineral, or a combination of both. The growing interest in standardized herbal medicines like 'Gandhaga Sarkkarai' highlights the importance of reliable practices within traditional and modern medical frameworks.

5) Study (Studying):
A study refers to the systematic investigation of a subject to discover or establish facts and principles. In this case, the study aims to examine and scientifically validate 'Gandhaga Sarkkarai' using advanced analytical techniques such as FTIR, ICP-OES, and TGA, ensuring that traditional formulations are assessed accurately for their efficacy.

6) Mineral:
Minerals are inorganic elements crucial for various biological functions and health. In the context of the study, the exploration of mineral content in 'Gandhaga Sarkkarai' emphasizes its significance in enhancing therapeutic effects, detailing how these elements contribute to the holistic approach of Siddha medicine in treating various ailments.

7) Medium:
In scientific studies, a medium can refer to the environmental conditions or substances that facilitate reactions or measurements. For the analysis of 'Gandhaga Sarkkarai,' the medium refers to various implementation measures, such as solvents or matrices used for preparing samples for FTIR or ICP-OES analysis, influencing the accuracy of the results.

8) Transformation (Transform, Transforming):
Transform indicates the process of changing or converting from one state, form, or structure to another. In the context of this study, it pertains to how herbal components are processed and analyzed using modern scientific methods to validate their traditional uses, ultimately bridging the gap between ancient practices and contemporary science.

9) Science (Scientific):
Scientific relates to the systematic enterprise that builds and organizes knowledge in the form of testable explanations and predictions about the universe. In this context, 'scientific' validates traditional Siddha formulations like 'Gandhaga Sarkkarai,' ensuring that ancient herbal practices are measured against rigorous testing and methodological standards.

10) Table:
A table in scientific literature organizes data systematically, providing clarity and accessibility for interpreting results. In the study, tables present findings from FTIR and ICP-OES analyses, displaying quantitative and qualitative information about the 'Gandhaga Sarkkarai' formulation, such as the presence and concentration of specific elements and compounds.

11) Rich (Rch):
Rich denotes an abundance of certain qualities or resources. The term highlights the extensive variety of medicinal plants and minerals used in Siddha medicine, reinforcing its potential therapeutic effectiveness. The study underscores the rich phytochemical composition of 'Gandhaga Sarkkarai,' drawing attention to its capability in treating various health issues.

12) Line:
In scientific contexts, 'line' often refers to a wavelength or spectrum line used in analytical chemistry or physics. The use of distinct line characteristics in techniques like ICP-OES aids in identifying and quantifying elements in 'Gandhaga Sarkkarai,' while ensuring data accuracy through the unique signatures each element emits.

13) Hand:
In this study, 'hand' may metaphorically refer to the skill or artistry in preparing herbal formulations. It emphasizes the expertise required in Siddha medicine to accurately mix and process components, highlighting the traditional craftsmanship involved, which is being validated through scientific analysis in modern contexts.

14) Phytochemical:
Phytochemicals are bioactive compounds found in plants that contribute to the health benefits of herbal medicines. The study focuses on identifying these compounds in 'Gandhaga Sarkkarai,' as they underline the healing properties and therapeutic potentials of the formulation, bridging traditional knowledge with modern pharmacological understanding.

15) Discussion:
Discussion is a critical analysis segment in research where findings are interpreted and contextualized. In this study, the discussion surrounds the implications of the FTIR, ICP-OES, and TGA results, comparing them to traditional claims about 'Gandhaga Sarkkarai,' ultimately reinforcing the need for rigorous validation of herbal medicines.

16) Developing:
Developing often refers to the progression and emergence of new scientific knowledge or technological advancements. In the study, developing highlights the evolving landscape of herbal medicine research, bridging traditional Siddha practices with modern methodologies, thus establishing a framework for understanding and validating these practices within a scientific context.

17) Knowledge:
Knowledge refers to the understanding derived from study or experience. In this study, it encompasses both traditional Siddha wisdom and contemporary scientific insights that validate herbal formulations. It emphasizes integrating ancient medicinal practices with modern research to harness and preserve valuable therapeutic lore for future generations.

18) Container:
A container refers to a vessel used to hold materials during experimentation. In the context of the study, specific containers enable proper sample preparation for processes like microwave digestion and ICP-OES analysis, forming part of the rigorous methodologies needed to ensure accurate and reliable experimental results.

19) Tamilnadu (Tamil-nadu):
Tamil Nadu is a southern state in India known for its rich cultural heritage and traditional medicine practices, including Siddha. The region's unique flora fosters a diverse range of medicinal plants, making Tamil Nadu a vital area for studying and standardizing traditional medicinal formulations like 'Gandhaga Sarkkarai' in contemporary scientific research.

20) Murukavel:
Murugavel is likely a reference to one of the authors or researchers involved in the study. As a co-author, he contributes to the collective expertise needed for conducting rigorous scientific validation of Siddha formulations, emphasizing collaborative efforts in advancing the understanding of traditional medicine in modern healthcare.

21) Gandhaka (Gamdhaka):
'Gandhaka' refers to sulfur in the context of Siddha medicine. As a key ingredient in 'Gandhaga Sarkkarai,' it is known for its therapeutic properties. This study explores the chemical composition and validation of 'Gandhaga Sarkkarai,' providing insights into how sulfur and other constituents contribute to its medicinal efficacy.

22) Disease:
Disease refers to a particular abnormal condition that affects the function of part or all of an organism. In the context of 'Gandhaga Sarkkarai,' it focuses on conditions treated using this Siddha formulation, exploring its effectiveness and historical significance in addressing various health issues per traditional medicine principles.

23) Filling (Filled):
Filling indicates the process of preparing samples or substances in laboratory settings, ensuring accurate measurements or analyses. In this study, 'filling' pertains to sample preparation techniques, particularly for thermogravimetric analysis, which requires meticulous handling to ensure that data on stability and decomposition are valid and reliable.

24) Surface:
Surface refers to the outermost layer of a sample or material. In analyses such as thermogravimetric analysis (TGA), the surface properties of 'Gandhaga Sarkkarai' and its physical state influence how it reacts to heat, providing insights into thermal stability, composition, and potential transformations under varying temperatures.

25) Powder:
Powder is a finely ground material used in various applications, often in pharmaceuticals for uniformity and bioavailability. In the study, 'Gandhaga Sarkkarai' was processed into a fine powder before being analyzed by spectroscopy and other methods, enabling accurate identification and quantification of its chemical constituents and therapeutic properties.

26) Madra:
The term 'Madra' might refer to a historical name or cultural reference linked to Chennai. While it recognizes the historical perspective of the city within the broader context of Indian medicine, its significance in the study lies primarily in contributing to the understanding of traditional practices in a modern scientific framework.

27) India:
India is the nation that features a multitude of traditional healing systems, including Siddha medicine. The study highlights India's rich heritage of medicinal plants and traditional knowledge, showcasing how indigenous practices are increasingly being validated through scientific research, integrating them into the global health landscape and preserving them for future generations.

28) Water:
Water serves as a vital solvent in numerous chemical and biological processes. In this study, it is fundamental for sample preparation in techniques like microwave digestion and ICP-OES, where the quality of water used can significantly influence the integrity and accuracy of the results obtained from analyzing 'Gandhaga Sarkkarai.'

29) Field:
Field denotes the area of study or expertise. In the context of this analysis and research, it represents the broader domain of pharmacology, herbal medicine, or Siddha practices. The study contributes to this field by providing empirical evidence for the effectiveness of traditional formulations and highlighting their potential roles in modern medicine.

30) Pain:
Pain is a complex, multifaceted experience often resulting from disease or injury. Siddha formulations like 'Gandhaga Sarkkarai' aim to alleviate various types of pain, particularly joint pain as indicated in traditional texts. The study seeks to affirm its efficacy in managing pain through modern scientific analyses, validating traditional claims.

Other Science Concepts:

[back to top]

Discover the significance of concepts within the article: ‘Validation of gandhaga sarkkarai via FTIR, ICP-OES, TGA analysis’. Further sources in the context of Science might help you critically compare this page with similair documents:

Therapeutic value, Herbo-mineral formulation, Phytotherapy, Siddha System, Scientific validation, Fourier transform infrared spectroscopy, Inductively coupled plasma optical emission spectrometry, Traditional medicinal system, Thermogravimetric analysis, Organic functional groups.

Let's grow together!

I humbly request your help to keep doing what I do best: provide the world with unbiased sources, definitions and images. Your donation direclty influences the quality and quantity of knowledge, wisdom and spiritual insight the world is exposed to.

Let's make the world a better place together!

Like what you read? Help to become even better: