Efficacy of diclofenac and ruta graveolens on orthodontic pain
a randomized comparative trial
Journal name: World Journal of Pharmaceutical Research
Original article title: Efficacy of diclofenac and ruta graveolens in the control of orthodontic separator pain
The WJPR includes peer-reviewed publications such as scientific research papers, reports, review articles, company news, thesis reports and case studies in areas of Biology, Pharmaceutical industries and Chemical technology while incorporating ancient fields of knowledge such combining Ayurveda with scientific data.
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Subtitle: a randomized comparative trial
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Dr. Siva Rami Reddy E., Dr. Parveen Kumar Sharma and Dr. Charanjeet Singh
World Journal of Pharmaceutical Research:
(An ISO 9001:2015 Certified International Journal)
Full text available for: Efficacy of diclofenac and ruta graveolens in the control of orthodontic separator pain
Source type: An International Peer Reviewed Journal for Pharmaceutical and Medical and Scientific Research
Doi: 10.20959/wjpr20204-16901
Copyright (license): WJPR: All rights reserved
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Summary of article contents:
Introduction
The study evaluated the pain perception and relief associated with orthodontic separator pain by comparing the efficacy of diclofenac, a commonly used non-steroidal anti-inflammatory drug (NSAID), and ruta graveolens, a homeopathic remedy. The research focused on measuring patients' discomfort during tooth separation in orthodontic treatments, assessing various factors such as the duration of pain, self-medication tendencies, and overall effectiveness of both treatments. A randomized comparative trial involving 30 patients was conducted to discern the pain-relief capabilities of these two interventions.
The Role of Orthodontic Separators in Treatment
Orthodontic separators, designed to create the necessary space for molar band placement, can lead to significant pain and discomfort. Their insertion between adjacent teeth generates pressure, resulting in discomfort typically peaking between four to twenty-four hours post-placement. The objective of separating teeth is to initiate tooth movement before banding, but this process is often accompanied by pain. Different types of separators and their effects on discomfort levels have been documented; for example, latex elastics tend to cause more pain compared to others. This emphasizes the need for effective analgesics during orthodontic procedures to ease patient discomfort.
Comparative Efficacy of Diclofenac and Ruta Graveolens
The trial categorized participants into two groups: one receiving diclofenac and the other receiving ruta graveolens. Pain was assessed at multiple intervals post-separator placement using a visual analogue scale (VAS). Although both treatments resulted in significant pain reduction over seven days, statistical analysis revealed no significant difference between the two groups at varying time points. While diclofenac displayed initial efficacy, particularly in the first twenty-four hours, ruta graveolens showed competitive results subsequently. This suggests that both treatments can effectively alleviate orthodontic separator pain, though they operate through different mechanisms.
Patient Demographics and Statistical Analysis
The study involved a balanced demographic of 30 cases, comprising equal numbers of male and female participants, aged 20 to 65 years. Detailed observations recorded baseline characteristics, pain levels, and responses to treatments. Advanced statistical techniques, including repeated measure ANOVA, demonstrated a statistically significant overall reduction in pain levels, although no singular treatment emerged as superior. The analysis underlines the individualized response to analgesics and the need for careful patient selection and monitoring during orthodontic treatment.
Conclusion
The findings from this comparative trial illustrate that both diclofenac and ruta graveolens are effective in managing orthodontic separator pain, enhancing patients' experiences during treatment. Notably, the results advocate the potential for homeopathic remedies like ruta graveolens to serve as viable alternatives to conventional pain relievers, evidenced by the absence of side effects. These insights have implications for clinical practice, suggesting that practitioners can consider both treatment options to improve patient comfort and adherence to orthodontic therapies. Further research is warranted to investigate long-term effects and broader applications of these pain management strategies.
FAQ section (important questions/answers):
What was the objective of the study on orthodontic separator pain?
The study aimed to evaluate pain perception, discomfort duration, self-medication levels, and compare the efficacy of diclofenac and ruta graveolens in managing orthodontic separator pain.
How many patients participated in this orthodontic pain study?
A total of 30 patients, aged 20 to 35, experiencing orthodontic separator pain, were selected for the study.
What remedies were compared in this clinical trial?
The trial compared the effectiveness of diclofenac, a conventional analgesic, and ruta graveolens, a homeopathic remedy, in alleviating orthodontic separator pain.
What were the significant findings regarding pain reduction?
Both diclofenac and ruta graveolens led to significant reductions in pain over seven days, indicating their effectiveness in managing orthodontic discomfort.
What were the inclusion criteria for study participants?
Participants included both sexes aged 20-35 years with orthodontic separator pain, who were not taking any NSAIDs or antibiotics.
Were there any reported side effects during the study?
No side effects were reported during the study for both diclofenac and ruta graveolens, making them safe options for pain management.
Glossary definitions and references:
Scientific and Ayurvedic Glossary list for “Efficacy of diclofenac and ruta graveolens on orthodontic pain”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.
1) Pain:
Pain is a central theme in this study, focusing on the discomfort caused by orthodontic separators. It refers to the unpleasant sensations experienced by patients during dental procedures, particularly from tooth separation. Understanding pain perception is crucial in assessing the efficacy of pain relief treatments like diclofenac and ruta graveolens.
2) Shiva (Siva):
Dr. Siva Rami Reddy E. is one of the lead researchers associated with this study. His involvement as a research scholar signifies the importance of academic contributions in exploring alternative treatments for pain management in orthodontics. His findings aim to enhance patient care and inform future therapeutic practices.
3) Study (Studying):
This randomized comparative trial serves as an essential study in the field of orthodontics, evaluating the effectiveness of two pain relief methods—diclofenac and ruta graveolens. The methodology, results, and discussions of the study aim to provide insights into the management of orthodontic separator pain and contribute to existing literature.
4) Rajasthan:
Rajasthan is the Indian state where the research was conducted, specifically within the Tantia University in Sri Ganganagar. Geographic context is important as it highlights the local population and demographics studied, as well as any regional variations in pain response and treatment efficacy related to orthodontic care.
5) Table:
Tables are used within the study to present statistical data and findings clearly. These visual representations help in understanding comparisons of pain scores and other measured values between the diclofenac and ruta graveolens groups. They are crucial in facilitating data analysis and interpretation during research.
6) Post:
The term 'post' refers to measurements taken after the application of treatments (diclofenac and ruta graveolens). This aspect of the study is critical as it evaluates pain levels at various time intervals, providing insights into the progress of pain relief and the effectiveness of the interventions studied.
7) Drug:
The term 'drugs' encompasses various medications, including diclofenac and ruta graveolens, evaluated in the study for pain relief. Understanding the pharmacological profiles and effects of these drugs is critical in establishing their validity and relevance as treatments for orthodontic pain.
8) Perception:
Pain perception is a key focus of this study, as it pertains to how patients experience and report pain during orthodontic treatment. Understanding the subjective nature of pain perception helps assess the effectiveness of the tested pain relief methods and improve patient management strategies.
9) India:
The study was conducted in India, which provides context regarding the cultural, social, and healthcare environments influencing patient responses and treatment access. Understanding the national healthcare landscape is crucial for drawing broader conclusions about the applicability of study findings in similar contexts.
10) Visit:
Patient visits refer to the scheduled appointments for the placement of orthodontic separators and subsequent evaluations. The follow-up visits are integral to the study, providing opportunities to assess pain levels and the success of the interventions over time, thereby enhancing patient care.
11) Blood:
Blood tests were included in the baseline investigations for participants. This is significant for ruling out systemic issues affecting pain perception or medication metabolism. Monitoring blood parameters ensures patient safety and lends credibility to the overall research methodology.
12) Rami:
Dr. Rami refers to Dr. Siva Rami Reddy E., a critical figure in the study conducting the research. His role as a research scholar underscores the importance of academic inquiry into practical healthcare issues, aiming to improve treatment approaches in orthodontics.
13) Male:
The study sample consisted of equal gender representation, including both male and female participants. Understanding gender distribution is important for recognizing potential differences in pain perception and response to treatment, ultimately contributing to tailored patient care in orthodontics.
14) Life:
The study addresses how pain management impacts patients' quality of life, particularly during orthodontic treatment. Effective pain relief can lead to better patient experiences and enhance compliance with orthodontic protocols, promoting overall dental health and satisfaction in life activities.
15) Tuberculosis:
Tuberculosis is mentioned as an exclusion criterion for participants in this study. This is crucial to ensure patient safety and account for any underlying health issues that could confound results or affect the individual's response to pain relief treatments.
16) Inflammation:
Inflammation is a key factor in pain experienced during orthodontic treatment. The study's focus on reducing inflammation through analgesics highlights the underlying mechanisms involved in orthodontic pain management and the rationale for choosing treatments like diclofenac.
17) Discussion:
The discussion section of the study provides interpretations and implications of the findings. It enables researchers to contextualize results within existing literature, evaluate the significance of observed outcomes, and suggest future directions for research in orthodontic pain management.
18) Irritation:
Irritation is a potential side effect associated with the use of NSAIDs like diclofenac. Understanding this aspect is important in evaluating the safety and tolerability of pain relief options for orthodontic patients and comparing them against alternative treatments such as ruta graveolens.
19) Antibiotic (Antibacterial):
Antibiotic usage is mentioned as an exclusion criterion in the study to prevent interactions or adverse effects that may skew the results regarding pain management. This indicates a thorough consideration of patient history and current treatments for an accurate assessment of drug efficacy.
20) Similarity:
The concept of similarity is important in this study as diclofenac and ruta graveolens are compared for their therapeutic effectiveness. Exploring similarities in their pain relief properties helps determine if homeopathic remedies can serve as a viable alternative to conventional analgesics.
21) Medicine:
The term 'medicine' refers to the broader field encompassing both conventional and alternative treatments, such as homoeopathy. The study contributes to this field by comparing the effectiveness of traditional pharmacological approaches versus alternative remedies in managing orthodontic pain.
22) Language:
Language plays a role in the study as patients were provided instructions in both English and Hindi for understanding pain assessment methods. Effective communication is crucial in clinical research to ensure participant engagement and accurate reporting of outcomes.
23) Filling (Filled):
The term 'filling' is relevant in discussing dental procedures that may interact with orthodontic treatment. Understanding how dental fillings affect the pain response and treatment effectiveness helps orthodontists provide tailored care to patients with different dental histories.
24) Edema (Oedema):
Oedema refers to swelling, which can occur due to the pressure and trauma associated with orthodontic treatments. The study’s identification of pain and potential inflammation underscores the need for effective pain management strategies to mitigate such symptoms also indicative of the complexity of orthodontic treatment effects.
25) Sharman (Sarma, Sharma, Sarman):
Dr. Parveen Kumar Sharma is one of the co-authors of the study, and his expertise contributes to the research's credibility. The collaborative nature of the study, involving multiple specialists, highlights the interdisciplinary approach essential to addressing complex healthcare issues such as orthodontic pain management.
26) Kumar:
Dr. Charanjeet Singh Kumar is another co-author of the study, contributing to its development and execution. His involvement alongside other researchers indicates the importance of team collaboration in producing meaningful results in healthcare research concerning pain relief methodologies.
27) Sugar:
Blood sugar levels were monitored as part of the baseline investigations for study participants. This is crucial to ensure that potential systemic health issues, such as diabetes, do not interfere with the assessment of pain perception and treatment response in orthodontic patients.
28) Hindi (Himdi):
Hindi is mentioned as the language in which instructions for recording pain responses were provided to the patients. Effective communication in a language familiar to participants ensures proper understanding and compliance, which is essential for accurately gathering data in clinical research.
29) Mola (Molgisu, Molgu, Momku):
The term 'mola' refers to the molar teeth, which require separation during orthodontic treatment for band placement. Understanding the anatomical and functional significance of molars is essential for orthodontic procedures, as their positioning affects treatment planning and patient comfort.
Other Science Concepts:
Discover the significance of concepts within the article: ‘Efficacy of diclofenac and ruta graveolens on orthodontic pain’. Further sources in the context of Science might help you critically compare this page with similair documents:
Ruta graveolens, Pain relief, Statistical analysis, Follow-up, Inclusion criteria, Exclusion criteria, Visual analogue scale, Clinical guidelines, Pain perception, Randomized comparative trial, Homoeopathy, Patient Discomfort.