Review of oxaceprol's safety and efficacy for osteoarthritis management.
Journal name: World Journal of Pharmaceutical Research
Original article title: A review on safety and efficacy of oxaceprol as antiinflammatory drug in the management of osteoarthritis
The WJPR includes peer-reviewed publications such as scientific research papers, reports, review articles, company news, thesis reports and case studies in areas of Biology, Pharmaceutical industries and Chemical technology while incorporating ancient fields of knowledge such combining Ayurveda with scientific data.
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Shivprasad Khose, Sanjay Bhawar and Santosh Dighe
World Journal of Pharmaceutical Research:
(An ISO 9001:2015 Certified International Journal)
Full text available for: A review on safety and efficacy of oxaceprol as antiinflammatory drug in the management of osteoarthritis
Source type: An International Peer Reviewed Journal for Pharmaceutical and Medical and Scientific Research
Doi: 10.20959/wjpr20205-16968
Copyright (license): WJPR: All rights reserved
Download the PDF file of the original publication
Summary of article contents:
Introduction
Osteoarthritis is a prevalent joint disorder characterized by the gradual loss of articular cartilage, leading to pain and stiffness, particularly in weight-bearing joints such as the knees and hips. Among the treatments for osteoarthritis, oxaceprol, a derivative of L-proline, has become a common choice in Europe for managing this condition. As a non-steroidal anti-inflammatory drug (NSAID), oxaceprol functions by reducing leukocyte infiltration in synovial joints, thereby mitigating inflammation associated with degenerative joint diseases.
Mechanism of Action
Oxaceprol's mechanism of action distinguishes it from traditional NSAIDs. While most NSAIDs primarily focus on inhibiting the synthesis of prostaglandins, oxaceprol acts by preventing the aggregation of leukocytes in joints. This unique action helps to reduce the inflammatory response and alleviate the symptoms of osteoarthritis, making it a valuable therapeutic option for patients suffering from joint disorders. Clinically, patients are typically prescribed an initial higher dose of 37.5 to 200 mg, which is gradually reduced as treatment progresses.
Side Effects and Precautions
Like all medications, oxaceprol may lead to side effects, including gastrointestinal issues such as nausea, vomiting, and abdominal pain. Neurologically, patients may experience dizziness and headaches. The administration of oxaceprol also necessitates certain precautions, particularly for patients who have undergone surgery, pregnant or lactating women, and children, who should consult healthcare providers before starting treatment. Additionally, oxaceprol can interact adversely with anticoagulants and other medications, necessitating careful consideration of the patient's overall medication regimen.
Comparative Efficacy
The efficacy and safety of oxaceprol were compared to diacerein through a study involving 60 patients with knee osteoarthritis. Both medications were found to effectively reduce pain on the visual analogue scale and improve mobility as assessed by the Lequesne index. Notably, oxaceprol demonstrated therapeutic equivalence to diclofenac, another commonly used NSAID, while being better tolerated, with fewer reported adverse events related to the medication. This comparison indicates that oxaceprol offers a viable alternative for osteoarthritis treatment, alongside ensuring patient safety and comfort.
Conclusion
In summary, oxaceprol presents itself as an effective and well-tolerated treatment for osteoarthritis, supporting its efficacy in reducing inflammation and pain. The typical dosage for effective management typically starts high and is gradually lowered, ensuring optimal therapeutic results. The findings underscore oxaceprol’s therapeutic advantages over other NSAIDs, emphasizing its role in enhancing the quality of life for patients suffering from osteoarthritis. Continued research and clinical practice focusing on individual patient needs may further solidify oxaceprol's place in osteoarthritis management.
FAQ section (important questions/answers):
What is Oxaceprol used for in medicine?
Oxaceprol is primarily used for treating Grade-I and II osteoarthritis, as well as degenerative joint disorders and inflammation of connective tissues. It's classified as a non-steroidal anti-inflammatory drug (NSAID).
How does Oxaceprol work in the body?
Oxaceprol works by inhibiting leukocyte infiltration in synovial joints, thus reducing inflammation without primarily affecting prostaglandin synthesis, which is the common action of other NSAIDs.
What is the recommended dosage for Oxaceprol?
The standard recommended dosage of Oxaceprol ranges from 37.5 to 200 mg per tablet. Initially, a higher dose is given, which is gradually reduced based on the treatment plan.
What side effects are associated with Oxaceprol?
Possible side effects of Oxaceprol include skin rashes, dizziness, headache, gastrointestinal issues like nausea, vomiting, and abdominal pain. It's essential to monitor for these and consult a physician if they occur.
Are there any precautions or contraindications for using Oxaceprol?
Yes, patients should consult a physician before using Oxaceprol if they have surgery planned, are pregnant or lactating, or if it's intended for children with joint disorders.
How does Oxaceprol compare to Diclofenac for osteoarthritis treatment?
Studies indicate Oxaceprol is therapeutically equivalent to Diclofenac but better tolerated, with fewer adverse events reported, making it a favorable option for osteoarthritis treatment.
Glossary definitions and references:
Scientific and Ayurvedic Glossary list for “Review of oxaceprol's safety and efficacy for osteoarthritis management.”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.
1) Drug:
Drugs encompass a wide range of substances used for medical treatment. The review compares oxaceprol to other anti-inflammatory drugs like diclofenac and diacerein. This comparison is vital as it highlights oxaceprol's unique mechanism and its role among therapeutic options for osteoarthritis, contributing to clinical decision-making.
2) Pain:
Pain is a key symptom of osteoarthritis, presenting as discomfort and distress in affected joints. Understanding pain levels helps in assessing treatment outcomes. The text mentions the visual analogue scale (VAS), used to measure pain intensity, providing crucial data on the effectiveness of oxaceprol in managing osteoarthritis-related pain.
3) Study (Studying):
A study in this context refers to a structured investigation aimed at determining the effectiveness and safety of oxaceprol in treating osteoarthritis. The findings from comparative studies, including VAS and Lequesne scale assessments, provide evidence-based results essential for healthcare providers and researchers in evaluating treatment efficacy.
4) Inflammation:
Inflammation is a physiological response that often contributes to pain and discomfort in osteoarthritis. Oxaceprol's mode of action involves reducing inflammation by inhibiting leukocyte infiltration in joints. This anti-inflammatory activity is critical in the management of osteoarthritis, as controlling inflammation can alleviate symptoms.
5) Disease:
Disease refers to a pathological condition affecting the body's function. Osteoarthritis, described in detail, is a degenerative joint disease leading to pain and decreased mobility, particularly in older populations. Understanding the disease is fundamental to developing effective treatment strategies, like using oxaceprol to improve patient outcomes.
6) Ahmednagar:
Ahmednagar is a city in Maharashtra, India, where the authors of the review study are based. Its mention emphasizes the geographical context of the study, indicating local research and pharmaceutical academic contributions to the global understanding of osteoarthritis treatment, particularly the role of oxaceprol.
7) Suffering:
Suffering in this context highlights the impact of osteoarthritis on patients' quality of life. It emphasizes the need for effective treatments to alleviate the pain and disability associated with this joint disorder. Recognizing the extent of suffering can drive research into better therapeutic solutions like oxaceprol.
8) Stiffness:
Stiffness refers to the difficulty in moving joints associated with osteoarthritis. This symptom often follows periods of inactivity, significantly affecting daily activities. The review underscores the importance of addressing stiffness in treatment regimens, as reducing this symptom is vital for improving patient mobility and quality of life.
9) Pravara:
Pravara refers to the institution associated with the authors of the review. It signifies an academic foundation for the research presented, indicating collaboration between fields such as pharmacy and pharmacology to explore effective treatments for conditions like osteoarthritis, particularly the role of oxaceprol.
10) Quality:
Quality relates to the standard of treatment and life experienced by patients. The review on oxaceprol highlights its potential to improve quality in managing osteoarthritis, asserting that proper medication can alleviate symptoms such as pain and stiffness, thus enhancing patients' overall well-being and functionality.
11) Pharmacological:
Pharmacological pertains to the study of drug action and its therapeutic effects. In the context of this review, it discusses oxaceprol's specific effects on reducing inflammation in osteoarthritis, emphasizing its unique pharmacological properties compared to other non-steroidal anti-inflammatory drugs, crucial for clinicians and researchers.
12) Pharmacology:
Pharmacology is the branch of medicine concerned with the uses, effects, and mechanisms of action of drugs. Understanding pharmacology helps in the assessment of how oxaceprol works as an anti-inflammatory agent in treating osteoarthritis, establishing its role in therapeutic protocols and advancing drug development.
13) Accumulation (Accumulating, Accumulate):
Accumulation refers to the build-up of certain substances, such as leukocytes in joints during inflammation. Oxaceprol's action targets this accumulation to reduce joint swelling and pain associated with osteoarthritis. Understanding this mechanism aids in explaining the drug's efficacy in controlling osteoarthritis symptoms.
14) Vomiting:
Vomiting is a potential side effect of using oxaceprol, as mentioned in the review. It highlights the importance of monitoring patient responses to medication. Awareness of such side effects is crucial for healthcare providers to ensure patient safety and inform them about potential adverse reactions.
15) Activity:
Activity refers to the physical functions and daily tasks affected by osteoarthritis. The review identifies how treatments like oxaceprol can impact patients' ability to engage in normal activities without pain, underscoring the objective of providing effective pain relief and improving mobility for better quality of life.
16) Pregnant:
Pregnant refers to women who are expecting a child. Caution is advised for this group when considering medications like oxaceprol, as the effects on fetal development are critical. This emphasizes the importance of consultation with healthcare providers to avoid potential risks during pregnancy.
17) Samtosha (Samtosa, Santosa, Santosha, Santosh):
Santosh is one of the authors of the review, representing the collaborative effort of multiple researchers in exploring oxaceprol’s efficacy and safety. The inclusion of authors' names adds credibility and authenticity to the research presented in the study, indicating diverse contributions from the field of pharmaceutical research.
18) Nausea:
Nausea is another side effect related to oxaceprol use, indicating that its administration can lead to gastrointestinal discomfort for some patients. Awareness of nausea as a side effect is essential for patient education and management in clinical practice, ensuring informed consent and monitoring during treatment.
19) Line:
Line refers to a visualization tool in the context of the visual analogue scale (VAS) used to measure pain. The use of a line format allows patients to easily indicate their perception of pain intensity. This methodology is important for gathering quantitative data on treatment effectiveness.
Other Science Concepts:
Discover the significance of concepts within the article: ‘Review of oxaceprol's safety and efficacy for osteoarthritis management.’. Further sources in the context of Science might help you critically compare this page with similair documents:
Comparative study, Safety and efficacy, Visual analogue scale, Osteoarthritis of Knee Joint, Non steroidal anti inflammatory drug, Management of Osteoarthritis, Leukocyte infiltration.