An updated review on various pharmacological activity of biophytum sensitivum

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Journal name: World Journal of Pharmaceutical Research
Original article title: An updated review on various pharmacological activity of biophytum sensitivum
The WJPR includes peer-reviewed publications such as scientific research papers, reports, review articles, company news, thesis reports and case studies in areas of Biology, Pharmaceutical industries and Chemical technology while incorporating ancient fields of knowledge such combining Ayurveda with scientific data.
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Author:

Lithashabin P. K., Sajith Kumar P. N., Rajagopal P. L., Arthi I., Anjana A. K. and Yamuna C. V.


World Journal of Pharmaceutical Research:

(An ISO 9001:2015 Certified International Journal)

Full text available for: An updated review on various pharmacological activity of biophytum sensitivum

Source type: An International Peer Reviewed Journal for Pharmaceutical and Medical and Scientific Research

Doi: 10.20959/wjpr20205-17402

Copyright (license): WJPR: All rights reserved


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Summary of article contents:

Introduction

Medicinal plants have been utilized for centuries for their therapeutic properties, and one such plant is Biophytum sensitivum, which belongs to the family Oxalidaceae. This herb is commonly found in tropical regions of Asia, Africa, America, and the Philippines. Traditionally, it has been used in Ayurvedic medicine to treat a range of ailments, including fever, malaria, tuberculosis, and various musculoskeletal conditions. Extensive research over the past few decades has highlighted its diverse pharmacological activities, confirming its role in modern herbal medicine.

Antidiabetic Activity

One of the significant pharmacological effects of Biophytum sensitivum is its antidiabetic activity. Research shows that aqueous extracts of the plant can significantly reduce blood glucose levels in diabetic rabbits. In studies involving sub-diabetic and mild-to-severe diabetic animals, administration of leaf extracts demonstrated a 25.9% to 37.7% decrease in glucose levels. Additionally, the extracts also improved oral glucose tolerance tests, indicating a potential stimulatory effect on pancreatic beta cells. These findings suggest that B. sensitivum could offer valuable benefits for the management of diabetes.

Antioxidant and Anti-inflammatory Properties

The plant exhibits considerable antioxidant and anti-inflammatory activities. In various experimental models, Biophytum sensitivum has shown the ability to inhibit lipid peroxidation and reduce levels of superoxide radicals. The extract's antioxidant properties were confirmed both in vitro and in vivo, as it significantly increased catalase and glutathione levels in tested organisms. Meanwhile, anti-inflammatory effects were evidenced through studies indicating that different extracts of the plant can reduce carrageenan-induced edema in animal models. These properties highlight its therapeutic potential for treating oxidative stress-related and inflammatory conditions.

Antibacterial and Antitumor Effects

Biophytum sensitivum also demonstrates impressive antibacterial and antitumor properties. In laboratory studies, various extracts of the plant were effective against multiple pathogenic bacteria, with acetone extracts showing the highest antibacterial potency. Additionally, research has indicated that the aqueous extract of the plant can inhibit tumor growth and prolong the lifespan of tumor-bearing mice, illustrating its relevance in cancer treatment and prevention. These findings elucidate the potential of B. sensitivum as a natural alternative in addressing infectious diseases and cancer.

Conclusion

In conclusion, Biophytum sensitivum is a versatile medicinal plant with a wealth of therapeutic properties, including antioxidant, anti-inflammatory, antidiabetic, antibacterial, and antitumor activities. Its rich phytochemical composition supports its traditional uses and underlines the importance of further studies, especially in areas such as anti-asthmatic properties, which remain largely unexplored. Overall, B. sensitivum presents a promising avenue for the development of natural remedies in modern medicine, reaffirming the crucial role of ethnopharmacology in therapeutic innovation.

FAQ section (important questions/answers):

What is Biophytum sensitivum and its traditional uses?

Biophytum sensitivum, belonging to the Oxalidaceae family, is an annual herb used in traditional medicine to treat various ailments, including fever, asthma, diabetes, inflammation, and skin diseases.

What are the main phytochemicals found in Biophytum sensitivum?

Phytochemical analysis reveals the presence of flavonoids, tannins, saponins, terpenes, steroids, amino acids, polysaccharides, and pectin in Biophytum sensitivum, contributing to its pharmacological activities.

What pharmacological activities does Biophytum sensitivum exhibit?

Biophytum sensitivum shows various pharmacological activities, including antioxidant, anti-inflammatory, antidiabetic, antibacterial, antifertility, nephroprotective, radioprotective, and immunomodulatory effects, demonstrating its high therapeutic potential.

How does Biophytum sensitivum benefit diabetic patients?

Aqueous leaf extracts of Biophytum sensitivum have demonstrated hypoglycemic effects, significantly reducing blood glucose levels in diabetes-induced rabbits, suggesting its potential use for diabetes management.

What are some applications of Biophytum sensitivum in medicine?

Biophytum sensitivum is used in herbal medicine as an antioxidant, anti-inflammatory agent, for wound healing, diabetes control, and treating various infections, highlighting its versatile medicinal properties.

Is Biophytum sensitivum effective against bacterial infections?

Yes, methanol, chloroform, acetone, and petroleum ether extracts of Biophytum sensitivum exhibit varying antibacterial activities against pathogenic bacterial strains, indicating its potential as a natural antimicrobial agent.

Glossary definitions and references:

Scientific and Ayurvedic Glossary list for “An updated review on various pharmacological activity of biophytum sensitivum”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.

1) Activity:
Activity refers to the various pharmacological effects demonstrated by Biophytum sensitivum. This encompasses effects such as antioxidant, anti-inflammatory, antitumor, antidiabetic, antibacterial, and immunomodulatory activities. The term highlights the plant's therapeutic potential, which has been the subject of numerous studies exploring these effects in medical settings.

2) Study (Studying):
Study refers to structured investigations carried out to understand the pharmacological properties and efficacy of Biophytum sensitivum. Various studies, including both in vitro and in vivo experiments, assess its effects on diseases, providing insights into its potential medicinal uses, safety profile, and mechanisms of action in biological systems.

3) Pharmacological:
Pharmacological relates to the branch of pharmacology that studies the interactions between biological systems and drugs or herbal substances like Biophytum sensitivum. It examines the therapeutic effects, dosing, mechanisms of action, and side effects of the plant, contributing to understanding its place within herbal medicine and modern therapeutic practices.

4) Disease:
Diseases refer to the various health conditions that Biophytum sensitivum is claimed to treat. The plant has been associated with treatment protocols for ailments like fever, diabetes, and infections, establishing its importance in herbal medicine and aligning traditional knowledge with contemporary medicinal applications.

5) Animal:
Animals in pharmacological studies often refer to the various species used to assess the safety and efficacy of Biophytum sensitivum. Research involves different animal models to ensure comprehensive data on its medical effects, absorption, distribution, metabolism, and excretion of its active constituents in living organisms.

6) Blood:
Blood is relevant in studies investigating the effects of Biophytum sensitivum on blood glucose and cholesterol levels. The plant's influence on blood parameters is crucial for understanding its potential in treating conditions like diabetes and hyperlipidemia, highlighting its therapeutic applications in managing systemic health conditions.

7) Antibiotic (Antibacterial):
Antibiotic refers to the substances derived from natural sources like Biophytum sensitivum that are capable of inhibiting bacterial growth. The identification of antibacterial properties within the plant encourages the exploration of its potential as an alternative or complementary antibiotic in treating infections, thus enhancing its medicinal value.

8) Medicine:
Medicine encompasses both traditional and modern practices that involve the use of Biophytum sensitivum for therapeutic purposes. The plant’s application in folk medicine emphasizes the blend of ancient wisdom with contemporary scientific validation, contributing to the development of novel treatments derived from natural sources.

9) Water:
Water is significant in the study of Biophytum sensitivum as many of its pharmacological effects are evaluated through aqueous extracts. The solvent extraction method is essential for isolating bioactive compounds, allowing researchers to assess the plant's therapeutic properties and efficacy in treating various ailments using water as a medium.

10) Ayurveda (Ayus-veda):
Ayurveda is a traditional system of medicine from India that utilizes Biophytum sensitivum for its therapeutic benefits. The plant is mentioned in Ayurvedic texts as beneficial for various ailments, emphasizing the importance of traditional knowledge in the exploration of natural remedies and their pharmacological validation in modern research.

11) Family:
Family relates to the botanical classification of Biophytum sensitivum, which belongs to the Oxalidaceae family. This classification is important for understanding the plant's chemical constituents, characteristics, and potential pharmacological properties shared among members of the same family in plant biological research.

12) Phytochemical:
Phytochemical refers to the bioactive compounds present in Biophytum sensitivum. These compounds, such as flavonoids and saponins, play a significant role in the plant’s pharmacological activities and therapeutic potential. Understanding the phytochemical composition is crucial for unraveling the mechanisms through which the plant operates at a molecular level.

13) Flavonoid:
Flavonoid is a specific type of phytochemical found in Biophytum sensitivum known for its antioxidant and anti-inflammatory properties. These compounds are essential for the plant's therapeutic activities, establishing the relevance of flavonoids in preventing and treating various diseases through their beneficial effects on human health.

14) Himalaya (Hima-alaya):
Himalaya similarly indicates the region that influences the availability and use of Biophytum sensitivum. Research involving plants from this area may highlight their unique adaptations and potential benefits, portraying the connection between geography, environment, and the pharmacological significance of indigenous flora.

15) Science (Scientific):
Science plays a crucial role in uncovering the pharmacological activities and therapeutic potentials of Biophytum sensitivum. Ongoing research within scientific disciplines facilitates the validation of traditional beliefs regarding the plant, aligning them with empirical evidence to support its use in modern medicinal practices and applications.

16) India:
India is the geographical origin of Biophytum sensitivum, where it has longstanding cultural and medicinal significance. The integration of the plant in traditional treatments reflects India's rich history of herbal medicine, prompting interest in its exploration and validation through both Ayurvedic and Western scientific approaches.

17) Edema (Oedema):
Edema represents a condition treated by Biophytum sensitivum, showcasing its therapeutic effects. The plant’s anti-inflammatory properties have been tested in various models, indicating its potential utility in alleviating swelling and inflammation, relevant for conditions that cause fluid accumulation in body tissues, making it important in pharmacological studies.

18) Male:
Male typically denotes the gender of animal subjects used in studies involving Biophytum sensitivum, such as male rodents in efficacy tests. Such specificity is critical in pharmacological research, as gender can influence drug metabolism and responses, providing important data for understanding treatment effects across different demographics.

19) Life:
Life signifies the potential of Biophytum sensitivum to support health and wellness. As a traditional remedy, the plant's use in promoting well-being and treating ailments reflects the broader concept of life-enhancing properties derived from nature, emphasizing the intersection of health, biology, and natural medicine.

20) Tuberculosis:
Tuberculosis is a specific disease mentioned as treatable with Biophytum sensitivum, demonstrating the plant's relevance in respiratory health. The historical and current implications for using the plant against such serious conditions underscore its importance in traditional medicine and provoke scientific validation of its efficacy against infectious diseases.

21) Accumulation (Accumulating, Accumulate):
Accumulation can relate to the buildup of certain substances in the body, which Biophytum sensitivum may help address. The plant's pharmacological activity in reducing lipid accumulation and other metabolic dysregulations may suggest its role in promoting healthier physiological states, which reflects the plant's therapeutic applicability in various disorders.

22) Inflammation:
Inflammation is a physiological response addressed by Biophytum sensitivum, highlighting its therapeutic potential. The plant's ability to alleviate inflammation through its active constituents supports its application in traditional medicine, reinforcing the demand for scientific validation of its efficacy in treating inflammatory diseases and conditions.

23) Pitapushpa (Pita-pushpa, Pitapuspa):
Pitapushpa is one of the vernacular names for Biophytum sensitivum. The various common names across different cultures signify the plant's recognition in traditional medicine practices. Understanding these names enriches cultural context and the importance of the plant in local healing systems, bridging traditional and scientific narratives.

24) Lakshmana (Laksmana):
Lakshmana is a regional vernacular name associated with Biophytum sensitivum, underlining the cultural significance of this plant in local medical traditions. Such names enrich the understanding of its use and importance across different communities, providing a diverse perspective on its applications in traditional herbal practices.

25) Sanskrit:
Sanskrit refers to the ancient language where many traditional texts on herbal medicine, including those discussing Biophytum sensitivum, were written. The language carries the history and knowledge of Ayurvedic practices, contributing to the documentation and preservation of knowledge regarding this plant and its therapeutic benefits.

26) Channel:
Channel may refer to biological or pharmacological pathways influenced by the constituents of Biophytum sensitivum, essential in understanding its action mechanisms. Researh on how these channels interact can enhance knowledge of the plant's therapeutic potential and implications for treating various medical conditions.

27) Marathi:
Marathi represents one of the regional languages spoken in India, where Biophytum sensitivum is recognized and used in traditional medicine. The integration of local names and practices in Marathi emphasizes the widespread cultural relevance and applications of the plant within various indigenous healthcare frameworks across the region.

28) Lajjalu:
Lajjalu is another vernacular name for Biophytum sensitivum, primarily used in certain Indian languages. The name reflects the cultural aspect of the plant's use in folk medicine, reinforcing its status as a remedy derived from traditional practices and the importance of such nomenclature in ethnopharmacology.

29) Kannada:
Kannada is a regional language of India where names for Biophytum sensitivum may vary. The recognition of the plant in different linguistic and cultural contexts highlights its significance and the potential variances in its applications and traditional medicine practices reflecting local healing systems.

30) Bengali:
Bengali refers to a linguistic and cultural group in India, where Biophytum sensitivum is acknowledged in traditional practices. The local names and uses in Bengali culture emphasize the diversity of knowledge surrounding the plant, revealing how various communities utilize it for its medicinal properties in their health systems.

31) Mukkuti:
Mukkuti is yet another vernacular name for Biophytum sensitivum, which underscores the local significance and recognition of the plant in traditional medicine. The terminology carries historical implications and cultural practices associated with its use, highlighting the importance of understanding local names in pharmacological studies.

32) Species:
Species denotes the scientific classification of Biophytum sensitivum as a distinct organism within the plant kingdom. This classification is crucial for studying its specific characteristics, relationship to other plants, and pharmacological properties, facilitating accurate identification and understanding in botanical and pharmacological research.

33) Siddha:
Siddha is a traditional system of medicine practiced mainly in South India, where Biophytum sensitivum is utilized. The incorporation of this plant into Siddha practice highlights the importance of traditional knowledge in therapeutic applications, prompting further investigation into its pharmacological relevance and empirical studies.

34) Yamuna:
Yamuna refers to one of the authors associated with the review of Biophytum sensitivum, reflecting collaboration in research. The designation highlights the collective effort among researchers to explore and document the pharmacological properties of the plant, emphasizing the importance of teamwork in scientific inquiry.

35) Anjana (Amjana):
Anjana is another author cited in the pharmacological review, shedding light on the collaborative aspect of research related to Biophytum sensitivum. The involvement of various authors indicates the collective contribution to understanding the plant's medicinal significance, reinforcing the interdisciplinary nature of such studies.

36) Aureus:
Aureus often refers to Staphylococcus aureus, a pathogenic bacterium tested against extracts of Biophytum sensitivum in antibacterial studies. Understanding the plant's effectiveness against such pathogens contributes to its relevance as a natural remedy and emphasizes the importance of phytochemical research in addressing antibiotic resistance.

37) Lajalu:
Lajalu is another vernacular name for Biophytum sensitivum, indicating its recognition in various cultures and communities. The importance of local names in pharmacological studies reflects the rich traditional knowledge and various applications of the plant in treating ailments, enhancing its significance as part of ethnomedicine.

38) Cancer:
Cancer is a critical disease area where Biophytum sensitivum has demonstrated potential therapeutic effects. Research into its antitumor properties enhances understanding of the plant's mechanism against malignancies, offering insights into natural treatment options and highlighting the significance of phytomedicine in cancer management.

39) Bitter:
Bitter refers to the taste of Biophytum sensitivum, which is associated with certain therapeutic properties in traditional medicine. The bitter taste often correlates with compound efficacy, suggesting the potential pharmacological effects the plant may have in stimulating digestion and metabolic processes through its bioactive constituents.

40) Kumar:
Kumar signifies one of the authors involved in the review process of Biophytum sensitivum. The designation emphasizes the collaborative nature of research that involves various individuals contributing their expertise to further understand and explore the medicinal relevance of the plant within pharmacological studies.

41) Hindi (Himdi):
Hindi is a prominent language in India, where Biophytum sensitivum is recognized and utilized in traditional medicinal practices. The inclusion of Hindi terminology enriches the cultural context and allows for better understanding of the plant's applications and acceptance in various cultural healthcare systems.

42) Fever:
Fever is a common symptom that Biophytum sensitivum is traditionally used to treat. The plant's antipyretic properties hold significance in herbal medicine, and research into these effects may provide insights into its efficacy in regulating body temperature and alleviating febrile conditions in patients.

43) Genu:
Genu refers to the biological context, usually indicating the knee or leg area, that may relate to conditions treated by Biophytum sensitivum. Understanding anatomical references helps contextualize the relevance of the plant in addressing specific ailments impacting mobility and musculoskeletal health.

44) Burning (Burn, Burned, Burnt):
Burn refers to a type of injury that can be treated using Biophytum sensitivum. The plant's application in burn treatment highlights its anti-inflammatory and healing properties, reinforcing the significance of herbal medicine in managing tissue injuries and promoting recovery in patients affected by burns.

45) Tamil:
Tamil is another regional language in India where Biophytum sensitivum is recognized. Understanding the local language and its cultural context helps to appreciate the various traditional practices and applications of the plant within indigenous medicine systems, thereby reinforcing its significance in healthcare.

46) Pupa:
Pupa is part of the life cycle of insects, and studies on Biophytum sensitivum's effects on larvicidal activity often involve pupa stages of mosquitoes. Understanding the impact of the plant at this developmental phase can suggest its ecological relevance and applications in pest control, contributing to integrated insect management strategies.

47) Beta:
Beta may refer to pancreatic beta-cells, which are significant in the context of Biophytum sensitivum's antidiabetic properties. Research indicates that the plant may stimulate these cells, promoting insulin production, which is crucial for regulating blood sugar levels and treating diabetes effectively.

48) Jala:
Jala, which translates to 'water' in Hindi and other languages, signifies the importance of aqueous extracts in studying Biophytum sensitivum. Water is often used as a solvent for extracting the plant's bioactive compounds, which are then evaluated for their therapeutic properties in research settings.

49) Drug:
Drug signifies the formulation derived from Biophytum sensitivum that is used to treat illnesses. The plant's bioactive compounds play a crucial role in identifying and developing drugs, emphasizing the potential for herbal medicines to evolve into pharaceutical treatments that align with current medical practices.

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Discover the significance of concepts within the article: ‘An updated review on various pharmacological activity of biophytum sensitivum’. Further sources in the context of Science might help you critically compare this page with similair documents:

Biophytum sensitivum, Antibiotic, Traditional medicine, Pharmacological activities, Phytochemical analysis, Anti-inflammatory, Immunomodulatory, Nephroprotective, Antioxidant, Anti pyretic, Hypocholesterolemic Effect, Larvicidal activity, Antihypertensive, Tropical Asia.

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