Journal name: World Journal of Pharmaceutical Research
Original article title: An update and literature review
The WJPR includes peer-reviewed publications such as scientific research papers, reports, review articles, company news, thesis reports and case studies in areas of Biology, Pharmaceutical industries and Chemical technology while incorporating ancient fields of knowledge such combining Ayurveda with scientific data.
This page presents a generated summary with additional references; See source (below) for actual content.
Subtitle: benzimidazoles as anti cancer agents
Original source:
This page is merely a summary which is automatically generated hence you should visit the source to read the original article which includes the author, publication date, notes and references.
Thatikayala Mahender
Download the PDF file of the original publication
World Journal of Pharmaceutical Research:
(An ISO 9001:2015 Certified International Journal)
Full text available for: An update and literature review
Source type: An International Peer Reviewed Journal for Pharmaceutical and Medical and Scientific Research
Doi: 10.20959/wjpr20205-17329
Copyright (license): WJPR: All rights reserved
Summary of article contents:
1) Introduction
Cancer is a major global health concern characterized by the uncontrolled proliferation of cells. It disproportionately affects women, with common types of cancer including breast, lung, and colorectal cancers. Projections indicate a significant increase in cancer cases, expecting 21.4 million new cases and 13.2 million deaths annually by 2030. Key factors contributing to the development of cancer encompass genetic predispositions, lifestyle choices such as tobacco use, and exposure to ionizing radiation. Amid these challenges, research into therapeutic agents is critical, particularly the exploration of various pharmacological compounds like benzimidazoles, which demonstrate a diverse range of medicinal properties, notably their anticancer activity.
2) Chemistry of Benzimidazole
Benzimidazole is a noteworthy heterocyclic compound formed by the fusion of a benzene ring with an imidazole. This structure imparts significant pharmacological activities, including anticancer, antimicrobial, anti-inflammatory, and analgesic properties. Researchers are increasingly focused on synthesizing benzimidazole derivatives to enhance their therapeutic efficacy. The compound's appeal lies in its potential to combat various diseases, with a particular emphasis on its role as an anticancer agent. The continued exploration of benzimidazole chemistry is integral to the development of effective treatments for cancer.
3) Anticancer Activity of Benzimidazole Derivatives
Numerous studies have identified various benzimidazole derivatives that exhibit notable anticancer activities across different cancer cell lines. For instance, compound N9, N18 showed a promising IC50 value against human colorectal cancer cells, indicating effective growth inhibition. Other derivatives, such as 3f and 3p, demonstrated compelling anticancer effects against liver, colon, and breast cancer cells with remarkably low IC50 values. Such findings underscore the potential of tailored benzimidazole compounds to serve as potent anticancer agents and highlight the ongoing pursuit of new derivatives that retain strong biological activity.
4) Trends in Research with Benzimidazole Derivatives
Research has consistently yielded new benzimidazole derivatives with varying degrees of anticancer effects. For example, compounds synthesized in recent studies showed effectiveness against a range of cancers such as lung (A549), breast (MCF-7), and colorectal cell lines. Notable examples include derivatives with IC50 values less than 1μM, illustrating their high potency. Additionally, the structural diversity and modifications in these compounds have led to enhanced selectivity and reduced side effects, positioning benzimidazole derivatives as promising candidates for future cancer therapeutics.
5) Conclusion
The exploration of benzimidazole and its derivatives reveals significant potential in the fight against cancer. Due to their wide array of biological activities, these compounds are of great interest in medicinal chemistry, prompting researchers to synthesize new derivatives with the aim of reducing cancer incidence and improving patient outcomes. The findings from various studies serve as a valuable resource for researchers focused on discovering innovative benzimidazole derivatives with enhanced anticancer properties. Continuous research and development in this area may lead to breakthroughs in the treatment of cancer, ultimately contributing to improved therapeutic strategies.
FAQ section (important questions/answers):
What are the main characteristics of cancer discussed in the review?
Cancer is characterized by uncontrolled cell proliferation. It predominantly affects women and is commonly found in forms such as breast, lung, and colorectal cancer.
What are benzimidazoles and their significance in medicine?
Benzimidazoles are heterocyclic compounds known for various pharmacological activities, including anticancer, antimicrobial, and anti-inflammatory properties, making them significant in medicinal chemistry.
What are the projected cancer statistics by 2030 mentioned in the text?
By 2030, it is projected that there may be 21.4 million new cancer cases annually, resulting in approximately 13.2 million cancer deaths worldwide.
Which types of cancer are most commonly referenced in the review?
The review predominantly references breast, lung, and colorectal cancers, which are among the most effective and common types affecting individuals globally.
What are some activities of benzimidazole derivatives in cancer research?
Benzimidazole derivatives show potential as anticancer agents, with multiple studies reporting their effectiveness against various cancer cell lines, including colorectal and breast cancer.
What acknowledgement does the author give at the end of the review?
The author acknowledges the Head of Jayamukhi Institute of Pharmaceutical Sciences for providing the necessary facilities to conduct the research work presented in the review.
Glossary definitions and references:
Scientific and Ayurvedic Glossary list for “An update and literature review”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.
1) Cancer:
Cancer refers to a group of diseases characterized by uncontrolled cell proliferation. It poses significant health risks globally, with high prevalence among women and men, particularly for types such as breast, lung, and colorectal cancer. This alarming trend strains healthcare systems and necessitates continued research for effective treatment agents, including benzimidazoles.
2) Activity:
In a pharmacological context, activity refers to the functional effects of a compound, such as benzimidazole derivatives, on biological systems. Anticancer activity indicates that these compounds can inhibit or kill cancer cells, which is crucial for developing new medications that can enhance current cancer therapies and improve patient outcomes.
3) Line:
Line often refers to a specific cell line used in laboratory research to study the properties and efficacy of new drugs. For instance, various cancer cell lines, such as Hela, are utilized to test the effectiveness of benzimidazole derivatives in inhibiting cancer cell growth and understanding the compounds' mechanisms of action.
4) Hela (Helá):
Hela cells are a continuous cell line derived from cervical cancer cells, known for their robustness and ease of use in research. They serve as a vital model for studying cancer biology and testing new anticancer drugs, making them essential in evaluating the effectiveness of benzimidazole derivatives highlighted in the review.
5) Pharmacological:
Pharmacological relates to the study of how drugs interact with biological systems. This field is integral in developing new medications, including the evaluation of benzimidazole compounds for their potential as anticancer agents. Understanding pharmacological properties helps researchers optimize therapeutic efficacy and minimize side effects for patients.
6) India:
India is notable in the context of the research discussed, as the study originates from the Jayamukhi Institute of Pharmaceutical Sciences in Warangal, Telangana. The country is increasingly contributing to global cancer research and drug development, addressing the rising incidence of cancer within its population and beyond.
7) Warangal:
Warangal is a city in Telangana, India, and serves as the location for the Jayamukhi Institute of Pharmaceutical Sciences, where this significant research is conducted. The city's academic institutions contribute to advancing the pharmaceutical sciences and developing potential cancer treatments, highlighting India's role in global health innovations.
8) Science (Scientific):
Science as a broader discipline underpins research methodologies and data interpretation in studies like those on benzimidazole derivatives. It provides the foundation for evidence-based conclusions and advancements in medicine, enabling researchers to identify and derive new compounds that could pave the way for effective cancer treatments.
9) Suffering:
Suffering refers to the physical and emotional pain experienced by individuals with diseases, including cancer. Addressing this suffering through effective treatments is the primary goal of pharmaceutical research, as highlighted in the study of benzimidazole compounds, which aim to alleviate patient distress and improve quality of life.
10) Disease:
Disease is a term that encapsulates ailments affecting the body's normal functioning. In the context of this review, it predominantly focuses on cancer, highlighting the urgent need for ongoing research and development of new therapeutic agents to combat the increasing incidence and impact of this challenging health crisis.
11) Sharman (Sarma, Sharma, Sarman):
Sharma represents a reference within the reviewed literature, particularly in studies or findings related to benzimidazole derivatives. Such references in research highlight the collaborative efforts within the scientific community to explore and enhance anticancer activities, emphasizing the importance of shared knowledge in advancing cancer therapies.
12) Death:
Death signifies the ultimate consequence of unresolved diseases, particularly in cancer, where significant mortality rates are prevalent. The urgent need to mitigate cancer-related deaths drives pharmaceutical research towards discovering effective treatments, such as benzimidazole derivatives, which aim to improve survival rates and patient outcomes in oncology.
13) Shrinivasa (Shri-nivasa, Srinivasa):
Srinivasa refers to another contributor in the reviewed studies, reminiscent of the collaborative nature of cancer research. Identifying various researchers underscores the collective effort to explore the therapeutic potential of new compounds, essential for advancing pharmacological sciences and creating more effective treatment strategies against cancer.
14) Medicine:
Medicine encompasses the science and practice of diagnosing, treating, and preventing diseases. This includes the exploration of novel pharmacological agents, like benzimidazole derivatives, aimed at combating cancer. An understanding of medicine is integral for researchers to devise strategies that effectively address complex health issues.
15) Sam (Sham):
Sham denotes a reference within the research literature that contributes to understanding the therapeutic potential of benzimidazole compounds. It exemplifies collaboration in the scientific community, showcasing how the collective efforts of various researchers can lead to significant advancements in cancer treatment innovations.
16) Gold (Golden):
Gold refers to a specific complex mentioned in the study involving Gold (III) pyridine-benzimidazole complexes, known for their anticancer activity. The exploration of metal complexes offers unique insights into novel therapeutic approaches, and their evaluation showcases the versatility and potential application in cancer treatment.
Other Science Concepts:
Discover the significance of concepts within the article: ‘An update and literature review’. Further sources in the context of Science might help you critically compare this page with similair documents:
Breast cancer, Pharmacological activities, Genetic factor, Biological evaluation, Colorectal Cancer, Lung cancer, IC 50 value, Molecular docking studies, Tumor growth inhibition, EC 50 value, Anti-cancer agent, Cancer statistics, Physical risk factors, Oral efficacy, Behavioral risk factor.