Evaluation of Erandadi Vati: Pharmacognostical and Pharmaceutical

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Journal name: World Journal of Pharmaceutical Research
Original article title: Pharmacognostical and pharmaceutical evaluation of polyherbal formulation erandadi vati
The WJPR includes peer-reviewed publications such as scientific research papers, reports, review articles, company news, thesis reports and case studies in areas of Biology, Pharmaceutical industries and Chemical technology while incorporating ancient fields of knowledge such combining Ayurveda with scientific data.
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Author:

Dr. Bhagwati Solanki, Prof. Anup Thakar, Dr. Rahul Gandhi, Harisha C. R., Shukla V. J.


World Journal of Pharmaceutical Research:

(An ISO 9001:2015 Certified International Journal)

Full text available for: Pharmacognostical and pharmaceutical evaluation of polyherbal formulation erandadi vati

Source type: An International Peer Reviewed Journal for Pharmaceutical and Medical and Scientific Research

Doi: 10.20959/wjpr20206-17561

Copyright (license): WJPR: All rights reserved


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Summary of article contents:

Introduction

The study conducted by Dr. Bhagwati Solanki and colleagues focuses on the pharmacognostical and pharmaceutical evaluation of a polyherbal formulation known as Erandadi Vati, which is traditionally used in Ayurvedic medicine primarily for the treatment of Amavata, or Rheumatoid arthritis. The purpose of the research is to standardize this formulation by assessing its quality, purity, safety, and efficacy based on the components' active principles. Through organoleptic assessment, pharmacognostical study, and physicochemical analysis, the study aims to facilitate the worldwide acceptance of Ayurvedic formulations like Erandadi Vati.

Organoleptic and Pharmacognostical Evaluation

The organoleptic evaluation of Erandadi Vati assesses its sensory characteristics, providing insights into its physical properties. The study revealed that the formulation presented a light brown color, a sweet odor, and a sweet-pungent taste, with a solid texture that was hard yet compressible. The pharmacognostical evaluation focused on identifying and authenticating the raw materials used in Erandadi Vati. Through morphological and organoleptic evaluations, along with powder microscopy, significant structures such as the oleoresin content of Shunthi (Zingiber officinale) and various cell types from Eranda (Ricinus communis) were documented, confirming the quality of the ingredients.

Physicochemical Analysis

A detailed physicochemical analysis of Erandadi Vati yielded important data on various analytical parameters. The study measured weight variation, hardness, loss on drying, ash value, and solubility in water and alcohol. Results indicated that the overall uniformity of the tablets was satisfactory, with a weight variation of just 4%, and the loss on drying was 23.32%. These analyses are critical for establishing the quality and consistency of the formulation, paving the way for regulatory acceptance and clinical use.

High-Performance Thin Layer Chromatography (HPTLC)

HPTLC analysis was performed on the methanolic extract of Erandadi Vati, allowing for the identification of its chemical constituents. The results revealed a total of 14 spots when viewed under UV light at 254 nm, and 13 spots at 366 nm, indicating the presence of multiple active ingredients within the formulation. This analytical approach assists in understanding the chemical profile of Erandadi Vati, which is vital for substantiating its therapeutic claims and efficacy in treating conditions like Amavata.

Conclusion

The comprehensive evaluation of Erandadi Vati demonstrates its potential as an effective Ayurvedic treatment for Amavata through pharmacognostical and physicochemical assessments. The findings indicate that the formulation meets high qualitative standards and all parameters discussed can serve as essential tools for its quality assessment. The outcomes of this study could provide foundational references for future research and standardization of Ayurvedic formulations, contributing to the broader acceptance and utilization of traditional medicine in modern healthcare systems.

FAQ section (important questions/answers):

What is the focus of the study on Erandadi Vati?

The study focuses on the pharmacognostical and pharmaceutical evaluation of Erandadi Vati, a polyherbal formulation used in Ayurveda, specifically for treating Amavata, or Rheumatoid arthritis.

What are the main ingredients in Erandadi Vati?

Erandadi Vati consists of three primary ingredients: Eranda (Ricinus communis) seeds, Sunthi (Zingiber officinale) rhizome, and Sharkara (sugar), all in equal proportions.

What methods were used to prepare Erandadi Vati?

The preparation involved grinding the ingredients into a fine powder, mixing them with a binding agent, forming granules, and finally compressing these into tablets using a tablet-making machine.

What physicochemical parameters were evaluated in Erandadi Vati?

Physicochemical analysis included evaluating tablet uniformity, hardness, loss on drying, ash values, and solubility in water and alcohol, among other parameters to ensure quality.

What were the results of the organoleptic evaluation?

The organoleptic evaluation of Erandadi Vati revealed it to be light brown in color, with a sweet odor and taste, while its texture was solid and hard yet compressible.

What significance does the study have for Ayurvedic formulations?

The study's findings provide standardization benchmarks for Erandadi Vati, promoting its quality assessment, safety, and efficacy, which is critical for broader acceptance in modern healthcare.

Glossary definitions and references:

Scientific and Ayurvedic Glossary list for “Evaluation of Erandadi Vati: Pharmacognostical and Pharmaceutical”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.

1) Vati:
Vati refers to a type of Ayurvedic formulation that typically comes in the form of medicinal tablets or pills. These formulations are often composed of various herbal and mineral ingredients, aimed at delivering therapeutic benefits in a concentrated form. In the context of Erandadi Vati, it serves as a polyherbal remedy specifically used for treating conditions such as Amavata (Rheumatoid arthritis).

2) Shunthi (Sunthi, Sumthi, Shumthi):
Sunthi, or ginger rhizome, is a primary ingredient in Erandadi Vati recognized for its anti-inflammatory and digestive properties. Its inclusion enhances the therapeutic efficacy of the formulation against conditions like Amavata, aiding in digestion and alleviating joint pain, thus playing a crucial role in the overall remedy.

3) Eranda (Eramda):
Eranda, or Ricinus communis (castor oil plant), is another critical component of Erandadi Vati. Its seeds are often used in traditional medicine for their purgative properties and role in detoxification. Eranda helps in balancing Vata dosha, making it effective for conditions like Amavata characterized by excess Vata disturbances.

4) Amavata (Ama-vata):
Amavata translates to 'rheumatoid arthritis' in Ayurveda, characterized by the accumulation of Ama (toxins) in the joints. The term signifies a condition resulting from poor digestion and vitiated Vata. Erandadi Vati is formulated to address this imbalance and aid in the cleansing and revitalization of bodily functions.

5) Drug:
The term 'drugs' broadly refers to any medicinal substances used for diagnosis, cure, treatment, or prevention of diseases. In this study, the focus is on the combination of herbs and their synergistic effects in Erandadi Vati, aiming to enhance its therapeutic claims for rheumatoid arthritis.

6) Study (Studying):
The term 'study' denotes the structured research undertaken to examine the pharmacological aspects of Erandadi Vati. It encompasses methodologies for analyzing its ingredients, evaluating their effectiveness, and ensuring the formulations meet safety and quality standards. The study's outcomes contribute to the wider acceptance of Ayurvedic therapies.

7) Solanki:
Dr. Bhagwati Solanki is the lead researcher mentioned in the article, whose work focuses on the pharmacognostical and pharmaceutical evaluation of Erandadi Vati. His contribution to the study is significant for establishing evidence-based practices in Ayurveda and enhancing the credibility of traditional medicine through scientific validation.

8) Table:
In this document, 'table' refers to organized data representations that summarize findings, such as the ingredients of Erandadi Vati, results from physicochemical analyses, and outcomes from pharmacognostical studies. Tables serve to present complex information in a clear and concise manner, facilitating easier comprehension and comparison.

9) Pharmacognostical:
Pharmacognostical refers to the branch of pharmacology dealing with the study of medicinal drugs derived from natural sources, primarily plants. The pharmacognostical evaluation conducted in this study identifies and authenticates the ingredients of Erandadi Vati, ensuring their quality and therapeutic characteristics align with Ayurvedic principles.

10) Ayurveda (Ayus-veda):
Ayurveda is a holistic system of medicine developed in ancient India, emphasizing a balance between mind, body, and spirit. It employs natural remedies, herbal formulations, and lifestyle changes to promote health and treat diseases. The study of Erandadi Vati is rooted in Ayurvedic practices, addressing specific conditions like Amavata.

11) Water:
Water plays an essential role in the formulation and preparation of Ayurvedic medicines, including Erandadi Vati. Its presence as a solvent in extraction processes is critical for isolating bioactive compounds from herbal materials. The study examines water solubility properties of the formulation, reflecting its potential efficacy in therapeutic applications.

12) Dravya:
Dravyas encompass all medicinal substances utilized in Ayurveda. This term is integral to the formulation of Erandadi Vati, as it includes the specific herbs and compounds that contribute to its therapeutic effects. A good understanding of various dravyas is essential for effective treatment planning in Ayurvedic medicine.

13) Basti:
Basti refers to a therapeutic enema treatment in Ayurveda used to eliminate toxins and balance doshas, specifically Vata. It is often used in conjunction with oral medicines like Erandadi Vati for comprehensive management of conditions like Amavata, enhancing detoxification and restorative processes in the body.

14) Rheumatoid arthritis:
Rheumatoid arthritis is a chronic inflammatory disorder that affects joints, characterized by pain, swelling, and potential joint erosion. In the Ayurvedic context, it is termed Amavata, necessitating a holistic approach for treatment. Herbal formulations like Erandadi Vati aim to alleviate symptoms and restore bodily harmony.

15) Shothahara (Sothahara, Shotha-hara):
Shothahara refers to the therapeutic properties that reduce swelling and inflammation. In the context of Erandadi Vati, the inclusion of ingredients with Shothahara qualities aims to combat the inflammatory nature of conditions like Amavata, promoting healing and relief from discomfort associated with arthritis.

16) Gujarat:
Gujarat is a state in India where the research was conducted. The study emphasizes traditional Ayurvedic practices rooted in the region. It serves as a hub for Ayurvedic education and research, contributing to the global understanding of herbal medicine and its applications, particularly regarding formulations like Erandadi Vati.

17) Quality:
Quality in this context refers to the assessment of the composition, effectiveness, and safety of the Ayurvedic formulation Erandadi Vati. The study emphasizes the importance of pharmacognostical and physicochemical evaluations to ensure that the final product meets the required medicinal standards for patient use.

18) Powder:
Powder in this context refers to the form in which the individual ingredients of Erandadi Vati are processed before formulation. Herbal materials are ground into a fine powder, facilitating the extraction of bioactive compounds and enabling better absorption when consumed, which is essential for maximizing the therapeutic potential.

19) Rasa (Rasha):
Rasa translates to 'taste' in Ayurveda and signifies the fundamental properties that influence a drug's therapeutic effect. Different rasas are associated with various dosha-balancing properties. In the study of Erandadi Vati, understanding rasa helps in tailoring the formulation for specific imbalances associated with Amavata.

20) Anuvasanabasti (Anuvasana-basti):
Anuvasana-basti is a specific type of enema in Ayurveda that utilizes herbal oils meant to nourish and soothe the body. Used alongside Erandadi Vati, it aims to enhance the management of Amavata by providing direct relief to affected areas, emphasizing the holistic healing approach of Ayurveda.

21) Saindhavadi:
Saindhavadi refers to a type of therapeutic Basti that uses rock salt. It is integrated into Ayurvedic practices for relieving pain and inflammation associated with conditions like Amavata. The term underscores the diverse methodologies in Ayurveda aimed at effectively addressing arthritic symptoms alongside herbal formulations like Erandadi Vati.

22) Performance:
Performance in this research context refers to how well Erandadi Vati demonstrates the expected therapeutic effects evaluated through pharmacognostical and pharmaceutical methods. The study assesses performance parameters, ensuring that the formulation manifests its intended benefits in treating conditions like Amavata.

23) Transformation (Transform, Transforming):
Transformed refers to the process of converting the powdered herbal ingredients into a specific form, often tablets or granules in the case of Erandadi Vati. This term signifies the pharmaceutical aspect of traditional formulations, emphasizing the importance of preparation methods in ensuring efficacy and dosage accuracy.

24) Observation:
Observation refers to the careful monitoring and recording of characteristics and effects during the research study of Erandadi Vati. This includes noting changes in organoleptic properties, physicochemical parameters, and therapeutic outcomes, allowing researchers to draw conclusions about the formulation's quality, effectiveness, and potential clinical applications.

25) Discussion:
The discussion segment of the research provides an analysis of the findings and their implications in the context of traditional medicine. Here, the researchers interpret results, reflecting on the pharmacognostical and pharmaceutical assessments of Erandadi Vati, positing how these contribute to the broader understanding of Ayurvedic formulations.

26) Accumulation (Accumulating, Accumulate):
Accumulate in this context refers to the gathering of Ama (toxins) in the joints, leading to the condition known as Amavata. The study highlights how specific ingredients in Erandadi Vati work synergistically to prevent accumulation and promote detoxification, thus addressing root causes of rheumatoid arthritis effectively.

27) Anuvasana:
Anuvasana refers to a methodical approach in Ayurveda involving the introduction of medicated oils or decoctions into the rectum. This technique is complementary to oral medications like Erandadi Vati, aiming to facilitate internal cleansing and alleviate vitiated Vata regarding conditions such as Amavata.

28) Tiktarasa:
Tiktarasa means 'bitter taste' in Ayurveda, and its presence in a formulation is associated with detoxifying properties. Compounds with Tiktarasa are used to correct imbalances in the body, particularly those involving digestion, making them beneficial in alleviating symptoms of diseases like Amavata when included in Erandadi Vati.

29) Katurasa (Katu-rasa):
Katu-rasa signifies 'pungent or spicy taste' in Ayurveda, which is often linked to increased digestion and metabolism. Ingredients in Erandadi Vati with Katu-rasa help stimulate digestive fire (Agni) and can contribute to the overall treatment efficacy for conditions like Amavata by promoting digestive health.

30) Pariksha (Pariksa):
Pariksha translates to 'examination' or 'evaluation' in Ayurveda, referring to the systematic analysis of a drug or component. In this study, Pariksha takes place through various assessments like pharmacognostical evaluations, aiming to validate the various characteristics and therapeutic potentials of Erandadi Vati.

31) Mandagni (Manda-agni, Mamdagni):
Mandagni translates to 'low digestive fire' in Ayurveda, representing a condition where the body fails to digest food effectively, resulting in the formation of Ama. This concept is crucial in Amavata's pathology. The ingredients of Erandadi Vati are specifically chosen to restore digestive fire and prevent Ama accumulation.

32) Vatahara (Vata-ahara):
Vatahara refers to the qualities of a substance that pacify or mitigate excess Vata dosha in the body. In treating conditions like Amavata, formulations like Erandadi Vati aim to balance Vata through ingredients that possess Vatahara properties, promoting overall health and reducing inflammatory symptoms.

33) Sharkara (Sarkara):
Sharkara, meaning sugar or jaggery in Ayurveda, serves as a sweetening agent in many formulations. In Erandadi Vati, Sharkara is included not only for palatability but also to balance other bitter or pungent taste components, ensuring a smoother user experience while preserving therapeutic functions.

34) Medicine:
Medicine generally refers to substances used for treating diseases. In the Ayurveda context, it emphasizes formulations derived from natural sources designed to restore health. Erandadi Vati acts as medicine for managing Amavata, reflecting the integration of ancient knowledge with contemporary scientific methodologies in herbal treatments.

35) Vitiation (Vitiated):
Vitiated refers to an imbalance or disturbance in the doshas (energies) within the body according to Ayurvedic principles. Conditions like Amavata emerge when either Vata, Pitta, or Kapha are vitiated. Erandadi Vati aims to address these imbalances by leveraging the healing properties of its herbal constituents, fostering harmonious bodily functions.

36) Langhana (Lamghana):
Langhana denotes a therapeutic process in Ayurveda aimed at promoting lightness in the body through the reduction of excess dosha, especially in cases of Ama accumulation. It is a key treatment principle for managing Amavata, where Erandadi Vati's components support this through their digestive and detoxifying properties.

37) Svedana:
Svedana translates to 'sweating' in Ayurveda, which is prescribed to alleviate certain chronic conditions by promoting circulation and releasing toxins. This therapeutic technique complements the effect of formulations like Erandadi Vati in treating Amavata, aiming to enhance detoxification and overall joint health through heat application.

38) Harisha (Harisa):
Harisha C. R. is one of the authors contributing to the research on Erandadi Vati. His expertise in pharmacognosy would be crucial in conducting the study, ensuring the rigorous evaluation of the herbal formulation within the framework of contemporary scientific research while respecting traditional Ayurvedic principles.

39) Pungent:
Pungent describes a strong taste typically associated with spices that can stimulate digestion and circulation. In Ayurvedic formulations, pungent qualities aid in alleviating Vata imbalances, making them essential for treating conditions like Amavata. Ingredients in Erandadi Vati possess this property to ensure therapeutic effectiveness.

40) Ruksha (Ruksa):
Ruksha translates to 'dry' or 'astringent' in Ayurvedic terminology, and it's used to describe substances that help reduce moisture and excess Kapha. In the formulation of Erandadi Vati, Ruksha properties are advantageous for counteracting inflammation associated with Amavata, balancing the body's doshas effectively.

41) Kshara (Ksara):
Kshara indicates 'alkaline' substances in Ayurveda and refers to their cleansing properties. These substances are often leveraged in treatments to enhance detoxification and help manage elevated doshas. In conjunction with Erandadi Vati, Kshara-based treatments are beneficial for overall recovery from conditions like Amavata.

42) Shukla (Sukla):
Shukla refers to purity or wholeness in Ayurvedic terms. It emphasizes the importance of using pure, authentic ingredients in formulations like Erandadi Vati to ensure their effectiveness and safety. The study stresses maintaining high standards of purity for establishing the credibility of the Ayurvedic system.

43) Nidana:
Nidana translates to the 'causal factors' or 'etiology' of a disease in Ayurveda. Understanding Nidana is vital in addressing conditions like Amavata, as it helps identify and mitigate the root causes contributing to symptom development. This concept underpins the holistic approach seen in Ayurvedic treatments, including Erandadi Vati.

44) Purity:
Purity refers to the absence of contaminants or adulterants in medicinal formulations. In the context of Erandadi Vati, purity is paramount for ensuring that the medicinal properties of the ingredients remain effective for therapeutic purposes. The study emphasizes standard quality checks to maintain formulation integrity.

45) Karma (Karman):
Karma denotes actions or treatments undertaken in Ayurveda aimed at restoring health. Each ingredient in Erandadi Vati is chosen based on its karmic properties—how they interact with the body's doshas. Understanding karma is crucial for designing effective Ayurvedic treatments for ailments like Amavata.

46) Kalka:
Kalka refers to a paste created from fresh herbs that are ground to release their potent extracts. In the preparation of Erandadi Vati, Kalka may be used to enhance the extract's efficacy, delivering concentrated herbal benefits crucial for treating conditions associated with vitiated doshas such as Amavata.

47) Ushna (Usna):
Ushna refers to the 'hot' quality in Ayurveda, often associated with certain herbs that stimulate digestion and circulation. Including Ushna components in Erandadi Vati is important for alleviating conditions like Amavata where excess Vata and cold properties are prevalent, helping to restore balance in the body.

48) Ahara:
Ahara translates to 'food' in Ayurveda and is a crucial aspect of health, concerned with dietary intake's quality and its impact on digestion and dosha balance. Understanding Ahara is essential for managing conditions like Amavata; thus, dietary recommendations often accompany herbal formulations like Erandadi Vati.

49) Sveda:
Sveda denotes sweating or perspiration in Ayurveda, which is considered beneficial for detoxification and improving circulation. This concept underpins various therapeutic practices in managing Amavata, as incorporating methods that encourage sweating alongside Erandadi Vati can optimize treatment outcomes and enhance the body’s overall well-being.

50) Kanda (Kamda):
Kanda refers to the rhizome of plants used in Ayurveda, particularly in formulations like Erandadi Vati. The inclusion of Kanda, such as Shunthi, is important due to its therapeutic properties contributing to overall health and effectiveness in managing conditions like Amavata through its beneficial effects on digestion and healing.

51) Sugar:
Sugar, identified here as Sharkara, serves as a sweetening agent in Ayurvedic medicine, improving the taste of formulations. Its role in Erandadi Vati is not merely for flavor; it also plays a significant part in balancing other ingredients and making the formulation more palatable, essential for patient compliance.

52) Katu:
Katu indicates a pungent or sharp taste within Ayurvedic frameworks, contributing to its therapeutic properties. The Katu elements in Erandadi Vati are vital for stimulating digestions and enhancing metabolic processes. Its integration supports alleviating imbalances associated with Vata, particularly in patients with Amavata.

53) Vata:
Vata is one of the three doshas in Ayurveda, characterized by qualities of movement, dryness, and coldness. It plays a fundamental role in many physiological processes. Imbalances in Vata are central to many ailments, including Amavata. Erandadi Vati seeks to restore balance to this dosha to alleviate symptoms effectively.

54) Vayu:
Vayu translates to 'air' in Sanskrit and symbolizes the dynamic aspects of bodily functions in Ayurveda. As a principle element governing Vata dosha, an imbalance in Vayu can lead to health issues like Amavata. Formulations such as Erandadi Vati aim to mitigate this imbalance, restoring bodily harmony.

55) Food:
Food refers to the sustenance consumed by individuals which, according to Ayurveda, plays a crucial role in maintaining balance among the doshas and promoting overall health. Dietary recommendations are essential in managing conditions like Amavata, highlighting the importance of integrating nutritional perspectives alongside herbal formulations like Erandadi Vati.

56) Shand (Sand):
In Ayurvedic practices, sand or materials like sand can be used therapeutically for fomentation or in creating detoxifying treatments. In managing conditions like Amavata, the application of sand may help induce sweating and improve circulation, complementing the effects of herbal formulations such as Erandadi Vati.

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Discover the significance of concepts within the article: ‘Evaluation of Erandadi Vati: Pharmacognostical and Pharmaceutical’. Further sources in the context of Science might help you critically compare this page with similair documents:

Panchakarma, Chakradatta, Physico-chemical analysis, Organoleptic evaluation, Pharmacognostical study, High performance thin layer chromatography (HPTLC), Pharmacognosy laboratory, Amavata treatment, Physicochemical Parameter, Ruksha sveda, Vatahara properties.

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