Review on antidiabetic activity of medicinal plants

| Posted in: Health Sciences Science Journals

Journal name: World Journal of Pharmaceutical Research
Original article title: Review on antidiabetic activity of medicinal plants
The WJPR includes peer-reviewed publications such as scientific research papers, reports, review articles, company news, thesis reports and case studies in areas of Biology, Pharmaceutical industries and Chemical technology while incorporating ancient fields of knowledge such combining Ayurveda with scientific data.
This page presents a generated summary with additional references; See source (below) for actual content.

Original source:

This page is merely a summary which is automatically generated hence you should visit the source to read the original article which includes the author, publication date, notes and references.

Author:

Bodkhe Suvarna Pandurang, Biradar Rutumbara Sangram, Biradar Vinod Rajendra, Muley Sagar Sopanrao


Download the PDF file of the original publication


World Journal of Pharmaceutical Research:

(An ISO 9001:2015 Certified International Journal)

Full text available for: Review on antidiabetic activity of medicinal plants

Source type: An International Peer Reviewed Journal for Pharmaceutical and Medical and Scientific Research

Doi: 10.20959/wjpr20207-17878

Copyright (license): WJPR: All rights reserved


Summary of article contents:

Introduction

Diabetes mellitus is a chronic metabolic disorder characterized by sustained hyperglycemia resulting from defects in insulin secretion, insulin action, or both. It impacts millions globally, with predictions suggesting that by 2030, the number of affected individuals may rise to 366 million. While insulin and oral hypoglycemic drugs serve as primary treatments, there is an imperative need to explore alternative remedies, especially those derived from medicinal plants. This review presents insights into the pathophysiology of diabetes, the classification of the condition, and highlights various medicinal plants that exhibit antidiabetic properties.

Understanding Diabetes Mellitus

Diabetes mellitus can be classified into several types: Type 1 diabetes, resulting from autoimmune destruction of insulin-producing beta cells; Type 2 diabetes, characterized by insulin resistance and observed primarily in older populations; and gestational diabetes, which occurs during pregnancy. The compelling epidemiological data reveals a higher prevalence of diabetes in certain ethnic groups, with a significant portion of the adult population in the United States classified as pre-diabetic. Long-term complications arising from uncontrolled diabetes include cardiovascular diseases, neuropathy, and retinopathy. The management of diabetes typically involves insulin therapy, pharmacotherapy, and lifestyle modifications, but these methods often come with limitations, prompting the exploration of plant-based therapies.

Antidiabetic Medicinal Plants

The review specifically discusses five notable medicinal plants recognized for their antidiabetic effects: Syzygium cumini, Aloe vera, Momordica charantia, Azadirachta indica, and Annona squamosa. These plants contain various bioactive compounds that contribute to their antidiabetic properties. For instance, Syzygium cumini contains anthocyanins and flavonoids, which enhance insulin secretion and reduce blood glucose levels. Similarly, Aloe vera is rich in vitamins and phytosterols that assist in glucose regulation. Each plant’s unique chemical profile underpins its efficacy, providing researchers with a foundation for developing alternative treatments for diabetes.

Mechanisms of Action

The antidiabetic activities of these medicinal plants are primarily attributed to their various chemical constituents, such as flavonoids, terpenoids, and glycosides. For example, Momordica charantia is noted for containing insulin-like compounds that mimic insulin functions and enhance glucose uptake in peripheral tissues. Azadirachta indica exhibits hypoglycemic effects by improving insulin secretion and reducing carbohydrate absorption in the gastrointestinal tract. Understanding these mechanisms is vital for developing therapeutic strategies that can complement traditional pharmacological treatments and address the rising diabetes prevalence effectively.

Conclusion

In conclusion, the growing incidence of diabetes calls for a diversified approach to its management, including the incorporation of herbal medicine. The medicinal plants outlined in this review not only offer a potent alternative but also warrant further investigation into their antidiabetic mechanisms and properties. By exploring these natural remedies, researchers, health professionals, and policymakers can develop more effective treatments that potentially minimize the complications associated with diabetes mellitus, significantly improving patient outcomes and quality of life.

FAQ section (important questions/answers):

What is diabetes mellitus and its common characteristics?

Diabetes mellitus is a chronic metabolic disorder characterized by chronic hyperglycemia due to deficiencies in insulin secretion or its action, altering carbohydrate, fat, and protein metabolism. It poses increased risks for vascular complications.

What are the major types of diabetes mellitus?

The major types of diabetes are Type 1, characterized by absolute insulin deficiency; Type 2, the most common, particularly in older populations; Gestational diabetes occurring during pregnancy; and pre-diabetes indicating elevated blood glucose without meeting diabetes criteria.

Which five medicinal plants show antidiabetic activity?

The five well-described antidiabetic plants include Syzygium cumini, Aloe vera, Momordica charantia, Azadiracta indica, and Annona squamosa, each containing secondary metabolites that contribute to their hypoglycemic effects.

What are the active chemical constituents in Syzygium cumini?

Syzygium cumini contains anthocyanins, glucosides, ellagic acid, flavonoids, and myricetin. These compounds are responsible for its antidiabetic properties by enhancing insulin release and reducing blood glucose levels.

How can Aloe vera aid in diabetes management?

Aloe vera contains vitamins, enzymes, and saponins that improve blood glucose levels. Animal studies show that its extracts can significantly reduce blood glucose and enhance overall glucose metabolism.

What methods are used to test the presence of flavonoids in extracts?

Chemical tests such as adding diluted HCl and zinc or magnesium, producing a reddish color indicate the presence of flavonoids in plant extracts.

Glossary definitions and references:

Scientific and Ayurvedic Glossary list for “Review on antidiabetic activity of medicinal plants”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.

1) Blood:
Blood is a vital fluid that circulates in the body's vascular system, carrying oxygen and nutrients to cells and removing waste products. In the context of diabetes, monitoring blood glucose levels is critical for managing the disease and understanding the effects of treatment, including herbal medicines.

2) Flavonoid:
Flavonoids are a group of plant compounds with antioxidant properties, which are often associated with various health benefits, including glucose regulation in diabetes. They enhance insulin secretion and improve pancreatic function, making them significant in the study of antidiabetic medicinal plants.

3) Panduranga (Pandurang, Pandu-ranga, Pamduramga):
Bodkhe Suvarna Pandurang is the corresponding author of the review paper, which focuses on the antidiabetic activity of various medicinal plants. The author's involvement emphasizes the importance of research in understanding how these plants can be utilized in diabetes management.

4) Animal:
The term 'animals' pertains to the subjects used in research studies to evaluate the effects of various treatments, including herbal extracts. Animal models help researchers understand how these treatments affect glucose levels and insulin sensitivity in vivo.

5) Diet:
Diet plays a crucial role in managing diabetes, as certain foods can influence blood sugar levels and overall health. The review highlights the integration of medicinal plants into dietary practices, offering alternative approaches to traditional therapies.

6) Activity:
Activity refers to the biological effects or actions of compounds found in medicinal plants. In the context of this review, it relates to the antidiabetic effects observed in studies, which demonstrate how specific plant extracts can alter glucose levels and improve insulin sensitivity.

7) Water:
Water is a fundamental solvent in biological processes, essential for extracting and preparing medicinal plant extracts. In the research, the use of water in herbal preparations ensures the solubility of active constituents, aiding their absorption and efficacy in treating diabetes.

8) Study (Studying):
The term 'study' refers to the systematic investigation aimed at discovering new knowledge about the antidiabetic effects of herbal plants. This review consolidates findings from various studies to present a comprehensive overview of effective treatments for diabetes.

9) Syzygium cumini:
Syzygium cumini, or jamun, is a medicinal plant recognized for its antidiabetic properties. The plant's seeds and leaves contain flavonoids and other active compounds that have been shown to lower blood sugar levels, making it an important subject in diabetes research.

10) Family:
In botanical classification, 'family' refers to a group of related plants sharing common characteristics. For example, Syzygium cumini belongs to the Myrtaceae family, which includes other plants with potential medicinal applications, highlighting the diversity of therapeutic agents available in nature.

11) Drug:
Drugs encompass a wide range of substances used to modify physiological functions for therapeutic purposes. The review contrasts chemical drugs used for diabetes management with natural alternatives derived from medicinal plants rich in antidiabetic compounds.

12) Momordica charantia:
Momordica charantia, also known as bitter melon, is a well-studied medicinal plant with significant antidiabetic properties. Its ability to mimic insulin responses and lower blood sugar levels makes it a valuable component of traditional and modern diabetes treatments.

13) Powder:
Powder indicates the form in which many herbal extracts are prepared for consumption or experimentation. In this review, powdered extracts of plants are often used to evaluate their pharmacological effects and effectiveness in lowering glucose levels in diabetic models.

14) Jamun:
Jamun refers to the fruit of Syzygium cumini, which is renowned for its therapeutic applications in controlling blood sugar levels. The fruit's constituents are valuable in both traditional and modern medicine for managing diabetes effectively.

15) India:
India is highlighted as the origin of many medicinal plants, including Syzygium cumini and Azadiracta indica, used traditionally for treating diabetes. The country's rich biodiversity contributes to the exploration of herbal remedies within modern pharmaceutical development.

16) Sugar:
Sugar, primarily glucose, is the main focus in diabetes management, as its regulation is critical for health. The review discusses how natural antidiabetic agents work to lower blood sugar levels and improve overall metabolic function.

17) Neem:
Neem, or Azadiracta indica, is a traditional medicinal plant with numerous health benefits, particularly in diabetes treatment. Its leaves have demonstrated hypoglycemic properties, contributing to its use in natural medicine and integrated health practices.

18) Medicine:
Medicines encompass both conventional pharmaceuticals and alternative therapies such as herbal remedies. The review advocates for exploring medicinal plants as viable options for diabetes management, highlighting their potential benefits in reducing complications.

19) Mineral:
Minerals are trace elements essential for numerous biochemical processes. They play a role in insulin function and glucose metabolism, and some medicinal plant extracts may influence mineral balance, which can affect diabetes outcomes.

20) Beta:
Beta cells in the pancreas are responsible for producing insulin. The review focuses on how various medicinal plants can improve the function of these cells, enhancing insulin secretion and contributing to better blood glucose control in diabetic individuals.

21) Maharashtra (Maharastra, Maha-rashtra):
Maharashtra is a state in India known for its biodiversity and traditional healing practices, making it a significant region for studying the medicinal properties of local plants in treating diseases like diabetes.

22) Suvarna:
Bodkhe Suvarna Pandurang is one of the authors contributing to the review paper. The authorship denotes the academic endeavor to explore and disseminate knowledge regarding the antidiabetic properties of various medicinal plants.

23) Science (Scientific):
Science refers to the systematic study of the structure and behavior of the physical and natural world. The review emphasizes the scientific basis for utilizing medicinal plants as alternative treatments for diabetes, grounded in research and evidence.

24) Gelatin:
Gelatin is a substance derived from collagen, often used in biological testing. Its presence in chemical tests indicates methods to detect specific compounds like phenolics or flavonoids in herbal extracts, crucial for unveiling the medicinal properties of plants.

25) Bitter:
Bitter refers to the taste profile often associated with certain medicinal plants like Momordica charantia. Bitterness can indicate the presence of bioactive compounds that are effective in managing blood sugar levels and are utilized in traditional medicine.

26) Asti (Ashti):
Ashti is a location in Maharashtra, India, potentially indicating the geographical context of the research or where certain medicinal plants may be sourced, contributing to the local understanding of herbal remedies for diabetes.

27) Table:
Table indicates organized data presentation within the review, summarizing key information about medicinal plants studied for antidiabetic properties, showcasing their efficacy, active constituents, and preparation methods for clarity and reference.

28) Food:
Food encompasses the biological substances ingested for nourishment. The review discusses integrating antidiabetic herbs into dietary habits, suggesting that diet plays a vital role in managing diabetes alongside herbal treatments.

29) Tree:
Tree often refers to larger plants like those of the Myrtaceae family (e.g., Syzygium cumini). Their fruit, bark, or leaves may have medicinal properties, highlighting the importance of tree species in herbal medicine and diabetes management.

30) Sign:
Sign relates to the indicators observed during research studies, such as changes in blood glucose levels in response to treatment with herbal remedies. These signs are essential for evaluating the effectiveness of antidiabetic therapies.

31) Rich (Rch):
Rich signifies abundance, particularly in terms of beneficial compounds within medicinal plants. The review emphasizes how certain herbs have rich phytochemical profiles that contribute to their antidiabetic effects and therapeutic potential.

32) Male:
Male is a term used in reference to gender in animal studies. The review might include male subjects to analyze how different characteristics impact the efficacy of antidiabetic treatments when experimenting with herbal extracts.

33) Trigonella foenum-graecum:
Trigonella foenum-graecum, commonly known as fenugreek, is recognized for its antidiabetic properties. The seeds of this plant have been shown to improve glucose tolerance and lower blood sugar levels, making it a focus of interest in diabetes research.

34) Valeriana wallichii:
Valeriana wallichii, commonly known as Indian Valerian, is a plant with potential medicinal applications. Although not as commonly highlighted in antidiabetic studies, its inclusion suggests a broader exploration of herbal solutions for diabetes management.

35) Argyreia nervosa:
Argyreia nervosa, also known as Hawaiian Baby Woodrose, is mentioned in the context of exploring a variety of plants for their medicinal properties, potentially investigating its effects on glucose metabolism and diabetes management.

36) Mangifera indica:
Mangifera indica, known as mango, has been researched for its potential health benefits. Its leaves have been traditionally used for managing diabetes, underscoring the importance of commonly consumed plants in therapeutic applications.

37) Ocimum sanctum:
Ocimum sanctum, or holy basil, is recognized for its adaptogenic properties. It is suggested that the plant may help in managing blood sugar levels, positioning it as a noteworthy herb in the holistic approach to diabetes treatment.

38) Asparagus racemosus:
Asparagus racemosus, commonly known as Shatavari, is a plant known for its reproductive health benefits. Its mention in relation to diabetes highlights the exploration of diverse plant sources in developing comprehensive antidiabetic treatments.

39) Ricinus communis:
Ricinus communis, or castor oil plant, is often studied for its various commercial and medicinal uses. Reference to this plant in the context of diabetes research indicates a wide-ranging interest in the benefits of diverse herbal remedies.

40) Pharmacotherapy:
Pharmacotherapy involves treating health conditions using medication. The review contrasts pharmacotherapy with herbal treatments, suggesting that a blend of traditional and modern methods may support more effective management of diabetes.

41) Hordeum vulgare:
Hordeum vulgare, or barley, is often acknowledged for its health benefits, including potential hypoglycemic effects. Its role in research reflects the exploration of dietary components and their impact on diabetes management.

42) Pharmacology:
Pharmacology is the science dealing with the study of drugs and their effects on living systems. This review is rooted in pharmacological principles, exploring how specific plant compounds can be utilized to manage blood sugar levels effectively.

43) Performance:
Performance in the context of this review relates to the efficacy of various treatments in clinical or experimental settings. The assessment of performance enables meaningful comparisons between conventional drugs and herbal remedies in managing diabetes.

44) Observation:
Observation entails systematically monitoring outcomes in research studies. In the context of this review, detailed observations help assess the effectiveness of different medicinal plants on blood sugar regulation in diabetic models.

45) Substance:
Substance indicates a particular matter with recognizable properties, often used to discuss compounds extracted from plants. In diabetes research, substances derived from medicinal plants are evaluated for their potential health benefits.

46) Fenugreek:
Fenugreek, or Trigonella foenum-graecum, is revered for its ability to improve blood sugar and insulin sensitivity. Its seeds contain fiber and various phytochemicals that may promote better diabetes management as explored in the review.

47) Container:
Container refers to any object used to hold or store herbal preparations or extracts. Proper storage containers preserve the integrity of the herbal active compounds, ensuring the efficacy of treatments for diabetes.

48) Toxicity:
Toxicity relates to the degree to which substances can harm organisms. In pharmacological studies, understanding the toxicity of medicinal plants is essential for determining safe dosages and long-term uses in treating diabetes.

49) Cinnamon:
Cinnamon is a spice noted for its beneficial effects on blood sugar levels. Its active constituents have been studied for their role in enhancing insulin sensitivity and managing diabetes, marking it as a valuable addition to dietary practices.

50) Relative:
Relative may refer to comparisons made in research studies to assess the effectiveness of different treatments. Understanding relative efficacy helps in determining the best approaches for managing diabetes comprehensively.

51) Liquorice (Licorice):
Licorice has been traditionally used for various ailments, including diabetes management. Its components may influence glucose metabolism and enhance the efficacy of other antidiabetic treatments, thus warranting investigation in the review.

52) Disease:
Disease refers to a pathological condition, with diabetes being a prevalent example characterized by altered metabolism. The review strives to identify plant-based treatments to alleviate symptoms and complications associated with this disease.

53) Account:
Account often signifies a record of observations or results following a specific investigation. In this context, it relates to documenting the outcomes achieved through the use of medicinal plants for treating diabetes.

54) Garlic:
Garlic (Allium sativum) is well-known for its numerous health benefits and is often included in discussions on diabetes management. Its components are believed to improve insulin sensitivity and support the reduction of blood sugar levels.

55) Sagar (Sagár):
Sagar is likely a reference to one of the contributing authors from the mentioned institution. Their contributions reflect collaborative efforts in researching medicinal plants and their effects on diabetes.

56) Ghana:
Ghana represents one of the geographic contexts for exploring the use of herbal medicine. The mention indicates global perspectives on using medicinal plants for treating diabetes and illustrates the cultural diversity of herbal therapies.

57) Glass:
Glass is commonly used to store and preserve herbal extracts and medicines. The use of glass containers ensures the stability and longevity of active ingredients, which is essential in the study of medicinal plants.

58) Ulcer:
Ulcer may denote one of the complications arising from unmanaged diabetes. The review implies the relevance of medicinal plants not only in managing glucose levels but also in preventing such complications.

59) Field:
Field relates to the area of study and research involving medicinal plants and their pharmacological effects. It denotes the multidisciplinary approach in exploring natural remedies for health conditions like diabetes.

60) Cina:
China plays a significant role in the prevalence of diabetes, with a large population affected by the disease. Its mention contextualizes the global urgency for effective treatments, including those derived from traditional medicinal practices.

61) Cage:
Cage emphasizes the controlled environment for conducting animal studies in diabetes research. Proper housing ensures that the physiological conditions are maintained accurately to study the effects of various treatments.

62) Egypt:
Egypt is included as a notable country in the worldwide landscape of diabetes prevalence, highlighting global health challenges. This gives context to the necessity of researching diverse medicinal plants effective for diabetes management.

63) Kola:
Kola refers to a plant known for its stimulatory properties and potential health benefits. The mention of kola plants indicates a wider exploration of herbal treatments used in traditional medicine for diabetes management.

64) Java:
Java, in this context, may refer to the Java plum (Syzygium cumini), a fruit associated with antidiabetic properties. Its inclusion in the review signifies the relevance of local plants in traditional medicine for managing diabetes.

65) Hand:
Hand may refer to the manual preparation and administration of herbal remedies. It underscores the traditional practices involved in utilizing medicinal plants effectively for diabetes management.

66) Milk:
Milk, while not directly related to the herbal treatments discussed, can represent the importance of dietary choices in managing diabetes. The review highlights the role nutrition plays alongside herbal medicine in controlling blood sugar levels.

67) Post:
Post may indicate follow-up assessments made after treatment in clinical studies. Observing effects after the administration of medicinal plants helps understand their efficacy and supports recommendations for diabetes management.

68) Pur:
Poor may refer to health disparities, particularly among populations with limited access to healthcare. The discussion around diabetes management may highlight how local plants can provide accessible treatment options for underserved communities.

Other Science Concepts:

[back to top]

Discover the significance of concepts within the article: ‘Review on antidiabetic activity of medicinal plants’. Further sources in the context of Science might help you critically compare this page with similair documents:

Aloe vera, Annona squamosa, Momordica charantia, Syzygium cumini, Flavonoid, Diabetes mellitus, Herbal medicine, Insulin resistance, Pre-diabetes, Vascular complications, Chronic hyperglycemia, Diet Therapy, Secondary metabolite, Phytonutrients, Clinical implication, Insulin deficiency, Chronic Metabolic Disorder, Long term complication, Animal Study, Chemical test, Antidiabetic medicinal plants, Active chemical constituent.

Let's grow together!

I humbly request your help to keep doing what I do best: provide the world with unbiased sources, definitions and images. Your donation direclty influences the quality and quantity of knowledge, wisdom and spiritual insight the world is exposed to.

Let's make the world a better place together!

Like what you read? Help to become even better: