Bhasma: Ayurvedic Nanoformulations and Their Therapeutic Potential

a herbal ayurvedic nanoformulation

| Posted in: Health Sciences Science

Journal name: World Journal of Pharmaceutical Research
Original article title: Bhasma
The WJPR includes peer-reviewed publications such as scientific research papers, reports, review articles, company news, thesis reports and case studies in areas of Biology, Pharmaceutical industries and Chemical technology while incorporating ancient fields of knowledge such combining Ayurveda with scientific data.
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Subtitle: a herbal ayurvedic nanoformulation

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Author:

Gulkari V. D. and Naghoshe D. R.


World Journal of Pharmaceutical Research:

(An ISO 9001:2015 Certified International Journal)

Full text available for: Bhasma

Source type: An International Peer Reviewed Journal for Pharmaceutical and Medical and Scientific Research

Doi: 10.20959/wjpr20207-17777

Copyright (license): WJPR: All rights reserved


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Summary of article contents:

Introduction

Ayurveda, a traditional Indian system of medicine, emphasizes a holistic approach to health by balancing physical, mental, and spiritual functions. A significant aspect of Ayurveda is Rasa-Shastra, which involves the preparation of herbomineral formulations known as Bhasmas. These are unique preparations involving metals, minerals, and herbs that undergo a process of purification and incineration. Bhasmas are renowned for their therapeutic benefits in managing various chronic ailments due to their nanoparticle nature, which enhances absorption and effectiveness. This article reviews the preparation, classification, standardization, and importance of Bhasmas, highlighting their historical and medicinal significance.

Preparation and Standardization of Bhasma

The preparation of Bhasma involves multiple steps including purification (Shodhana), wet trituration (Bhavana), and incineration (Marana). During Shodhana, raw materials are freed of impurities to enhance their therapeutic effects; Bhavana involves mixing materials to increase surface area and facilitate reaction during incineration. The final step, Marana, converts the material into ash through intense heating, resulting in a product that exhibits nanoparticle characteristics. Given the potential toxicity of the raw ingredients, standardization is crucial to ensure quality, safety, and efficacy. Traditional tests and modern analytical methods, such as X-ray diffraction and atomic absorption spectroscopy, are employed to confirm the identity and assess the quality of Bhasmas.

Biological and Pharmacological Properties of Bhasma

Bhasmas possess significant biological and pharmacological properties, including their roles in immunomodulation and enhancing therapeutic efficacy. The preparation process transforms toxic metals and minerals into nontoxic formats, effectively breaking them down into bioavailable particles that can be easily absorbed by the body. These conversions allow Bhasmas to be used in the treatment of various ailments, such as diabetes, respiratory disorders, and anemia, by providing essential minerals and helping to detoxify harmful substances in the body. The holistic benefits of Bhasmas are well-documented in Ayurveda, demonstrating their potential in modern therapeutic applications.

Classification and Types of Bhasma

Bhasmas are classified based on their source materials into three main categories: metal-based, mineral-based, and herbal Bhasmas. Each type has specific properties, uses, and therapeutic applications. The classification often correlates with the color and appearance of the product, which is indicative of its composition and intended use. Notable examples include Swarna Bhasma (gold ash), which is used for its immunostimulatory properties, and Tamra Bhasma (copper ash) for treating digestive disturbances. The diverse range of Bhasmas and their derived formulations allows for targeted treatments for various health conditions within the framework of Ayurvedic medicine.

Conclusion

Bhasmas represent a unique and valuable aspect of Ayurvedic medicine, combining traditional knowledge with modern scientific validation. Their complex preparation processes and specific applications underscore the importance of standardization to ensure safety and efficacy. As researchers continue to explore the potential uses of Bhasmas in modern health care, their holistic and therapeutic properties promise innovative pathways in both preventive and curative medicine. The ongoing study of Bhasmas not only enhances the understanding of ancient practices but also paves the way for integrating these formulations into contemporary therapeutic contexts, addressing various health challenges in today's society.

FAQ section (important questions/answers):

What is Bhasma in Ayurveda and its significance?

Bhasma refers to a unique Ayurvedic metallic or mineral preparation, created through incineration. It has been used since the 7th century A.D. for treating chronic ailments and is valued for its therapeutic benefits and holistic healing properties.

How are Bhasmas classified in Ayurvedic medicine?

Bhasmas are classified based on color, appearance, and the dominant metal or mineral group. They include categories like metal-based, mineral-based, and herbal Bhasmas, each serving different therapeutic purposes.

What is the process of preparing Bhasma?

The preparation involves several stages: Shodhana (purification), Bhavana (wet trituration), Jarana (pellet formation), and Marana (incineration). This rigorous process ensures the removal of impurities and enhances therapeutic properties.

What modern techniques are used to evaluate Bhasmas?

Modern evaluation techniques include X-ray diffraction, Fourier transform infrared spectroscopy, and atomic absorption spectroscopy. These methods help characterize Bhasma's chemical composition, particle size, and standardize its quality.

What health benefits are associated with using Bhasma?

Bhasmas are believed to enhance immunity, support detoxification, assist in balancing minerals, and help alleviate various health issues such as chronic diseases, anemia, and digestive disorders.

Can you provide examples of marketed Bhasma products and their uses?

Some marketed Bhasma products include Heerak Bhasma for cancers and immunity disorders, Swarna Bhasma for enhancing immunity, and Navrattankalpamrit Ras for various chronic ailments like anemia and diabetes management.

Glossary definitions and references:

Scientific and Ayurvedic Glossary list for “Bhasma: Ayurvedic Nanoformulations and Their Therapeutic Potential”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.

1) Bhasma (Bhasman):
Bhasma refers to a unique Ayurvedic preparation made from metals, minerals, or animal derivatives that have undergone incineration. It is known for its therapeutic properties and is believed to be non-toxic when prepared correctly. Bhasmas play a crucial role in Ayurveda’s holistic approach to health and treatment of chronic ailments.

2) Mineral:
Minerals encompass a wide range of inorganic elements critical for bodily functions such as bone health, metabolic processes, and enzymatic activities. In the context of Bhasma, they are often combined and incinerated with herbs to enhance their healing properties and reduce toxicity for medicinal use.

3) Gold (Golden):
Gold, known for its purity and healing properties, is used in Ayurvedic formulations such as Swarna Bhasma. This form is believed to bestow strength, enhance immunity, and support overall vitality. Its unique properties make it a valuable component in traditional Ayurvedic medicine for treating various health conditions.

4) Ayurveda (Ayus-veda):
Ayurveda is an ancient system of medicine originating from India, focusing on holistic health through balance in the mind, body, and spirit. It employs various natural substances, including Bhasma, to promote healing and prevent disease. Ayurveda’s principles guide the understanding of health and wellness.

5) Puta:
Puta refers to a specific heating process in the preparation of Bhasma, involving repeated heating cycles at controlled temperatures. This method aims to transform the properties of the raw materials and ensures their effectiveness and safety as therapeutic agents in Ayurvedic medicine.

6) Surface:
In the context of Bhasma and nanoparticle characterization, surface properties are crucial as they influence the absorption and bioavailability of the preparations in the human body. Techniques such as scanning electron microscopy (SEM) are used to analyze the surface morphology to ensure quality and efficacy.

7) Marana:
Marana is the process of incineration or calcination utilized in the production of Bhasma. This critical step transforms raw metals and minerals into a therapeutically active ash, breaking down solid materials to enhance absorption and reduce toxicity, making them suitable for medicinal use.

8) Table:
In this context, a 'table' often refers to organized data presentation, outlining various classifications, procedures, and comparisons related to Bhasma and its ingredients. Tables help to systematically convey complex information, making it easier to understand and utilize in research and application.

9) Purification:
Purification, or Shodhana, is a crucial step in the preparation of Bhasma. This process removes impurities from raw materials, ensuring that the final product is safe and effective for therapeutic use. Purification aims to enhance the beneficial properties while minimizing any potential toxicity.

10) Nature:
The nature of Bhasma refers to its inherent characteristics, such as composition, particle size, and reactivity. Understanding the nature of Bhasma helps practitioners ascertain its therapeutic potential and suitability for specific health conditions in Ayurvedic treatments.

11) Drug:
Drugs encompass various medicinal compounds, including Bhasma and herbal formulations in Ayurveda. The careful preparation and application of these substances are key to achieving desired health outcomes.

12) Quality:
Quality in the context of Bhasma preparation signifies the product's effectiveness, purity, and safety for therapeutic use. Rigorous standardization and testing processes are essential to ascertain the quality of Bhasma, ensuring its readiness for clinical application.

13) Heating:
Heating in Bhasma preparation encompasses various processes, including Marana and Puta. Controlled heating transforms the physical and chemical properties of starting materials, leading to the production of therapeutically active nanoparticles that can be effectively absorbed by the body.

14) Silver:
Silver, like gold, is used in Ayurvedic medicine in the form of Rajata Bhasma. It is valued for its antimicrobial properties and is said to support immune function. It may be utilized in various formulations aimed at treating infections and improving overall health.

15) Varna:
Varna refers to the color of Bhasma, which can indicate its quality and specific characteristics. Color variety arises from the types of metals or minerals used and their preparation process, contributing to the identification and classification of different Bhasmas.

16) Shodhana (Sodhana):
Shodhana, or purification, is a foundational process in Ayurveda that prepares raw materials by removing impurities. This step is essential in creating Bhasma, ensuring that the final product is safe for consumption and effective in treatment protocols.

17) Sharava (Sarava):
Sarava refers to the earthen pots employed in Bhasma preparation, integral for heating and transforming raw materials. Their use underscores traditional methods in preparing effective and safe Ayurvedic remedies.

18) Tamra:
Tamra refers to copper in Ayurvedic terms and is often processed into Tamra Bhasma. It is valued in Ayurveda for its essential role in maintaining overall health, particularly in treating conditions related to digestion and blood disorders.

19) Pishti (Pisti):
Pishti refers to powdered forms of materials used in Ayurveda, often in conjunction with Bhasma. The term emphasizes the careful preparation and grinding processes that empower these formulations to enhance their effectiveness and facilitate better absorption in the body.

20) Animal:
Animals in Ayurveda represent sources of various derivatives utilized in Bhasma preparation. Their inclusion highlights the comprehensive approach Ayurveda takes toward utilizing all elements of nature for healing.

21) Powder:
Powdering is an essential process in the preparation of Bhasma and other Ayurvedic medicines. This technique increases the surface area available for absorption and interaction with the body's systems, enhancing the overall efficacy of the formulations.

22) Karma (Karman):
Karma, in the context of Ayurveda, refers to the actions or processes involved in preparing herbal and mineral formulations. Various karmas, such as Shodhana and Marana, are crucial to creating effective and safe medicines for treatment.

23) Rakta:
Rakta refers to the red color and is often associated with blood in Ayurveda. In the context of Bhasma, methods such as Lohitikarana are used to impart a red hue to certain formulations, enhancing their therapeutic properties.

24) Water:
Water plays a significant role in the preparation of Bhasma and Ayurvedic medicines. It is used in various contexts, such as during purification or as a solvent for herbal extracts, ensuring the proper consistency and efficacy of the final product.

25) Loha:
Loha is the term for metal in Ayurveda, often used to refer to essential metals involved in the preparation of Bhasma. Metals undergo specific processing techniques to render them non-toxic and therapeutically beneficial.

26) Mica:
Mica, or Abhraka, is a mineral used in Ayurveda, especially in the formation of Bhasma. Its unique physical properties make it valuable in various formulations, contributing to holistic treatments of conditions like respiratory issues and metabolic disorders.

27) Abhraka:
Abhraka refers to mica in Ayurvedic terminology and is used in Bhasma formulations. It is believed to support respiratory health and is characterized by its unique physical properties, helping in the effective treatment of various ailments.

28) Cancer:
Cancer signifies a group of diseases characterized by abnormal cell growth. In Ayurveda, treatments may include Bhasma derived from herbs and minerals aimed at supporting the immune system and potentially alleviating symptoms associated with cancer.

29) Indian:
Indian refers to the cultural and historical context of Ayurveda, rooted in the Indian subcontinent. The traditional applications of Bhasma reflect this rich heritage, emphasizing natural and holistic approaches to health care practiced over centuries.

30) Pearl:
Pearls, or Mukta, are prized in Ayurveda and are often incorporated into Bhasma formulations. Their cooling and soothing properties are believed to support skin health and overall bodily functions, showcasing the application of gems in Ayurveda.

31) Blood:
Blood plays a central role in Ayurvedic medicine, linked to life and vitality. Many Bhasma formulations target blood conditions, such as anemia, using specific herbs and minerals believed to enhance its quality and overall health.

32) Coral:
Corals, represented as Pravala in Ayurveda, are utilized for their rich calcium content. They play a significant role in Bhasma formulations aimed at addressing deficiencies and promoting skeletal health.

33) Amritikarana (Amrtikarana, Amriti-karana):
Amritikarana is a post-operative procedure in Bhasma preparation aimed at enhancing the therapeutic properties of the final product. This process ensures the efficacy and safety of Bhasma by further refining its characteristics.

34) Tamrabhasma (Tamra-bhasma):
Tamra Bhasma is a specific Ayurvedic preparation made from copper. It is traditionally used to treat conditions like anemia and digestive disorders, emphasizing the therapeutic roles that various metals play in holistic health.

35) Medicine:
Medicines encompass therapeutic agents like Bhasma, which combine the healing properties of various natural substances. The holistic approach of Ayurveda emphasizes tailored medicinal solutions for diverse health conditions.

36) Bhavana (Bha-vana):
Bhavana denotes the process of wet trituration in Bhasma preparation, blending and refining materials to enhance therapeutic effects. This critical step improves the final product's consistency and increases its surface area for better absorption.

37) Krishna (Krsna):
Krishna, often meaning 'dark' in Sanskrit, can refer to the color of certain Bhasmas. Colors are essential in Ayurveda, indicating the properties and applications of various formulations, guiding practitioners in selecting appropriate treatments.

38) Yashada (Yasada):
Yashada refers to zinc in Ayurveda and is utilized in Bhasma formulations. Its significance includes various health benefits, such as supporting immune function and overall vitality in traditional therapeutic practices.

39) Dhatu:
Dhatu translates to 'metal' or 'element' in Ayurveda, crucial in formulating medications like Bhasma. Understanding the properties of different dhatu is vital for their appropriate application in traditional healing practices.

40) Vanga (Vamga):
Vanga is the Ayurvedic term for tin, often incorporated into Bhasma formulations. Its historical significance and therapeutic properties are recognized in traditional medicine, particularly for its role in treating digestive and metabolic disorders.

41) Fever:
Fever is a clinical sign often treated in Ayurveda with various Bhasma preparations. These formulations are intended to address underlying causes and restore balance within the body, enhancing the immune response.

42) Kukkutaputa:
Kukkutaputa is a specific heating method used in the preparation of Bhasma. This method is chosen based on the type of material being processed to ensure optimal transformation and efficacy of the final product.

43) Measurement:
Measurements refer to the quantitative assessment of various properties during the Bhasma preparation process. Accurate measurements are crucial for maintaining quality, efficacy, and safety in Ayurvedic formulations.

44) Depression:
Depression is a mood disorder that may be addressed through Ayurvedic practices, including the use of Bhasma. Certain formulations aim to enhance mental well-being and emotional stability, supporting holistic treatment approaches.

45) Toxicity:
Toxicity relates to the harmful effects that certain raw materials may have in their unprocessed forms. The Bhasma preparation process is designed to eliminate toxicity, transforming harmful metals into safe therapeutic substances.

46) Disease:
Disease is any deviation from normal physiological function, often treated in Ayurveda through personalized remedies that include Bhasma. Tactics focus on restoring harmony within the body to promote healing.

47) Rajata:
Rajata refers to silver in Sanskrit and is used in various Ayurvedic preparations. Its therapeutic applications in medicine highlight the significance of metals in enhancing health and addressing specific conditions.

48) Mukta:
Mukta refers to pearls in Ayurveda, which are often ground into powder for use in medicinal formulations. They are valued for their supposed cooling effects and potential benefits in skin and blood health.

49) Horn:
Horn, commonly used in Ayurvedic preparations, represents the use of animal-derived substances in creating Bhasma. Its therapeutic effects contribute to a diverse range of applications in traditional herbal medicine.

50) Naga (Nag):
Naga, or lead, is an important element used in Ayurvedic therapies. Properly prepared for use in Bhasma, it is seen as having balancing properties for various health conditions, emphasizing the significance of metallurgical processes in Ayurveda.

51) Tinospora cordifolia:
Tinospora cordifolia, known as Guduchi, is a revered herb in Ayurveda recognized for its immunomodulatory and anti-inflammatory effects. It is often combined with Bhasma to enhance therapeutic outcomes in treating various health conditions.

52) Burning sensation:
Burning sensation refers to a common symptom in various health conditions. Ayurveda uses specific Bhasma formulations to address underlying causes, aiming to restore balance and alleviate discomfort associated with such sensations.

53) Pharmacological:
Pharmacological refers to the study of medications and their effects on biological systems. In Ayurveda, understanding the pharmacological aspects of Bhasma formulations aids in assessing their therapeutic efficacy and safety for various diseases.

54) Pradhana-karma:
Pradhana-karma represents the main therapeutic actions involved in preparing Bhasma. This critical phase focuses on incineration and transformation of materials to achieve desired medicinal properties and efficacy in treatments.

55) Paschat-karma:
Paschat-karma refers to the post-operative processes applied to enhance the therapeutic properties of Bhasma. These additional steps ensure efficacy, safety, and acceptance of the final product in holistic treatments.

56) Dhatubhasma (Dhatu-bhasma):
Dhatu-bhasma signifies Bhasma derived from specific metals, underlining the importance of elemental sources in Ayurvedic preparations. These formulations are tailored for their physiological benefits and therapeutic applications.

57) Civilization:
Civilization encompasses the historical context of Ayurveda and its practices, underscoring the cultural significance of Bhasma in healing traditions. Understanding this backdrop fosters appreciation for ancient knowledge systems still relevant today.

58) Apunarbhava (Apunar-bhava):
Apunarbhava is a term describing the irreversibility of certain processes in Bhasma preparation, indicating that once transformed, these substances cannot revert to their original forms. This concept highlights the permanence of the therapeutic changes achieved.

59) Conch-shell:
Conch-shells hold spiritual and medicinal significance in Ayurveda. Their inclusion in Bhasma formulations is believed to enhance properties of the remedy, symbolizing the blend of tradition and therapeutic application.

60) Purvakarma (Purvakarman, Purva-karman):
Purva-karma refers to the preparatory actions taken before the main therapeutic processes in Bhasma synthesis. This foundational phase emphasizes purification and initial treatments aimed at optimizing effectiveness and safety.

61) Knowledge:
Knowledge in the Ayurvedic context refers to understanding the principles and techniques underlying the preparation and use of Bhasma and other remedies. This expertise is essential for effectively addressing health issues and promoting wellness.

62) Substance:
Substances encompass the variety of natural materials used in Ayurvedic medicine, including herbs, minerals, and organic matter. The careful selection and preparation of these substances are crucial for effective treatments.

63) Pradhana:
Pradhana refers to the primary or essential components in Bhasma preparation. Understanding these critical aspects is key to ensuring that formulations are prepared correctly for optimal therapeutic efficacy.

64) Gajaputa (Gaja-puta):
Gajaputa is a specific heating technique used in preparing Bhasma, occurring under controlled environments to ensure effective transformation. This method is tailored to the physical properties of the materials involved.

65) Rasayana (Rasa-ayana):
Rasayana refers to the aspect of Ayurveda focused on rejuvenation and strengthening the body’s systems. Bhasma formulations often play a significant role in Rasayana therapies, enhancing vitality and promoting longevity.

66) Activity:
Activity in this context refers to the pharmacological effects produced by Bhasma and its constituent elements. Understanding these activities is paramount for effective treatment planning in Ayurveda.

67) Bleeding:
Bleeding represents a clinical symptom that may be addressed in Ayurveda using specific Bhasma formulations. These remedies aim to restore balance and treat the root causes of excessive bleeding utilizing natural substances.

68) Burning (Burn, Burned, Burnt):
Burn refers to discomfort that can arise from various health issues. Ayurveda uses targeted Bhasma preparations to address such symptoms, promoting healing and restoring balance.

69) Science (Scientific):
Scientific denotes the systematic study of natural phenomena, including the principles behind Ayurveda and Bhasma preparation. Modern scientific methods enhance the understanding and evaluation of traditional healing practices.

70) Dravya:
Dravyas signify materials, particularly in the Ayurvedic context, encompassing a wide range of substances used in therapeutic processes, including those in Bhasma preparations for health restoration.

71) Kapota:
Kapota is the term for pigeon in Ayurveda, often symbolizing purity and balance. In the context of Bhasma, it relates to specific materials and processes used to enhance the formulations.

72) Jarana:
Jarana is a term describing the drying and pre-treatment phase in Bhasma preparation. This crucial step readies materials for subsequent heating, enhancing their therapeutic efficacy and ensuring proper utilization.

73) Purity:
Purity pertains to the quality of Bhasma, emphasizing the absence of contaminants and the efficacy of the ingredients used. Ensuring purity is vital for safe and effective Ayurvedic treatments.

74) Firing:
Firing refers to the heating process essential to transform raw materials into Bhasma. This critical step alters the physical and chemical properties, yielding a form that is both safe and therapeutically effective.

75) Nagapura (Naga-pura):
Nagpur is a city known for its educational institutions related to Ayurveda. It serves as a hub for research and development in the field, where studies on Bhasma and traditional practices continue to thrive.

[Note: The above list is limited to 75. Total glossary definitions available: 182]

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