Comparison of PRF vs. Osteon II in treating periodontal defects.

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Journal name: World Journal of Pharmaceutical Research
Original article title: A clinical and radiographic comparison of plateletrich- fibrin and beta tri-calcium phosphate + hydroxyapetite alloplastic bone graft (osteon ii ®) in the treatment of periodontal intrabony defects
The WJPR includes peer-reviewed publications such as scientific research papers, reports, review articles, company news, thesis reports and case studies in areas of Biology, Pharmaceutical industries and Chemical technology while incorporating ancient fields of knowledge such combining Ayurveda with scientific data.
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Author:

Dr. Surya Suprabhan, Dr. Suchetha A., Dr. Sapna N., Dr. Darshan B.M., Dr. Apoorva S.M. and Dr. Divya Bhat


World Journal of Pharmaceutical Research:

(An ISO 9001:2015 Certified International Journal)

Full text available for: A clinical and radiographic comparison of plateletrich- fibrin and beta tri-calcium phosphate + hydroxyapetite alloplastic bone graft (osteon ii ®) in the treatment of periodontal intrabony defects

Source type: An International Peer Reviewed Journal for Pharmaceutical and Medical and Scientific Research

Doi: 10.20959/wjpr20207-17823

Copyright (license): WJPR: All rights reserved


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Summary of article contents:

Introduction

Periodontal disease is characterized by the inflammation of the gums, formation of periodontal pockets, and loss of attachment and alveolar bone around teeth. Effective periodontal therapy aims to regenerate lost supporting tissues, which encompass cementum, periodontal ligament, and bone. To achieve this, various regenerative techniques have been explored, including the use of bone grafts, substitutes, guided tissue regeneration, and growth factors like Platelet-rich fibrin (PRF). This study focuses on comparing the clinical and radiographic efficacy of PRF with a synthetic bone graft material, Osteon II® (comprising 70% β-tricalcium phosphate and 30% hydroxyapatite), in treating periodontal intrabony defects.

The Role of Platelet-Rich Fibrin (PRF)

PRF is an autologous preparation of platelet-rich plasma that promotes healing and tissue regeneration. Its slow polymerization during centrifugation creates a favorable scaffold for healing, supporting cell migration, proliferation, and differentiation. Previous studies have indicated that PRF enhances the healing processes in periodontal defects, attributed to the growth factors it contains. The study highlights that PRF can effectively contribute to the regeneration of periodontal tissues, providing a beneficial environment for bone and soft tissue healing in the context of periodontal therapy.

Efficacy of Osteon II® Bone Graft

Osteon II®, a synthetic material composed of 70% β-tricalcium phosphate and 30% hydroxyapatite, is known for its osteoconductive properties, permitting bone ingrowth while maintaining volume. Its advantages include the absence of a donor site requirement, high availability, and reduced risk of disease transmission. The study found that this graft material also led to significant improvements in probing pocket depth, clinical attachment level, and bone fill after the surgical treatment of intrabony defects. The results demonstrated that the benefits of using Osteon II® were comparable to those observed with PRF, indicating its potential as a viable option for periodontal regeneration.

Clinical Comparisons and Outcomes

In this study, 15 patients with intrabony defects were evaluated over a timeline of three months and six months post-surgically. Key parameters including probing pocket depth (PPD), clinical attachment level (CAL), and gingival recession were statistically analyzed. Both treatment modalities (PRF and Osteon II®) showed significant reduction in PPD and improvements in CAL, with no significant differences noted between the two groups across various evaluation timelines. This suggests that both approaches are effective in managing periodontal defects, with an additional affirmation of the importance of oral hygiene.

Conclusion

The study concludes that both PRF and Osteon II® bone graft significantly improve periodontal health by promoting regeneration of intrabony defects, resulting in enhanced tissue healing and stability. While both treatments showed similar efficacy, PRF, as an autologous and cost-effective biomaterial, may present additional advantages in clinical applications. Overall, the findings support the use of both PRF and Osteon II® for periodontal therapy, indicating their effectiveness as regenerative materials in managing periodontal intrabony defects.

FAQ section (important questions/answers):

What was the aim of the study involving PRF and Osteon II?

The study aimed to compare the clinical and radiographic efficacy of Platelet-rich fibrin (PRF) and a bone graft consisting of 70% beta-tricalcium phosphate and 30% hydroxyapatite (Osteon II) in treating periodontal intrabony defects.

How many patients were involved in this study?

A total of 15 patients were included in the study, with 30 surgical sites treated using either open flap debridement with PRF or Osteon II graft.

What clinical parameters were assessed in the study?

Clinical parameters assessed included probing pocket depth (PPD), clinical attachment level (CAL), and gingival recession (GR), all recorded at baseline, 3 months, and 6 months post-surgery.

What were the main findings regarding probing pocket depth?

Both PRF and Osteon II showed significant reductions in probing pocket depth at 3 and 6 months, indicating effective treatment of intrabony defects.

Which material showed better results in terms of patient outcomes?

The study concluded that both PRF and Osteon II provided similar outcomes, but PRF may be a more advantageous option due to its autologous nature and cost-effectiveness.

What limitations were noted in the study's findings?

Key limitations included a small sample size and variability in defect dimensions, which could affect the generalizability of the results.

Glossary definitions and references:

Scientific and Ayurvedic Glossary list for “Comparison of PRF vs. Osteon II in treating periodontal defects.”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.

1) Study (Studying):
The term 'Study' refers to a systematic investigation aimed at acquiring knowledge or understanding about a specific subject. In the context of clinical research, a study evaluates the efficacy of treatments (like PRF and Osteon II) in periodontal therapy, providing empirical evidence that may guide future clinical practice and treatment strategies.

2) Table:
In research documents, 'Table' refers to a systematic arrangement of data or information, often presented in rows and columns. Tables provide a concise way to present and compare results, such as clinical parameters in this study. They enhance readability and allow for quick reference to numerical data, facilitating data interpretation.

3) Hygiene (Hygienic):
'Hygiene' encompasses practices that promote health and prevent disease, particularly through cleanliness and maintenance of sanitary conditions. In dental practice, proper oral hygiene is crucial for preventing periodontal disease and ensuring the effectiveness of treatments. Hygiene practices significantly influence outcomes in periodontal therapy, as shown through assessed indices in the study.

4) Rich (Rch):
'Rich' in this context refers to the quality of having a high concentration of beneficial components, specifically in reference to 'Platelet-Rich Fibrin' (PRF). PRF, as a regenerative material, derives from a patient's blood, offering a wealth of growth factors essential for healing and tissue regeneration in periodontal surgery.

5) Blood:
'Blood' is a vital fluid in the human body, containing cells and proteins that play essential roles in various physiological processes, including healing and immune response. In this study, blood is a key component for obtaining PRF, which is integral to enhancing tissue regeneration during periodontal treatment.

6) Beta:
'Beta' refers to Beta-tricalcium phosphate (β-TCP), an alloplastic bone graft material discussed in the study. It has osteoconductive properties, promoting new bone growth, and is used alongside hydroxyapatite for treating periodontal defects, contributing to positive clinical outcomes as observed in the comparative analysis of treatment techniques.

7) Post:
'Post' signifies the period following an event or intervention, commonly used in clinical research to describe follow-up assessments. In this study, 'postoperative' evaluations at 3 and 6 months help investigate the long-term efficacy of treatments like PRF and β-TCP, providing data on healing and periodontal regeneration.

8) Pur:
'Poor' is often used to describe inadequate conditions. In this study, it refers to poor oral hygiene, which can significantly adversely affect periodontal health. Patients were excluded based on poor hygiene status, emphasizing the importance of maintaining good oral care for successful periodontal treatment outcomes.

9) Male:
'Male' identifies one of the two primary biological sexes in humans. In clinical studies, gender classification helps in analyzing variations in treatment outcomes based on biological differences. In this study, the gender distribution of participants adds context to the results and may indicate the potential influence of sex on periodontal response.

10) Inflammation:
'Inflammation' is the body's response to injury or infection, often resulting in redness, swelling, and pain. In periodontal disease, inflammation signifies the body's reaction to plaque accumulation. Understanding inflammation's role is crucial in this study, as effective treatment aims to reduce it, restore tissue health, and prevent disease progression.

11) Antibiotic (Antibacterial):
'Antibiotic' refers to drugs used to combat bacterial infections. In periodontal therapy, antibiotics may be prescribed to manage infection and inflammation post-surgery. This study discusses antibiotic use as part of the postoperative care regimen to ensure optimal healing and minimize complications, enhancing treatment success in periodontal defects.

12) Activity:
'Activity' refers to actions or processes, often indicating metabolic or physiological functions. In this study, it pertains to the biological activity of growth factors in PRF that stimulate healing and tissue regeneration. Understanding these activities is crucial for evaluating the effectiveness of regenerative therapies in periodontal treatment.

13) Dressing:
'Dressing' is a sterile covering applied to surgical wounds to protect them from infection and promote healing. In this study, a non-eugenol periodontal dressing was used post-surgery to shield the surgical area. Effective dressings are vital for patient comfort and ensuring adequate healing conditions for optimal treatment outcomes.

14) Disease:
'Disease' refers to a pathological condition that negatively impacts bodily functions. In the context of this study, periodontal disease causes loss of connective tissue and alveolar bone around teeth. Understanding its mechanisms aids in developing effective treatments aimed at regeneration and healing of affected periodontal tissues.

15) Sharman (Sarma, Sarman, Sharma):
'Sharma' refers to one of the authors cited in the research, indicating previous work or findings relevant to this study. Reference to Sharma and other authors helps establish a knowledge base for discussing current research, showcasing the continuum of scientific exploration in periodontal treatment methodologies.

16) Filling (Filled):
'Filled' denotes the action of placing a material into a defect or cavity. In this study, both PRF and β-TCP graft materials were 'filled' into periodontal intrabony defects, highlighting a critical procedural aspect that influences healing and regeneration outcomes, which are central to evaluating treatment efficacy.

17) Surya (Shurya):
'Surya' is the name of the lead researcher in this study. It represents the human element behind the work, underscoring the collaborative nature of scientific research. Naming authors acknowledges their contributions and credibility, essential for accountability and recognition in the academic community.

18) Silk:
'Silk' refers to the type of suturing material used in the surgical procedures. In the study, 3-0 braided silk sutures were utilized for closing incisions post-graft placement. The choice of suture material impacts healing outcomes, as it must balance strength and biocompatibility to facilitate proper wound closure.

19) Transmission:
'Transmission' in this context refers to the transfer of diseases. In periodontal studies, understanding disease transmission enhances awareness of risk factors involved in periodontal health. In this study, patient selection included criteria to mitigate disease transmission risks, ensuring a clearer evaluation of treatment effectiveness without confounding factors.

20) Discussion:
'Discussion' is a section in research papers where findings are interpreted and contextualized within existing literature. It allows authors to articulate the implications of their study's results, address potential limitations, and suggest future research directions. In this study, the discussion connects clinical outcomes to previously established knowledge.

21) Tamilnadu (Tamil-nadu):
'Tamilnadu' is a state in India, emphasizing the geographical context of the study conducted at a dental college located there. Geographic localization can influence the demographic profile of study participants and thus, the results of clinical research, offering insights into regional health patterns and treatment responses.

22) Pregnant:
'Pregnant' refers to the condition of carrying a developing fetus. In this study, pregnant individuals were excluded from participation, as pregnancy can affect periodontal health and tissue response to treatment. Exclusion criteria ensure that results are not confounded by pregnancy-related physiological changes, leading to clearer conclusions.

23) Incision:
'Incision' refers to the surgical cut made to access underlying structures during a procedure. In periodontal surgery, proper incision techniques are critical for optimal healing and minimizing trauma to tissues. The study details specific incision methods to ensure effective access and treatment of periodontal defects.

24) Mineral:
'Mineral' typically refers to inorganic substances essential for various bodily functions. In the context of the study, it may relate to the calcium phosphate components in β-TCP, critical for bone regeneration. Understanding these materials aids in the evaluation of their role in enhancing healing and tissue regeneration.

25) Company:
'Company' reflects the organizations responsible for producing the materials used in the study, such as graft materials and surgical supplies. Identifying companies contributes to transparency in research, allowing for replication of methods and materials, essential for ensuring reliability and consistency in scientific investigations.

26) Repair:
'Repair' indicates the biological processes that restore tissue integrity after injury. In periodontal therapy, the objective is to repair lost supporting structures. The study evaluates the effectiveness of PRF and β-TCP in facilitating tissue repair in periodontal defects, which is crucial for restoring oral health.

27) Divya:
'Divya' refers to one of the authors of the study. The inclusion of author names acknowledges their contributions to the research process and promotes accountability. Author recognition is crucial in academic publishing, as it attributes findings and ideas to the individuals responsible for the work.

28) Pandu (Pamdu, Pamde):
'Pandu' references the D.A.P.M. R.V. Dental College in Bangalore, India, where the study was conducted. Identifying the institution underscores its role in advancing dental research and education. This also contextualizes the study within the framework of regional healthcare and academic collaboration in the field of dentistry.

29) India:
'India' denotes the country where the research was conducted. The geographical context influences participant demographics, healthcare systems, and the prevalence of periodontal disease. This information is essential for understanding the applicability of research findings within specific populations and enhances the relevance of the study's outcomes.

30) Chang:
'Chang' is the surname of a researcher whose work is cited within the study. Including citations establishes a lineage of research, showing how current studies build upon prior findings. It enhances the credibility of the work and positions it within the broader scientific discourse related to periodontal therapies.

31) Sugar:
'Sugar' refers to glucose or simple carbohydrates that can influence systemic health, including periodontal health. Elevated blood sugar levels, as seen in diabetes, can adversely affect healing and tissue response. In this study, controlling blood sugar levels was part of the inclusion criteria to ensure participant health.

32) Hand:
'Hand' refers to the types of instruments used in performing procedures. Effective hands-on techniques are crucial for successful surgical outcomes in periodontal therapy. The mention of 'hand' instruments underscores the manual dexterity and precision required in surgical settings for optimal graft placement and healing.

33) Dish (Dis):
'Dish' denotes the sterile container used for preparing PRF in this study. Maintaining a sterile environment during surgical procedures is crucial to prevent infections and ensure patient safety. The use of a sterile dappen dish emphasizes protocols followed for tissue handling and preparation in clinical settings.

34) Life:
'Life' encompasses the biological existence of individuals, particularly in the context of health and disease. The ultimate aim of periodontal therapy is to enhance the quality of life through effective treatments. This study contributes to understanding how interventions can restore oral functions critical to overall well-being.

35) Dog:
'Dogs' refer to the animal subjects often used in comparative studies to evaluate surgical techniques before human application. Research on periodontal defects in animals, including dogs, helps refine methodologies and understand biological responses, guiding clinical practices and enhancing human healthcare through evidence-based treatment strategies.

Other Science Concepts:

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Discover the significance of concepts within the article: ‘Comparison of PRF vs. Osteon II in treating periodontal defects.’. Further sources in the context of Science might help you critically compare this page with similair documents:

Statistical analysis, Ethical Clearance, Gender distribution, Plaque index, Gingival index, Age distribution, Probing pocket depth, Clinical attachment level, Limitations of Study, Gingival Recession, Clinical parameter, Platelet-rich-fibrin, Periodontal intrabony defects, Bone fill, Regenerative periodontal surgery, Open flap debridement, Surgical protocol.

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