Eval of Medhya Churna in relation to cerebral palsy.
Journal name: World Journal of Pharmaceutical Research
Original article title: Pharmacognostical and pharmaceutical evaluation of medhya churna–w.s.r. to cerebral palsy
The WJPR includes peer-reviewed publications such as scientific research papers, reports, review articles, company news, thesis reports and case studies in areas of Biology, Pharmaceutical industries and Chemical technology while incorporating ancient fields of knowledge such combining Ayurveda with scientific data.
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Dr. Miral Dobariya, Harisha C. R., Shukla V. J., Dr. K. S. Patel and Dr. V. K. Kori
World Journal of Pharmaceutical Research:
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Full text available for: Pharmacognostical and pharmaceutical evaluation of medhya churna–w.s.r. to cerebral palsy
Source type: An International Peer Reviewed Journal for Pharmaceutical and Medical and Scientific Research
Doi: 10.20959/wjpr20208-18064
Copyright (license): WJPR: All rights reserved
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Summary of article contents:
1) Introduction
Cerebral Palsy (CP) is recognized as the most prevalent motor disability affecting children, classified as a series of stable disorders that hinder movement and posture development due to non-progressive impairments in the brain during infancy or fetal stages. The condition often coexists with various disturbances, including sensory, cognitive, and behavioral issues, alongside musculoskeletal complications. Although Ayurveda lacks a direct reference to Cerebral Palsy, the manifestations appear to align closely with what is termed "Vata Vyadhi." This study seeks to analyze the standardization and evaluation of Medhya Churna, an Ayurvedic formulation traditionally used to manage neuropsychiatric disorders, to confirm its identity, purity, and efficacy.
2) Pharmacognostical Evaluation of Medhya Churna
The pharmacognostical study included a comprehensive examination of the cellular components found within Medhya Churna. Various key characteristics such as color, odor, taste, and texture were documented, revealing a greenish ash color, slightly aromatic odor, and smooth texture. Microscopic analyses identified relevant cellular structures, including pitted vessels and cork cells from Guduchi, starch grains from Vacha, and crystal fibers from Yashtimadhu. These findings confirm the identity of the raw materials, supporting the formulation's authenticity and potential therapeutic properties.
3) Physicochemical Analysis
Physicochemical assessments of Medhya Churna were conducted to evaluate its quality and stability. Key parameters such as loss on drying, ash value, water-soluble and alcohol-soluble extracts, and pH were analyzed. The results indicated a loss on drying of 8.09% w/w and an ash value of 14.60% w/w, suggesting the formulation is relatively stable and contains minimal impurities. The water-soluble extractability of 17.02% w/w and alcohol-soluble extract of 10.05% w/w show that Medhya Churna has favorable solubility characteristics, further validating the selection of its ingredients for therapeutic use.
4) High Performance Thin Layer Chromatography (HPTLC) Findings
HPTLC profiling of Medhya Churna was employed to investigate the presence of specific phytoconstituents. The analysis revealed six distinct spots at 254 nm and seven at 366 nm, indicating the formulation's complexity and its potential active ingredients. These results highlight the formulation's therapeutic efficacy and underscore the necessity for further studies to elucidate these individual components and their respective pharmacological actions.
5) Conclusion
In conclusion, the study thoroughly established the pharmacognostical and physicochemical qualities of Medhya Churna, affirming its identity and confirming that it meets the initial standards set by the Ayurvedic Pharmacopoeia of India. The findings underscore the importance of standardization in Ayurvedic formulations to ensure consistent quality and efficacy. While this preliminary analysis provides valuable insights into Medhya Churna, future investigations should focus on identifying the active chemical constituents responsible for its therapeutic effects, which could further enhance its application in the treatment of conditions like Cerebral Palsy.
FAQ section (important questions/answers):
What is Cerebral Palsy and its common causes?
Cerebral Palsy (CP) is a non-progressive disorder affecting movement and posture, commonly caused by brain injury during fetal or infant development. It is the most prevalent motor disability in children.
What is the purpose of the study on Medhya Churna?
The study aims to standardize Medhya Churna through pharmacognostical and physicochemical evaluations, confirming its identity, purity, and quality, as it is used in managing neuropsychiatric disorders like Cerebral Palsy.
How was Medhya Churna prepared for the study?
Medhya Churna was prepared according to the Ayurvedic Formulary of India by individually powdering and mixing specified proportions of the ingredients, then storing the final mixture in airtight containers.
What are the key ingredients in Medhya Churna?
The key ingredients of Medhya Churna include Bramhi, Shankhpushpi, Yashtimadhu, Guduchi, Pippali, and Vacha, each contributing unique medicinal properties aimed at enhancing neurological function.
What physicochemical analyses were performed on Medhya Churna?
Physicochemical analyses included loss on drying, ash value, water soluble extract, alcohol soluble extract, and pH measurement to assess the quality and stability of Medhya Churna.
What were the findings from the HPTLC analysis?
The HPTLC analysis revealed 6 spots at 254 nm and 7 spots at 366 nm, indicating various components present in Medhya Churna, which may relate to its therapeutic effects.
Glossary definitions and references:
Scientific and Ayurvedic Glossary list for “Eval of Medhya Churna in relation to cerebral palsy.”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.
1) Medhya:
Medhya refers to the Ayurvedic classification of herbs known for their cognitive and mental health benefits. In the context of the Medhya Churna formulation under study, it emphasizes the potential of these herbs to enhance memory, intelligence, and overall mental wellbeing, particularly relevant in management of conditions such as Cerebral Palsy.
2) Water:
Water is a crucial solvent in the extraction and preparation of herbal formulations. In the context of the Medhya Churna, the water-soluble extractive value indicates the degree to which the formulation can dissolve in water, thereby affecting the bioavailability and efficacy of its active components in therapeutic applications.
3) Drug:
Drugs, in the context of the study, refer to the various herbal components that make up Medhya Churna. Understanding the pharmacognostical characteristics of these drugs ensures that their medicinal properties are preserved and effectively utilized in treating neurological disorders.
4) Study (Studying):
The study is a systematic investigation into the properties and efficacy of Medhya Churna through pharmacognostical, physicochemical, and HPTLC analyses. It aims to validate traditional knowledge with scientific evidence, ensuring that the formulation meets quality standards and can be reliably used in Ayurvedic practice.
5) Vaca:
Vacha, or Acorus calamus, is one of the key ingredients in Medhya Churna. Known for its cognitive-enhancing properties, it plays an essential role in supporting mental functions, making it particularly relevant in the management of conditions like cerebral palsy by promoting speech and intelligence.
6) Quality:
Quality refers to the standard of the herbs used in Medhya Churna and their preparation. Ensuring the quality of herbal formulations is crucial for safety and effectiveness in treatment, affecting their reliability in clinical settings and adhering to Ayurvedic pharmacopoeia standards.
7) Performance:
Performance pertains to how well the Medhya Churna works in achieving its therapeutic effects. This includes its pharmacological activity and patient response, which are critical in evaluating its efficacy in treating conditions such as cerebral palsy and supporting neurological health.
8) Powder:
Powder indicates the final form of Medhya Churna after processing. The fine powder consistency enhances the solubility and absorption of the herbal components, facilitating their therapeutic action, thereby making it suitable for administration in Ayurvedic treatments for neuropsychiatric disorders.
9) Table:
Table in this context refers to the organized presentation of data, such as the ingredients and their proportions in Medhya Churna. It helps in clearly communicating the formulation's components, aiding in standardization and quality control within Ayurvedic practice.
10) Pharmacognostical:
Pharmacognostical refers to the study of the biological, chemical, and physical properties of drugs derived from natural sources. This approach in examining Medhya Churna ensures the identification, purity, and efficacy of the herbal components used in managing cerebral palsy.
11) Pippali (Pippalin):
Pippali, or Piper longum, is a significant herb in Medhya Churna known for its role as a Rasayana and its ability to enhance bioavailability of other components. It contributes to the overall effectiveness of the formulation in addressing cognitive and neurological disorders.
12) India:
India is the country of origin for Ayurvedic practices and formulations such as Medhya Churna. The cultural and historical context surrounding Indian Ayurveda informs the traditional uses and significance of such herbal remedies in treating conditions like cerebral palsy.
13) Phytochemical:
Phytochemical refers to the chemical compounds derived from plants which possess potential health benefits. Investigating these compounds in Medhya Churna is essential for understanding its therapeutic effects and validating traditional claims with scientific evidence in herbal medicine.
14) Yashtimadhu (Yastimadhu, Yashti-madhu):
Yashtimadhu, or Glycyrrhiza glabra, is an ingredient in Medhya Churna known for its sweet taste and soothing properties. Its role in the formulation is to support cognitive functions and overall mental well-being, important for managing neurodevelopmental conditions.
15) Madhura:
Madhura translates to sweetness in taste, indicating the flavor profile of Medhya Churna. The properties of Madhura herbs in Ayurvedic medicine suggest a beneficial effect on the body’s elements and can enhance patient compliance through palatable formulations.
16) Shankhapushpi (Sankhapuspi, Samkhapuspi):
Shankhapushpi, or Convolvulus pluricaulis, is an important component of Medhya Churna credited with improving memory and cognitive functions. Its inclusion reflects a targeted approach to treating cerebral palsy by enhancing neuropsychological health.
17) Ayurveda (Ayus-veda):
Ayurveda is the traditional system of medicine originating from India that emphasizes balance in bodily systems. Medhya Churna as an Ayurvedic formulation manifests the principles of holistic healing, seeking to restore mental clarity and cognitive function particularly in children with cerebral palsy.
18) Rasayana (Rasa-ayana):
Rasayana refers to the rejuvenating aspects of Ayurveda focusing on enhancing life quality and longevity. Medhya Churna embodies these principles, positioning itself as a therapeutic option to improve mental function and well-being in conditions like cerebral palsy.
19) Purity:
Purity relates to the quality of the herbs in Medhya Churna, ensuring that they are free from contaminants and adulterants. This concept is vital in maintaining therapeutic effectiveness and safety for those using the formulation in treatment.
20) Nature:
Nature alludes to the organic characteristics and inherent properties of the ingredients within Medhya Churna. Understanding the natural attributes of these herbs provides insight into their therapeutic roles and how they contribute to the overall efficacy of the formulation.
21) Tikta:
Tikta denotes bitterness, a taste associated with several Ayurvedic ingredients. In Medhya Churna, the presence of Tikta herbs may contribute to their physiological effects, particularly in balancing bodily functions and promoting health in neurodevelopmental disorders.
22) Kanda (Kamda):
Kanda refers to the root part of certain medicinal plants like Yashtimadhu and Guduchi utilized in Medhya Churna. The roots often contain concentrated phytochemicals contributing to the healing properties, reinforcing the formulation's therapeutic objectives.
23) Rasa (Rasha):
Rasa translates to 'taste' but also conveys the essence or therapeutic effect of a substance in Ayurveda. Understanding Rasa in the context of Medhya Churna informs how the combination of tastes and properties may synergistically enhance cognitive functions.
24) Vata:
Vata is one of the three doshas in Ayurveda representing air and space. Cerebral Palsy is often analagized to Vata Vyadhi, highlighting how imbalances in this dosha could manifest in neurological symptoms, guiding the therapeutic focus of Medhya Churna.
25) Tinospora cordifolia:
Tinospora cordifolia, known as Guduchi, is a major ingredient of Medhya Churna praised for its immunomodulatory properties. This herb aids the formulation's ability to bolster physiological function and enhance recovery processes in neurodevelopmental issues.
26) Piper longum:
Piper longum, or Pippali, is included in Medhya Churna for its actions enhancing digestion and bioavailability of other herbal constituents. Its role is crucial in maximizing the therapeutic benefit of the formulation, particularly for cognitive development.
27) Acorus calamus:
Acorus calamus, referred to as Vacha, is utilized in Medhya Churna for stimulating intellect and enhancing speech capabilities. Its specific benefits align with the needs of children dealing with conditions such as cerebral palsy, wherein speech and cognition may be impaired.
28) Observation:
Observation in this research reflects the careful examination and analysis of Medhya Churna’s components, ensuring that the study maintains accuracy in documenting the properties and effects of the formulation according to Ayurvedic principles.
29) Vatavyadhi (Vata-vyadhi):
Vata-vyadhi refers to diseases caused by imbalances in the Vata dosha, encompassing various neurological and psychological issues. The recognition of Cerebral Palsy as Vata-vyadhi emphasizes the importance of balancing this dosha in treatment plans, including the use of Medhya Churna.
30) Perception:
Perception relates to how sensory information is processed and understood, which is particularly relevant in studying the cognitive effects of Medhya Churna. Enhancing perception is essential in the context of developing therapies for mental and cognitive health.
31) Discussion:
Discussion refers to the analysis and interpretation of findings from the study of Medhya Churna. This section allows for the integration of results with existing literature, facilitating a deeper understanding of the formulation's role in addressing cerebral palsy and cognitive disorders.
32) Developing:
Developing signifies the growth and changes occurring in the nervous system, particularly in infants and children. Understanding the nuances of cognitive development is essential when considering the role that Medhya Churna could play in supporting children with brain or movement disorders.
33) Container:
Container refers to the storage method for Medhya Churna, ensuring that it is kept in an airtight environment to maintain its effectiveness. Proper storage is crucial for preserving the quality and extending the shelf life of herbal formulations.
34) Activity:
Activity denotes the functional capabilities of the body and mind. In evaluating Medhya Churna, examining how it influences physical and cognitive activity in children with disorders like cerebral palsy is imperative for gauging therapeutic success.
35) Epilepsy:
Epilepsy is a neurological condition often associated with cerebral palsy that presents challenges in management. Understanding such comorbidities is crucial for holistic treatment approaches with formulations like Medhya Churna, which aim to improve overall cognitive health.
36) Shushka (Suska):
Shushka translates to dryness in Ayurveda, which can be associated with certain health conditions affecting the body and mind. Identifying the properties of Shushka ingredients in Medhya Churna may contribute to addressing symptomatic dryness or imbalances within the body.
37) Snigdha:
Snigdha refers to the quality of being unctuous or oily in Ayurveda. The presence of Snigdha properties in some ingredients of Medhya Churna can be beneficial for promoting nourishment and moisture balance in physiological processes.
38) Gujarat:
Gujarat is the region in India where the research on Medhya Churna was conducted. This geographic context is important in understanding local Ayurvedic traditions and practices surrounding the formulation and its application in neuropsychiatric disorders.
39) Harisha (Harisa):
Harisha refers to one of the authors and contributors to the study on Medhya Churna. Individual contributions from experts underscore the collaborative effort in advancing research within Ayurveda and ensuring scientific rigor in evaluating traditional formulations.
40) Samana (Shamana):
Shamana refers to palliative treatments aimed at alleviating symptoms or imbalances in Ayurveda. The inclusion of Shamana properties in Medhya Churna points to its intent to provide relief in managing cognitive and neurological conditions, particularly in children.
41) Disease:
Disease refers to pathological conditions impacting health, such as cerebral palsy. Understanding the nature of disease and its symptoms guides the selection of therapeutic formulations like Medhya Churna that aim to address underlying imbalances.
42) Insect:
Insect, referring to pests that can contaminate herbal formulations, emphasizes the necessity of maintaining a clean preparation environment for Medhya Churna to ensure safety and efficacy in therapeutic uses.
43) Shukla (Sukla):
Shukla is another author involved in the research study of Medhya Churna. The contributions from different researchers highlight the collaborative nature of scientific study in Ayurveda, vital for validating traditional practices through rigorous investigation.
44) Vipaka:
Vipaka refers to the post-digestive effect of a substance in Ayurveda, influencing how it impacts the body after consumption. In analyzing Medhya Churna, understanding its Vipaka can provide insight into its metabolic effects and therapeutic efficacy.
45) Pipali:
Pipali, or Piper longum, is an important component in Medhya Churna known for its potent bioenhancing properties. Its presence supports the efficacy of the formulation, improving absorption and increasing the therapeutic effects of other herbs in the mixture.
46) Vyadhin (Vyadhi):
Vyadhi denotes diseases or disorders in Ayurveda. Recognizing cerebral palsy as a Vyadhi leads to specific therapeutic approaches using formulations like Medhya Churna, aiming to address the underlying imbalances and promote healing.
47) Bitter:
Bitter describes a fundamental taste found in some Ayurvedic medicines, including components of Medhya Churna. Bitterness is associated with stimulating digestion and detoxification, key aspects of maintaining bodily health and rebalancing doshas.
48) Phala:
Phala refers to the fruit or outcome within the Ayurvedic context, emphasizing the results and effects of using Medhya Churna on health. It reflects the potential therapeutic results expected from the formulation in terms of cognitive and physical improvement.
49) Kapha:
Kapha is one of the doshas in Ayurveda associated with earth and water. Understanding the role of Kapha in health and disease is pivotal when using formulations like Medhya Churna, which may help balance this dosha in patients.
50) Patel:
Patel signifies one of the authors involved in the research study of Medhya Churna. Recognition of contributors to scientific literature illustrates the collaborative efforts required to advance Ayurvedic research and validate traditional knowledge.
51) Balya:
Balya refers to properties in Ayurveda that promote strength and vitality. The inclusion of Balya herbs in Medhya Churna suggests its intent to fortify cognitive resources and improve the overall health of individuals with developmental disabilities.
52) Guru:
Guru signifies heaviness in the Ayurvedic context, relating to the property of some herbs in Medhya Churna. Understanding Guru qualities can help elucidate the formulation’s effects on digestion and metabolism, contributing to its therapeutic profile.
53) Yoga:
Yoga, broadly refers to the systems of practices and philosophies endorsing holistic health. In the context of Ayurveda, it reflects the integration of physical, mental, and spiritual well-being aimed at enhancing therapeutic outcomes through formulations like Medhya Churna.
54) Guna:
Guna denotes the qualities or characteristics of substances in Ayurveda. Identifying the Guna of ingredients in Medhya Churna informs practitioners about the potential therapeutic actions and healing properties intrinsic to the formulation.
55) Kori:
Kori is part of the group of researchers contributing to the study of Medhya Churna. Acknowledging the work of various scholars is essential in legitimizing the application of Ayurvedic formulations through rigorous methodological research.
56) Mula:
Mula refers to the root part of the plants used in Medhya Churna. Roots often contain high concentrations of bioactive compounds, crucial for therapeutic efficacy, showcasing the importance of sourcing the proper components to ensure quality in herbal medicine.
57) Sign:
Sign refers to identifiable characteristics or manifestations of a condition. Understanding the signs of cerebral palsy is vital to guide the formulation strategy for Medhya Churna to address specific symptoms associated with the condition.
58) Life:
Life signifies the concept of vitality and health. In the context of Medhya Churna, the formulation aims to enhance quality of life by supporting cognitive functions and managing neurodevelopmental conditions effectively.
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