Case report: Guillain-Barré syndrome in HIV and spinal TB patient.

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Journal name: World Journal of Pharmaceutical Research
Original article title: A case report on guillain barre syndrome with history of hiv and spinal tuberculosis
The WJPR includes peer-reviewed publications such as scientific research papers, reports, review articles, company news, thesis reports and case studies in areas of Biology, Pharmaceutical industries and Chemical technology while incorporating ancient fields of knowledge such combining Ayurveda with scientific data.
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Original source:

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Author:

Azgari Begum, Syeda Maimoona Maqsood, Sania Mehveen, Lubna Muzaffar Hussain and Dr. S. P. Srinivas Nayak


World Journal of Pharmaceutical Research:

(An ISO 9001:2015 Certified International Journal)

Full text available for: A case report on guillain barre syndrome with history of hiv and spinal tuberculosis

Source type: An International Peer Reviewed Journal for Pharmaceutical and Medical and Scientific Research

Doi: 10.20959/wjpr202010-18566

Copyright (license): WJPR: All rights reserved


Download the PDF file of the original publication


Summary of article contents:

Introduction

Guillain-Barre syndrome (GBS) is a rare autoimmune disorder characterized by the immune system attacking healthy nerve cells in the peripheral nervous system, leading to symptoms such as weakness, numbness, and paralysis. The condition has a median annual incidence of 1.3 cases per 100,000 people, with males being more affected than females. The case presented discusses a 47-year-old female with a history of Human Immunodeficiency Virus (HIV) and spinal tuberculosis who was hospitalized with lower limb paralysis, indicative of GBS. Early recognition and prompt treatment are crucial for managing this potentially life-threatening condition.

Diagnosis and Symptoms of Guillain-Barre Syndrome

The diagnosis of GBS is marked by the rapid onset of weakness and paralysis, accompanied by areflexia (absence of reflexes). The patient's initial presentation included febrile status, tachycardia, and lower limb paralysis. Laboratory tests revealed anemia and thrombocytopenia. Notable physical findings confirmed motor weakness and sensory deficits, ultimately leading to a provisional diagnosis of GBS. The clinical journey emphasizes the importance of identifying prior infectious diseases, as GBS often follows infections, particularly viral ones.

Treatment Approaches for Guillain-Barre Syndrome

Management of GBS often involves plasma exchange and immunoglobulin therapy, both of which can help alleviate symptoms and enhance recovery. In the discussed case, the patient received advanced pharmacological treatments, including neuromodulators and analgesics, along with nutritional support and physiotherapy to promote recovery. The treatment plan emphasizes a multidisciplinary approach, integrating pharmacological and non-pharmacological strategies to maximize the patient's rehabilitation and minimize complications.

Complications and Prognosis

Patients with GBS face various complications, including residual numbness, cardiovascular issues, and a risk of deep vein thrombosis due to immobility. The prognosis for GBS is variable; while many patients experience significant recovery, with 40-80% able to walk unaided within six months, others may have a prolonged recovery time. Mortality rates range from 4-7%, making early diagnosis and intervention a crucial factor in improving outcomes.

Conclusion

Guillain-Barre syndrome is a serious, albeit rare, autoimmune disorder that necessitates prompt diagnosis and treatment. The interplay between underlying conditions, such as HIV and spinal tuberculosis, may exacerbate the clinical presentation of GBS, as observed in the case study. Overall, an awareness of GBS's symptoms, effective treatment protocols, and a strong support system for patients are essential components in managing this debilitating condition and enhancing patient recovery.

FAQ section (important questions/answers):

What is Guillain-Barre syndrome and how does it affect the body?

Guillain-Barre syndrome (GBS) is a rare autoimmune disorder where the immune system attacks peripheral nerve cells, leading to weakness, numbness, tingling, and potentially paralysis.

What are the common symptoms associated with Guillain-Barre syndrome?

Common symptoms include weakness and tingling in legs, which can progress to paralysis, numbness, and absent reflexes. Some patients may also experience respiratory issues.

How is Guillain-Barre syndrome diagnosed in patients?

Diagnosis involves assessing symptoms of progressive motor weakness, absent reflexes, and patient history, including previous infections, such as HIV or tuberculosis.

What are the current treatments available for Guillain-Barre syndrome?

Current treatments include plasmapheresis, immunoglobulin therapy, analgesics for pain relief, and physiotherapy for muscle strength and flexibility.

What complications can arise from Guillain-Barre syndrome?

Complications include persistent numbness, heart problems, blood clotting, and pressure sores due to immobility. A strong support system is crucial during recovery.

What is the typical recovery timeline for Guillain-Barre syndrome patients?

Patients typically start to recover within six months, with some regaining mobility fully within three years. However, the recovery timeline varies by individual.

Glossary definitions and references:

Scientific and Ayurvedic Glossary list for “Case report: Guillain-Barré syndrome in HIV and spinal TB patient.”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.

1) Barre:
Barre refers to the Guillain-Barre syndrome (GBS), a rare autoimmune disorder that causes the immune system to attack peripheral nerve cells, leading to various neurological symptoms such as weakness, numbness, and paralysis. Understanding GBS is essential for proper diagnosis and treatment, as timely intervention is crucial to manage its potentially severe effects.

2) Nayak:
Nayak is the surname of one of the authors, Dr. S. P. Srinivas Nayak, who contributed to the case report on Guillain-Barre syndrome. Attribution to authors is important in academic writing, providing credibility and accountability to the research presented and allowing readers to trace information back to its sources.

3) Blood:
Blood plays a crucial role in diagnosing and monitoring conditions like Guillain-Barre syndrome (GBS). Blood tests can reveal abnormalities, such as elevated white blood cell counts or other lab values indicating infection or immune response, which are necessary to understand the patient's overall health and to guide treatment options.

4) Tuberculosis:
Tuberculosis (TB) is discussed in the case report as the patient has a history of spinal TB, which is relevant because infections like TB can complicate or trigger autoimmune responses, including GBS. The correlation between TB and GBS is significant as it informs clinicians about underlying conditions that may affect treatment and prognosis.

5) Pharmacological:
Pharmacological refers to the medications and treatments used to manage diseases such as Guillain-Barre syndrome. Understanding pharmacological interventions, including plasma exchange and immunoglobulin therapy, is crucial for healthcare professionals to effectively alleviate symptoms and improve patient outcomes, as well as to prevent complications associated with the condition.

6) Disease:
Disease is a fundamental concept in medical literature, highlighting abnormal physiological conditions. In the context of Guillain-Barre syndrome, discussing the disease helps to define its clinical features, causes, and implications for patient care, thereby facilitating a deeper understanding of its impact on the patient's overall health and treatment pathways.

7) Table:
Table refers to the data presentation format used in the case report to convey laboratory results and treatment regimens clearly and concisely. Using tables enhances the readability of complex information, making it easier for healthcare professionals to analyze and interpret the data, thus supporting effective clinical decision-making.

8) Pain:
Pain is a significant symptom reported in many neurological conditions, including Guillain-Barre syndrome. Understanding and managing pain is essential for the quality of life of affected individuals. The case report elaborates on pain management strategies, highlighting the importance of addressing symptoms to enhance recovery and overall patient care.

9) Viru:
Although 'Viru' appears in the context of 'virus,' its mention underlines the role of viral infections (such as HIV) in triggering Guillain-Barre syndrome. Identifying viral causes is critical for healthcare providers to better understand the multi-factorial nature of GBS and tailor treatment and prevention strategies accordingly.

10) Family:
Family support is critical in the recovery process of patients with conditions like Guillain-Barre syndrome. Involving family members in care can alleviate stress, enhance emotional wellbeing, and provide the necessary assistance during rehabilitation efforts, highlighting the importance of a strong support network in patient recovery and rehabilitation.

11) Sign:
Sign, in a medical context, refers to observable phenomena or symptoms indicating a disease's presence. Identifying signs such as weakness and areflexia in Guillain-Barre syndrome is vital for accurate diagnosis and effective management, emphasizing the need for thorough clinical assessments during patient evaluations.

12) Inflammation:
Inflammation is a key process in autoimmune disorders like Guillain-Barre syndrome, where the immune system improperly attacks nerve cells. Understanding inflammation aids in grasping the mechanisms of the disease, guiding treatment decisions aimed at controlling the inflammatory response and preventing further nerve damage.

13) Discussion:
Discussion in medical literature allows for the exploration of case-specific findings, comparisons with existing knowledge, and implications for practice. It provides a platform for evaluating treatment effectiveness, understanding patient experiences, and suggesting future research directions related to Guillain-Barre syndrome and co-occurring conditions.

14) Developing:
Developing refers to the progression or emergence of symptoms related to diseases like Guillain-Barre syndrome. Documenting the timeline of symptom development is essential for diagnosis and treatment, as it provides insight into the disease's nature and informs clinicians on how best to intervene.

15) Irritation:
Irritation can describe symptoms experienced by patients with neurological diseases, such as tingling or discomfort. Recognizing irritation as a symptom helps caregivers understand patient experiences better and highlights the importance of addressing such issues in treatment plans to improve comfort and quality of life.

16) Inference:
Inference is the logical deduction made based on available evidence, such as clinical findings and test results. Accurate inference in diagnosing Guillain-Barre syndrome is essential for determining the most appropriate treatment strategies and improving patient outcomes, reinforcing the need for thorough analysis of clinical data.

17) Relative:
Relative can imply a comparison or association between conditions, such as the relative risk factors for developing Guillain-Barre syndrome in patients with prior infections, like HIV. Recognizing relative risk informs clinicians about patient histories that may complicate or impact treatment and management of GBS.

18) Insect:
Similar to 'insects,' 'insect' is part of the medical terminology used to describe the peculiar sensations experienced by patients with Guillain-Barre syndrome. Understanding these sensory experiences can aid in building awareness among healthcare providers regarding the diverse and often unusual symptoms related to neurological disorders.

19) India:
India is referenced as the geographical context where the case of Guillain-Barre syndrome with tuberculosis has been reported. Understanding regional health trends, prevalence of diseases like TB, and their associations with autoimmune disorders provides essential insights for public health strategies and clinical practices in similar populations.

20) Pulse:
Pulse refers to the physiological measurement of heart rate, which can indicate overall cardiovascular health. In patients with Guillain-Barre syndrome, monitoring pulse is necessary to detect potential cardiovascular issues that may arise as complications of the syndrome, allowing for timely interventions to protect patient health.

21) Study (Studying):
Study refers to the systematic investigation or case report that presents findings on Guillain-Barre syndrome and its connections to conditions like HIV and TB. Such studies contribute valuable knowledge to the medical community regarding disease presentation, treatment options, and multi-faceted patient care approaches.

22) Drug:
Drug is often synonymous with medication but also refers to specific chemical substances used for treatment. In the context of Guillain-Barre syndrome, discussions on specific drugs and their mechanisms help clinicians choose appropriate therapies, ensuring effective management of symptoms and supporting patient recovery.

23) Diet:
Diet pertains to the nutritional management of patients with Guillain-Barre syndrome, emphasizing the importance of dietary interventions in supporting recovery. A high-energy and high-protein diet is recommended to reduce muscle wasting and improve overall health, underlining the role of nutrition in the rehabilitation process.

24) Male:
Male references the demographic aspect of Guillain-Barre syndrome, which displays a slight predominance in males compared to females. Understanding this demographic pattern is essential for epidemiological studies and can help healthcare providers recognize risk factors when diagnosing and treating affected patients.

Other Science Concepts:

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Discover the significance of concepts within the article: ‘Case report: Guillain-Barré syndrome in HIV and spinal TB patient.’. Further sources in the context of Science might help you critically compare this page with similair documents:

Chronic condition, Neurological disorder, Guillain-Barre syndrome, Physiotherapy, Treatment option, Human immunodeficiency virus, Ascending Paralysis, Acute inflammatory demyelinating polyradiculoneuropathy, Non-pharmacological therapy, Immunoglobulin therapy, Spinal tuberculosis, Plasmapheresis, Areflexia, Progressive motor weakness, CSF protein.

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