Analytical study of shadbindu gritha –a polyherbal preparation
Journal name: World Journal of Pharmaceutical Research
Original article title: Analytical study of shadbindu gritha –a polyherbal preparation
The WJPR includes peer-reviewed publications such as scientific research papers, reports, review articles, company news, thesis reports and case studies in areas of Biology, Pharmaceutical industries and Chemical technology while incorporating ancient fields of knowledge such combining Ayurveda with scientific data.
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Swapna Alva, G. Shrinivasa Acharya, Ashwini M. J. and Suchitra N. Prabhu
World Journal of Pharmaceutical Research:
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Full text available for: Analytical study of shadbindu gritha –a polyherbal preparation
Source type: An International Peer Reviewed Journal for Pharmaceutical and Medical and Scientific Research
Doi: 10.20959/wjpr202010-18468
Copyright (license): WJPR: All rights reserved
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Summary of article contents:
Introduction
The study focuses on the analytical standardization of Shadbindu Ghrita, a polyherbal Ayurvedic formulation primarily utilized for the treatment of rhinitis. The formulation includes several herbal ingredients such as Bhringaraja (Eclipta alba), Lavanga (Syzygium aromaticum), Yashtimadhu (Glycyrrhiza glabra), Kushta (Saussurea lappa), Shunti (Zingiber officinalis), and clarified butter. The objective was to assess the quality, efficacy, and identity of the formulation by applying various analytical methods to ensure its standardization for clinical use.
Saponification Value
The saponification value is a critical parameter that measures the molecular weight and chain length of fatty acids within Shadbindu Ghrita. A saponification value of 179.50 indicates that the formulation is composed of short-chain fatty acids, which are beneficial for absorption through the nasal mucosa. This property enhances the pharmacokinetic profile of the drug, enabling better therapeutic efficacy. Understanding the saponification value is essential for validating the formulation's suitability for medicinal use and ensuring its effectiveness in treating conditions like rhinitis.
Acid Value and its Implications
The acid value is another essential parameter reflecting the formulation's quality. It indicates the amount of free fatty acids produced as a result of hydrolysis, which could detrimentally impact the formulation's shelf life and effectiveness. A well-controlled acid value contributes to the stability and longevity of Shadbindu Ghrita. By monitoring this parameter, researchers can better understand the formulation's properties and potentials for deterioration over time, highlighting the importance of maintaining appropriate storage conditions and usage timelines.
HPTLC Analysis
High-Performance Thin Layer Chromatography (HPTLC) was employed in the study to further standardize Shadbindu Ghrita. The analytical technique revealed multiple distinct spots at various retention factors (Rf values) under differing UV conditions. Specifically, the scans at 254 nm identified five peaks, while those at 366 nm showed three peaks, and subsequent derivatization revealed eleven peaks. This extensive profiling serves to confirm the presence of different active constituents within the formulation, supporting its diversity and therapeutic potential.
Conclusion
In conclusion, the analytical study of Shadbindu Ghrita establishes significant quality benchmarks through organoleptic and physicochemical characterizations. The parameters, including saponification and acid values, along with HPTLC results, indicate that the formulation adheres to acceptable standards for clinical applications. These findings not only affirm the high-quality nature of Shadbindu Ghrita but also contribute to the broader efforts in standardizing Ayurvedic formulations for enhanced therapeutic validity in modern healthcare practices.
FAQ section (important questions/answers):
What is the purpose of drug standardization in Ayurveda?
The purpose of drug standardization is to determine the quality, efficacy, and identity of Ayurvedic formulations, ensuring that they meet safe and effective standards for use in clinical practice.
What constituents are found in Shadbindu ghrita?
Shadbindu ghrita is a polyherbal formulation that includes Bhringaraja, Lavanga, Yashtimadhu, Kushta, Shunti, and ghrita (clarified butter), which are beneficial in treating rhinitis.
What methods are used to analyze Shadbindu ghrita's quality?
Quality analysis of Shadbindu ghrita includes physicochemical tests like refractive index, saponification value, acid value, rancidity tests, and High-Performance Thin Layer Chromatography (HPTLC).
What were the organoleptic characteristics of Shadbindu ghrita?
The organoleptic characteristics of Shadbindu ghrita include a greenish-yellow color, granular semisolid appearance, and an aromatic odor, indicating its quality.
What does the saponification value indicate about Shadbindu ghrita?
The saponification value of Shadbindu ghrita, measured at 179.50, indicates the molecular weight and chain length of the fatty acids, suggesting good permeability through the nasal mucosa.
What conclusions can be drawn from the HPTLC analysis results?
The HPTLC analysis showed multiple peaks at different wavelengths, demonstrating the presence of various active constituents and confirming the quality of Shadbindu ghrita.
Glossary definitions and references:
Scientific and Ayurvedic Glossary list for “Analytical study of shadbindu gritha –a polyherbal preparation”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.
1) Ghrita (Ghrta):
Ghrita, a term in Ayurveda, refers to a type of medicinal ghee or clarified butter infused with herbs, promoting health and wellness. It serves therapeutic properties, particularly in treating various ailments when used in medicinal formulations, representing a blend of oil and herbal medicine in traditional practice.
2) Water:
Water is essential in both the preparation of Ayurvedic formulations and as a solvent for extracting active compounds from plants. In the context of 'Shadbindu ghrita', water assists in combining and refining ingredients, making optimal use of their therapeutic properties, ensuring the effectiveness of the final product.
3) Drug:
Drugs represent the various medicinal formulations derived from herbal ingredients. In the context of 'Shadbindu ghrita', understanding the nature of these drugs and their roles in treatment protocols is essential for integrating Ayurveda with conventional medical practices.
4) Ayurveda (Ayus-veda):
Ayurveda is a traditional Indian system of medicine focusing on balancing the body, mind, and spirit through natural remedies, including herbal preparations like 'Shadbindu ghrita'. It relies on ancient texts and practices aimed at holistic health, emphasizing the importance of natural substances for therapeutic purposes.
5) Table:
Tables are used in the study to present organized data, facilitating the comprehension of various analytical results such as organoleptic and physicochemical properties. They provide a clear comparison of findings, making it easier for researchers and practitioners to evaluate the quality and effectiveness of the formulations analyzed.
6) Bindu (Bimdu):
In the term 'Shadbindu', 'bindu' refers to a drop or point, often signifying concentration or potency in Ayurvedic formulations. It represents a significant aspect of herbal medicine, signifying the essence of the preparation, vital for understanding the traditional meanings and applications of various formulations.
7) Shash (Sad, Sas, Sash, Shad, Shas):
'Shad' translates to six in Sanskrit, representing the six key herbal components used in 'Shadbindu ghrita'. This number is significant in Ayurveda, where specific combinations of herbs enhance therapeutic efficacy, making the preparation a well-rounded formulation for treating ailments like rhinitis effectively.
8) Quality:
Quality in the context of drugs and formulations encompasses purity, potency, and efficacy. The analytical study of 'Shadbindu ghrita' aims to establish its quality parameters, ensuring that it meets the standards required for effective treatment and is safe for patient use in clinical practice.
9) Ghi (Ghee):
Ghee, a form of clarified butter used extensively in Indian cooking and Ayurveda, acts as a carrier for herbs in formulations like 'Shadbindu ghrita'. It enhances absorption of active constituents and provides therapeutic benefits, highlighting its significance as a foundational ingredient in Ayurvedic medicine.
10) Study (Studying):
The study represents a systematic investigation aimed at understanding the properties, efficacy, and standardization of 'Shadbindu ghrita'. It utilizes various analytical techniques to assess the formulation's quality, contributing valuable insights for its potential clinical applications in treating specific health conditions.
11) clarified butter:
Clarified butter is the primary component of 'Shadbindu ghrita', serving as a medium for delivering herbal active ingredients. It is integral in Ayurvedic medicine for its nourishing properties, promoting digestion, and enhancing the therapeutic effects of the combined herbs, allowing for better absorption and efficacy.
12) Karnataka:
Karnataka, a state in India, is home to many Ayurvedic institutions and practices. It serves as the location of the study and the preparation of 'Shadbindu ghrita', emphasizing the regional significance of Ayurveda and the availability of traditional knowledge and resources for research in herbal medicine.
13) India:
India is the birthplace of Ayurveda, an ancient system of medicine rooted in philosophy and nature. Its rich culture and tradition of herbal remedies provide a vast repository for studies like that of 'Shadbindu ghrita', illustrating the country's significant contribution to holistic health and wellness approaches worldwide.
14) Saussurea lappa:
Saussurea lappa, known as Kushta in Ayurveda, is one of the key ingredients in 'Shadbindu ghrita'. It is valued for its medicinal properties, particularly in treating respiratory ailments and skin issues. The presence of this herb contributes to the overall effectiveness of the formulation.
15) Bhringaraja (Bhrngaraja, Bhringa-raja, Bhrimgaraja):
Bhringaraja, or Eclipta alba, is a crucial Ayurvedic herb known for its restorative properties and benefits for hair and skin health. Its incorporation in 'Shadbindu ghrita' enhances the formulation's therapeutic value, promoting wellness and addressing ailments through traditional herbal medicine.
16) Yashtimadhu (Yastimadhu, Yashti-madhu):
Yashtimadhu, or Glycyrrhiza glabra, is another vital herb in 'Shadbindu ghrita'. Known for its soothing properties, it aids in respiratory health and has anti-inflammatory effects. This herb's inclusion underscores the importance of natural remedies in achieving balance and health in Ayurvedic practices.
17) Substance:
In this context, 'substance' refers to the various components that make up 'Shadbindu ghrita', specifically the active ingredients derived from herbs. Understanding these substances and their properties is crucial for determining the formulation's therapeutic efficacy and safety for users.
18) Lavanga (Lavamga):
Lavanga, known as Syzygium aromaticum or clove, is an important herbal ingredient in 'Shadbindu ghrita'. Its antibacterial and anti-inflammatory properties enhance the formulation’s effectiveness, showcasing the synergistic benefits of combining various herbs to achieve holistic therapeutic outcomes in Ayurveda.
19) Shrinivasa (Shri-nivasa, Srinivasa):
Shrinivasa refers to G. Shrinivasa Acharya, one of the contributors in this study. His expertise in Ayurveda and research plays a significant role in the standardization and analytical evaluation of 'Shadbindu ghrita', reflecting the collaborative nature of research in traditional medicine.
20) Discussion:
The discussion section is crucial for interpreting the results obtained from the study of 'Shadbindu ghrita'. It provides context, critiques methods, and relates findings to existing knowledge, guiding the understanding of the formulation’s quality, advantages, and areas for further research in Ayurveda.
21) Container:
A container is essential in the preparation and storage of 'Shadbindu ghrita', ensuring the integrity and preservation of the formulation. Proper containment prevents contamination and degradation, which is vital for maintaining the quality and efficacy of Ayurvedic medicines across time.
22) Science (Scientific):
Science, as a discipline, provides methodologies and frameworks essential for understanding and validating Ayurvedic formulations like 'Shadbindu ghrita'. It bridges traditional knowledge with modern research, facilitating the exploration of herbal remedies within scientific contexts, ensuring safety, efficacy, and quality assurance.
23) Disease:
Disease, in a broader sense, underscores the necessity for effective treatments like 'Shadbindu ghrita'. The research highlights the role of traditional formulations in managing health conditions, reinforcing the importance of integrating Ayurvedic practices into contemporary medicinal frameworks for effective healthcare solutions.
24) Prabhu:
Prabhu refers to Suchitra N. Prabhu, a research officer contributing to the study. Her involvement emphasizes the collaborative efforts in evaluating and standardizing 'Shadbindu ghrita', showcasing the importance of interdisciplinary teamwork in advancing Ayurvedic research and practices.
25) Purity:
Purity signifies the absence of contaminants and the integrity of the components in 'Shadbindu ghrita'. High purity standards are crucial for the formulation’s effectiveness, safety, and acceptability as a medicinal product, ensuring that users receive the full benefits intended by the Ayurvedic tradition.
26) Field:
Field refers to the domain of study and practice, in this case, Ayurveda. It encompasses the knowledge, techniques, and applications of herbal medicine, illustrating how 'Shadbindu ghrita' fits into broader health and wellness strategies within the Ayurvedic framework.
27) Line:
Line refers to the measured results and standards depicted in research. It signifies the clarity and continuity of findings related to 'Shadbindu ghrita', ensuring that the research accurately contributes to the understanding of its properties, quality, and therapeutic potential.
28) Fire:
Fire is an essential element in the preparation of 'Shadbindu ghrita', symbolizing the traditional methods used for extracting and combining ingredients through controlled heating. It serves a functional purpose in enhancing the efficacy of the formulation while also representing the transformative power of the Ayurvedic process.
29) Life:
Life embodies the holistic perspective of Ayurveda, aiming to promote balance and wellness through natural remedies like 'Shadbindu ghrita'. This concept emphasizes the importance of health in achieving overall well-being, highlighting how traditional practices contribute to the quality of life for individuals.
Other Science Concepts:
Discover the significance of concepts within the article: ‘Analytical study of shadbindu gritha –a polyherbal preparation’. Further sources in the context of Science might help you critically compare this page with similair documents:
Bhringaraja, Yashtimadhu, Kusta, Sumti, clarified butter, HPTLC, Refractive index, Saponification value, Iodine value, Acid value, Unsaponifiable matter, Rancidity test, Drug standardization.
Concepts being referred in other categories, contexts and sources.