Pharmaceutical and analytical study of panchatikta ghrita

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Journal name: World Journal of Pharmaceutical Research
Original article title: Pharmaceutical and analytical study of panchatikta ghrita
The WJPR includes peer-reviewed publications such as scientific research papers, reports, review articles, company news, thesis reports and case studies in areas of Biology, Pharmaceutical industries and Chemical technology while incorporating ancient fields of knowledge such combining Ayurveda with scientific data.
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Author:

Dr. Vijay Pratap Singh, BAMS, Dr. Sameet Masand M.D.(Ayu.) RS & BK, Dr. Jaganath Keshav M.D. (Ayu.) RS & BK and Dr. Sudhaldev Mohapatra M.D. (Ayu.) Phd RS & BK


World Journal of Pharmaceutical Research:

(An ISO 9001:2015 Certified International Journal)

Full text available for: Pharmaceutical and analytical study of panchatikta ghrita

Source type: An International Peer Reviewed Journal for Pharmaceutical and Medical and Scientific Research

Doi: 10.20959/wjpr202011-18712

Copyright (license): WJPR: All rights reserved


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Summary of article contents:

Introduction

Panchatikta Ghrita, a traditional Ayurvedic formulation, emphasizes the integration of herbal and fatty substances intended for therapeutic applications. Ayurveda, with its roots in ancient Indian Vedic texts like the Atharvaveda and Rigveda, details a holistic approach to health, highlighting the importance of balancing life energies. The current study aims to explore the pharmaceutical properties, standardization processes, and analytical evaluations of Panchatikta Ghrita. The study acknowledges the significance of Sneha Kalpana, a method for preparing medicinal formulations using lipid mediums like ghee and oil.

Pharmaceutical Processing of Sneha Kalpana

Sneha Kalpana, meaning the formulation of oily substances, plays a vital role in Ayurvedic medicine. It involves utilizing fatty materials combined with herbal preparations (kalka) to extract both water- and fat-soluble medicinal properties. This method can yield various forms depending on their intended use. The preparation process includes primary stages such as Sneha Murchhana (a special pharmaceutical procedure to improve fat quality) and Sneha Paka (the actual cooking phase with medicinal herbs). The efficacy of Sneha Kalpana is attributed to its ability to enhance the bioavailability of drugs, increase stability, and prolong the shelf life of the formulation.

Standardization of Ayurvedic Formulations

Standardization is crucial in ensuring the quality and efficacy of Ayurvedic formulations like Panchatikta Ghrita. This process involves raw material standardization, process standardization, and finished product standardization to establish reliable production methods. Analytical quality control helps confirm that each batch meets the required criteria, including the consistent content of active compounds. Such standardization ensures the therapeutic properties of the formulation while providing a framework for reliable clinical applications and promoting the integrity of Ayurvedic practices.

Analytical Evaluation Techniques

The analytical study of Panchatikta Ghrita focuses on parameters such as acid value, viscosity, rancidity, and microbiological analysis. Assessing acid value helps determine the quality of the oil and its stability, while viscosity gives insights into the formulation’s density and efficacy. Microbiological analysis ensures the safety of formulations by preventing contamination from harmful microorganisms. Results from these analytical evaluations provide critical insights into the stability and therapeutic potential of Panchatikta Ghrita, thus influencing its applicability in Ayurvedic treatments.

Conclusion

The comparative analysis of Panchatikta Ghrita prepared through classical methods (with Murchita Ghrita) and non-Murchita processes indicates that while the latter is cost-effective, the former offers higher therapeutic value and stability. The study's findings emphasize the need for rigorous analytical methodologies and standardization practices in the preparation of traditional Ayurvedic formulations. By integrating these methods, the efficacy, safety, and quality of Ayurvedic medicines can be assured, supporting the continuous evolution and recognition of Ayurveda in contemporary healthcare.

FAQ section (important questions/answers):

What is the focus of the study on Panchatikta Ghrita?

The study aims to evaluate the pharmaceutical and analytical properties of Panchatikta Ghrita, standardize its preparation, and assess its efficacy based on traditional Ayurvedic principles.

What does 'Sneha' and 'Kalpana' mean in Ayurveda?

In Ayurveda, 'Sneha' refers to fat or fatty substances, while 'Kalpana' denotes a pharmaceutical process for preparing medicaments, combining these elements to enhance therapeutic actions.

How does the preparation of Panchatikta Ghrita differ between methods?

The preparation of Panchatikta Ghrita using traditional Murchita Ghrita involves more time and effort, resulting in a higher therapeutic value compared to methods using non-Murchita Ghrita.

What are the advantages of Sneha Kalpana in Ayurvedic formulations?

Sneha Kalpana enhances the extraction of active principles, improves drug absorption, preserves medicinal properties, and allows for versatile internal and external usage.

What parameters are evaluated in the analytical study of Panchatikta Ghrita?

The analytical study assesses acid value, viscosity, rancidity, and the presence of heavy metals to determine the quality, stability, and therapeutic potential of Panchatikta Ghrita.

What conclusion was drawn regarding the cost and therapeutic value of Panchatikta Ghrita?

While Panchatikta Ghrita prepared by non-Murchita Ghrita is more economical, the analytical study shows that the classical method yields a product with greater therapeutic value.

Glossary definitions and references:

Scientific and Ayurvedic Glossary list for “Pharmaceutical and analytical study of panchatikta ghrita”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.

1) Sneha:
Sneha refers to fatty substances or oils within Ayurvedic medicine. It plays a crucial role in the preparation of medicinal formulations, enhancing the absorption of active ingredients in herbal therapies. The different properties of Sneha facilitate the stabilization and effectiveness of treatments.

2) Ghrita (Ghrta):
Ghritas is the plural form of Ghrita, indicating multiple types of clarified butter used in Ayurvedic medicine. Each variety serves distinct therapeutic purposes, and their formulations often enhance the effectiveness of herbal treatments through enhanced absorption.

3) Kalpana:
Kalpana denotes the pharmaceutical process in Ayurveda of preparing medicated formulations. It involves various methods of combining ingredients to create effective medicinal preparations. Understanding Kalpana is vital for practitioners to create remedies that adhere to traditional standards and efficacy.

4) Drug:
Drugs in Ayurveda are substances derived from herbs, minerals, or animal sources used for therapeutic benefits. The practice emphasizes the selection and preparation of quality drugs that align with individual constitution and health conditions, ensuring safe and effective treatments.

5) Paka:
Paka describes the cooking or formulation process in Ayurveda for creating specific types of medicinals. Different stages of Paka influence the properties and efficacy of the final product, thereby dictating the therapeutic use of Sneha kalpas like Ghrita.

6) Dravya:
Dravyas is the plural form of Dravya, encompassing various substances utilized in Ayurvedic formulations. Understanding the diverse characteristics and therapeutic potentials of Dravyas is fundamental for practitioners to create effective treatments tailored to individual patient needs.

7) Taila (Thaila):
Taila refers to oils extracted from various plant sources in Ayurveda. Like Ghrita, Taila serves as a medium for extracting active ingredients from herbs, vital for various therapeutic preparations. It is essential in external applications as well as internal treatments.

8) Samhita:
Samhita signifies a collection of texts in Ayurveda, such as Charaka Samhita and Sushruta Samhita. These texts serve as foundational documents that outline medical practices, herbal formulations, and methodological approaches to treatment, guiding practitioners in their therapeutic endeavors.

9) Water:
Water is an essential component in Ayurvedic formulations, often used as a solvent for extracting medicinal properties from herbs. Its quality can affect the efficacy of Ayurvedic preparations significantly, thus it is carefully considered during the preparation processes.

10) Study (Studying):
In the context of Ayurveda, study refers to the systematic examination of medicinal formulations, their properties, and effects on health. Rigorous study helps in the standardization, safety, and efficacy of Ayurvedic medicines, ensuring they provide the intended health benefits.

11) Kalpa:
Kalpas refer to various types of formulations in Ayurveda, each designed for specific therapeutic purposes. This includes Sneha kalpas like Ghrita and Taila modalities, fundamental to Ayurvedic pharmacology and patient care practices.

12) Quality:
Quality in Ayurvedic formulations pertains to the purity and efficacy of the ingredients and final products. It is ensured through stringent standards during preparation and processing, focusing on achieving consistent therapeutic outcomes while minimizing potential toxicity.

13) Ayurveda (Ayus-veda):
Ayurveda is an ancient system of medicine from India that focuses on holistic health, integrating physical, mental, and spiritual well-being. It emphasizes natural remedies, lifestyle practices, and the balance of bodily energies (doshas) for maintaining health and preventing disease.

14) Kalka:
Kalka refers to a fine paste made from herbs and other natural materials used in Ayurvedic preparations. This preparation method enhances the release of active compounds, facilitating their effectiveness in various therapeutic applications as part of Sneha kalpa.

15) Substance:
In Ayurveda, substance relates to any material used in medicinal formulations. This can include plant extracts, minerals, or animal products, each chosen for their unique medicinal properties, contributing to the therapeutic efficacy of Ayurvedic healing.

16) Vaidya:
Vaidyas, or Ayurvedic practitioners, serve as the custodians of traditional healing wisdom. They carry forward the principles of Ayurveda through patient care, emphasizing individualized treatments and holistic approaches derived from ancient texts.

17) Dravadravya (Drava-dravya):
Drava-dravya refers to liquid substances used in Ayurvedic formulations, such as water, decoctions, or juices. These are critical for integrating and facilitating the medicinal properties of solid Dravyas in therapeutic preparations.

18) Siddhi:
Siddhi denotes the perfection or successful achievement in the preparation of Ayurvedic medicines. It indicates the attainment of desirable properties and effectiveness in dosage forms, ensuring that therapeutic goals are met through meticulous preparation.

19) Drava:
Drava refers to liquid mediums or components in Ayurveda, essential for either dissolving or carrying solid herbal preparations in medicinal formulations. Their role is crucial in enhancing the bioavailability of active ingredients for therapeutic effects.

20) Vidyotini:
Vidyotini is a type of commentary or text in Ayurveda that elucidates teachings from ancient scriptures. Such commentaries help in understanding and interpreting classical texts, supporting practitioners in the application of Ayurvedic principles.

21) Lakshana (Laksana):
Lakshana refers to the characteristics or attributes of medicinal substances in Ayurveda. Understanding Lakshana is crucial for practitioners to identify the quality, efficacy, and appropriate use of drugs and formulations in treatment.

22) Varanasi (Varanashi):
Varanasi is a city in India known for its historical significance in Ayurveda. It serves as an educational hub for Ayurvedic studies and herbal medicine traditions, promoting the continuation of ancient knowledge and practices.

23) Medicine:
Medicine in Ayurveda encompasses the holistic practice of healing that integrates natural remedies, dietary guidelines, and lifestyle adjustments to restore health, emphasizing individualized care and prevention of disease through a balance of the body's energies.

24) Nature:
Nature refers to the inherent qualities and properties of substances used in Ayurvedic formulations. Understanding the nature of each ingredient is essential for practitioners to devise effective treatment plans and predict their interactions within the body.

25) Nasya (Nashya):
Nasya is a therapeutic procedure in Ayurveda involving the administration of medicated oils or powders through the nasal passages. It is used to treat conditions afflicting the head and neck while enhancing the functionality of the sensory organs.

26) Hindi (Himdi):
Hindi is one of the primary languages spoken in India and is often used in Ayurvedic texts and commentaries. As accessibility increases, Hindi translations of ancient teachings aid broader understanding and practice of Ayurvedic principles.

27) Yoni (Yonin):
Yoni refers to the source or origin of substances in Ayurveda. It denotes two primary classifications – Sthavara (plant-based) and Jangama (animal-based), leading to a better understanding of medicinal preparation sources tailored to specific ailments.

28) Discussion:
Discussion in the context of Ayurveda pertains to the collaborative examination and interpretation of therapeutic methods and medicinal properties. It is integral in academic and clinical settings for fostering critical approaches to Ayurvedic practices.

29) Abhyanga (Abhyamga):
Abhyanga is an Ayurvedic therapeutic massage with warm oils. It enhances blood circulation, alleviates stress, and revitalizes the body, embodying the essence of holistic care in Ayurveda while supporting overall health and relaxation.

30) Sthavara:
Sthavara refers to immobile or stationary substances in Ayurveda, primarily plants. Understanding Sthavara helps practitioners select appropriate herbal materials for therapies, essential for creating safe and effective formulations in herbal medicine.

31) Sanskrit:
Sanskrit is the ancient language of Ayurvedic texts, acting as the primary medium for documenting knowledge, principles, and practices of Ayurveda. Proficiency in Sanskrit enhances the understanding of classical texts and their application in modern contexts.

32) Ashtanga (Astanga, Ashtan-anga):
Astanga refers to the 'eight branches' of Ayurveda, which include different areas of specialization. Recognizing these branches is essential for practitioners to deliver comprehensive care, addressing various aspects of health and disease management.

33) Heating:
Heating in the context of Ayurvedic preparations refers to the process of cooking or processing herbs and Ghrita. It alters properties, enhances therapeutic potential, and promotes the extraction of active ingredients for medicinal use.

34) Mineral:
Minerals, as used in Ayurveda, represent essential natural substances that contribute to healing. Their inclusion in formulations assists in addressing specific deficiencies and promoting overall health, highlighting the holistic essence of Ayurvedic medicine.

35) Sharman (Sarma, Sarman, Sharma):
Sharma is a common surname in India, often linked to scholars and practitioners in Ayurveda. Individuals with this name may contribute to the field through studies, practices, or texts that explore and enhance Ayurvedic knowledge.

36) Khara:
Khara refers to coarse or harsh aspects in Ayurvedic terms, usually used to denote the characteristics of certain preparations or substances. Understanding Khara can help practitioners choose appropriate formulations for specific health conditions.

37) Veda:
Vedic refers to the ancient scriptures that form the foundation of Hindu philosophy and science, including Ayurveda. These texts guide the principles of health, healing, and spiritual practices essential for holistic well-being.

38) Pana:
Pana is a term for oral administration of herbal remedies in Ayurveda. It emphasizes the use of liquid formulations that provide systemic benefits, supporting the idea that proper administration contributes significantly to therapeutic efficacy.

39) Ghi (Ghee):
Ghee is another term for clarified butter in Ayurveda. Known for its numerous health benefits, Ghee serves as a rich carrier for active herbal components, enhancing the medicinal value of preparations while providing nourishment and stability.

40) Life:
Life, in terms of Ayurveda, signifies the holistic approach to health, emphasizing the balance among body, mind, and spirit. The Ayurvedic perspective nurtures life by advocating preventative care through lifestyle adjustments and natural remedies.

41) Sushruta-samhita (Susruta-samhita):
Susruta-samhita is another name for Sushruta-samhita, which details various surgical methodologies and principles in Ayurveda. This text is vital for understanding the rich history of surgical practices and their relevance in contemporary Ayurvedic medicine.

42) Karnapurana (Karna-purana):
Karnapurana is a specific Ayurvedic procedure that involves the application of medicated oils in the ears. This treatment supports auditory health and showcases the personalized approach of Ayurveda towards treating sensory organ-related afflictions.

43) Mridupaka (Mrdupaka):
Mrdu-paka emphasizes the gentle heating process in Ayurvedic formulations. Such methods target the preservation of active ingredients, which ensures that medicinal benefits remain potent and effective in therapies and treatments.

44) Anuvasana:
Anuvasana refers to a therapeutic enema using medicated oils in Ayurveda. It plays a vital role in managing various disorders, facilitating the absorption of healing substances while enhancing rectal health and detoxification.

45) Knowledge:
Knowledge is a core aspect in Ayurveda, ensuring practitioners are well-versed in herbal properties, treatment methodologies, and patient care. Continuous learning through ancient texts reinforces the effectiveness of Ayurvedic practices in promoting health.

46) Madhyama:
Madhyama signifies the medium cooking stage in Ayurvedic preparations. It indicates the balanced heating process that optimizes the release of active constituents without compromising their integrity, essential for effective medicinal formulations.

47) Amapaka (Ama-paka):
Ama-paka refers to the stage of cooking where impurities are removed in Ayurvedic preparations. This purification process enhances the stability and efficacy of herbal formulations, ensuring that they provide desired therapeutic outcomes.

48) Samgraha (Sangraha):
Samgraha is a collection or compilation of Ayurvedic texts and teachings. These encompass a wide range of knowledge, aiding practitioners in accessing vital information for effective patient care and comprehensive understanding of Ayurvedic principles.

49) Dharana:
Dharana refers to practices of holding or concentrating the mind, crucial for fostering mental clarity in Ayurvedic philosophy. It underlines the significance of mental health as part of overall wellness, integrating physical and psychological well-being.

50) Akalka:
A-kalka signifies the absence of the kalka or herbal paste in specific preparations. Its relevance lies in studying the variations in formulations that use whole herbs versus those that are finely processed, affecting the therapeutic properties of medicines.

51) Jangama (Jamgama):
Jangama refers to the mobile or movable sources in Ayurveda, primarily animal-based materials. Understanding Jangama helps practitioners in identifying appropriate ingredients for specific formulations and treatments, contributing to effective Ayurvedic practices.

52) Disease:
Disease in Ayurveda is viewed as a disruption of the body's natural harmony and balance. The aim is to treat and prevent disease through holistic approaches, focusing on restoring equilibrium among the body's doshas, mind, and spirit.

53) Science (Scientific):
Science in the context of Ayurveda relates to the systematic study and understanding of herbal medicines, their interactions, and therapeutic effects. The scientific approach complements traditional knowledge ensuring evidence-based practices in modern Ayurvedic medicine.

54) Acarya:
Acarya refers to a teacher or scholar in Ayurveda. They are pivotal in transmitting ancient knowledge, guiding practitioners in the application of Ayurvedic principles, and ensuring the integrity of traditional practices is upheld.

55) Madhya:
Madhya refers to the medium stage of processing, particularly in cooking methods like Paka. It signifies a balanced approach to formulating medicines that optimize the benefits of active ingredients while retaining their original properties.

56) Dagdha:
Dagdha signifies burnt, indicating a possible alteration in substances resulting from excessive heating in Ayurvedic preparations. Understanding Dagdha is crucial for identifying effective and safe practices in creating herbal remedies.

57) Medium:
Medium, in the context of Ayurveda, refers to the various substances used in formulations, which facilitate the extraction of active ingredients. The selection of the right medium influences the therapeutic properties and efficacy of the final product.

58) Dadhi:
Dadhi refers to yogurt or buttermilk in Ayurveda, utilized often in medicinal preparations for its cooling properties. It is critical in balancing doshas and as a vehicle for delivering other active ingredients in treatments.

59) Mridu (Mrdu):
Mrdu characterizes the delicate or soft aspects in Ayurvedic medicines and treatments. This is essential in specifying the appropriate methods for preparing and administering therapies for better healing outcomes.

60) Majja:
Majja represents marrow or bone marrow in Ayurveda, considered to have significant medicinal properties. Its usage is of great importance in formulations aimed at nourishing and rejuvenating the body, particularly in maintaining skeletal health.

61) Kanji (Kamji):
Kanji is a fermented beverage made from rice and water, known for its probiotic benefits in Ayurveda. Its role involves supporting digestive health and overall well-being, reflecting the traditional diet's emphasis on fermented foods.

62) Takra:
Takra refers to buttermilk in Ayurveda, which has cooling and digestive properties. It is used as a vehicle for various drugs and helps improve digestion and balance within the body.

63) Hara:
Hara denotes the act of removal or destruction, often associated with the purifying aspects of Ayurvedic treatments aimed at eliminating toxins or resolving imbalances in the body.

64) Vasa (Vasha):
Vasa refers to a specific type of fat derived from animal sources, utilized in various Ayurvedic preparations. Like Ghrita, it serves as a medium for extracting beneficial compounds and enhancing therapeutic potency.

65) Anga (Amga):
Anga refers to branches or limbs in Ayurveda, commonly associated with the different divisions of knowledge and practice. Understanding Angas enriches the awareness of various applications within Ayurvedic medicine.

66) Diet:
Diet in Ayurveda is pivotal for maintaining health and preventing disease. It promotes an understanding of balancing nourishment with the individual’s constitution, ensuring the right nutrients are provided to foster optimal health.

67) Line:
In Ayurveda, line refers to the lineage of knowledge transmission, the teachings of different Acaryas, and the historical progression of Ayurvedic practices. It is crucial for preserving authentic wisdom and practices throughout generations.

68) New Delhi:
New Delhi symbolizes the site of modern Ayurvedic education and practices in India, where various institutions and practitioners converge to promote traditional healing while integrating contemporary scientific research and methodologies.

69) Ashtangasamgraha (Astangasamgraha, Astangasangraha, Ashtanga-samgraha, Ashtanga-sangraha, Ashtangasangraha):
Astanga-samgraha is an ancient Ayurvedic text that covers the eight branches of Ayurveda. It serves as a comprehensive guide for practitioners in navigating various aspects of health and healing.

70) Ghritakalpana (Ghrtakalpana, Ghrita-kalpana):
Ghrta-kalpana refers to the specific methods of preparing Ghrita in Ayurveda. Understanding these techniques is crucial for practitioners to create potent and effective herbal formulations that enhance therapeutic effects.

71) Civilization:
Civilization denotes the historical and cultural development that shaped Ayurvedic practices. It reflects the social contexts and traditions influencing health practices and the evolution of healing systems.

72) Atharvaveda (Atharva-Veda):
Atharvaveda is one of the four Vedas in Hindu scripture, providing foundational knowledge for Ayurveda. It includes references to medicinal practices, thereby influencing the formulation and therapeutic principles in Ayurveda.

73) Calculation:
Calculation in Ayurveda involves analyzing and quantifying the components of formulations to ensure accuracy and standards in dosage. This practice enhances the reliability of treatments and their outcomes.

74) Performance:
Performance relates to the effectiveness and efficiency of Ayurvedic treatments. Through careful formulation and practice, the performance of medicines is upheld, ensuring they meet the intended therapeutic goals.

75) Pancatikta (Panca-tikta, Pancan-tikta, Pamcatikta):
Pancatikta refers specifically to a combination of five bitter herbs used in the preparation of Panchatikta Ghrita. These ingredients are essential for developing formulations that promote health and prevent disease.

[Note: The above list is limited to 75. Total glossary definitions available: 131]

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Discover the significance of concepts within the article: ‘Pharmaceutical and analytical study of panchatikta ghrita’. Further sources in the context of Science might help you critically compare this page with similair documents:

Sushruta-samhita, Dravadravya, Panchatiktaghrita, Quality Control, Ayurvedic formulation, Standard operating procedure, Loss on drying, Sneha Kalpana, Acid value, Peroxide value, Kalka Dravya, Heavy metal, Microbiological analysis, Rancidity, Snehapaka, Pharmaceutical properties.

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