A review on neurologic manifestations in major electrolytic abnormalities

| Posted in: Health Sciences Science

Journal name: World Journal of Pharmaceutical Research
Original article title: A review on neurologic manifestations in major electrolytic abnormalities
The WJPR includes peer-reviewed publications such as scientific research papers, reports, review articles, company news, thesis reports and case studies in areas of Biology, Pharmaceutical industries and Chemical technology while incorporating ancient fields of knowledge such combining Ayurveda with scientific data.
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Original source:

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Author:

Aiswarya Vasavan, Chitra C. Nair, Ammu S., Shaiju S. Dharan, Abdulla Shareef, Aleena Roy and Amal John James


World Journal of Pharmaceutical Research:

(An ISO 9001:2015 Certified International Journal)

Full text available for: A review on neurologic manifestations in major electrolytic abnormalities

Source type: An International Peer Reviewed Journal for Pharmaceutical and Medical and Scientific Research

Doi: 10.20959/wjpr202015-19289

Copyright (license): WJPR: All rights reserved


Download the PDF file of the original publication


Summary of article contents:

Introduction

The article provides a comprehensive review of the neurologic manifestations associated with major electrolytic abnormalities. Both central and peripheral nervous system disturbances can arise from imbalances in electrolytes, significantly influencing brain function. The authors highlight that these disturbances are primarily functional rather than structural, and can lead to severe, potentially life-threatening complications if not recognized and treated promptly. Understanding the association between electrolyte levels and neurological symptoms is crucial for effective management.

Seizures as a Neurologic Manifestation of Electrolyte Disturbances

One of the most significant aspects discussed in the paper is the occurrence of seizures as a result of various electrolyte imbalances. Specific disturbances, such as hyponatremia (low sodium), hypocalcemia (low calcium), and hypomagnesemia (low magnesium), are particularly implicated in the development of seizures. The paper emphasizes that seizures often manifest when serum sodium levels fall below critical thresholds, specifically as the sodium concentration decreases below 115-120 mEq/L. Neurologic symptoms like irritability, confusion, and gait disturbances may precede more severe outcomes, such as convulsions and unconsciousness, underlining the necessity for rapid intervention.

Causes and Diagnosis of Electrolyte Disturbances

A detailed examination of the causes of electrolyte disturbances is also provided. Factors contributing to conditions like hyponatremia include excessive fluid intake, congestive heart failure, and certain medications, among others. Conversely, hypernatremia can result from dehydration or excessive sodium intake. The authors stress the importance of diagnosing these imbalances, including a thorough serum chemistry evaluation, especially in populations at higher risk, such as the elderly. The text notes that between 15-30% of acute symptomatic seizures in older adults can be traced back to toxic or metabolite causes, thus emphasizing the need for careful diagnostic practices.

Management and Treatment Approaches

The review outlines various management strategies for correcting electrolyte abnormalities. For instance, the treatment of hyperkalemia (high potassium) involves a stepwise approach depending on severity, including the use of diuretics, glucose plus insulin, and in extreme cases, calcium to stabilize cardiac membranes. Similarly, for hyponatremia, hypertonic saline may be administered to restore sodium levels effectively, though this must be done cautiously to prevent osmotic demyelination. The treatment protocols highlight that timely management of these electrolyte disturbances is essential to prevent neurological complications.

Conclusion

In summary, the review accentuates the critical interplay between electrolyte levels and neurologic functions. It underscores the role of prompt diagnosis and treatment of electrolyte imbalances in preventing significant neurologic manifestations, including seizures. The paper advocates for a high degree of clinical vigilance and a proactive approach in managing electrolyte disorders, especially in vulnerable patient populations. Successful intervention can lead to favorable outcomes and mitigate the risk of permanent brain damage associated with prolonged disturbances.

FAQ section (important questions/answers):

What are the neurologic manifestations related to electrolyte disturbances?

Neurologic manifestations include seizures, confusion, headache, and dizziness, resulting from imbalances in sodium, potassium, calcium, and magnesium levels.

What are the causes of hyponatremia and its effects?

Hyponatremia can result from conditions like heart failure, excessive fluid intake, and certain medications. It may cause neurological symptoms, including seizures, especially when sodium levels drop below 125 mEq/L.

How can hyperkalemia affect neurological functions?

Hyperkalemia, defined as potassium levels exceeding 5 mEq/L, can lead to muscle weakness, paralysis, and respiratory failure, ultimately affecting the central nervous system.

What treatments are available for hypocalcemia?

Hypocalcemia can be treated with intravenous calcium administration, typically using calcium gluconate or calcium chloride, to quickly restore normal calcium levels and alleviate symptoms.

What prevention strategies exist for electrolyte disturbances?

Preventive measures include maintaining hydration, monitoring medications, and managing underlying health conditions to avoid rapid changes in electrolyte levels that can lead to neurological issues.

Why is early identification of electrolyte disturbances crucial?

Early identification is essential to promptly correct imbalances, preventing severe complications such as permanent brain damage and ensuring better outcomes for affected patients.

Glossary definitions and references:

Scientific and Ayurvedic Glossary list for “A review on neurologic manifestations in major electrolytic abnormalities”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.

1) Vacavan:
Vasavan refers to Aiswarya Vasavan, the lead author of the review article discussing neurologic manifestations associated with electrolyte imbalances. Their contributions underline the importance of understanding how electrolyte disturbances affect the central and peripheral nervous systems, thereby guiding diagnosis and treatment in clinical practice.

2) Water:
Water serves as a fundamental solvent in biological systems, helping to maintain cellular homeostasis and transport nutrients. Electrolyte disturbances can significantly affect water balance in the body, leading to conditions such as hyponatremia and hypernatremia, which can result in neurological symptoms including seizures and confusion.

3) Drug:
A drug is a chemical substance used for medical purposes, including the treatment of electrolyte imbalances. The review emphasizes how specific drugs, such as diuretics and antidepressants, can contribute to altered electrolyte levels, thus impacting neurological function, making careful monitoring essential.

4) Disease:
Diseases often lead to or exacerbate electrolyte disturbances, which can result in significant neurologic consequences. Understanding this relationship is vital for preventing complications and managing patients effectively.

5) Depression:
Depression, in this context, relates to central nervous system (CNS) dysfunction as a result of electrolyte imbalances, particularly hyponatremia and hypernatremia. The article highlights how such disturbances can lead to mood changes, confusion, and other cognitive impairments crucial for patient assessment.

6) Activity:
Activity in this context pertains to both neuronal and muscular functions that are influenced by proper electrolyte balance. Disturbances in electrolytes can lead to altered cellular activity, impacting neurophysiological processes and leading to symptoms such as seizures or muscle weakness.

7) Science (Scientific):
Science underpins the systematic study of electrolyte disturbances and their neurologic manifestations. The findings from such studies help develop guidelines for identifying, treating, and managing conditions associated with electrolytic imbalances, contributing significantly to clinical knowledge.

8) Table:
Tables in medical research summarize data succinctly, such as the various degrees of electrolyte disturbances and their associated neurologic symptoms. This helps clinicians quickly assess the severity of a patient's condition and decide on appropriate treatment protocols.

9) Coma:
Coma is a state of prolonged unconsciousness that can result from severe electrolyte imbalances. The review discusses how conditions like hyponatremia can lead to neurological emergencies, including coma, illustrating the critical need for the prompt diagnosis and treatment of these imbalances.

10) Life:
Life is fundamentally influenced by homeostasis, with electrolytes playing a crucial role in maintaining cellular functions. Proper electrolyte balance is vital for life, as disturbances can lead to severe health issues including seizures, confusion, and potential fatal outcomes without appropriate treatment.

11) Kerala:
Kerala is a state in India where the study was conducted, highlighting regional healthcare challenges related to electrolyte disturbances. Understanding local healthcare practices and patient demographics is important for addressing these conditions effectively in the community and enhancing clinical outcomes.

12) India:
India is the country of origin for the research, emphasizing the need for awareness and management of electrolyte imbalances within its diverse population. Exploring regional factors, including nutrition and healthcare access, can improve patient care strategies across the nation.

13) Edema (Oedema):
Edema refers to the abnormal accumulation of fluid in tissues, which can result from electrolyte imbalances, particularly hypernatremia or hyponatremia. Recognizing edema as a symptom helps clinicians assess the severity of electrolyte disturbances and their potential impact on patient health.

14) Death:
Death serves as the ultimate consequence of untreated or mismanaged electrolyte imbalances. The review stresses the importance of recognizing and treating these imbalances promptly to avoid severe outcomes, including mortality, emphasizing the critical nature of clinical vigilance.

15) Sign:
The term sign pertains to observable indicators that healthcare professionals use to assess electrolyte disturbances. Recognizing clinical signs associated with electrolyte imbalances is crucial for diagnosis and treatment planning in patients presenting with neurological symptoms.

16) Malnutrition:
Malnutrition can lead to electrolyte imbalances due to inadequate intake of essential nutrients. The review emphasizes the importance of addressing nutritional factors in managing patients with neurological manifestations related to electrolytic disturbances, underscoring the interconnection between diet and health.

17) Mineral:
Minerals, such as sodium, potassium, calcium, and magnesium, are vital electrolytes necessary for normal physiological functions. The review highlights how disturbances in these essential minerals can lead to significant neurological symptoms, emphasizing their crucial role in health and disease.

18) Nausea:
Nausea is a common symptom associated with electrolyte imbalances, particularly hyponatremia. The review indicates the importance of recognizing nausea as an early sign that may prompt further evaluation for underlying electrolyte disturbances in clinical patients.

19) Reason:
Reason pertains to the underlying causes of electrolyte disturbances, which can be multifactorial, including medications, diseases, and dietary issues. Understanding these reasons helps clinicians devise effective management strategies for patients experiencing neurologic manifestations.

20) Line:
Line refers to defined protocols or guidelines in medical practice. Understanding electrolyte imbalances requires adherence to lines of treatment based on current clinical evidence to ensure appropriate management of patients presenting with neurologic symptoms.

21) Human body:
The human body relies on a balanced distribution of electrolytes for normal functioning, including neurological health. The review highlights that disturbances can lead to significant clinical implications, emphasizing the interconnectedness of body systems and the importance of electrolyte regulation.

22) Measurement:
Measurement refers to the practice of quantifying biochemical markers such as electrolyte levels in patient care. Precise measurement helps in diagnosing conditions, informing treatment decisions, and tracking changes in the patient’s electrolyte status over time.

23) Alleviation:
Alleviation pertains to the reduction of symptoms associated with electrolyte disturbances, such as seizures or confusion. Effective treatment strategies aim for the alleviation of these symptoms through appropriate management of underlying imbalances, improving patient quality of life.

24) Developing:
Developing new treatment protocols for managing electrolyte disturbances is essential for improving clinical outcomes. This involves continuous research and adaptation of evidence-based practices to address the complexities associated with electrolyte imbalances and their neurologic impacts.

25) Drowsiness:
Drowsiness can be a symptom of electrolyte imbalances, particularly hyponatremia. The review highlights drowsiness as an important neurologic symptom that requires clinical attention, as it can indicate more severe underlying disturbances needing urgent intervention.

26) Antibiotic (Antibacterial):
The term antibiotic can refer to medications that may impact electrolyte levels as a side effect. Understanding the interactions between antibiotics and electrolyte disturbances is vital for healthcare providers to manage potential complications effectively.

27) Evolution:
Evolution in this context relates to the progressive understanding of the relationship between electrolyte imbalances and neurological function. Continuous research and clinical observations lead to advancements in treatment approaches and improve patient care strategies over time.

28) Toxicity:
Toxicity refers to the harmful effects that can arise from imbalances in electrolytes or the intake of toxic substances. Recognizing toxicity as a potential cause of neurologic symptoms is critical for accurate diagnosis and appropriate management in clinical settings.

29) Vomiting:
Vomiting is a common symptom associated with severe electrolyte imbalances, particularly when sodium levels are low. The review discusses the importance of recognizing vomiting as a clinical sign that may indicate the need for immediate electrolyte evaluation and management.

30) Swelling:
Swelling, or edema, can result from electrolyte imbalances affecting tissue fluid distribution. It serves as a physical sign of underlying disturbances, highlighting the need for proper diagnosis and management of these conditions to prevent further complications.

31) Bleeding:
Bleeding can occur in severe cases of electrolyte imbalances, particularly when associated with trauma or underlying conditions. The review indicates the importance of monitoring for bleeding risks in patients with significant electrolyte disturbances and neurologic symptoms.

32) Relative:
Relative conditions refer to the context in which electrolyte disturbances are assessed in patients. Understanding the relative impact on neurologic symptoms is essential for healthcare providers to tailor treatment protocols effectively based on individual patient needs.

33) Delusion (Deluded):
Delusion can occur as a neurocognitive symptom stemming from severe electrolyte imbalances like hyponatremia. Recognizing delusions as signs of electrolyte disturbances is crucial for timely intervention and treatment planning in affected patients.

34) Neurosis:
Neurosis reflects various psychological disorders that may manifest as symptoms related to electrolyte disturbances. The review implies a relationship between psychiatric manifestations and electrolyte imbalance, underscoring the need for comprehensive patient evaluations.

35) Vertigo:
Vertigo, a sensation of spinning or loss of balance, can be associated with electrolyte imbalances, particularly in hyponatremia. Recognizing vertigo as a symptom of electrolyte disturbances helps guide further evaluation and management.

36) Dhanya:
Dhanya Dharman is acknowledged in the article as a guiding figure for the authors, representing mentorship and knowledge that supports the development of research on electrolyte imbalances and their neurological implications.

37) Ulcer:
An ulcer refers to a sore that develops on the lining of the stomach or intestine, which can be impacted by electrolyte disturbances and fluid imbalances. Understanding the implications of electrolyte levels on ulcer formation is essential in holistic patient management.

38) Fever:
Fever can induce changes in electrolyte balance due to altered metabolism and hydration levels. Recognizing the connection between fever and electrolyte disturbances is crucial for effective patient assessment and treatment strategies.

39) Post:
Post refers to sequelae or outcomes following an episode of electrolyte disturbance. Understanding the post-episode status is essential for comprehensive patient care management to prevent further complications.

Other Science Concepts:

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Discover the significance of concepts within the article: ‘A review on neurologic manifestations in major electrolytic abnormalities’. Further sources in the context of Science might help you critically compare this page with similair documents:

Proper functioning, Headache, Electrolyte imbalance, Normal saline, Gait disturbance, Hyponatremia, Hypokalemia, Electrolyte disturbances, Hypomagnesemia, Hypercalcemia, Sodium concentration, Hyperkalemia, Cerebral edema, Hypocalcemia, Hypernatremia, Seizure, Neurologic manifestation.

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